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List of works by Nicole Thielens

A model system for the study of the assembly and regulation of human complement C3 convertase (classical pathway)

scientific article published on 01 June 1986

A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.

scientific article

A study of a covalent-like interaction between soluble nascent C4b and C4-binding protein

scientific article published on 01 June 1982

Activation of classical pathway of complement cascade by soluble oligomers of prion.

scientific article published in December 2007

Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q.

scientific article published on July 1994

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex

scientific article published on 17 October 2018

Analysis of the N-linked oligosaccharides of human C1s using electrospray ionisation mass spectrometry

scientific article published on 01 January 1995

Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers

scientific article published on 29 July 2018

Arrangement of the C1 complex of complement.

scientific article published on December 1990

Assembly and enzymatic properties of the catalytic domain of human complement protease C1r.

scientific article published on 9 July 2001

Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.

scientific article published on 20 December 2006

Assembly of the C1 complex.

scientific article published on December 1993

Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus

scientific article

Autoantibodies targeting ficolin-2 in systemic lupus erythematosus patients with active nephritis.

scientific article published on 17 October 2017

C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome

scientific article published on 05 November 2019

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules

scientific article published on 7 March 2018

C1q restrains autoimmunity and viral infection by regulating CD8+T cell metabolism

scientific article published in Science

C1q: A fresh look upon an old molecule

scientific article

C4 binding to artificial systems

scientific article published on 01 October 1981

Catalytically inactive Gla-domainless factor Xa binds to TFPI and restores ex vivo coagulation in hemophilia plasma

scientific article published on 5 October 2017

Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2.

scientific article

Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2

scientific article

Characterization of the interaction between collectin 11 (CL-11, CL-K1) and nucleic acids ⬇️

scientific article published on August 14, 2013

Chemical characterization and location of ionic interactions involved in the assembly of the C1 complex of human complement

scientific article published on 01 December 1993

Classical complement pathway components C1r and C1s: purification from human serum and in recombinant form and functional characterization.

scientific article published in January 2014

Comparative study of the fluid-phase proteolytic cleavage of human complement subcomponents C4 and C2 by C1s and C1r2-C1s2

scientific article published on 01 January 1984

Competition of complement proteins and specific antibodies for binding to HIV-1 envelope antigens

scientific article published on 01 January 1994

Complement C1r serine protease contributes to kidney fibrosis

scientific article published on 11 September 2019

Complement protein C1q recognizes a conformationally modified form of the prion protein.

scientific article

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway ⬇️

scientific article published on March 4, 2013

Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen

scientific article published on 23 December 2016

Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?

scientific article

Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway.

scientific article published on 4 October 2016

Editorial: The Role of Complement in Health and Disease

Editorial: The double life of M-ficolin: what functions when circulating in serum and tethered to leukocyte surfaces? ⬇️

scientific article published on 01 September 2011

Effect of lactoperoxidase-catalyzed iodination on the calcium-dependent interactions of human C.hivin.1s. Location of the iodination sites ⬇️

scientific article published on July 23, 1991

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

scientific article

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.

scientific article published on 16 March 2016

First Membrane Proximal External Region-Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations

scientific article published on August 2016

Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules.

scientific article

Functional characterization of the recombinant human C1 inhibitor serpin domain: insights into heparin binding.

scientific article published on 29 March 2010

Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1.

scientific article

Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children

scientific article

HIV and human complement: mechanisms of interaction and biological implication.

scientific article

HIV-1 and HIV-2 isolates differ in their ability to activate the complement system on the surface of infected cells

scientific article published on 01 July 1993

HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120.

scientific article

Headless C1q: a new molecular tool to decipher its collagen-like functions

scientific article published on 31 August 2020

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

scientific article published on 30 October 2013

Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes

scientific article published on 22 May 2017

Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.

scientific article

Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.

