List of works - Nancy Ruddle

A dendritic-cell-stromal axis maintains immune responses in lymph nodes

scientific article

A humanized mouse model of autoimmune insulitis.

scientific article published on 29 January 2014

A switch in pathogenic mechanism in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in IFN-γ-inducible lysosomal thiol reductase-free mice

scientific article

A yeast‐based recombinogenic targeting toolset for transgenic analysis of human disease genes ⬇️

scientific article published on 01 October 2010

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

scientific article published on 14 November 2019

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice

scientific article

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

Basics of Inducible Lymphoid Organs

scientific article published on 26 June 2020

Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses

scientific article published on 16 September 2011

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

scientific article

Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions

scientific article published in Science

Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis

scientific article published on 10 October 2016

Depletion of CD4(+)CD25(+) T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens

scientific article published on November 2009

Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.

scientific article

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent

scientific article published in January 2007

Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase ⬇️

scientific article published on May 5, 2003

Focal experimental autoimmune encephalomyelitis in the Lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor

scientific article published in October 2010

Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma ⬇️

scientific article published on November 30, 2012

Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue

scientific article

High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature ⬇️

scientific article published on January 1, 2011

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

scientific article

I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue

scientific article published in November 2004

Identification of a new stromal cell type involved in the regulation of inflamed B cell follicles

scientific article

Impaired lymphatic contraction associated with immunosuppression

scientific article published on 7 November 2011

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.

scientific article

Lymphatic vessel function in head and neck inflammation

scientific article published on September 2013

Lymphatic vessels and tertiary lymphoid organs

scientific article published on 03 March 2014

Lymphocyte traffic in lymphoid organ neogenesis: differential roles of Ltalpha and LTalphabeta

scientific article

Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection

scientific article published on 01 March 2005

Lymphoid organ development: from ontogeny to neogenesis

scientific article

Lymphotoxin and TNF: how it all began-a tribute to the travelers

scientific article

Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin

scientific article

Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production

scientific article published on 10 February 2020

Lymphotoxin-alpha contributes to lymphangiogenesis

scientific article

MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection

scientific article published in August 2004

Obituary. Charles A. Janeway, Jr. (1943-2003).

scientific article

Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology

scientific article

Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.

scientific article published in March 2014

Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs

scientific article

ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets ⬇️

scientific article published on February 4, 2012

Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice

scientific article

Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein ⬇️

scientific article published on May 7, 2011

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

scientific article

Role of lymphotoxin alpha in T-cell responses during an acute viral infection.

scientific article

Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response

scientific article published on August 2009

Synchrony of high endothelial venules and lymphatic vessels revealed by immunization

scientific article published in September 2006

Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response

scientific article published on July 28, 2012

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation

scientific article published on 23 September 2015

The role of AIRE in human autoimmune disease

scientific article

Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules

scholarly article

Workshop Summary: Roles of the TNF Family in Normal Development and Cancer ⬇️

scientific article published on 01 January 2011

List of works by Nancy Ruddle

A dendritic-cell-stromal axis maintains immune responses in lymph nodes

A humanized mouse model of autoimmune insulitis.

A switch in pathogenic mechanism in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in IFN-γ-inducible lysosomal thiol reductase-free mice

A yeast‐based recombinogenic targeting toolset for transgenic analysis of human disease genes ⬇️

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

Basics of Inducible Lymphoid Organs

Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions

Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis

Depletion of CD4(+)CD25(+) T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens

Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent

Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase ⬇️

Focal experimental autoimmune encephalomyelitis in the Lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor

Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma ⬇️

Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue

High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature ⬇️

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue

Identification of a new stromal cell type involved in the regulation of inflamed B cell follicles

Impaired lymphatic contraction associated with immunosuppression

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.

Lymphatic vessel function in head and neck inflammation

Lymphatic vessels and tertiary lymphoid organs

Lymphocyte traffic in lymphoid organ neogenesis: differential roles of Ltalpha and LTalphabeta

Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection

Lymphoid organ development: from ontogeny to neogenesis

Lymphotoxin and TNF: how it all began-a tribute to the travelers

Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin

Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production

Lymphotoxin-alpha contributes to lymphangiogenesis

MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection

Obituary. Charles A. Janeway, Jr. (1943-2003).

Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology

Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.

Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs

ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets ⬇️

Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice

Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein ⬇️

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

Role of lymphotoxin alpha in T-cell responses during an acute viral infection.

Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response

Synchrony of high endothelial venules and lymphatic vessels revealed by immunization

Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation

The role of AIRE in human autoimmune disease

Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules

Workshop Summary: Roles of the TNF Family in Normal Development and Cancer ⬇️