List of works - Karen Ashe

'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

scientific article published on 09 June 2010

A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins

scientific article published on 18 April 2019

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

scientific article published on 30 July 2019

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients

scientific article published on 30 July 2019

A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

scientific article published on 02 March 2020

A specific amyloid-beta protein assembly in the brain impairs memory

scientific journal article published in 2006. 14 July 2022 Editor’s Note: readers are advised to use caution when using results reported therein.

A tale about tau.

scientific article published in August 2007

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

scientific article

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

scientific article published in April 2007

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

scientific article

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

scientific article published on November 2005

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

scientific article published on 31 July 2008

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

scientific article published in June 2000

Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

scientific article published on 12 May 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

scientific journal article

Brain amyloid-β oligomers in ageing and Alzheimer's disease

scientific article

Caspase-2 cleavage of tau reversibly impairs memory

scientific article published on 10 October 2016

Cellular prion protein and class-specific Aβ oligomers mediate plaque-associated cytopathology in a mouse model of Alzheimer’s disease

Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile

scientific article published on 6 May 2015

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

scientific article

Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults ⬇️

scientific article published on May 1, 2013

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

scientific article published in March 2008

Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice

scientific article published on 04 November 2019

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

scientific article

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

scientific article

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

scientific article published on 01 November 1999

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

scientific article

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

scientific article published on 06 June 2019

Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau ⬇️

scientific article published on June 18, 2012

Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice

scientific article

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

scientific article published on August 2000

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

scientific article published on 01 January 2008

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

scholarly article

Learning and memory in transgenic mice modeling Alzheimer's disease

scientific article

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

scientific article

Mechanisms of memory loss in Abeta and tau mouse models.

scientific article published in August 2005

Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease.

scientific article published in January 2006

More than a FAD: the in vivo effects of disease-linked presenilin-1 mutations

scientific article published in March 2015

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

scientific article

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

scientific article (publication date: 2005)

Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures.

scientific article published on 08 June 2008

Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction

scientific article published on 13 June 2019

Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

scientific article published on 01 January 2000

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

scientific article

Prions, prionoids and pathogenic proteins in Alzheimer disease

scientific article published on 03 December 2012

Probing the biology of Alzheimer's disease in mice

scientific article

Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease

scholarly article by Alix de Calignon et al published October 2012 in Neuron

Propagation of tau pathology in a model of early Alzheimer's disease

scientific article (publication date: 23 February 2012)

Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice

scientific article published on January 2017

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

scientific article published on 4 June 2015

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

scientific article

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

scientific journal article

Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model

scientific article published on 01 October 1999

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies ⬇️

scientific article published on 22 October 2019

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration ⬇️

scientific article published on December 22, 2010

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?

scientific article published on 09 May 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

scientific article

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

scientific article

β-Amyloid oligomers in aging and Alzheimer's disease

scientific article published on 04 July 2013

List of works by Karen Ashe

'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients

A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

A specific amyloid-beta protein assembly in the brain impairs memory

A tale about tau.

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Caspase-2 cleavage of tau reversibly impairs memory

Cellular prion protein and class-specific Aβ oligomers mediate plaque-associated cytopathology in a mouse model of Alzheimer’s disease

Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults ⬇️

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau ⬇️

Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

Learning and memory in transgenic mice modeling Alzheimer's disease

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

Mechanisms of memory loss in Abeta and tau mouse models.

Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease.

More than a FAD: the in vivo effects of disease-linked presenilin-1 mutations

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures.

Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction

Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

Prions, prionoids and pathogenic proteins in Alzheimer disease

Probing the biology of Alzheimer's disease in mice

Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease

Propagation of tau pathology in a model of early Alzheimer's disease

Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies ⬇️

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration ⬇️

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

β-Amyloid oligomers in aging and Alzheimer's disease