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List of works by Lachlan H Thompson

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

scientific article

Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins

scientific article published on 12 July 2019

Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into parkinsonian mice.

scientific article

Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice.

scientific article

Characterization of Meteorin--an evolutionary conserved neurotrophic factor.

scientific article published on 4 March 2009

Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice.

scientific article published on 10 October 2015

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

scientific article published on 2 October 2011

Developing stem cell-based therapies for neural repair

scientific article

Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease

scientific article

Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator.

scientific article published on August 2004

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

scholarly article

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

scientific article

Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain

scientific article

Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.

scientific article published in May 2005

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.

scientific article published in August 2012

Generation of striatal projection neurons extends into the neonatal period in the rat brain.

scientific article published on 5 November 2012

Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells

scientific article

Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.

scientific article

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

scientific article published on 24 July 2014

Histological characterization and quantification of newborn cells in the adult rodent brain

scientific article published on 22 June 2021

Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways.

scientific article published on 24 August 2017

Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.

scientific article published in July 2005

Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis.

scientific article published on 23 June 2009

In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway

scientific article

Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.

scientific article published in October 2005

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

scientific article published on 22 October 2019

Lentiviral delivery of meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model.

scientific article

Local injection of Endothelin-1 in the early neonatal rat brain models ischemic damage associated with motor impairment and diffuse loss in brain volume

scientific article published on 06 October 2018

Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation.

scientific article published on 15 February 2017

Long-Term Motor Deficit and Diffuse Cortical Atrophy Following Focal Cortical Ischemia in Athymic Rats

scientific article published on 17 December 2019

Meningeal cells influence midbrain development and the engraftment of dopamine progenitors in Parkinsonian mice.

scientific article published on 20 February 2015

Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis

scientific article published on 12 February 2018

Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease.

scientific article published on 13 December 2013

Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon

scientific article published on 24 January 2006

Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation.

scientific article published on 22 March 2012

Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.

scientific article published on 17 June 2008

Novel pluripotent stem cell lines for enriched grafting in Parkinson's disease

scientific article published on 01 February 2020

Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury

scientific article published on 05 July 2016

Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke.

scientific article

Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells

scientific article published on 22 April 2015

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.

scientific article

Specification of murine ground state pluripotent stem cells to regional neuronal populations.

scientific article published on 22 November 2017

Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation.

scientific article published on January 2012

The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease

scientific article

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain

scientific article published on 31 October 2019

Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors

scientific article

Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts

scientific article published on January 2009

Transplantation of fetal midbrain dopamine progenitors into a rodent model of Parkinson's disease

scientific article published in January 2013

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease.

scientific article published on 24 August 2012

Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model

scientific article published in 2022