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List of works by Hiroshi Sakagami

1,3-diaryl-2-propenones and 2-benzylidene-1,3-indandiones: a quest for compounds displaying greater toxicity to neoplasms than normal cells

scientific article published in September 2010

1-(3-aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: a novel group of tumour-selective cytotoxins.

scientific article

1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells

scientific article published on 27 March 2008

2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance

scientific article published on 17 April 2009

27-norlanostane glycosides from the bulbs of Muscari paradoxum

scientific article published in December 2004

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins

scientific article published on 4 January 2016

3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins

scientific article

3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy

scientific article published on 24 December 2009

3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells

scientific article published on April 2002

3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity

scientific article published on 13 March 2007

3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.

scientific article published on March 2005

6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins

scientific article published on 10 February 2017

A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.

scientific article

A chronological research on parasitic endemic disease, "Katayama-disease" (Schistosomiasis japonica) in Hiroshima Prefecture in the 20th century (the 3rd communication on the historical research on Schistosomiasis japonica in Hiroshima Prefecture).

scientific article published in January 2007

A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus.

scientific article published in November 2009

A comparative in vitro efficacy of conventional rotatory and chemomechanical caries removal: Influence on cariogenic flora, microhardness, and residual composition.

scientific article published on November 2014

A new and 23 known cardenolide glycosides from Thevetia neriifolia seeds and their cytotoxic activities against human oral carcinoma cell lines

scientific article published on 22 January 2020

A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities ⬇️

scientific article

ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

scientific article published on 28 April 2020

Adhesion and Proliferation of Osteoblastic Cells on Hydroxyapatite-dispersed Ti-based Composite Plate

scientific article published on 01 July 2019

Aestivalosides A-L, twelve pregnane glycosides from the seeds of Adonis aestivalis

scientific article published on 19 March 2018

Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model

scientific article published on 22 April 2015

Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis.

scientific article published on 31 October 2009

Amurensiosides L-P, five new cardenolide glycosides from the roots of Adonis amurensis

scientific article published on January 2015

Analysis of apoptosis signaling pathway in human cancer cells by codeinone, a synthetic derivative of codeine.

scientific article published in May 2003

Analysis of type of cell death induced by topoisomerase inhibitor SN-38 in human oral squamous cell carcinoma cell lines

scientific article

Anti-HIV and immunomodulation activities of cacao mass lignin-carbohydrate complex.

scientific article published on March 2011

Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk lignin fractions

scientific article

Anti-Halitosis Effect of Toothpaste Supplemented with Alkaline Extract of the Leaves of Sasa senanensis Rehder

scientific article

Anti-UV Activity of Alkaline Extract of the Leaves of Sasa senanensis Rehder.

scientific article published on September 2011

Anti-UV activity of Kampo medicines and constituent plant extracts: re-evaluation with skin keratinocyte system

scientific article

Anti-UV activity of Lentinus edodes mycelia extract (LEM).

scientific article published on September 2011

Anti-UV activity of lignin-carbohydrate complex and related compounds

scientific article published on January 2013

Anti-UV activity of newly-synthesized water-soluble azulenes.

scientific article published on January 2013

Anti-UV/HIV activity of Kampo medicines and constituent plant extracts

scientific article

Anti-inflammatory Activity of Hangeshashinto in IL-1β-stimulated Gingival and Periodontal Ligament Fibroblasts

scientific article

Anti-inflammatory potential of Rikkosan based on IL-1β network through macrophages to oral tissue cells

scientific article published in July 2014

Anti-stress activity of mulberry juice in mice.

scientific article published on July 2006

Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions

scientific article

Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity

scientific article

Antitumor potential of three herbal extracts against human oral squamous cell lines

scientific article

Antiviral and Antitumor Activity of Licorice Root Extracts.

scientific article published on January 2016

Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.

scientific article

Apoptosis-inducing activity of cisplatin (CDDP) against human hepatoma and oral squamous cell carcinoma cell lines.

scientific article published on March 2004

Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.

scientific article published on May 2006

Application of semiempirical method to estimate the cytotoxic activity of gallic acid and its related compounds.

scientific article published in May 2003

Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation

scientific article published on 01 May 2020

Bimodal effect of glycyrrhizin on macrophage nitric oxide and prostaglandin E2 production.

scientific article published on September 2008

Bioactivities of anastasia black (Russian sweet pepper).

scientific article published on May 2005

Biological activities and possible dental application of three major groups of polyphenols

scientific article published on 27 September 2014

Biological activity of 3-formylchromones and related compounds.

scientific article published on September 2007

Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract

scientific article published in May 2012

Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions

scientific article published on March 2004

Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple

scientific article published in August 2005

Biological activity of luteolin glycosides and tricin from Sasa senanensis Rehder.

scientific article published on September 2011

Biological activity of persimmon (Diospyros kaki) peel extracts

scientific article published in May 2003

Biological impact of contact with metals on cells

scientific article published on 01 September 2006

Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients.

scientific article published on March 2013

Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis

scientific article published in February 2003

Bulbinelonesides A-E, phenylanthraquinone glycosides from the roots of Bulbinella floribunda

scientific article

COX-2 as possible target for the inhibition of PGE2 production by Rikko-san in activated macrophage.

scientific article

Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts

scientific article published on August 2002

Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol.

scientific article published on 5 February 2016

Carotenoid composition and in vitro pharmacological activity of rose hips.

scientific article

Cell death induced by nutritional starvation in mouse macrophage-like RAW264.7 cells.

scientific article published on January 2009

Cell death-inducing activity of opiates in human oral tumor cell lines.

scientific article

Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells

scientific article published on 01 November 2018

Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol

scientific article published on 31 October 2018

Changes in amino acid metabolism during activation of mouse macrophage-like cell lines

scientific article published on November 2010

Changes in fluoride sensitivity during in vitro senescence of normal human oral cells

scientific article published on 01 May 2005

Changes in intracellular concentrations of polyamines during apoptosis of HL-60 cells.

scientific article published on November 2003

Changes in salivary amino acid composition during aging.

scientific article published on November 2010

Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol

scientific article published on March 2013

Chemical constituents of Lycoris albiflora and their cytotoxic activities

scientific article published on 01 February 2011

Chemical constituents of the bulbs of Habranthus brachyandrus and their cytotoxic activities ⬇️

scientific article published on October 2009

Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.

scientific article published on 21 November 2017

Comparative analysis of apoptosis-inducing activity of codeine and codeinone

scientific article published in March 2003

Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines

scientific article

Comparative study of biological activity of three commercial products of Sasa senanensis Rehder leaf extract.

scientific article

Comparison of cytotoxicity and radical scavenging activity between tea extracts and Chinese medicines.

scientific article published in November 2003

Concentration-dependent effect of Rikko-san on the prostaglandin E2 production by mouse macrophage-like cells

scientific article published on July 2006

Convallasaponin A, a new 5beta-spirostanol triglycoside from the rhizomes of Convallaria majalis. ⬇️

scientific article published in February 2007

Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity.

scientific article published on July 2005

Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities ⬇️

scientific article published in January 2002

Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells

scientific article published on 4 February 2010

Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells

scientific article published on 3 April 2007

Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata

scientific article published on November 2016

Cytotoxic activity of azulenequinones against human oral tumor cell lines.

scientific article

Cytotoxic activity of azulenes against human oral tumor cell lines.

scientific article published on November 2003

Cytotoxic activity of benzo[b]cyclohept[e][1,4]oxazines

scientific article published on July 2013

Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.

scientific article published on March 2004

Cytotoxic activity of selected trifluoromethyl ketones against oral tumor cells

scientific article published on 01 November 2006

Cytotoxic activity of styrylchromones against human tumor cell lines

scientific article

Cytotoxic activity of tropolones against human oral tumor cell lines.

scientific article published on November 2003

Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper

scientific article published in April 2003

Cytotoxic and radical scavenging activity of blended herbal extracts.

scientific article

Cytotoxic potential of phenothiazines.

scientific article published on September 2006

Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).

scientific article published in November 2003

Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells

scientific article

Cytotoxicity and radical modulating activity of Moxa smoke.

scientific article

Cytotoxicity and type of cell death induced by local anesthetics in human oral normal and tumor cells.

scientific article

Cytotoxicity and type of cell death induced by midazolam in human oral normal and tumor cells.

scientific article

Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines

scientific article published on May 1, 2013

Cytotoxicity of dental compounds towards human oral squamous cell carcinoma and normal oral cells.

scientific article published on January 2013

Cytotoxicity of direct current with antibacterial agents against host cells in vitro

scientific article published on 01 October 2005

Cytotoxicity of nocobactins NA-a, NA-b and their ferric complexes assessed by semiempirical molecular orbital method.

scientific article

Cytotoxicty and radical modulating activity of isoflavones and isoflavanones from Sophora species.

scientific article published on May 2004

DNA microarray analysis of signaling pathway in macrophages stimulated by lignin-carbohydrate complex from lentinus edodes mycelia (LEM) extract.

scientific article published on July 2010

Decline of superoxide dismutase activity during antioxidant-induced apoptosis in HL-60 cells

scientific article

Declined asparagine synthetase mRNA expression and enhanced sensitivity to asparaginase in HL-60 cells committed to monocytic differentiation.

scientific article published in April 2009

Dental Application of Natural Products

scientific article published on 14 February 2018

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

scientific article published on 10 July 2007

Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides.

scientific article published on 23 October 2016

Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma

scientific article published on 26 August 2020

Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.

scientific article

Disruption of amino acid metabolism in human myelogenous leukemic cell lines destined to die after contact with metal plates.

scientific article published on September 2007

Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease.

scientific article published on 17 February 2012

Distribution of lignin-carbohydrate complex in plant kingdom and its functionality as alternative medicine.

scientific article published on 12 June 2010

Diurnal changes in salivary amino acid concentrations.

scientific article published on November 2010

Diverse biological activities of fermented pine seed shell extract.

scientific article published in May 2002

Diverse biological activity of Odontioda Marie Noel 'Velano' extracts

scientific article published on May 2011

Diverse biological activity of Odontoglossum Harvengtense 'Tutu' bulb extracts.

scientific article published on May 2011

EBV LMP1 in Gingival Epithelium Potentially Contributes to Human Chronic Periodontitis via Inducible IL8 Production

scientific article published on 01 November 2019

EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland

scientific article published on 01 June 2003

Effect of CO2 laser irradiation on hormesis induction in cultured oral cells.

scientific article

Effect of CO₂ laser irradiation on hormesis induction in human pulp and periodontal ligament fibroblasts

scientific article

Effect of Sairei-to and its ingredients on prostaglandin E2 production by mouse macrophage-like cells.

scientific article published on September 2008

Effect of Sasa senanensis Rehder extract on NO and PGE2 production by activated mouse macrophage-like RAW264.7 cells

scientific article published on September 2009

Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage.

scientific article

Effect of Small-molecule GSK3 Antagonist on Differentiation of Rat Dental Pulp Cells into Odontoblasts

scientific article published on 01 May 2020

Effect of anesthetics on malignant tumor cells (A review)

scientific article

Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines

scientific article published on November 2005

Effect of antioxidants, oxidants, metals and saliva on cytotoxicity induction by sodium fluoride

scientific article published on September 2003

Effect of antitumor agents on cytotoxicity induction by sodium fluoride.

