List of works by Henk-Jan Guchelaar

5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot study

scientific article

A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

scientific article published on 31 March 2015

A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma.

scientific article published on 28 February 2018

A brighter future for the implementation of pharmacogenomic testing

scientific article published on 31 August 2016

A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis

article

A combination of two truncating mutations in USH2A causes more severe and progressive hearing impairment in Usher syndrome type IIa.

scientific article published on 15 June 2016

A computerized adverse drug event alerting system using clinical rules: a retrospective and prospective comparison with conventional medication surveillance in the Netherlands

scientific article published in March 2011

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

scientific article published on 11 December 2018

A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making

scientific article published on 02 May 2018

A decade of pharmacogenomics research on tyrosine kinase inhibitors in metastatic renal cell cancer: a systematic review

scientific article published on 3 February 2016

A nationwide cross-sectional survey of pharmacy students on pharmacogenetic testing in The Netherlands

scientific article published on 23 February 2018

A nationwide survey of pharmacists' perception of pharmacogenetics in the context of a clinical decision support system containing pharmacogenetics dosing recommendations.

scientific article published on 23 January 2017

A novel specific pyrosequencing method for genotyping FCGR3A rs396991 without coamplification of homologous gene FCGR3B.

scientific article

A pharmacological rationale for improved everolimus dosing in oncology and transplant patients

scientific article published on 06 May 2018

A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans

scientific article published on September 2000

A splinter

scientific article published on 01 June 2001

A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application?

scientific article published on 30 July 2011

A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis

scientific article

A validated assay for the simultaneous quantification of six tyrosine kinase inhibitors and two active metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

scientific article published on 17 August 2013

ABSTRACTS OF THE DUTCH SOCIETY OF CLINICAL PHARMACOLOGY AND BIOPHARMACY MEETING OF MARCH 27 2009

scholarly article published November 2009 in British Journal of Clinical Pharmacology

Aberrant CYP2D6 metabolizer phenotypes do not show increased frequency in patients undergoing ECT after antidepressant therapy

scientific article published on 30 July 2015

Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats

scientific article published on 2 February 2005

Abstracts of the Dutch Society of Clinical Pharmacology and Biopharmacy meeting of March 26, 2013

scholarly article published 19 September 2014 in British Journal of Clinical Pharmacology

Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab

scientific article

Acute effects of high-dose furosemide on residual renal function in CAPD patients

scientific article published in July 2003

Acute hepatitis in a patient using a Chinese herbal tea--a case report

scientific article published on 01 February 1998

Adverse drug reactions on sexual functioning: a systematic overview

scientific article published on 25 January 2019

Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy

scientific article published in June 2008

Alternative methods to a TaqMan assay to detect a tri-allelic single nucleotide polymorphism rs757210 in the HNF1β gene

scientific article published on 21 October 2011

An accelerated stability study of 5-flucytosine in intravenous solution

scientific article published on 01 February 1999

An association study of riluzole serum concentration and survival and disease progression in patients with ALS.

scientific article published on 26 September 2007

An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora.

scientific article published in May 2003

Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics

scientific article

Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model.

scientific article published on January 1998

Apoptosis: molecular mechanisms and implications for cancer chemotherapy

scientific article published on June 1997

Application of the Bow-Tie model in medication safety risk analysis: consecutive experience in two hospitals in the Netherlands

scientific article published in January 2009

Are Angiotensin II Receptor Antagonists Safe in Patients With Previous Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema?

scientific article published on 01 January 2001

Assessing the Implementation of Pharmacogenomic Panel-Testing in Primary Care in the Netherlands Utilizing a Theoretical Framework

scientific article published on 17 March 2020

Assessment of ethnic differences in sunitinib outcome between Caucasian and Asian patients with metastatic renal cell carcinoma: a meta-analysis.

scientific article

Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis

scientific article

Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.

scientific article

Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer

scientific article published on 24 August 2010

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for and CD39

article

Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma.

scientific article

Beneficial Effects of the mTOR Inhibitor Everolimus in Patients with Advanced Medullary Thyroid Carcinoma: Subgroup Results of a Phase II Trial

scientific article

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

scientific article

Breath tests to phenotype drug disposition in oncology

scientific article

Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmaco

scientific article published on 8 November 2013

CORRIGENDUM: Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

scientific article published on 01 July 2017

CYP1A2 activity is an important determinant of clozapine dosage in schizophrenic patients

scientific article

CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study

scientific article

CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial

CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial

scientific article published on 11 July 2013

CYP2D6 genotype- and endoxifen-guided tamoxifen dose escalation increases endoxifen serum concentrations without increasing side effects.

