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List of works by Robert E Widdop

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.

scientific article published on April 2011

A Series of Analogues to the ATR Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

scientific article published on 24 January 2019

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia.

scientific article published in October 2014

A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function

scientific article published on 07 February 2011

ANG II type 2 receptors and neural control of intrarenal blood flow

scientific article published on 20 July 2006

AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR.

scientific article

AT2 receptors contribute to acute blood pressure-lowering and vasodilator effects of AT1 receptor antagonism in conscious normotensive but not hypertensive rats.

scientific article published on 22 December 2004

Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.

scientific article published in November 2004

Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke.

scientific article published on 26 February 2009

Angiotensin AT2 receptors: cardiovascular hope or hype?

scientific article

Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats.

scientific article

Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system

scientific article published on August 2013

Cardiovascular status following combined angiotensin-converting enzyme and AT1 receptor inhibition in conscious spontaneously hypertensive rats.

scientific article

Central administration of PD 123319 or EXP-3174 inhibits effects of angiotensin II ⬇️

scientific article published on January 1, 1993

Central autonomic integration of psychological stressors: focus on cardiovascular modulation.

scientific article

Characterisation of vasopressin V(1A), angiotensin AT(1) and AT(2) receptor distribution and density in normotensive and hypertensive rat brain stem and kidney: effects of restraint stress

scientific article published on 01 November 2000

Characterization of post-junctional alpha-adrenoceptors in the rat isolated perfused femoral artery

scientific article published on 01 May 1987

Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA/NO

scientific article published on 03 March 2011

Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply

scientific article published on 01 November 2013

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

scientific article published on 5 January 2015

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

scientific article published in October 2017

Decorated self-assembling β(3)-tripeptide foldamers form cell adhesive scaffolds.

scientific article published on 4 March 2016

Differential blockade of central effects of angiotensin II by AT2-receptor antagonists.

scientific article

Differential cardiovascular responses to stressors in hypertensive and normotensive rats

scientific article published on 12 November 2004

Differential haemodynamic effects of endothelin receptor antagonist, SB 209670, in conscious hypertensive and normotensive rats

scientific article published on 01 September 1999

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice.

scientific article published on 11 December 2014

Differential regulation by AT(1) and AT(2) receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta.

scientific article

Direct AT₂ receptor stimulation is athero-protective and stabilizes plaque in apolipoprotein E-deficient mice.

scientific article

Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

scientific article (publication date: 2014)

Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits.

scientific article

Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo.

scientific article published on 5 November 2015

Effect of acute and chronic treatment with the angiotensin II subtype 1 receptor antagonist EXP 3174 on baroreflex function in conscious spontaneously hypertensive rats

scientific article published on 01 February 1995

Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model.

scientific article published on 17 January 2010

Effects of angiotensin II AT1- or AT2-receptor antagonists on drinking evoked by angiotensin II or water deprivation in rats.

scientific article

Effects of capsaicin on cutaneous vasodilator responses in humans

scientific article published on September 1, 1992

Effects of the CCK(A) receptor antagonists SR 27897B and PD140548 on baroreflex function in conscious rats

scientific article published on 01 October 1997

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II.

scientific article

Electrophysiological studies of the cholecystokininA receptor antagonists SR27897B and PD140548 in the rat isolated nodose ganglion

scientific article published on 01 May 1996

Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats.

scientific article published on 18 August 2008

Expression of c-fos and NGFI-A messenger RNA in the medulla oblongata of the anaesthetized rat following stimulation of vagal and cardiovascular afferents

scientific article published on May 1, 1992

Functional role of angiotensin II AT2 receptor in modulation of AT1 receptor‐mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide ⬇️

scientific article published on October 6, 2003

Ganging up on angiotensin II type 1 receptors in vascular remodeling

scientific article published on 04 June 2012

Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor.

scientific article published on 28 December 2010

Influence of Angiotensin II Subtype 2 Receptor (AT(2)R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (AT(1)R) Blockade

scientific article published on 4 March 2012

Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2-receptor antagonists given after the AT1-receptor antagonist, EXP 3174 ⬇️

scientific article published on November 1, 1992

Lack of a centrally-mediated antihypertensive effect following acute or chronic central treatment with AT1-receptor antagonists in spontaneously hypertensive rats.

scientific article published in December 1995

Minocycline treatment attenuates microglia activation and non-angiotensin II [125I] CGP42112 binding in brainstem following nodose ganglionectomy.

scientific article published on 13 September 2005

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis.

scientific article published on 25 September 2015

Morphology and Function of the Lamb Ileum following Preterm Birth

scientific article published on 29 January 2018

Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo.

scientific article

Nitroxyl donors retain their depressor effects in hypertension.

scientific article published on 12 July 2013

Non-angiotensin II [(125)I] CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: comparison with markers for activated microglia

scientific article published on 01 January 2004

Non-invasive tests of neurovascular function: reduced axon reflex responses in diabetes mellitus of man and streptozotocin-induced diabetes of the rat ⬇️

scientific article published on May 19, 1988

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

scientific article published on 28 August 2015

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

scientific article published on 20 March 2017

Preprogalanin mRNA is increased in vagal motor neurons following axotomy

scientific article published on July 1, 1992

Presence of functional vasopressin V1 receptors in rat vagal afferent neurones

scientific article published on September 28, 1992

Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor.

scientific article

Regional haemodynamic effects of the novel AT1 receptor antagonist, CV-11974, in conscious rats

scientific article published on 01 January 1994

Regional hemodynamic effects of the AT1 receptor antagonist CV-11974 in conscious renal hypertensive rats.

scientific article published on December 1995

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.

scientific article published on October 2011

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

scientific article published on 15 January 2014

Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice

scientific article published on 01 October 2012

Role of inflammation and the angiotensin type 2 receptor in the regulation of arterial pressure during pregnancy in mice.

scientific article

Role of the brain renin-angiotensin system in the maintenance of blood pressure in conscious spontaneously hypertensive and sinoaortic baroreceptor-denervated rats ⬇️

scientific article published on September 1, 1997

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease.

scientific article published in August 2014

Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor

scientific article published on 27 August 2014

Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity

scientific article published on 04 May 2020

Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats.

scientific article

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2.

scientific article

The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent

scientific article published on 26 October 2011

The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice.

scientific article published on 26 July 2017

The influence of atropine and atenolol on the cardiac haemodynamic effects of NG-nitro-l-arginine methyl ester in conscious, Long Evans rats ⬇️

scientific article published on March 1, 1992

The protective arms of the renin-angiontensin system in stroke.

scientific article published on July 2014

Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anaesthetized rats.

scientific article

Update on the angiotensin AT(2) receptor.

scientific article published on February 2013

Vascular reactivity to angiotensin II in blood-perfused kidneys of hypertensive diabetic rats

scientific article published on 01 August 1996

Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice.

scientific article published on 6 May 2010

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