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List of works by Fred E Cohen

A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery ⬇️

scientific article published on February 17, 1998

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv ⬇️

scientific article published on October 31, 1997

A diffusion--collision--adhesion model for the kinetics of myoglobin refolding

scientific article

A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure ⬇️

scientific article published on June 15, 1992

A predicted consensus structure for the C terminus of the beta and gamma chains of fibrinogen

scientific article published in February 1997

A predicted consensus structure for the N-terminal fragment of the heat shock protein HSP90 family

scientific article published in March 1997

A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice

scientific article

A segment-based approach to protein secondary structure prediction ⬇️

scientific article published on February 4, 1992

A surface of minimum area metric for the structural comparison of proteins

scientific article

A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice

scientific article published on January 2000

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

scientific article

Adding backbone to protein folding: why proteins are polypeptides

scientific article published on January 1996

Affinity-tagged miniprion derivatives spontaneously adopt protease-resistant conformations

scientific article

An Expert System for Secondary Structure Prediction

An evolutionary trace method defines binding surfaces common to protein families

scientific article (publication date: 29 March 1996)

Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone ⬇️

scientific article published on January 25, 1991

Analysis and prediction of structural motifs in the glycolytic enzymes ⬇️

scientific article published on June 26, 1981

Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha

scientific article published in September 2000

Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance ⬇️

scientific article published on April 1, 1981

Analysis of the sequence and structural features of the left-handed beta-helical fold

scientific article published in October 2008

Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change

scientific article

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

scientific article

Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling

scientific article published in November 1991

Artificial neural networks for pattern recognition in biochemical sequences

scientific article

Aryl ureas represent a new class of anti-trypanosomal agents

scientific article

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

scientific article (publication date: October 1999)

Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors

scientific article

Automatic extraction of protein point mutations using a graph bigram association.

scientific article

Bayesian statistical analysis of protein side‐chain rotamer preferences ⬇️

scientific article published on August 1, 1997

Beta-breakers: an aperiodic secondary structure

scientific article published in September 1991

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

scientific article

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro

scientific article

Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model

scientific article published on May 1996

Branched polyamines cure prion-infected neuroblastoma cells

scientific article

COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

scientific article

Cell division modulates prion accumulation in cultured cells

scholarly article

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei

scientific article

Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases

scientific article published in August 1994

Co-evolution of proteins with their interaction partners

scientific article published on June 2000

Co-evolutionary analysis reveals insights into protein-protein interactions.

scientific article

CoMFA and HQSAR of acylhydrazide cruzain inhibitors

scientific article published in June 2002

Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

scientific article

Computer-aided drug discovery and design

Computer-assisted drug discovery--a review

scientific article

Conformational attractors on the Ramachandran map.

scientific article

Conformational propagation with prion-like characteristics in a simple model of protein folding

scientific article published on April 2001

Conformational switching in designed peptides: the helix/sheet transition

scientific article

Conformational transitions in peptides containing two putative alpha-helices of the prion protein.

scientific article published in July 1995

Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

scholarly article

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

scientific article

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

scientific article

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

scientific article

Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH.

scientific article

Definition of liver tumors in the presence of diffuse liver disease: comparison of findings at MR imaging with positive and negative contrast agents

scientific article published in January 1997

Developing therapeutics for the diseases of protein misfolding

scientific article

Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation

scientific article published in February 2002

Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation

scientific article published on 21 July 2006

Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds

scientific article published on April 2007

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

scientific article

Dominant-negative inhibition of prion replication in transgenic mice

scientific article

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss

scientific article published in September 2000

Eight prion strains have PrPSc molecules with different conformations ⬇️

scientific article (publication date: October 1998)

Electron crystallography of the scrapie prion protein complexed with heavy metals

scientific article published on 23 August 2007

Elimination of prions by branched polyamines and implications for therapeutics

scientific article

Engineering the prion protein using chemical synthesis

scientific article published in November 2001

Entamoeba histolytica: computer-assisted modeling of phosphofructokinase for the prediction of broad-spectrum antiparasitic agents

scientific article

Evaluation of current techniques for ab initio protein structure prediction

scientific article

Evidence for assembly of prions with left-handed beta-helices into trimers

scholarly article

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation ⬇️

scientific article published on September 16, 1997

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex

scientific article published on July 1996

Evolutionary, mechanistic, and predictive analyses of the hydroxymethyldihydropterin pyrophosphokinase family of proteins

scientific article

Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.