scientific article

CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.

scientific article

Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil.

scientific article

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials.

scientific article published on 10 June 2013

Cardiotoxicity of cytotoxic drugs

scientific article

Ciprofloxacin-phenytoin interaction.

scientific article published in April 1997

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

scientific article published on 31 January 2018

Clinical Pharmacokinetics and Pharmacodynamics of the Epidermal Growth Factor Receptor Inhibitor Panitumumab in the Treatment of Colorectal Cancer.

scientific article published in April 2018

Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease

scientific article published on December 2009

Clinical and pharmacogenetic factors associated with irinotecan toxicity

scientific article published on 16 June 2008

Clinical development of gene- and cell-based therapies: overview of the European landscape

scientific article

Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer

scientific article published on January 2009

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure

scientific article published in July 2012

Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen

scientific article published on 30 April 2019

Clinical pharmacokinetics of tyrosine kinase inhibitors

scientific article

Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients

scientific article published on June 2015

Co-ordinated isolation of CD8(+) and CD4(+) T cells recognizing a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immunotherapy

scientific article

Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection

scientific article

Comment on: Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate

scientific article published on 13 July 2009

Comment on: The pharmacogenetics of methotrexate.

scientific article published on 25 January 2008

Comment: global formulary review: how do we integrate pharmacogenomic information?

scientific article published on 20 July 2011

Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group.

scientific article

Concordance of genotype for polymorphisms in DNA isolated from peripheral blood and colorectal cancer tumor samples

scientific article

Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review

scientific article published on 08 July 2011

Confirmation practice in pharmacogenetic testing; how good is good enough?

scientific article published on 21 December 2018

Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer.

scientific article published on 24 April 2010

Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study

scientific article published on 12 June 2009

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

scientific article

Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity

scientific article published on August 2007

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

scientific article published on 19 October 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how? - Authors' reply

scientific article published on 01 February 2019

Description of the EuroTARGET cohort: A European collaborative project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity.

scientific article published on 3 April 2017

Detailed analysis of IFNg response upon activation permits efficient isolation of cytomegalovirus-specific CD8+ T cells for adoptive immunotherapy

scientific article published in June 2009

Development of a computerised alert system, ADEAS, to identify patients at risk for an adverse drug event

scientific article published in December 2010

Development of a pharmacokinetic model of mitotane: toward personalized dosing in adrenocortical carcinoma

scientific article published on 01 February 2015

Development of cell therapy medicinal products by academic institutes

scientific article

Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing

scientific article published on 12 June 2019

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants

article

Differences in 5-hydroxytryptamine-3B haplotype frequencies between Asians and Caucasians.

scientific article

Direct access of drugs to the human brain after intranasal drug administration?

scientific article published in May 2003

Discontinuation of ropinirole and pramipexole in patients with Parkinson's disease: clinical practice versus clinical trials

scientific article published on 15 July 2008

Does use of estrogens decrease the Breslow thickness of melanoma of the skin? Oral contraceptives and hormonal replacement therapy

scientific article published on 01 October 2009

Dopamine agonists and ischemic complications in Parkinson's disease: a nested case-control study.

scientific article published on 22 July 2011

Dried blood spot analysis for therapeutic drug monitoring of pazopanib

scientific article

EU decision-making for marketing authorization of advanced therapy medicinal products: a case study

scientific article published on 21 March 2018

Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease.

scientific article published on 9 July 2016

Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease

scientific article

Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus

scientific article published on November 2010

Effect of CYP3A4*22, CYP3A5*3, and CYP3A Combined Genotypes on Cyclosporine, Everolimus, and Tacrolimus Pharmacokinetics in Renal Transplantation

scientific article published on 12 February 2014

Effect of CYP3A4*22, CYP3A5*3, and CYP3A combined genotypes on tamoxifen metabolism.

scientific article published on 28 August 2017

Effect of cigarette smoking on imatinib in patients in the soft tissue and bone sarcoma group of the EORTC.

scientific article

Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.

scientific article published on 12 April 2010

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST.

