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List of works by Ruediger Klein

A role for the Ras signalling pathway in synaptic transmission and long-term memory ⬇️

scientific article published on November 20, 1997

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

scientific article published in April 2008

Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking ⬇️

scientific article published on July 28, 2011

Axon Guidance: Opposing EPHects in the Growth Cone

scientific article published on 01 April 2005

Bidirectional Eph-ephrin signaling during axon guidance

scientific article

Bidirectional modulation of synaptic functions by Eph/ephrin signaling.

scientific article

Cell Sorting during Regenerative Tissue Formation ⬇️

scientific article published on 01 October 2010

Central amygdala circuits modulate food consumption through a positive-valence mechanism

scientific article published on 21 August 2017

Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors.

scientific article published on 2 April 2015

Cortical circuit alterations precede motor impairments in Huntington's disease mice

scientific article published on 29 April 2019

Coupling Met to specific pathways results in distinct developmental outcomes

scientific article

Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality

scientific article

Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen

scientific article (publication date: 24 May 2002)

Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2

scientific journal article

Eph receptors and ephrin ligands. essential mediators of vascular development.

scientific article

Eph/ephrin signaling in morphogenesis, neural development and plasticity.

scientific article published in October 2004

Eph/ephrin signalling during development

scientific article

EphA4 receptor shedding regulates spinal motor axon guidance

scientific article published on 25 September 2014

EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin

scientific article published on 01 September 2007

EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion

scientific article published on April 2014

EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord

scientific article published on 01 August 2006

EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.

scientific article published on 14 September 2003

Ephrin signalling in the developing nervous system

scientific article published on 7 March 2014

Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration.

scientific article published in September 2013

Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control

scientific article

Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube

scientific article

EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

scientific journal article

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

scientific article published on 01 July 2000

Excitatory Eph receptors and adhesive ephrin ligands.

scientific article

Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance.

scientific article published on 27 June 2016

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development ⬇️

scientific article published on 22 October 2014

FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons

scientific journal article

Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease

scientific article published on 19 August 2021

Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".

scientific article published in November 2003

GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons.

scientific article published on 25 November 2010

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation

scientific article published on December 2008

Genetic analysis of EphA-dependent signaling mechanisms controlling topographic mapping in vivo.

scientific article published on 11 October 2006

Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance.

scientific article

Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain

scientific journal article

Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development

scientific article published on 13 August 2019

Hippocampal plasticity requires postsynaptic ephrinBs.

scientific article

Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus.

scientific article published in September 2002

In Situ Architecture and Cellular Interactions of PolyQ Inclusions

scientific article published on 29 August 2017

Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila

scientific article

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

scientific article

Integration of guidance cues: parallel signaling and crosstalk ⬇️

scientific article published on February 26, 2013

Intrinsic Circuits in the Lateral Central Amygdala

scientific article published on January 2017

Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.

scientific article

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

scientific journal article

Mechanism of TrkB-mediated hippocampal long-term potentiation

scientific journal article

Mechanisms of ephrin-Eph signalling in development, physiology and disease.

scientific article

Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.

scientific article published in December 1997

Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools.

scientific article published on August 2003

Multimodal Eph/Ephrin signaling controls several phases of urogenital development

scientific article published on 22 June 2016

Multiple roles for hepatocyte growth factor in sympathetic neuron development.

scientific article published in May 1998

Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function.

scientific article

Neuron-astrocyte communication and synaptic plasticity.

scientific article published on 12 May 2010

Novel effector function for an old receptor

scientific article published on 01 January 2002

Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.

scientific article

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

scientific article published on 2 June 2017

Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.

scientific article published in August 1998

Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling ⬇️

scientific article published on March 20, 2013

RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.

scholarly article

Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain

scientific journal article

Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice

scientific article published on 01 February 1997

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules

scientific article

Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells.

scientific article

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants

scientific article published on 28 January 2014

Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.

scientific article published in August 2008

Rüdiger Klein: reading the guideposts for axon guidance. Interview by Caitlin Sedwick.

scientific article published on July 2011

Signaling by Eph receptors and their ephrin ligands ⬇️

scientific article published on June 1, 1998

Signaling from axon guidance receptors

scientific article

Signalling mechanisms

scientific article published on 16 May 2007

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells ⬇️

scientific article (publication date: February 1993)

Structural Perspectives on Axon Guidance

scientific article

Structural basis of latrophilin-FLRT interaction

scientific journal article

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

scientific article

Super-complexes of adhesion GPCRs and neural guidance receptors

scientific article published on 19 April 2016

Survival of inner ear sensory neurons in trk mutant mice

scientific article published on 01 June 1997

TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes.

scientific article published on May 2006

The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling

scientific article published on July 1997

The Neurotrophin Receptors TrkA and TrkB are Inhibitory for Neurite Outgrowth ⬇️

scientific article published on 01 June 1995

The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons

scholarly article

The axon's balancing act: cis- and trans-interactions between Ephs and ephrins

scientific article published on 01 July 2011

The composition of EphB2 clusters determines the strength in the cellular repulsion response.

scientific article published on 27 January 2014

The eph receptor family:axonal guidance by contact repulsion ⬇️

scientific article published on September 1, 1997

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease ⬇️

scientific article published on August 4, 2011

The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta.

scientific article published on December 2004

The trk proto-oncogene encodes a receptor for nerve growth factor ⬇️

scientific article published on April 5, 1991

The trkB tyrosine protein kinase is a receptor for neurotrophin-4

scientific article published on May 1, 1992

Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.

scientific article

Topography in hippocampal mossy fiber plasticity.

scientific article published in March 2010

TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla.

scientific article published in September 1998

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

scientific journal article

Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression.

scientific article published in October 2007

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.

scientific article

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 ⬇️

scientific article published on September 6, 1991

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