scientific article published on 6 November 2009

Human complement protein C9 is a calcium binding protein. Structural and functional implications

scientific article published on 01 May 1988

Human complement serine proteases C1r and C1s and their proenzymes

scientific article published on 01 January 1993

Human complement subcomponent C2: purification and proteolytic cleavage in fluid phase by C1s, C1r2-C1s2 and C1

scientific article published on 01 May 1982

Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41

scientific article

Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

scientific article

Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55

scientific article published on 01 May 2007

Impact of the surface charge of polydiacetylene micelles on their interaction with human innate immune protein C1q and the complement system.

scientific article published on 2 December 2017

In vitro analysis of complement-dependent HIV-1 cell infection using a model system.

scientific article published on April 1999

Interaction of C1 with HIV-1.

scientific article published in December 1993

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

scientific article published on 14 March 2019

Interaction of C1q and mannan-binding lectin with viruses.

scientific article

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.

scientific article published on 5 December 2017

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

scientific article published on 26 December 2018

Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals

scientific article published in November 2003

M-ficolin and leukosialin (CD43): new partners in neutrophil adhesion

scientific article published on 13 December 2011

M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules

scientific journal article

MASP interactions with plasma-derived MBL

scientific article published on 18 May 2012

Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages

scientific article published on 01 June 2000

Mode of PEG Coverage on Carbon Nanotubes Affects Binding of Innate Immune Protein C1q.

scientific article

Modified low density lipoproteins differentially bind and activate the C1 complex of complement

scientific article published on 30 August 2006

Molecular organization of human Ficolin-2.

scientific article published on 3 April 2006

Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism

scientific article

MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis

scientific article

Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions

scientific article published on March 2012

Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition

scientific article published on 22 February 2023

Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner

scientific article

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

scientific article published on 21 July 2015

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement

scientific article published on 27 September 2016

Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein ⬇️

scientific article published on March 21, 2013

Purification and characterization of C4-binding protein from human serum

scientific article published on 01 September 1981

Purification of human complement subcomponent C4. C4 cleavage by C1s.

scientific article published on July 1979

Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement

scientific article published on 24 October 2018

Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway

scientific article published on 15 November 2019

Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex

scientific article published on May 5, 1992

Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin.

scientific article

Soluble C3 proconvertase and convertase of the classical pathway of human complement. Conditions of stabilization in vitro.

scientific article published on March 1985

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.

scientific article published on 2 March 2016

Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope

scientific article

Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch

scientific article

Structural changes in C4 produced by cleavage with C1-s

scientific article published on 01 June 1980

Structural insights into the Slit-Robo complex

scientific article

Structural insights into the recognition properties of human ficolins.

scientific article published on 06 August 2009

Structure and activation of the C1 complex of complement: unraveling the puzzle.

scientific article

Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.

scientific article

Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex.

scientific article

Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions.

scientific article published on October 2011

Structure of the C1 complex of complement.

scientific article published on 12 July 2017

Structure, function and molecular genetics of human and murine C1r.

scientific article

Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

scientific article

Studies on the interactions between C-reactive protein and complement proteins.

scientific article published on 18 January 2007

Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement

scientific article published on 01 May 2003

Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2

scientific article

The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease

scientific article published on 01 April 2020

The Role of the Individual Domains in the Structure and Function of the Catalytic Region of a Modular Serine Protease, C1r ⬇️

scientific article published on November 1, 2001

The Serine Protease Domain of MASP-3: Enzymatic Properties and Crystal Structure in Complex with Ecotin

scientific article

The atypical serine proteases of the complement system

scientific article published on January 1, 1998

The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases

scientific article published on 03 January 2008

The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three different regions of gp41, the transmembrane glycoprotein of HIV-1, and share antigenic homology.

scientific article

The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers

scientific article

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

scientific article

Two Different Missense C1S Mutations, Associated to Periodontal Ehlers-Danlos Syndrome, Lead to Identical Molecular Outcomes

scientific article published on 18 December 2019

Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection

article

Ultrastructure of human C4-binding protein: proposition for a new model

article published in 1985

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