scientific article

Effect of genetic polymorphisms in genes encoding GST isoenzymes on BU pharmacokinetics in adult patients undergoing hematopoietic SCT.

scientific article published on 28 March 2011

Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation.

scientific article

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

scientific article published in November 2005

Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

scientific article

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

scientific article published on April 2006

Efficiency and mechanism of antigen-specific CD8+ T-cell activation using synthetic long peptides

scientific article published in February 2012

Emphasizing the value of phenotyping in patients receiving tamoxifen

scientific article published on 19 December 2011

Epidemiology of extracutaneous melanoma in the Netherlands

scientific article published on 25 May 2010

Erratum to: Making sense of big data in health research: towards an EU action plan

scientific article

Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis

scientific article

Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case-control study.

scientific article

Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

scientific article published on 20 April 2017

Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy

scientific article published on 9 November 2015

Evaluation of clinical implementation of prospective DPYD genotyping in 5-fluorouracil- or capecitabine-treated patients

scientific article

Evaluation of predictive tests for screening for dihydropyrimidine dehydrogenase deficiency.

scientific article published on 16 July 2013

Evaluation of rule effectiveness and positive predictive value of clinical rules in a Dutch clinical decision support system in daily hospital pharmacy practice

scientific article published on 7 May 2013

Everolimus in Patients With Advanced Follicular-Derived Thyroid Cancer: Results of a Phase II Clinical Trial

scientific article published on 01 February 2017

Everolimus pharmacokinetics and its exposure-toxicity relationship in patients with thyroid cancer.

scientific article published on 11 May 2016

Excision Repair Cross-Complementation group 1 (ERCC1) C118T SNP does not affect cellular response to oxaliplatin

scientific article published on 9 November 2013

Explaining variability in ciclosporin exposure in adult kidney transplant recipients

scientific article

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

scientific article published in April 2009

Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array

scientific article published on 16 June 2009

Exploratory analysis of 1936 SNPs in ADME genes for association with busulfan clearance in adult hematopoietic stem cell recipients.

scientific article

Exploratory analysis of candidate germline gene polymorphisms in breast cancer patients treated with neoadjuvant anthracycline-containing chemotherapy and associations with febrile neutropenia.

scientific article published on 20 August 2015

Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients

scientific article published on 01 February 2007

Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

scientific article published on 10 May 2016

Exposure to phototoxic NSAIDs and quinolones is associated with an increased risk of melanoma

scientific article published on 8 March 2013

Failing hormones

scientific article published on 01 November 2011

FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.

scientific article published in January 2015

Feasibility of pharmacy-initiated pharmacogenetic screening for CYP2D6 and CYP2C19.

scientific article published on 8 October 2011

Flexible and Scalable Full-Length CYP2D6 Long Amplicon PacBio Sequencing.

scientific article published on 3 January 2017

Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions

scientific article (publication date: August 2000)

Flucytosine: correlation between toxicity and pharmacokinetic parameters.

scientific article

Fluoropyrimidine toxicity in patients with dihydropyrimidine dehydrogenase (DPD) splice site variant: the need for further revision of dose and schedule.

scientific article

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

scientific article published on 25 September 2018

Formulas for calculating body surface area

scientific article published in February 2002

Formulation, quality control and shelf life of the experimental cytostatic drug cyclopentenyl cytosine

scientific article published on 01 April 2006

Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis

scientific article published in February 2010

Further characterization of a ¹³C-dextromethorphan breath test for CYP2D6 phenotyping in breast cancer patients on tamoxifen therapy.

scientific article published on 20 April 2015

GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group.

scientific article published on 16 September 2008

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis

scientific article published in December 2009

Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population

scientific article

Genetic markers of treatment response in rheumatoid arthritis

scientific article published on October 2006

Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.

scientific article published on 30 October 2015

Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib

scientific article published on 24 January 2017

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

scientific article published on 19 November 2010

Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors

scientific article published on 04 February 2019

Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib.

scientific article

Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy

scientific article published on 17 August 2018

Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate.

