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List of works by Kristine Freude

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity.

scientific article

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

scientific journal article

Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease

scientific article published on 18 July 2019

Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons.

scientific article

Dementia, Brain Disorders and Molecular Mechanisms

scientific article published on 28 March 2019

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1.

scientific article published on 28 September 2016

Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome.

scientific article

Essential Roles of Lactate in Müller Cell Survival and Function.

scientific article published on 11 April 2018

Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals.

scientific article published on 19 January 2017

Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1.

scientific article published on 24 September 2016

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B.

scientific article published on 16 June 2016

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B.

scientific article published on 16 June 2016

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1.

scientific article published on 28 December 2015

Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM).

scientific article published on 17 November 2016

Generation of transgene-free porcine intermediate type induced pluripotent stem cells

scientific article published on 03 December 2018

Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene

scientific article published on 24 December 2018

Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene

scientific article published on 07 February 2019

Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing

scientific article published on 01 December 2019

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

scientific article published on 14 September 2020

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

scientific article published on 16 October 2021

Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

scientific article published on 20 April 2017

Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics

scientific article

Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

scientific article published on 11 February 2019

Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead.

scientific article published on 12 December 2014

Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

scientific article published on 01 August 2019

Initial embryology and pluripotent stem cells in the pig--The quest for establishing the pig as a model for cell therapy.

scientific article published on 14 September 2015

Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

scientific article published on 17 August 2018

Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency.

scientific article published on 26 October 2016

Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges

scientific article published on June 2017

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

scientific article published on 27 April 2019

Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation

scientific article (publication date: December 2003)

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.

scientific article published in December 2017

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation.

scientific article published on 21 December 2015

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.

scientific article

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

scientific journal article

Oocytes, embryos and pluripotent stem cells from a biomedical perspective

scientific article published on 23 October 2019

Optimization of three-dimensional imaging on in vitro produced porcine blastocysts and chimeras for stem cell testing: a technology report

scientific article published on 25 February 2015

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

scientific article published on 06 February 2017

Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells.

scientific article published on 3 January 2017

Systems Biology and Stem Cell Pluripotency: Revisiting the Discovery of Induced Pluripotent Stem Cell

scientific article

The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published in 2022

Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

scientific article

WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA

scientific article published on 6 November 2018

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