List of works - Hans Grönlund

A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS.

scientific article

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens

scientific article published on 03 October 2019

A molecular model of type I allergy: identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FcepsilonRI interaction and reacts with receptor-bound IgE.

scientific article published in September 2001

A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitro.

scientific article

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands

scientific article published on 22 July 2013

Allergens in dog extracts: Implication for diagnosis and treatment

scientific article published on 15 April 2019

Allergy testing in children with persistent asthma: comparison of four diagnostic methods

scientific article

An in vitro model for the allergen-IgE-FcARI interaction

scientific article published on 01 February 1999

Anoctamin 2 identified as an autoimmune target in multiple sclerosis

scientific article

Antibody profiles and self-reported symptoms to pollen-related food allergens in grass pollen-allergic patients from northern Europe

scientific article published on 01 February 2005

Basophil activation testing, IgG, and IgG4 in the diagnosis of dog allergy in children with and without a dog at home

scientific article published on 04 December 2019

Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy.

scientific article

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy

scientific article published on 01 December 2002

Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse.

scientific article

Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4

scientific article

Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat.

scientific article

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

scientific article published on 15 August 2016

Dendritic cell-derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response.

scientific article published on 25 August 2015

Designing a multimer allergen for diagnosis and immunotherapy of dog allergic patients

scientific article

Detection of an allergen in dog dander that cross-reacts with the major cat allergen, Fel d 1

scientific article published on 01 January 2007

Diversity of allergens contained in dog saliva. Reply

scientific article

Dog saliva - an important source of dog allergens

scientific article published on 7 March 2013

Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial.

scientific article published on 16 September 2014

Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants

article

Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli.

scientific article

High basophil allergen sensitivity (CD-sens) is associated with severe allergic asthma in children

article

Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis

scientific article published on 12 May 2008

Highly sensitive ELISA-based assay for quantification of allergen-specific IgE antibody levels

scientific article published on 17 April 2020

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction.

scientific article published on June 2014

Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.

scientific article

IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma.

scientific article published on 17 February 2012

Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine

article

In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity

scientific article

Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins

scientific article published on 31 January 2006

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

scientific article published on 30 March 2012

Low Levels of Endotoxin Enhance Allergen-Stimulated Proliferation and Reduce the Threshold for Activation in Human Peripheral Blood Cells

Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men.

scientific article published on 19 July 2008

Mammalian-derived respiratory allergens - implications for diagnosis and therapy of individuals allergic to furry animals

scientific article

Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy

scientific article published in 2022

Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4.

scientific article published on October 1997

Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies. Diabetes Incidence Study in Sweden (DISS)

scientific article published on 01 April 2000

Prevalence of severe childhood asthma according to the WHO

scientific article published on 04 June 2014

Production, crystallization and preliminary X-ray diffraction analysis of the allergen Can f 2 from Canis familiaris.

scientific article published on 24 April 2009

Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d 1.

scientific article published on 23 May 2003

Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice.

scientific article published on 31 January 2009

Recombinant Bet v 1 vaccine for treatment of allergy to birch pollen.

scientific article published on December 2010

Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations

scientific article published on 01 October 1998

Recommendations for the allergy management in the primary care.

scientific article published on 15 March 2014

Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics.

scientific article published on 27 January 2014

Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the

scientific article published on 01 November 1999

Structural changes and allergenic properties of β-lactoglobulin upon exposure to high-intensity ultrasound

Structural characterization of the tetrameric form of the major cat allergen Fel d 1

scientific article

The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA.

scientific article

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1.

scientific article

The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT).

scientific article

Three-Dimensional Structure of Fel d 1, the Major Allergen in Cat

scientific article published on 01 September 2003

Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy

article

Vaccination with genetically engineered allergens prevents progression of allergic disease.

scholarly article

[Biological engineering for new asthma therapy]

scientific article published on 01 June 2008

List of works by Hans Grönlund

A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS.

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens

A molecular model of type I allergy: identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FcepsilonRI interaction and reacts with receptor-bound IgE.

A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitro.

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands

Allergens in dog extracts: Implication for diagnosis and treatment

Allergy testing in children with persistent asthma: comparison of four diagnostic methods

An in vitro model for the allergen-IgE-FcARI interaction

Anoctamin 2 identified as an autoimmune target in multiple sclerosis

Antibody profiles and self-reported symptoms to pollen-related food allergens in grass pollen-allergic patients from northern Europe

Basophil activation testing, IgG, and IgG4 in the diagnosis of dog allergy in children with and without a dog at home

Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy.

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy

Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse.

Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4

Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat.

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

Dendritic cell-derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response.

Designing a multimer allergen for diagnosis and immunotherapy of dog allergic patients

Detection of an allergen in dog dander that cross-reacts with the major cat allergen, Fel d 1

Diversity of allergens contained in dog saliva. Reply

Dog saliva - an important source of dog allergens

Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial.

Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants

Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli.

High basophil allergen sensitivity (CD-sens) is associated with severe allergic asthma in children

Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis

Highly sensitive ELISA-based assay for quantification of allergen-specific IgE antibody levels

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction.

Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.

IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma.

Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine

In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity

Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

Low Levels of Endotoxin Enhance Allergen-Stimulated Proliferation and Reduce the Threshold for Activation in Human Peripheral Blood Cells

Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men.

Mammalian-derived respiratory allergens - implications for diagnosis and therapy of individuals allergic to furry animals

Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy

Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4.

Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies. Diabetes Incidence Study in Sweden (DISS)

Prevalence of severe childhood asthma according to the WHO

Production, crystallization and preliminary X-ray diffraction analysis of the allergen Can f 2 from Canis familiaris.

Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d 1.

Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice.

Recombinant Bet v 1 vaccine for treatment of allergy to birch pollen.

Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations

Recommendations for the allergy management in the primary care.

Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics.

Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the

Structural changes and allergenic properties of β-lactoglobulin upon exposure to high-intensity ultrasound

Structural characterization of the tetrameric form of the major cat allergen Fel d 1

The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA.

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1.

The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT).

Three-Dimensional Structure of Fel d 1, the Major Allergen in Cat

Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy

Vaccination with genetically engineered allergens prevents progression of allergic disease.

[Biological engineering for new asthma therapy]