scientific article published on January 2013

Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatment

scientific article published on 01 August 2011

Genetics of rheumatoid arthritis contributes to biology and drug discovery

scientific article

GenoChip CYP2D6 macroarray as a method to genotype for CYP2D6 variants: results of a validation study in a Caucasian population

scientific article published on 01 May 2015

Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer

scientific article published on 29 July 2015

Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab

scientific article published in PLoS ONE

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

scientific article

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis

scientific article

Genotype-Guided Thiopurine Dosing Does not Lead to Additional Costs in Patients With Inflammatory Bowel Disease

scientific article published on 01 July 2019

Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients

scientific article published on 13 October 2016

Genotyping of DNA samples isolated from formalin-fixed paraffin-embedded tissues using preamplification

scientific article

Germline variants in the CYP19A1 gene are related to specific adverse events in aromatase inhibitor users: a substudy of Dutch patients in the TEAM trial

article

Glutathione S-transferase polymorphisms are not associated with population pharmacokinetic parameters of busulfan in pediatric patients.

scientific article published in August 2008

Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients

scientific article

Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial.

scientific article published in April 2010

High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study

scientific article

High-quality genotyping data from formalin-fixed, paraffin-embedded tissue on the drug metabolizing enzymes and transporters plus array.

scientific article published on January 2015

Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors

scientific article published on February 2014

Hurdles in clinical implementation of academic advanced therapy medicinal products: A national evaluation

scientific article published on 5 April 2016

Hyperthermic isolated regional perfusion of the limb with carboplatin

scientific article published on 01 December 2000

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

scientific article

Impact of chemotherapy-induced nausea and vomiting on quality of life in indonesian patients with gynecologic cancer

scientific article

Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

article

Implementation of Pharmacogenomics in Everyday Clinical Settings

scientific article published on 01 January 2018

Implementation of a computerized physician medication order entry system at the Academic Medical Centre in Amsterdam

scientific article published on 01 June 2003

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

scientific article published on 27 December 2016

Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project

scientific article published on 9 February 2018

Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin

scientific article published on 13 November 2006

Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach

scientific article published on September 1997

Individualized dosing of tyrosine kinase inhibitors: are we there yet?

scientific article published on 22 September 2014

Individualizing calcineurin inhibitor therapy in renal transplantation--current limitations and perspectives.

scientific article published on January 2010

Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

scientific article

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.

scientific article

Influence of initial use of serotonergic antidepressants on antiparkinsonian drug use in levodopa-using patients

scientific article published on 03 January 2007

Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.

scientific article published on 10 May 2015

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

scientific article

Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults

scientific article published on 8 April 2008

Insights into the role of heritable genetic variation in the pharmacokinetics and pharmacodynamics of anticancer drugs

scientific article published on June 2007

Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01)

scientific article

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene

scientific article

Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS.

scientific article published on October 2001

Is rectal administration an alternative route for imatinib?

scientific article published on 08 February 2007

Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin?

scientific article published on 22 October 2007

Just how feasible is pharmacogenetic testing in the primary healthcare setting?

scientific article published on 01 April 2012

Lapatinib for advanced or metastatic breast cancer

scientific article published on 3 April 2012

Limited antitumor-effect associated with toxicity of the experimental cytotoxic drug cyclopentenyl cytosine in NOD/scid mice with acute lymphoblastic leukemia

scientific article published on 24 April 2007

Liposomal drug formulations in cancer therapy: 15 years along the road

scientific article published on 29 September 2011

Liquid chromatography-tandem mass spectrometry outperforms fluorescence polarization immunoassay in monitoring everolimus therapy in renal transplantation

scientific article published in August 2010

Low literacy and written drug information: information-seeking, leaflet evaluation and preferences, and roles for images

scientific article published on 21 September 2016

MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer

scientific article published in April 2013

Making sense of big data in health research: Towards an EU action plan

scientific article

Marginal increase of sunitinib exposure by grapefruit juice

scientific article

Medical education in pharmacogenomics-results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx).

scientific article

Medication error due to ambiguous labelling of a commercial product

scientific article published in February 2004

Medication errors: hospital pharmacist perspective

scientific article

Melanoma incidence and exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers

scientific article published on 07 November 2009

Meta-analysis on the association of VEGFR1 genetic variants with sunitinib outcome in metastatic renal cell carcinoma patients

scientific article

Midazolam as a phenotyping probe to predict sunitinib exposure in patients with cancer

scientific article published on 23 October 2013

Minimum Effective Doses of Succinylcholine and Rocuronium During Electroconvulsive Therapy: A Prospective, Randomized, Crossover Trial

scientific article published on 10 March 2016

Mitotane has a strong and a durable inducing effect on CYP3A4 activity.