scientific article published in January 1991

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors

scientific article

Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray

scientific article

Folding of prion protein to its native alpha-helical conformation is under kinetic control

scientific article

Four helix bundle diversity in globular proteins

scientific article published on March 1994

GPCRDB information system for G protein-coupled receptors

scientific article

GRAFTER: a computational aid for the design of novel proteins

scientific article

Genes contributing to prion pathogenesis

scientific article

Helix-helix packing angle preferences for finite helix axes

scientific article published in December 1998

Helix‐helix packing angle preferences for finite helix axes

article

Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix ⬇️

scientific article published on July 1, 1997

High-level expression and characterization of a purified 142-residue polypeptide of the prion protein

scientific article

Hydrogen bonds involving sulfur atoms in proteins.

scientific article

Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice ⬇️

scientific article published on December 23, 1997

Identification of candidate proteins binding to prion protein

scientific journal article

Identification of functional surfaces of the zinc binding domains of intracellular receptors ⬇️

scientific article published on December 5, 1997

Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy

scientific article published on November 2000

Identification of two prion protein regions that modify scrapie incubation time

scientific article

Imaging of mediastinal tumors

scientific article published on 18 February 2010

Improvements in protein secondary structure prediction by an enhanced neural network

scientific article published on July 1990

In vitro antimalarial activity of chalcones and their derivatives

scientific article published on December 1995

Influence of pregnancy and folic acid on phenytoin metabolism by rat liver microsomes ⬇️

scientific article (publication date: 1978)

JEvTrace: refinement and variations of the evolutionary trace in JAVA

scientific article

Leishmania major:Molecular Modeling of Cysteine Proteases and Prediction of New Nonpeptide Inhibitors ⬇️

scientific article published on November 1, 1997

Lipitoids — novel cationic lipids for cellular delivery of plasmid DNA in vitro ⬇️

scientific article published on June 1, 1998

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics

scientific article published in March 2001

MacMatch: a tool for pattern-based protein secondary structure prediction.

scientific article published in June 1993

Mapping the early steps in the pH-induced conformational conversion of the prion protein

scientific article

Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site

scientific article published in September 1995

Meeting review: the Second meeting on the Critical Assessment of Techniques for Protein Structure Prediction (CASP2), Asilomar, California, December 13-16, 1996.

scientific article

Mimicking dominant negative inhibition of prion replication through structure-based drug design

scientific article published on May 2000

Modeling protein structures: construction and their applications.

scientific article

Modeling protein-ligand complexes

scientific article

Molecular modeling of the misfolded insulin subunit and amyloid fibril

scientific article published on December 2009

Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family

scientific article

Molecular properties of complexes formed between the prion protein and synthetic peptides ⬇️

scientific article published on July 25, 1997

Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma

scientific article published on 2 February 2012

Multiple sequence information for threading algorithms

scientific article

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

scientific article published on February 2004

Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor

scientific article

N-terminally tagged prion protein supports prion propagation in transgenic mice

scientific article

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains ⬇️

scientific article published on April 14, 1998

Natural and synthetic prion structure from X-ray fiber diffraction

scientific article published on 28 September 2009

Natural ligands of nuclear receptors have conserved volumes

scientific article published on August 1, 1998

New local potential useful for genome annotation and 3D modeling

scientific article

New strategies for pharmaceutical design

scientific article published on January 1993

Nosocomial pneumonia and the main victim: the older person – measures for ventilator-associated pneumonia control

scientific article published on 23 June 2009

Novel method for the rapid evaluation of packing in protein structures

scientific article

On the prediction of protein structure: The significance of the root-mean-square deviation

scientific article

On the use of chemically derived distance constraints in the prediction of protein structure with myoglobin as an example

scientific article

Origins of structural diversity within sequentially identical hexapeptides

scientific article

Pairwise sequence alignment below the twilight zone

scientific article (publication date: 23 March 2001)

Pathologic conformations of prion proteins ⬇️

scientific article published on January 1, 1998

Pathological features of radiofrequency ablation (RFA) renal scar CT-imaging in a swine model

scientific article

Pathway complexity of prion protein assembly into amyloid

scientific article published on 23 March 2002

Pattern recognition and protein structure prediction

scholarly article

Pattern-based approaches to protein structure prediction.

scientific article

Physical studies of conformational plasticity in a recombinant prion protein

scientific article

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

scientific article

Potential danger of extending SMBG techniques to hospital wards

scientific article published in May 1986

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

scientific article

Prediction of the tertiary structure of the alpha-subunit of tryptophan synthase

scientific article

Prediction of the three-dimensional structure of human growth hormone

scientific article

Prion Protein Biology ⬇️

scientific article published on May 1, 1998

Prion Protein Isoforms, a Convergence of Biological and Structural Investigations ⬇️

scientific article published on August 18, 1995

Prion Protein Selectively Binds Copper(II) Ions ⬇️

scientific article published on May 19, 1998

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

scientific article

Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform

scientific article

Prion protein amyloid: separation of scrapie infectivity from PrP polymers.