scientific article published in November 2003

Effect of contact with titanium alloys on the proliferation of mouse osteoblastic cells in culture

scientific article

Effect of endodontic agents on cytotoxicity induction by sodium fluoride

scientific article published in November 2003

Effect of itraconazoles on the production of pro-inflammatory substances in mouse macrophage-like cells

scientific article published on September 2010

Effect of lignins and their precursors on nitric oxide, citrulline and asparagine production by mouse macrophage-like Raw 264.7 cells.

scientific article published in September 2002

Effect of poly-herbal formula on NO production by LPS-stimulated mouse macrophage-like cells.

scientific article published in November 2002

Effect of saliva, epigallocatechin gallate and hypoxia on Cu-induced oxidation and cytotoxicity

scientific article published on 01 July 2007

Effect of simulated orthodontic forces on fluoride-induced cytotoxicity in MC3T3-E1 osteoblast-like cells.

scientific article published in March 2009

Effect of three fluoride compounds on the growth of oral normal and tumor cells.

scientific article

Effect of three herbal extracts on NO and PGE2 production by activated mouse macrophage-like cells.

scientific article

Effect of tropolone, azulene and azulenequinone derivatives on prostaglandin E2 production by activated macrophage-like cells.

scientific article

Effect of two different groups of Chinese medicines on nitric oxide production by mouse macrophage-like cells.

scientific article

Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells

scientific article published on 4 December 2015

Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.

scientific article published on September 2014

Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line

scientific article published on March 2014

Effects of isoflavones from Sophora species on the growth and activation of a mouse macrophage-like cell line

scientific article published on July 2002

Effects of prenylflavanones from Sophora species on growth and activation of mouse macrophage-like cell line

scientific article

Efficient utilization of licorice root by alkaline extraction

scientific article published on 01 September 2014

Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas

scientific article published on 15 March 2017

Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone

scientific article published on January 2016

Enhancement of Dectin-2 gene expression by lignin-carbohydrate complex from Lentinus edodes mycelia extract (LEM) in a mouse macrophage-like cell line.

scientific article published on April 2011

Enhancement of cytotoxic activity of sodium fluoride against human periodontal ligament fibroblasts by water pressure.

scientific article published in November 2006

Enhancement of sodium fluoride-induced cell death by centrifugal force

scientific article published on January 2006

Establishment of a Primary Culture System of Human Periodontal Ligament Cells that Differentiate into Cementum Protein 1-expressing Cementoblast-like Cells

article

Estimation of relationship between descriptors and cytotoxicity of newly synthesized 1,2,3,4-tetrahydroisoquinoline derivatives.

scientific article published on October 2009

Estimation of relationship between structure of newly synthesized dihydroimidazoles determined by a semiempirical molecular-orbital method and their cytotoxicity

scientific article published in December 2009

Estimation of relationship between the structure of 1,2,3,4-tetrahydroisoquinoline derivatives determined by a semiempirical molecular-orbital method and their cytotoxicity.

scientific article

Estimation of relationship between the structure of trihaloacetylazulene derivatives determined by a semiempirical molecular-orbital method (PM5) and their cytotoxicity

scientific article published on March 2010

Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices

scientific article

Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure

scientific article published on August 2013

Factors that affect the type of cell death induced by chemicals

scientific article

Furostanol glycosides from the rhizomes of Helleborus orientalis.

scientific article published on 19 June 2010

Further Quantitative Structure-Cytotoxicity Relationship Analysis of 3-Styrylchromones

scientific article published on 01 January 2020

Gene Expression Analysis of Cultured Rat-Endothelial Cells after Nd:YAG Laser Irradiation by Affymetrix GeneChip Array

scientific article

Glutathione can efficiently prevent direct current-induced cytotoxicity

scientific article published on 11 April 2008

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Hormetic and UV-protective effects of azulene-related compounds.

scientific article published on January 2011

Hormetic and anti-radiation effects of tropolone-related compounds.

scientific article published on November 2010

Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives

scientific article

Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44.

scientific article published on 20 September 2016

Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra.

scientific article

Hydrolyzable tannins of tamaricaceous plants. V. Structures of monomeric-trimeric tannins and cytotoxicity of macrocyclic-type tannins isolated from Tamarix nilotica (1).

scientific article

Hydroquinone-induced apoptosis in HL-60 cells.

scientific article

Hypoxia and reoxygenation augment bone-resorbing factor production from human periodontal ligament cells.

scientific article published in September 2007

In Vitro Anti-tumor Activity of Azulene Amide Derivatives

scientific article published in May 2018

In Vitro Antitumor Activity of Alkylaminoguaiazulenes

scientific article published in May 2018

In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs

scientific article published on 01 December 2019

In search of new biological activities of isolates from Odontoglossum Harvengtense 'Tutu'

scientific article published on 01 November 2012

Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin

scientific article

Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines

scientific article published on 01 July 2019

Induction of apoptosis by beta-diketones in human tumor cells.

scientific article

Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line.

scientific article

Induction of apoptosis by morphine in human tumor cell lines in vitro

scientific article published on March 2007

Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line

scientific article published on September 2007

Induction of cell death by pro-oxidant action of Moxa smoke.

scientific article

Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds.

scientific article published on September 2005

Induction of early apoptosis marker by morphine in human lung and breast carcinoma cell lines

scientific article published in May 2003

Induction of non-apoptotic cell death by Odontioda Marie Noel 'Velano' extracts in human oral squamous cell carcinoma cell lines.

scientific article

Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells.

scientific article

Induction of non-apoptotic cell death in human oral squamous cell carcinoma cell lines by Rhinacanthus nasutus extract

scientific article

Induction of prostaglandin E2 production by TiO2 nanoparticles in human gingival fibroblast

scientific article published in March 2014

Induction of tumor-specific cytotoxicity and apoptosis by doxorubicin

scientific article

Infections with gastrointestinal parasitic helminths indigenous to Japan and their treatment historically studied in an attempt to control the diseases in countries where they are still rampant: (1) the Jomon to Edo periods.

scientific article published in January 2009

Inhibition by Moxa smoke of NO production and iNOS expression in mouse macrophage-like cells Raw 264.7.

scientific article

Inhibition by Rikko-san and its major ingredients of LPS-stimulated nitric oxide production by mouse macrophage-like cells.

scientific article

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC.

scientific article published in July 2003

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones.

scientific article published on November 2005

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenes.

scientific article published on November 2004

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by benzocycloheptoxazines.

scientific article published in September 2008

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones

scientific article published in November 2004

Inhibition of NO production by activated macrophages by phenolcarboxylic acid monomers and polymers with radical scavenging activity

scientific article

Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by benzo[b]cyclohept[e] [1,4]oxazine and 2-aminotropone derivatives.

scientific article published on September 2009

Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulene derivatives

scientific article published in January 2008

Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulenes

scientific article published on July 2006

Inhibition of branching morphogenesis of mouse fetal submandibular gland by sodium fluoride--protection by epidermal growth factor

scientific article published in March 2005

Inhibition of prostaglandin E2 production by flavone and its related compounds.

scientific article

Interaction between dental metals and antioxidants, assessed by cytotoxicity assay and ESR spectroscopy.

scientific article

Introduction to the Special Issue "Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions"

scientific article published on 28 April 2019

Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan

Karataviosides G-K, five new bisdesmosidic steroidal glycosides from the bulbs of Allium karataviense

scientific article

Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum.

scientific article published on December 2003

Lignin-like activity of Lentinus edodes mycelia extract (LEM).

scientific article published on July 2010

List of Contributors

Mechanical, antibacterial and bond strength properties of nano-titanium-enriched glass ionomer cement.

scientific article published on May 2015

Microwave-assisted synthesis and bioevaluation of new sulfonamides.

scientific article published on December 2017

Mitochondrial control of cell death induction by sodium 5,6-benzylidene-L-ascorbate

scientific article

Modulation of branching morphogenesis of fetal mouse submandibular gland by sodium ascorbate and epigallocatechin gallate.

scientific article published in September 2005

Molecular requirements of lignin-carbohydrate complexes for expression of unique biological activities.

scientific article

Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.

scientific article published on January 2016

Morphological features of osteoblasts cultured on ultraviolet-irradiated titanium plates

scientific article published on July 2011

Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder

scientific article published on September 2010

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors

scientific article published on 16 January 2018

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones

scientific article published on 08 September 2018

New biological activities of Rhinacanthins from the root of Rhinacanthus nasutus

scientific article published on February 2013

New biological activity of Rhinacanthus nasutus extracts.

scientific article published on May 2011

New diarylheptanoids and diarylheptanoid glucosides from the rhizomes of Tacca chantrieri and their cytotoxic activity

scientific article published in March 2002

New phenolic Mannich bases with piperazines and their bioactivities

scientific article published on 07 June 2019

Niacin esters of chalcones with tumor-selective properties

scientific article published on 2 June 2016

Non-apoptotic cell death induced by nutritional starvation in J774.1 mouse macrophage-like cell line.

scientific article

Norlanostane and lanostane glycosides from the bulbs of Chionodoxa luciliae and their cytotoxic activity ⬇️

scientific article

Novel cytotoxic phenanthrenequinone from Odontioda Marie Noel 'Velano'.

scientific article published on January 2012

Oleanane and taraxerane glycosides from the roots of Gomphrena macrocephala.

scientific article

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability.

scientific article

Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants

scientific article published on 01 July 2018

Partial purification of cytotoxic substances from moxa extract.

scientific article published in September 2002

Photodynamic Therapy with Pyoktanin Blue and Diode Laser for Elimination of Enterococcus faecalis

scientific article published on 01 July 2018

Pilot clinical study of Sasa senanensis Rehder leaf extract treatment on lichenoid dysplasia.

scientific article

Pilot study of changes in salivary metabolic profiles induced by template therapy.

scientific article published in November 2012

Platelet-derived growth factor exerts disparate effects on odontoblast differentiation depending on the dimers in rat dental pulp cells

scientific article published on 22 January 2004

Polyhydroxylated spirostanol saponins from the tubers of Dioscorea polygonoides

scientific article published in July 2005

Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra.

scientific article published in December 2003

Production of bioactive triterpenes by Eriobotrya japonica calli.

scientific article published in February 2002

Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex

scientific article

Protection against copper-induced cytotoxicity by inclusion of gold

scientific article published on 01 July 2012

Protection by antioxidants of copper-induced decline of proliferation and SOD activity

scientific article published in January 2005

Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder

scientific article published in March 2018

Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity

scientific article published on 22 September 2010

QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer

scientific article published on 01 April 2019

QSAR of molecular structure and cytotoxic activity of vitamin K2 derivatives with concept of absolute hardness.

scientific article published on November 2007

Quantification of enhanced osteoblastic adhesion to ultraviolet-treated titanium plate.

scientific article published on July 2010

Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection

scientific article published on 06 October 2020

Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives

scientific article published on 01 July 2018

Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones

scientific article published on 01 December 2019

Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones

scientific article published in February 2018

Quantitative Structure-Cytotoxicity Relationship of 2-Styrylchromones

scientific article published on 01 December 2019

Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives

scientific article published on 01 August 2018

Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.

scientific article published on October 2015

Quantitative Structure-Cytotoxicity Relationship of Aurones

scientific article published in November 2017

Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives

scientific article published on 01 July 2019

Quantitative Structure-Cytotoxicity Relationship of Chalcones

scientific article published on March 2017

Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters

scientific article published in February 2018

Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones

scientific article published on 01 June 2018

Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters

scientific article

Quantitative Structure-Cytotoxicity Relationship of Oleoylamides

scientific article published on October 2015

Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones

scientific article published on 01 August 2018

Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones

scientific article published on November 2016

Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.