scientific article

More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing

scientific article published on 20 June 2017

Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1.

scientific article published on September 2006

Myelosuppression by sunitinib is flt-3 genotype dependent.

scientific article published on 3 August 2010

Nasal drug delivery to the cerebrospinal fluid: transport of a lipophilic compound.

scientific article

Non-Cancer Drug Repurposing Candidates for Renal Cell Carcinoma

scientific article published on 01 March 2019

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

scientific article

Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study

scientific article published on 9 July 2009

Novel insights in pharmacogenetics of drug response in Parkinson's disease.

scientific article published in February 2010

Once-daily intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics and early clinical outcomes

scientific article published on October 2006

Optimalization of the clinical pharmacogenetic model to predict methotrexate treatment response: the influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond.

scientific article published in August 2009

Outcomes of an antimicrobial control program in a Dutch hospital

scientific article published on 01 August 2004

PROCEEDINGS OF THE DUTCH SOCIETY FOR CLINICALPHARMACOLOGY AND BIOPHARMACY 7 April 2000.

scientific article published in November 2000

PROCEEDINGS OF THE DUTCH SOCIETY OF CLINICAL PHARMACOLOGY AND BIOPHARMACY MEETING OF OCTOBER 4TH 2005

scholarly article published 15 March 2006 in British Journal of Clinical Pharmacology

Pathway analysis to identify genetic variants associated with efficacy of adalimumab in rheumatoid arthritis.

scientific article

Patients' beliefs about medicine are associated with early thiopurine discontinuation in patients with inflammatory bowel diseases

scientific article published on 8 November 2017

Patients' preferences for visuals: differences in the preferred level of detail, type of background and type of frame of icons depicting organs between literate and low-literate people

scientific article published on 31 October 2014

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis

scholarly article by Thierry Dervieux et al published January 2012 in Pharmacogenetics and Genomics

Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years

scientific article published on 19 September 2007

Personalised drug repositioning for Clear Cell Renal Cell Carcinoma using gene expression.

scientific article published on 27 March 2018

Personalized busulfan and treosulfan conditioning for pediatric stem cell transplantation: the role of pharmacogenetics and pharmacokinetics

scientific article published on 16 April 2014

Pharmaceutical pictograms for low-literate patients: Understanding, risk of false confidence, and evidence-based design strategies.

scientific article published on 19 December 2016

Pharmacist-Initiated Pre-Emptive Pharmacogenetic Panel Testing with Clinical Decision Support in Primary Care: Record of PGx Results and Real-World Impact

scientific article published on 29 May 2019

Pharmacogenetic biomarkers for predicting drug response.

scientific article published on 24 May 2014

Pharmacogenetic information in clinical guidelines - the European perspective.

scientific article published on 20 February 2018

Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer.

scientific article published on 3 November 2010

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

scientific article published on 10 September 2009

Pharmacogenetics in chemotherapy of colorectal cancer

scientific article published on January 2009

Pharmacogenetics in electroconvulsive therapy and adjunctive medications.

scientific article published on 26 June 2015

Pharmacogenetics in oncology: a promising field

scientific article published on January 2010

Pharmacogenetics in the cancer clinic: from candidate gene studies to next-generation sequencing

scientific article published on 21 January 2014

Pharmacogenetics in the clinic.

scientific article published in September 2013

Pharmacogenetics in transplant patients: mind the mix

scientific article published on 24 May 2013

Pharmacogenetics in treatment of rheumatoid arthritis.

scientific article published on January 2010

Pharmacogenetics of EGFR and VEGF inhibition

scientific article

Pharmacogenetics of antiparkinsonian drug treatment: a systematic review.

scientific article published on February 2007

Pharmacogenetics of small-molecule tyrosine kinase inhibitors: Optimizing the magic bullet.

scientific article published on December 2010

Pharmacogenetics of taste: turning bitter pills sweet?

scientific article published on January 2014

Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors

scientific article

Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle.

scientific article published in July 2010

Pharmacogenetics: From Bench to Byte

scientific article published on 06 February 2008

Pharmacogenetics: call to action

scientific article published on 31 August 2011

Pharmacogenetics: current status and future perspectives.

