List of works - Bernard T. Golding

1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

scientific article

1-{2-[4-(2,4-Dinitrophenyl)piperazin-1-yl]ethyl}-4-aza-1-azoniabicyclo[2.2.2]octane chloride

2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).

scientific article

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

scientific article published on January 2003

8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).

scientific article

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

scientific article

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase ⬇️

scientific article (publication date: 7 November 2016)

Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.

scientific article

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment

scientific article

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

scientific article published in November 2008

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer ⬇️

scientific article published on October 8, 2012

Crystal structure and putative mechanism of 3-methylitaconate-delta-isomerase from Eubacterium barkeri

scientific article

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype ⬇️

scientific article published on November 16, 2010

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.

scientific article

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

scientific article

Designing inhibitors of cyclin-dependent kinases

scientific article

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in

scientific article

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

scientific article published in December 2005

Experimental Study of Hydrogen Bonding Potentially Stabilizing the 5′‐Deoxyadenosyl Radical from Coenzyme B12 ⬇️

scientific article published on October 18, 2012

Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

scientific article (publication date: 7 February 2005)

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors

scientific article

Hydrogen Bonds Guide the Short‐Lived 5′‐Deoxyadenosyl Radical to the Place of Action ⬇️

scientific article published on September 3, 2012

Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water

scientific article published in 2018

Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.

scientific article

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

scientific article

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

scientific article published on 22 February 2018

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

scientific article published on 11 February 2011

Mechanism of enzymatic Birch reduction: stereochemical course and exchange reactions of benzoyl-CoA reductase

scientific article

Mechanism-based design, synthesis and biological studies of N⁵-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents

scientific article

Molecular hijacking of siroheme for the synthesis of heme and d1 heme

scientific article published on 3 October 2011

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

scientific article

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of [...]

scientific article

Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase

scientific article published in August 2007

Revisiting the reaction of hydroxyl radicals with vicinal diols in water

scientific article published on 14 December 2011

SYNTHESIS AND STABILITY OF 3-HYDROXYANAGRELIDE, A BIOLOGICALLY POTENT METABOLITE OF ANAGRELIDE

Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach

scientific article

Small-molecule MDM2-p53 inhibitors: recent advances

scientific article published on January 2015

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

scientific article published in October 2006

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

scientific article published on 23 April 2007

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

scientific article

The impact of Brexit on British science: Also Sprach Zunderland

scientific article published in March 2017

List of works by Bernard T. Golding

1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

1-{2-[4-(2,4-Dinitrophenyl)piperazin-1-yl]ethyl}-4-aza-1-azoniabicyclo[2.2.2]octane chloride

2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase ⬇️

Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer ⬇️

Crystal structure and putative mechanism of 3-methylitaconate-delta-isomerase from Eubacterium barkeri

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype ⬇️

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

Designing inhibitors of cyclin-dependent kinases

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

Experimental Study of Hydrogen Bonding Potentially Stabilizing the 5′‐Deoxyadenosyl Radical from Coenzyme B12 ⬇️

Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors

Hydrogen Bonds Guide the Short‐Lived 5′‐Deoxyadenosyl Radical to the Place of Action ⬇️

Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water

Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

Mechanism of enzymatic Birch reduction: stereochemical course and exchange reactions of benzoyl-CoA reductase

Mechanism-based design, synthesis and biological studies of N⁵-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents

Molecular hijacking of siroheme for the synthesis of heme and d1 heme

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of [...]

Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase

Revisiting the reaction of hydroxyl radicals with vicinal diols in water

SYNTHESIS AND STABILITY OF 3-HYDROXYANAGRELIDE, A BIOLOGICALLY POTENT METABOLITE OF ANAGRELIDE

Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach

Small-molecule MDM2-p53 inhibitors: recent advances

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

The impact of Brexit on British science: Also Sprach Zunderland