List of works - Thomas J.D. Jørgensen

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

scientific article published on 13 June 2018

A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

scientific article

A phosphorylation tag for uranyl mediated protein purification and photo assisted tag removal

scientific article

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.

scientific article

Affinity capture of biotinylated proteins at acidic conditions to facilitate hydrogen/deuterium exchange mass spectrometry analysis of multimeric protein complexes.

scientific article

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

scientific article published on 10 May 2006

An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.

scientific article published on 26 October 2016

An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin.

scientific article published in June 2016

An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1).

scientific article

Analysis of Translocation-Competent Secretory Proteins by HDX-MS.

scientific article

Avoiding H/D Scrambling with Minimal Ion Transmission Loss for HDX-MS/MS-ETD Analysis on a High-Resolution Q-TOF Mass Spectrometer

scientific article published on 19 May 2020

Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

scientific article published on 03 May 2006

Characterizing the dynamics of α-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry

scientific article published on 11 December 2013

Co-existence of two different α-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry.

scientific article published on 16 April 2014

Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

scientific article published on 18 August 2015

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.

scientific article

Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability.

scientific article published on 14 July 2016

Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

scientific article published on 13 October 2007

Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

scientific article published on 20 March 2019

Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry

scientific article

Dissecting the interaction between transglutaminase 2 and fibronectin

scientific article

Effect of Metals in Biomimetic Dimetal Complexes on Affinity and Gas-Phase Protection of Phosphate Esters.

scientific article

Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

scientific article published on 23 December 2013

Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

scientific article

Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

scientific article

Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2.

scientific article published on 26 October 2016

Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling.

scientific article

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

scientific article published on 30 October 2013

Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

scientific article

Highly selective enrichment of phosphorylated peptides using titanium dioxide

scientific article published on 01 January 2006

Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.

scientific article

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

scientific article published on 04 October 2012

Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies

scientific article

Interconverting conformations of variants of the human amyloidogenic protein beta2-microglobulin quantitatively characterized by dynamic capillary electrophoresis and computer simulation

scientific article published on 01 June 2006

Local transient unfolding of native state PAI-1 associated with serpin metastability

scientific article published on 22 July 2014

Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome

scientific article published on 05 April 2018

Loss of Ammonia during Electron-Transfer Dissociation of Deuterated Peptides as an Inherent Gauge of Gas-Phase Hydrogen Scrambling

scientific article published on 29 October 2010

Mapping temperature-induced conformational changes in the Escherichia coli heat shock transcription factor sigma 32 by amide hydrogen exchange.

scientific article

Mass spectrometric analysis of protein interactions.

scientific article

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

scientific article

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

scientific journal article

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From <i>Bothrops asper</i> Venom

scientific article published on 01 January 2021

Molecular identification of the insect adipokinetic hormone receptors

scientific article

On the formation of radical dications of protonated amino acids in a "microsolution" of water or acetonitrile and their reactivity towards the solvent.

scientific article

On the photostability of peptides after selective photoexcitation of the backbone: prompt versus slow dissociation.

scientific article published in August 2014

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.

scientific article

Rapid desalting of protein samples for on-line microflow electrospray ionization mass spectrometry

scientific article published on 29 December 2004

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

scientific article published on 27 June 2019

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

scientific article published on 28 November 2016

Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris

scientific article

Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

scientific article published on 09 November 2011

Spatially resolved protein hydrogen exchange measured by subzero-cooled chip-based nanoelectrospray ionization tandem mass spectrometry.

scientific article published on 26 April 2012

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

scientific article

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

scientific article published on 3 January 2016

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

scientific article published on 8 December 2016

The formation of heterodimers by vancomycin group antibiotics

scientific article published on 01 February 2000

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

scientific article

Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers

article

Ultraviolet Photodissociation of Protonated Peptides and Proteins Can Proceed with H/D Scrambling

scientific article published on 09 December 2020

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

scientific article published on 07 February 2020

Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.

scientific article

Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products

scientific article published on 20 April 2017

Vancomycin in vacuo

Variants of β2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature

scientific article published on 01 June 2006

List of works by Thomas J.D. Jørgensen

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

A phosphorylation tag for uranyl mediated protein purification and photo assisted tag removal

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.

Affinity capture of biotinylated proteins at acidic conditions to facilitate hydrogen/deuterium exchange mass spectrometry analysis of multimeric protein complexes.

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.

An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin.

An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1).

Analysis of Translocation-Competent Secretory Proteins by HDX-MS.

Avoiding H/D Scrambling with Minimal Ion Transmission Loss for HDX-MS/MS-ETD Analysis on a High-Resolution Q-TOF Mass Spectrometer

Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

Characterizing the dynamics of α-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry

Co-existence of two different α-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry.

Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.

Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability.

Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry

Dissecting the interaction between transglutaminase 2 and fibronectin

Effect of Metals in Biomimetic Dimetal Complexes on Affinity and Gas-Phase Protection of Phosphate Esters.

Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2.

Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling.

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

Highly selective enrichment of phosphorylated peptides using titanium dioxide

Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies

Interconverting conformations of variants of the human amyloidogenic protein beta2-microglobulin quantitatively characterized by dynamic capillary electrophoresis and computer simulation

Local transient unfolding of native state PAI-1 associated with serpin metastability

Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome

Loss of Ammonia during Electron-Transfer Dissociation of Deuterated Peptides as an Inherent Gauge of Gas-Phase Hydrogen Scrambling

Mapping temperature-induced conformational changes in the Escherichia coli heat shock transcription factor sigma 32 by amide hydrogen exchange.

Mass spectrometric analysis of protein interactions.

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From <i>Bothrops asper</i> Venom

Molecular identification of the insect adipokinetic hormone receptors

On the formation of radical dications of protonated amino acids in a "microsolution" of water or acetonitrile and their reactivity towards the solvent.

On the photostability of peptides after selective photoexcitation of the backbone: prompt versus slow dissociation.

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.

Rapid desalting of protein samples for on-line microflow electrospray ionization mass spectrometry

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris

Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

Spatially resolved protein hydrogen exchange measured by subzero-cooled chip-based nanoelectrospray ionization tandem mass spectrometry.

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

The formation of heterodimers by vancomycin group antibiotics

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers

Ultraviolet Photodissociation of Protonated Peptides and Proteins Can Proceed with H/D Scrambling

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.

Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products

Vancomycin in vacuo

Variants of β2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature