Advanced search

Authors whose works are in public domain in at least one jurisdiction

List of works by Karen MacKenzie

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

scientific article published in April 2018

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells

scientific article

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

scientific article published on 06 September 2016

A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts.

scientific article published on 6 November 2007

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts

scientific article published on 09 August 2016

Assessment and quantification of telomerase enzyme activity.

scientific article

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

scientific article published on 30 November 2004

Differentially expressed genes from RNA-Seq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols

scientific article

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

scientific article published on 2 May 2011

Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study

scientific article published on 17 February 2016

Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization.

scientific article

FLT-3: a new focus in the understanding of acute leukemia

scientific article (publication date: June 2005)

Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc.

scientific article published on July 2013

Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.

scientific article published in February 2007

Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization.

scientific article published on 10 August 2004

Induction of vascular endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway.

scientific article

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes

scientific article

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

scientific article

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

scientific article published on 13 April 2016

Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

scientific article published in September 2000

Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells.

scientific article published on 7 July 2010

Modeling human endothelial cell transformation in vascular neoplasias

scientific article

Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.

scientific article published in June 2002

Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53

scientific article published on 01 October 1997

New prospects for targeting telomerase beyond the telomere.

scientific article published on 24 June 2016

Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.

scientific article published on October 2005

Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo.

scientific article published on 11 May 2006

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias

scientific article

Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout

scientific article published on 13 August 2015

Telomerase promotes formation of a telomere protective complex in cancer cells

scientific article published on 02 October 2019

Telomere length of cord blood-derived CD34(+) progenitors predicts erythroid proliferative potential

scientific article published on 08 March 2007

Telomere-Driven Karyotypic Complexity Concurs with p16INK4a Inactivation in TP53-Competent Immortal Endothelial Cells

scientific article published on 01 November 2006

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells ⬇️

scientific article published on January 1, 2002

Therapeutic targeting of replicative immortality

scientific article

Up-regulation of Survivin during Immortalization of Human Myofibroblasts Is Linked to Repression of Tumor Suppressor p16INK4a Protein and Confers Resistance to Oxidative Stress ⬇️

scientific article published on February 28, 2013

Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

scientific article

V-myc in a simple, single gene retroviral vector causes rapid induction of leukemia and concomitant apoptosis following bone marrow transplantation ⬇️

scientific article published on April 1, 1998

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

p21(WAF1) modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia.

scientific article published on 27 October 2015

p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

scientific article

Paulina is supported by:

About Paulina

Help