scientific article

Quantitative structure-activity relationship analysis of 4-trifluoromethylimidazole derivatives with the concept of absolute hardness.

scientific article published in November 2007

Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones

scientific article published on April 2014

Quantitative structure-cytotoxicity relationship analysis of 3-formylchromone derivatives by a semiempirical molecular-orbital method with the concept of absolute hardness

scientific article published in January 2008

Quantitative structure-cytotoxicity relationship analysis of 5-trifluoromethyloxazole derivatives by a semiempirical molecular-orbital method with the concept of absolute hardness

scientific article

Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its derivatives by semi-empirical molecular-orbital method

scientific article published in November 2005

Quantitative structure-cytotoxicity relationship analysis of coumarin and its derivatives by semiempirical molecular orbital method.

scientific article published on July 2006

Quantitative structure-cytotoxicity relationship analysis of phenoxazine derivatives by semiempirical molecular-orbital method.

scientific article published on November 2007

Quantitative structure-cytotoxicity relationship of 3-styrylchromones

scientific article published on October 2014

Quantitative structure-cytotoxicity relationship of newly synthesised trihaloacetylazulenes determined by a semi-empirical molecular-orbital method (PM5).

scientific article published on February 2011

Quantitative structure-cytotoxicity relationship of newly synthesized tropolones determined by a semiempirical molecular-orbital method (PM5).

scientific article

Quantitative structure-cytotoxicity relationship of phenylpropanoid amides

Quantitative structure-cytotoxicity relationship of piperic acid amides.

scientific article published on September 2014

Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline

scientific article published on January 2016

Quest for anti-inflammatory substances using IL-1β-stimulated gingival fibroblasts.

scientific article published on September 2011

Radical scavenging activity and cytotoxicity of ferulic acid.

scientific article published on September 2002

Radical scavenging activity and cytotoxicity of phenethyl ether and cinnamic amide derivatives.

scientific article published on May 2002

Rapid changes in amino acid and polyamine metabolism during copper-induced cell death of human gingival fibroblast.

scientific article published in September 2007

Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption

scientific article published in November 2017

Re-evaluation of anti-inflammatory activity of mastic using activated macrophages.

scientific article published in July 2009

Re-evaluation of anti-inflammatory potential of eugenol in IL-1β-stimulated gingival fibroblast and pulp cells

scientific article

Re-evaluation of antitumor activity of Cepharanthin.

scientific article

Re-evaluation of cytotoxicity and iron chelation activity of three beta-diketones by semiempirical molecular orbital method.

scientific article

Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin.

scientific article published on September 2006

Recent Progress of Basic Studies of Natural Products and Their Dental Application

scientific article published on 25 December 2018

Relationship between differentiation-inducing activity and hypercalcemic activity of hexafluorotrihydroxyvitamin D3 derivatives.

scientific article

Relationship between electronic structure and cytotoxic activity of azulenequinones and trihaloacetylazulenes

scientific article published on September 2007

Relationship between electronic structure and cytotoxic activity of azulenes

scientific article published on May 2006

Relationship between electronic structure and cytotoxic activity of dopamine and 3-benzazepine derivatives

scientific article published in July 2004

Relationship between electronic structure and cytotoxic activity of tropolones

scientific article published on May 2006

Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling

scientific article published on 17 June 2015

Role of free radicals and metal ions in direct current-induced cytotoxicity

scientific article

Search for Drugs Used in Hospitals to Treat Stomatitis

Search for New Type of Anticancer Drugs with High Tumor Specificity and Less Keratinocyte Toxicity

scientific article published in November 2017

Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method.

scientific article

Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics

scientific article

Selective antibacterial and apoptosis-modulating activities of mastic.

scientific article published on March 2009

Selective toxicity and type of cell death induced by various natural and synthetic compounds in oral squamous cell carcinoma.

scientific article published on March 2007

Sequential cytotoxicity: a theory examined using a series of 3,5-bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and related phosphonic acids

scientific article published on 17 September 2010

Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.

scientific article published in March 2011

Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity

scientific article published on 14 June 2010

Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-κB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway

scientific article

Spirostanol pentaglycosides from the underground parts of polianthestuberosa

scientific article published in October 2002

Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity

scientific article published on 7 November 2017

Steroidal constituents isolated from the seeds of Withania somnifera

scientific article published on 20 September 2019

Steroidal glycosides from Furcraea foetida and their cytotoxic activity ⬇️

scientific article published on October 2009

Steroidal glycosides from the bulbs of Ornithogalum thyrsoides

scientific article published in October 2004

Steroidal glycosides from the leaves of Cestrum nocturnum

scientific article

Stimulation of arginine consumption and asparagine production in LPS-activated macrophages.

scientific article

Structural characterization of anti-UV components from Sasa senanensis Rehder extract

scientific article published on January 2013

Structural requirements of hydroxylated coumarins for in vitro anti-Helicobacter pylori activity.

scientific article published in September 2003

Structure-activity relationships of alpha, beta-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells.

scientific article published on March 2004

Structure-cytotoxic activity relationships of simple hydroxylated coumarins

scientific article published in July 2003

Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl (m-GO-m-GOG)-Type Ellagitannins from the Galls of Tamarix aphylla

scientific article published on 18 September 2019

Synergism of Alkaline Extract of the Leaves of Sasa senanensis Rehder and Antiviral Agents

scientific article published on January 2016

Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis

scientific article published on 01 January 2018

Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases

scientific article published on 4 September 2016

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity

scientific article published on 20 December 2018

Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones.

scientific article published on 19 July 2016

Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides

scientific article published on 30 March 2016

Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.

scientific article

Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors

scientific article published on 28 June 2019

Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities.

scientific article published on 6 August 2015

Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities.

scientific article

Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors

scientific article published on 28 August 2019

Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones

scientific article published on 01 December 2019

Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines

scientific article published on 31 August 2016

The Chemistry of Bioactive Mesoionic Heterocycles

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones

scientific article published on 29 March 2008

The redox state of glutathione regulates the hypoxic induction of HIF-1.

scientific article published on 29 January 2009

Three new flavonoids, proanthocyanidin, and accompanying phenolic constituents from Feijoa sellowiana.

scientific article published on 3 January 2018

Triterpene glycosides from the tubers of Anemone coronaria ⬇️

scientific article published in July 2009

Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity ⬇️

scientific article

Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines

scientific article published on November 2007

Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.

scientific article published in August 2009

Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines

scientific article published on November 2005

Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde

scientific article published on December 2010

Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.

scientific article published in April 2009

Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.

scientific article

Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound.

scientific article

Tumor-specific cytotoxicity and type of cell death induced by gefitinib in oral squamous cell carcinoma cell lines.

scientific article published in December 2009

Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure

scientific article published on January 2009

Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines.

scientific article

Tumor-specific cytotoxicity and type of cell death induced by sodium 5,6-benzylidene-L-ascorbate.

scientific article

Tumor-specific cytotoxicity of 3,5-dibenzoyl-1,4-dihydropyridines

scientific article published on May 2005

Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids

scientific article published on May 2005

Tumor-specificity and radical scavenging activity of poly-herbal formula.

scientific article published in March 2002

Tumor-specificity and type of cell death induced by phenoxazines.

scientific article published on November 2007

Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.

scientific article published on January 2007

Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols.

scientific article

Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines.

scientific article published on September 2006

Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones

scientific article published on 30 March 2016

Type of cell death induced by alpha-trifluoromethyl acyloins in oral squamous cell carcinoma.

scientific article published on January 2009

Type of cell death induced by seven metals in cultured mouse osteoblastic cells

scientific article published on July 2010

Type of cell death induced by various metal cations in cultured human gingival fibroblasts

scientific article published on July 2010

[The search for tumor-specific cytotoxic agents: relation to apoptosis-inducing activity]

scientific article published on 01 May 2006

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