scientific article published in January 2010

Pharmacogenetics: from bench to byte--an update of guidelines

scientific article

Pharmacogenomics, a novel section in the European Journal of Human Genetics

scientific article published on 02 July 2018

Pharmacokinetic-pharmacodynamic modeling of the inhibitory effect of erythromycin on tumour necrosis factor-alpha and interleukin-6 production

scientific article published on 01 December 2001

Pharmacokinetics and safety of cetuximab in a patient with renal dysfunction.

scientific article published on 6 April 2014

Pharmacokinetics and safety of panitumumab in a patient with chronic kidney disease.

scientific article published on 23 November 2017

Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency.

scientific article published on 18 May 2011

Pharmacokinetics of panitumumab in a patient with liver dysfunction: a case report

scientific article published on 21 November 2013

Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype.

scientific article published in April 2008

Pharmacokinetics of treosulfan in pediatric patients undergoing hematopoietic stem cell transplantation.

scientific article published in August 2014

Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy.

scientific article

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review

scientific article published on 07 September 2020

Phenotyping drug disposition in oncology

scientific article published on 04 January 2012

Plasmid derived external quality controls for genetic testing

scientific article published on 01 January 2013

Polymorphisms in endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) predict sunitinib-induced hypertension

scientific article

Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer.

scientific article published on June 2017

Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers

scientific article published on 24 July 2015

Population pharmacokinetics and pharmacogenetics of everolimus in renal transplant patients

scientific article published on 01 July 2012

Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients.

scientific article

Population pharmacokinetics of flucytosine: comparison and validation of three models using STS, NPEM, and NONMEM.

scientific article published in December 2000

Population pharmacokinetics of lenalidomide in multiple myeloma patients.

scientific article published on 30 December 2016

Population pharmacokinetics of treosulfan in paediatric patients undergoing hematopoietic stem cell transplantation

scientific article published on 01 July 2019

Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease

scientific article published on 4 December 2006

Prediction of flucytosine-induced thrombocytopenia using creatinine clearance

scientific article

Preventing adverse drug events in hospital practice: an overview

scientific article published on October 2007

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time.

scientific article published on 21 December 2015

Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry

scientific article

Quantitative determination of melatonin in human plasma and cerebrospinal fluid with high-performance liquid chromatography and fluorescence detection

scientific article

Quantitative determination of thalidomide in human serum with high-performance liquid chromatography using protein precipitation with trichloroacetic acid and ultraviolet detection

scientific article published on 01 November 1999

Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl chloride

scientific article published on 01 December 1998

Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

scientific article

Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.

scientific article

Recommendations on management of EGFR inhibitor-induced skin toxicity: a systematic review.

scientific article

Regarding: 'Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array'

scientific article published on June 2010

Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis

scientific article published on 01 September 2006

Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer

scientific article published on 15 April 2011

Relationship between specific adverse events and efficacy of exemestane therapy in early postmenopausal breast cancer patients

scientific article published on 02 August 2012

Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers

scientific article

Replication of a genetic variant in ACYP2 associated with cisplatin-induced hearing loss in patients with osteosarcoma.

scientific article

Reply to R. Ferraldeschi et al

Response: Limited sampling strategies for once daily tacrolimus exposure monitoring

article by D J A R Moes et al published 2 March 2016 in European Journal of Clinical Pharmacology

Riluzole serum concentrations in patients with ALS: associations with side effects and symptoms.

scientific article published in October 2003

Risk and the sense of safety

scientific article published on 01 June 2003

Risk assessment in clinical pharmacy

scientific article

Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype

scientific article published on 15 September 2017

SLC04A1, SLC22A2 and SLC28A2 variants not related to methotrexate efficacy or toxicity in rheumatoid arthritis patients

scientific article published on 27 April 2018

Safety and efficacy of the addition of simvastatin to cetuximab in previously treated KRAS mutant metastatic colorectal cancer patients.

scientific article

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.

scientific article published in September 2015

Short-term variation in plasma mitotane levels confirms the importance of trough level monitoring

scientific article published on 08 September 2014

Simultaneous determination of clozapine, norclozapine and clozapine-N-oxide in human plasma by high-performance liquid chromatography with ultraviolet detection

scientific article

Simultaneous determination of flucytosine and fluorouracil in human plasma by high-performance liquid chromatography

scientific article

Simultaneous isolation of CD8(+) and CD4(+) T cells specific for multiple viruses for broad antiviral immune reconstitution after allogeneic stem cell transplantation

scientific article published in April 2011

Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer.

scientific article published on 18 August 2017

Sirolimus and everolimus in kidney transplantation

scientific article

Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers

article

Statin use is not associated with improved progression free survival in cetuximab treated KRAS mutant metastatic colorectal cancer patients: results from the CAIRO2 study

scientific article

Sunitinib-induced hypertension in CYP3A4 rs4646437 A-allele carriers with metastatic renal cell carcinoma.

scientific article published on 26 January 2016

Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study

scientific article published on 24 January 2019

Tamoxifen metabolism and efficacy in breast cancer- a prospective multicentre trial

scientific article published on 19 February 2018

Technologies for Pharmacogenomics: A Review

scientific article published on 04 December 2020

The Dutch model for clinical pharmacology: collaboration between physician- and pharmacist--clinical pharmacologists

scientific article published on 13 March 2008

The Dutch vision of clinical pharmacology.

scientific article published on April 2009

The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity

scientific article

The Oxford Handbook of Clinical Pharmacy.

scientific article published on 20 February 2008

The Risk of Cancer in Users of Statins

scientific article published on 01 June 2004

The Ubiquitous Pharmacogenomics consortium: making effective treatment optimization accessible to every European citizen

scientific article published on 07 July 2017

The antioxidant N-acetylcysteine does not delay disease onset and death in a transgenic mouse model of amyotrophic lateral sclerosis

scientific article published on 01 August 1998

The challenges of developing a 'medical-grade' genome

scientific article published on 01 March 2012

The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen

scientific article

The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly

scientific article published on 28 October 2009

The extent and effects of patient involvement in pictogram design for written drug information: a short systematic review

scientific article published on 07 May 2018

The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine

scientific article published on 3 January 2017

The impact of estimated tumour purity on gene expression-based drug repositioning of Clear Cell Renal Cell Carcinoma samples

The possibility of obtaining marketing authorization of orphan pharmaceutical compounding preparations: 3,4-DAP for Lambert-Eaton Myasthenic Syndrome

scientific article published on 27 November 2017

The potential role of computerisation and information technology in improving prescribing in hospitals

scientific article published on 01 June 2003

The role of pharmacogenetics in capecitabine efficacy and toxicity

scientific article

The role of pharmacogenetics in drug disposition and response of oral glucose-lowering drugs

scientific article published on October 2013

The role of pharmacogenetics in the treatment of osteosarcoma

scientific article published on 25 June 2016

The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients.

scientific article published on 13 May 2010

The use of the 13C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.

scientific article published on 11 December 2012

Therapeutic drug monitoring of tacrolimus and mycophenolic acid in outpatient renal transplant recipients using a volumetric dried blood spot sampling device

scientific article published on 15 October 2018

Therapeutic drug monitoring to individualize the dosing of pazopanib: a pharmacokinetic feasibility study

scientific article published on 01 June 2015

Therapeutic modulation of k-ras signaling in colorectal cancer

scientific article published on 02 June 2010

Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis

article

Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis.

scientific article published on 15 September 2008

Transcriptome Signature Reversion as a Method to Reposition Drugs Against Cancer for Precision Oncology

scientific article published on 01 March 2019

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

scientific article published on 12 August 2015

Translating pharmacogenomics: challenges on the road to the clinic

scientific article

Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia.

scientific article published on 25 January 2011

Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio

scientific article

UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study.

scientific article published on July 2008

Ubiquitous Pharmacogenomics (U-PGx): The time for implementation is now. An Horizon2020 program to drive pharmacogenomics into clinical practice

scientific article published on 02 January 2017

Understanding clinical development of chimeric antigen receptor T cell therapies

scientific article published on 19 April 2017

Unlicensed pharmaceutical preparations for clinical patient care: Ensuring safety

scientific article published on 19 October 2017

Use of angiotensin receptor antagonists in patients with ACE inhibitor induced angioedema

scientific article published in August 2004

Use of plasmid-derived external quality control samples in pharmacogenetic testing

scientific article published on September 2008

Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients

scientific article published on 10 January 2019

Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping

scientific article

Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction

scientific article published on 29 August 2012

What do we need to make genetic biomarker-guided treatment for renal cell carcinoma a reality?

scientific article published on 14 December 2016

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