List of works - Kunihiro Hayakawa

Alkaline phosphatase vs luciferase as secreted reporter molecules in vivo.

scientific article published in April 2005

Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

scientific article published on 27 April 2007

Bioassay-based screening of microorganisms that degrade dioxin using substrate-immobilized microtubes.

scientific article published on 3 October 2005

Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus.

scientific article published on October 2008

Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. ⬇️

scientific article

Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.

scientific article published on 29 October 2007

Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis.

scientific article published on 8 January 2018

Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients

scientific article published on 26 December 2017

Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells.

scientific article published on 13 March 2013

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons

scientific article

ER stress depresses NF-kappaB activation in mesangial cells through preferential induction of C/EBP beta

scientific article

Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells.

scientific article published on October 2005

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

scientific journal article

High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing.

scientific article published in July 2006

Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2α pathway.

scientific article published on 15 June 2011

Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP).

scientific article

Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds.

scientific article published on 21 June 2005

Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis

scientific article published on 19 November 2015

Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.

scientific article

Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder.

scientific article

Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response.

scientific article published on 17 December 2007

JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation.

scientific article published on 22 August 2017

Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.

scientific article

MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling

scientific article published on 14 February 2019

Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor -- dioxin responsive element signaling pathway.

scientific article published on June 2006

Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata.

scientific article

Priming of glomerular mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli.

scientific article published on February 2006

Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia.

scientific article published on 28 July 2006

Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo.

scientific article published in August 2005

RhoH deficiency induces psoriasis-like chronic dermatitis by promoting T17 cell polarization

scientific article published on 17 October 2018

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes.

scientific article published on 5 July 2006

Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.

scientific article published on 7 February 2011

Selective deletion of adipocytes, but not preadipocytes, by TNF-alpha through C/EBP- and PPARgamma-mediated suppression of NF-kappaB.

scientific article published on 21 June 2010

Spontaneous activation of the NF-kappaB signaling pathway in isolated normal glomeruli.

scientific article published on 16 May 2006

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.

scientific article published on 17 September 2008

Suppression of nephrin expression by TNF-alpha via interfering with the cAMP-retinoic acid receptor pathway.

scientific article

The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study

scientific article published on 25 October 2016

Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress.

scientific article published on 6 September 2007

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection

scientific article

List of works by Kunihiro Hayakawa

Alkaline phosphatase vs luciferase as secreted reporter molecules in vivo.

Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

Bioassay-based screening of microorganisms that degrade dioxin using substrate-immobilized microtubes.

Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus.

Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. ⬇️

Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.

Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis.

Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients

Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells.

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons

ER stress depresses NF-kappaB activation in mesangial cells through preferential induction of C/EBP beta

Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells.

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing.

Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2α pathway.

Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP).

Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds.

Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis

Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.

Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder.

Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response.

JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation.

Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.

MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling

Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor -- dioxin responsive element signaling pathway.

Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata.

Priming of glomerular mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli.

Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia.

Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo.

RhoH deficiency induces psoriasis-like chronic dermatitis by promoting T17 cell polarization

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes.

Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.

Selective deletion of adipocytes, but not preadipocytes, by TNF-alpha through C/EBP- and PPARgamma-mediated suppression of NF-kappaB.

Spontaneous activation of the NF-kappaB signaling pathway in isolated normal glomeruli.

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.

Suppression of nephrin expression by TNF-alpha via interfering with the cAMP-retinoic acid receptor pathway.

The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study

Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress.

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection