Search filters

List of works by Roman Hajek

1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens

scientific article published on 22 May 2012

A first Czech analysis of 1887 cases with monoclonal gammopathy of undetermined significance

scientific article published on 6 April 2017

A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma

scientific article published on 28 December 2019

A phase I/II dose-escalation study investigating all-oral ixazomib-melphalan-prednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma

scientific article published on 28 June 2018

A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS).

scientific article

Activity of aldehyde dehydrogenase in B-cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors.

scientific article

Additional genetic abnormalities significantly worsen poor prognosis associated with 1q21 amplification in multiple myeloma patients.

scientific article published on 6 June 2012

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients.

scientific article published on 25 November 2017

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

scientific article published on 01 July 2018

Association of aneuploidy category with centrosome amplification in multiple myeloma

scientific article published on 03 June 2011

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: a pooled analysis.

scientific article published on 23 December 2016

Biobanking strategy and sample preprocessing for integrative research in monoclonal gammopathies.

scientific article published on 30 March 2017

Bone marrow plasma cell separation - validation of separation algorithm.

scientific article published on 31 January 2012

Bortezomib, thalidomide and dexamethasone, with or without cyclophosphamide, for patients with previously untreated multiple myeloma: 5-year follow-up.

scientific article published on 7 July 2015

CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma

scientific article published on 08 October 2016

Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease.

scientific article

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

scientific article

Carfilzomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study ENDEAVOR (NCT01568866) according to age subgroup.

scientific article

Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial

scientific article published on 23 August 2017

Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma

scientific article published on 28 February 2019

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma.

scientific article published on 20 July 2016

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma

article

Carfilzomib, lenalidomide, and dexamethasone in patients with relapsed multiple myeloma categorised by age: secondary analysis from the phase 3 ASPIRE study

scientific article

Carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR.

scientific article

Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment

scientific article

Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia ⬇️

scientific article published on July 3, 2013

Centrosome amplification and clonal evolution in multiple myeloma: Short review.

scientific article

Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma.

scientific article published on 21 January 2010

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma.

scientific article published on 28 May 2016

Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial

scientific article

Chimeric antigen receptor T-cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network

scientific article published on 22 August 2019

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

scientific article published on 21 September 2015

Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance

scientific article

Cladribine (2-chlorodeoxyadenosine) in frontline chemotherapy for adult Langerhans cell histiocytosis: A single-center study of seven cases ⬇️

scientific article published on August 31, 2012

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

scientific article published on 23 March 2013

Clinical predictors of long-term survival in newly diagnosed transplant eligible multiple myeloma - an IMWG Research Project

scientific article published on 23 November 2018

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

scientific article published on 16 January 2015

Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project

scientific article

Complete remission of multiple myeloma associated scleredema after bortezomib-based treatment.

scientific article published on 15 November 2012

Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial

scientific article published on 13 December 2011

Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2.

scientific article published on 03 February 2011

Consensus statement from European experts on the diagnosis, management, and treatment of multiple myeloma: from standard therapy to novel approaches.

scientific article published on August 2010

Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma

article

Continuous Therapy Versus Fixed Duration of Therapy in Patients With Newly Diagnosed Multiple Myeloma.

scientific article

Current applications of multiparameter flow cytometry in plasma cell disorders

scientific article published on 20 October 2017

Cytogenetics in multiple myeloma patients progressing into extramedullary disease.

scientific article

Cytokine analysis in a patient with relapsing Kikuchi-Fujimoto disease

scientific article published on 06 December 2011

Dendritic cell biology and the application of dendritic cells to immunotherapy of multiple myeloma.

scientific article

Deregulated expression of long non-coding RNA UCA1 in multiple myeloma

scientific article

Design and rationale of FOCUS (PX-171-011): a randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)

scientific article

Detection of tumor-specific marker for minimal residual disease in multiple myeloma patients.

scientific article

Development and validation of a novel risk stratification algorithm for relapsed multiple myeloma

scientific article published on 06 August 2019

Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview

scientific article published on 7 June 2016

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients

scientific article published on 20 December 2019

Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study.

scientific article published on 6 April 2017

Efficacy and safety of Id-protein-loaded dendritic cell vaccine in patients with multiple myeloma--phase II study results.

scientific article published in January 2012

Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes

scientific article published on 25 April 2017

Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation.

scientific article published on 10 April 2009

European Myeloma Network guidelines for the management of multiple myeloma-related complications

scientific article

European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma

scientific article published on February 2014

European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma.

scientific article published on 31 August 2010

European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias

scientific article published on 23 July 2018

European perspective on multiple myeloma treatment strategies in 2014

scientific article

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

scientific article published on 21 April 2017

Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors.

scientific article published on January 2010

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

scientific article

Factors that influence health-related quality of life in newly diagnosed patients with multiple myeloma aged ≥ 65 years treated with melphalan, prednisone and lenalidomide followed by lenalidomide maintenance: results of a randomized trial

scientific article

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma.

scientific article

Flow cytometry in immunoglobulin light chain amyloidosis: Short review.

scientific article published on 13 July 2015

Flow cytometry-based enumeration and functional characterization of cd8 t regulatory cells in patients with multiple myeloma before and after lenalidomide plus dexamethasone treatment ⬇️

scientific article published on August 6, 2013

Focus on monoclonal antibodies targeting B-cell maturation antigen (BCMA) in multiple myeloma: update 2020

scientific article published on 20 November 2020

From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives

scientific article

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment.

scientific article

Gain of 1q21 is an unfavorable genetic prognostic factor for multiple myeloma patients treated with high-dose chemotherapy.

scientific article published on 18 January 2010

Gain(1)(q21) is an unfavorable genetic prognostic factor for patients with relapsed multiple myeloma treated with thalidomide but not for those treated with bortezomib

scientific article published on 04 January 2013

Generation of antigen-loaded dendritic cells in a serum-free medium using different cytokine combinations

scientific article published on 01 February 2003

Genome-wide screening of cytogenetic abnormalities in multiple myeloma patients using array-CGH technique: a Czech multicenter experience.

scientific article

Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).

scientific article published on 4 April 2017

Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance

scientific article published on 9 May 2016

Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report

scientific article

Health-Related Quality of Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.

scientific article published on 6 September 2016

Health-related quality of life in the ENDEAVOR study: carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed/refractory multiple myeloma

article

High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma

scientific article

High-risk multiple myeloma: different definitions, different outcomes?

scientific article published on 28 September 2013

Identification of patients with smouldering multiple myeloma at ultra-high risk of progression using serum parameters: the Czech Myeloma Group model

scientific article published on 12 March 2020

IgM myeloma: A multicenter retrospective study of 134 patients

scientific article published on 6 April 2017

Immunomodulatory drugs in AL amyloidosis

scientific article

Immunoparesis in MGUS - Relationship of uninvolved immunoglobulin pair suppression and polyclonal immunoglobuline levels to MGUS risk categories

scientific article published on 17 August 2015

Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study

scientific article published on 05 August 2016

Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH.

scientific article published in January 2014

Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.

scientific article

Induction by lenalidomide and dexamethasone combination increases regulatory cells of patients with previously untreated multiple myeloma

scientific article published on 31 January 2012

Interdigitating dendritic cell sarcoma of the leg.

scientific article

Interleukin-2 Activation of Haematopoietic Stem Cells

scientific article published on 01 January 2002

International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation

scientific article

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders

scientific article

International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation

scientific article published on 04 June 2009

International Myeloma Working Group recommendations for global myeloma care

scientific article published on 09 October 2013

International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)

scientific article published on 16 October 2020

International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100).

scientific article published on 25 June 2009

Interpreting clinical trial data in multiple myeloma: translating findings to the real-world setting

scientific article published on 09 November 2018

Lenalidomide proved effective in multisystem Langerhans cell histiocytosis

scientific article published on 21 November 2011

Lenalidomide, melphalan, and prednisone, followed by lenalidomide maintenance, improves health-related quality of life in newly diagnosed multiple myeloma patients aged 65 years or older: results of a randomized phase III trial.

scientific article published on 14 December 2012

Lenalidomide: a new treatment option for Castleman disease

scientific article published on 05 December 2011

Levels of CEACAM6 in Peripheral Blood Are Elevated in Patients with Plasma Cell Disorders: A Potential New Diagnostic Marker and a New Therapeutic Target?

scientific article published on 27 January 2019

Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response

scientific article published on 26 September 2009

Light chain-induced acute renal failure can be reversed by bortezomib-doxorubicin-dexamethasone in multiple myeloma: results of a phase II study.

scientific article

Long-term outcomes of autologous transplantation in multiple myeloma: significant survival benefit of novel drugs in post-transplantation relapse.

scientific article published in December 2009

Maintenance Treatment and Survival in Patients With Myeloma: A Systematic Review and Network Meta-analysis

scientific article published on 01 October 2018

Management of adverse events associated with ixazomib plus lenalidomide/dexamethasone in relapsed/refractory multiple myeloma

scientific article

Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN)

scientific article published on 22 May 2020

Measuring diffuse metabolic activity on FDG-PET/CT: new method for evaluating Langerhans cell histiocytosis activity in pulmonary parenchyma.

scientific article published on 14 December 2011

Mechanism of immunomodulatory drugs in multiple myeloma.

scientific article

Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma: A Comparison with Real-Time PCR.

scientific article published on 26 August 2015

Molecular heterogeneity and centrosome-associated genes in multiple myeloma.

scientific article

Monoclonal antibodies - A new era in the treatment of multiple myeloma.

scientific article published on 24 August 2015

Monoclonal antibodies in the treatment of AL amyloidosis: co-targetting the plasma cell clone and amyloid deposits

scientific article published on 18 February 2020

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management

scientific article

Monotherapy with low-dose thalidomide for relapsed or refractory multiple myeloma: better response rate with earlier treatment

scientific article published on 04 September 2007

Multicentered patient-based evidence of the role of free light chain ratio normalization in multiple myeloma disease relapse.

scientific article published on 26 March 2015

Multiple myeloma associated IgA pemphigus: treatment with bortezomib- and lenalidomide-based regimen

scientific article published on 01 December 2011

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

article

MyelomA Genetics International Consortium

scientific article published on 03 January 2012

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma.

scientific article published on 20 September 2013

Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation

scientific article published on 01 January 2010

Nestin expression throughout multistep pathogenesis of multiple myeloma

scientific article published on 16 December 2013

Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing.

scientific article published on 17 February 2018

Novel risk stratification algorithm for estimating the risk of death in patients with relapsed multiple myeloma: external validation in a retrospective chart review

scientific article published on 14 July 2020

Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma.

scientific article

Optimization of immunomagnetic selection of myeloma cells from bone marrow using magnetic activated cell sorting.

scientific article published on 7 August 2010

Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: consensus statement

scientific article published on 04 February 2011

Outcome of patients with multiple myeloma and hypertension treated with angiotensin-I-converting enzyme inhibitors during high-dose chemotherapy

scientific article published on 01 January 2005

PD-1/PD-L1 inhibitors in haematological malignancies: update 2017.

scientific article

PD-1/PD-L1 inhibitors in multiple myeloma: The present and the future

scientific article published on 8 November 2016

Phenotype of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance

scientific article published on 01 January 2009

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group

scientific article

Plasma cell leukemia: from biology to treatment

scientific article published on 16 March 2015

Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma

scientific article

Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma

scientific article published on 01 January 2010

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

scientific article published on 2 May 2018

Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.

scientific article published in January 2005

Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients.

scientific article published on 7 January 2018

Prognostic significance of morphological assessment of plasma cells in multiple myeloma

scientific article published on 01 January 2011

Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma

scientific article published on 08 April 2014

Proteasome inhibitors in AL amyloidosis: focus on mechanism of action and clinical activity.

scientific article published on 20 September 2016

Proteomic Analysis in Multiple Myeloma Research ⬇️

scientific article published on January 1, 2011

Real-world effectiveness and safety of ixazomib-lenalidomide-dexamethasone in relapsed/refractory multiple myeloma

scientific article published on 01 April 2020

Real-world outcomes and factors impacting treatment choice in relapsed and/or refractory multiple myeloma (RRMM): a comparison of VRd, KRd, and IRd

scientific article published on 09 March 2020

Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

scientific article published on 19 August 2020

Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders.

scientific article published on March 2010

Salvage treatment with upfront melphalan 100 mg/m(2) and consolidation with novel drugs for fulminant progression of multiple myeloma.

scientific article published on 19 November 2009

Second autologous transplantation for multiple myeloma patients relapsing after the first autograft -- a pilot study for the evaluation of experimental maintenance therapies. Report of the prospective non-randomized pilot study of the Czech Myeloma

scientific article published on 01 June 2004

Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient data

scientific article

Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients

scientific article published on 02 July 2018

Sepsis and septic shock. II. Treatment.

scientific article published on March 1995

Serum miR-29a as a marker of multiple myeloma.

scientific article

Shared structural features of the 9aaTAD family in complex with CBP.

scientific article

Similar efficacy of thalidomide- and bortezomib-based regimens for first relapse of multiple myeloma

scientific article published on 05 March 2011

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t[11;14]

scientific article published on 25 November 2018

Soft-tissue extramedullary multiple myeloma prognosis is significantly worse in comparison to bone-related extramedullary relapse.

scientific article published on 13 September 2013

Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients

scientific article published on 26 March 2011

Successful Anakinra Therapy in 2 Patients with Schnitzler Syndrome ⬇️

scientific article published on April 26, 2011

Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 R

scientific article

TGF-β - an excellent servant but a bad master

scientific article

Thalidomide maintenance treatment increases progression-free but not overall survival in elderly patients with myeloma.

scientific article

The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma

scientific article published on 01 September 2018

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network

scientific article

The effect of a cardiopulmonary bypass system with biocompatible coating on fibrinogen levels determined by the TEG – functional fibrinogen method: preliminary results ⬇️

scientific article published on July 8, 2011

The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets

scientific article published in PLoS ONE

The miR-29 family in hematological malignancies.

scientific article published on 04 July 2014

The problems of proteinuria measurement in urine with presence of Bence Jones protein ⬇️

scientific article published on February 1, 2011

The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma

scientific article published on 12 June 2013

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

scientific article published on 26 May 2017

The start of a new wave: Developments in proteasome inhibition in multiple myeloma

scientific article

Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response

scientific article published on 28 May 2018

Treatment and outcome patterns in European patients with Waldenström's macroglobulinaemia: a large, observational, retrospective chart review

scientific article published on 01 July 2018

Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma.

scientific article

Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma

scientific article published on 16 November 2018

Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies

scientific article published on 21 June 2018

Venetoclax: A new wave in hematooncology.

scientific article published on 22 February 2018

Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study

scientific article

Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection.

scientific article

Paulina is supported by:

About Paulina

Help