scientific article

Prion protein gene variation among primates

scientific article

Prion protein gene variation among primates

scientific article published in January 1997

Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

scientific article

Prion protein peptides induce alpha-helix to beta-sheet conformational transitions

scientific article published in April 1995

Prion protein structure and scrapie replication: theoretical, spectroscopic, and genetic investigations

scientific article published on January 1, 1996

Prions, peptides and protein misfolding

scientific article

Prions: so many fibers, so little infectivity

scientific article published on April 2004

Proposed structure of the A domains of factor VIII by homology modelling

scientific article published in September 1995

Proposed three-dimensional structure for the cellular prion protein

scientific article published on July 1994

Protease-sensitive synthetic prions

scientific article

Protein conformational landscapes: energy minimization and clustering of a long molecular dynamics trajectory

scientific article

Protein folding ⬇️

doctoral thesis by Fred E. Cohen

Protein folding. Effect of packing density on chain conformation

scientific article published in May 1991

Protein misfolding and prion diseases

scientific article

Protein model structure evaluation using the solvation free energy of folding

scientific article published on April 1990

Protein structure predictions: new theoretical approaches.

scientific article

Quantitative traits of prion strains are enciphered in the conformation of the prion protein

scientific article published in January 2000

Recall bias in a prospective cohort study of acute time-varying exposures: example from the herpetic eye disease study

scientific article

Recombinant scrapie-like prion protein of 106 amino acids is soluble

scientific article published on December 1996

Reconstruction of low-resolution three-dimensional density maps from one-dimensional small-angle X-ray solution scattering data for biomolecules

article by Dirk Walther et al published 1 April 2000 in Journal of Applied Crystallography

Retroperitoneal fibrosis: a systemic effect of beta-blocker eyedrops?

scientific article

Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein

scientific article published on June 2000

Scrapie prions: a three-dimensional model of an infectious fragment

scientific article published in January 1995

Scrapie prions: a three-dimensional model of an infectious fragment

scientific article published in January 1996

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei

scientific article

Searching for new antimalarial therapeutics amongst known drugs

scientific article

Secondary structure assignment for alpha/beta proteins by a combinatorial approach

scientific article published in October 1983

Secondary structure prediction and unrefined tertiary structure prediction for cyclin A, B, and D.

scientific article published in January 1996

Selective neuronal targeting in prion disease

scientific article published on December 1997

Self-assembly of recombinant prion protein of 106 residues

scientific article published on March 2000

Separation of scrapie prion infectivity from PrP amyloid polymers

scientific article

Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure ⬇️

scientific article published on April 14, 1998

Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein

scientific article published in July 2009

Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration

scientific article

Solution structure of Syrian hamster prion protein rPrP(90-231).

scientific article

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform ⬇️

scientific article published on September 16, 1997

Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition

scientific article

Strain-specified characteristics of mouse synthetic prions

scientific article

Strain-specified relative conformational stability of the scrapie prion protein

scientific article

Structural clues to prion replication

scientific article

Structural studies of the scrapie prion protein by electron crystallography

scientific article

Structure from function: screening structural models with functional data

scientific article

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

scientific article

Structure prediction in a post-genomic environment: a secondary and tertiary structural model for the initiation factor 5A family

scientific article

Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells

scientific article published on 24 July 2006

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics

scientific article published on January 2007

Structure-based design of parasitic protease inhibitors

scientific article published on September 1996

Structure-based inhibitor design by using protein models for the development of antiparasitic agents

scientific article

Structures of prion proteins and conformational models for prion diseases

scientific article published in January 1996

Structure−Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics

article published in 2007

Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR Methodologies ⬇️

scientific article published on January 17, 2002

Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance

scientific article published in October 1990

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain

scientific article

Synthetic mammalian prions

scientific article

Taxonomy and conformational analysis of loops in proteins.

scientific article

The Status of the Telescope Array experiment

article

The impact of whole genome sequence data on drug discovery--a malaria case study

scientific article

The interview in dental clinical examination: the role of reformulation

scientific article

The origins of protein secondary structure. Effects of packing density and hydrogen bonding studied by a fast conformational search

scientific article published in August 1994

The parallel beta helix of pectate lyase C: something to sneeze at.

scientific article

The prion folding problem.

scientific article published in February 1997

The three-dimensional structure of prion protein: implications for prion disease ⬇️

scientific article published on August 1, 1998

Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation ⬇️

scientific article published on May 1, 1995

Therapeutic approaches to protein-misfolding diseases

scientific article

Thermodynamics of model prions and its implications for the problem of prion protein folding

scientific article published in February 1999

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues

scientific article

Topological distribution of four-alpha-helix bundles

scientific article

Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly

scientific article

Two different neurodegenerative diseases caused by proteins with similar structures

scientific article

Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors

scientific article

X-ray diffraction of scrapie prion rods and PrP peptides

scientific article published in September 1995

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