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List of works by F. Susan Wong

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse

scientific article published on 01 March 2003

A novel method for concurrent visualization of immunostain under light and electron microscopy in pancreatic islets

scientific article published on 01 December 1998

A predictive CD8+ T cell phenotype for T1DM progression

scientific article published on 01 April 2020

A reproducible method for the expansion of mouse CD8+ T lymphocytes.

scientific article published on 17 January 2015

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

scientific article published on 14 June 2017

Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1

scientific article published on August 1998

Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice

scientific article published on 11 January 2018

Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice.

scientific article published on 21 January 2016

Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

scientific article published on 18 January 2017

Adult-onset autoimmune diabetes

scientific article published on 22 September 2022

Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes

scientific article published on 01 August 2007

Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells

scientific article published on 22 February 2019

An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes ⬇️

scientific article published on September 10, 2011

An islet-specific pulse of TGF-β abrogates CTL function and promotes β cell survival independent of Foxp3+ T cells.

scientific article published on 7 January 2011

Analysis of human T-cell receptor V beta gene usage following immunization to tetanus toxoid in vivo

article

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus

scientific article

Anti-CD20 treatment prolongs syngeneic islet graft survival and delays the onset of recurrent autoimmune diabetes

scientific article published on 01 December 2008

Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity

scientific article

Antibiotics, gut microbiota, environment in early life and type 1 diabetes.

scientific article

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

scientific article published on 30 June 2017

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.

scientific article

B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model.

scientific article published on 28 March 2018

B cells in autoimmune diabetes

scientific article published on 10 November 2005

B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes.

scientific article

Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes

scientific article published on 3 September 2016

CD5+ B-cells at the onset of type I diabetes and in the prediabetic period

scientific article published on 01 July 1994

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

scientific article

CD8+ T-cells and their interaction with other cells in damage to islet beta-cells.

scientific article published on June 2008

Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice.

scientific article published on 5 February 2009

Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study.

scientific article published on 12 March 2018

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes.

scientific article published on 27 February 2013

Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction

scientific article published on 06 April 2007

Cross talk between circadian rhythms and the microbiota

scientific article published on 08 October 2020

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

scientific article published on 01 May 1999

Developing a novel model system to target insulin-reactive CD8 T cells

scientific article published on 01 December 2008

Dietary short-chain fatty acids protect against type 1 diabetes.

scientific article published on April 2017

Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice

scientific article

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

scientific article published on 17 June 2015

Endoplasmic reticulum targeting alters regulation of expression and antigen presentation of proinsulin

scientific article published on 28 April 2014

Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice

scientific article published in Scientific Reports

Evidence for a persistent, major excess in all cause admissions to hospital in children with type-1 diabetes: results from a large Welsh national matched community cohort study.

scientific article published on 13 April 2015

Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.

scientific article published in August 2002

Fine-Needle Aspiration Biopsy of the Lymph Node: A Novel Tool for the Monitoring of Immune Responses after Skin Antigen Delivery.

scientific article

Formulation of hydrophobic peptides for skin delivery via coated microneedles

scientific article published on 9 March 2017

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

scientific article published on January 1998

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

scientific article

How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders?

scientific article

How does B-cell tolerance contribute to the protective effects of diabetes following induced mixed chimerism in autoimmune diabetes?

scientific article published on 01 June 2014

Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.

scientific article

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7

scientific article published on 01 April 2002

Hydrodynamic gene delivery in human skin using a hollow microneedle device.

scientific article published on 27 February 2017

Hyperglycaemia does not affect antigen-specific activation and cytolytic killing by CD8+ T cells in vivo

scientific article published on 10 August 2017

IFN-alpha can both protect against and promote the development of type 1 diabetes

scientific article published on 01 December 2008

IFN-gamma affects homing of diabetogenic T cells

scientific article published on 01 December 2001

IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes

scientific article published on 06 April 2010

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice

scientific article published on 09 March 2011

IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice

scientific article

Identification of Islet Antigen-Specific CD8 T Cells Using MHCI-Peptide Tetramer Reagents in the Non Obese Diabetic (NOD) Mouse Model of Type 1 Diabetes

scientific article published on 01 January 2016

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

scientific article

Identifying the 'Achilles Heel' of type 1 diabetes

scientific article published on 24 December 2020

Immune and Pancreatic β Cell Interactions in Type 1 Diabetes.

scientific article published on 19 September 2016

Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

scientific article published in Nature

Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative

scientific article published on 01 November 2011

Immunotargeting of insulin reactive CD8 T cells to prevent diabetes

scientific article published on 20 September 2010

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

scientific article

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice ⬇️

scientific article published on September 1, 1998

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

scientific article published on 14 November 2007

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

scientific article published on 19 January 2016

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse.

scientific article published on July 1997

Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.

scientific article

Innate and adaptive immune responses are highly interconnected at many levels

scientific article published on 01 February 2009

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

scientific article

Insulin-dependent diabetes mellitus and its animal models.

scientific article

Investigation of the role of B-cells in type 1 diabetes in the NOD mouse

scientific article published on 01 October 2004

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society ⬇️

scientific article published on 05 October 2010

Long term effect of gut microbiota transfer on diabetes development

scientific article

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

scientific article published on 07 June 2018

MRI appearance of the pancreas in patients with cystic fibrosis: a comparison of pancreas volume in diabetic and non-diabetic patients.

scientific article

Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs

scientific article published on 23 September 2015

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.

scientific article published on August 2017

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

scientific article published on 12 September 2016

Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes.

scientific article published on 28 December 2015

Modulation of the immune system by the gut microbiota in the development of type 1 diabetes

scientific article published on 19 September 2018

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.

scientific article

Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype

scientific article published on 2 February 2021

Natural protection from type 1 diabetes in Non Obese Diabetic (NOD) mice is characterised by a unique pancreatic islet phenotype

scientific article published on 10 January 2021

Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.

scientific article

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

scientific article published on 4 June 2017

Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice

scientific article published on 01 April 1999

Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.

scientific article published on 5 August 2016

Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.

scientific article

Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation.

scientific article published in February 1998

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

scientific article published on 07 March 2016

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

scientific article published on 20 November 2008

Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.

scientific article published on 28 May 2013

Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity

scientific article published on 25 June 2018

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

scientific article published on 01 February 2004

Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells.

scientific article

Stimulating IL-13 receptors on T cells: a new pathway for tolerance induction in diabetes?

scientific article

Susceptibility to autoimmune thyroiditis in Down's syndrome is associated with the major histocompatibility class II DQA 0301 allele

scientific article published on 01 September 1994

T cells recognizing a peptide contaminant undetectable by mass spectrometry.

scientific article

T-Cell Receptor Constant β Chain Polymorphisms and Susceptibility to Type 1 Diabetes

scientific article published on 01 December 1992

TCR germline polymorphisms in diabetes.

scientific article

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells

scientific article

TGF-γ signaling is required for the function of insulin-reactive T regulatory cells.

scientific article published in June 2006

TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice.

scientific article published on 16 August 2013

TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells

scientific article published on 28 June 2018

Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.

scientific article published on 9 December 2005

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

scientific article published on 17 October 2016

The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD Mice ⬇️

scientific article published on April 4, 2012

The Gut Microbiome in the NOD Mouse.

scientific article published on April 2016

The Role of Toll-Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice

article

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.

scientific article published in March 2004

The gut microbiota and Type 1 Diabetes.

scientific article published on 4 June 2015

The human T cell receptor V beta repertoire of normal peripheral blood lymphocytes before and after mitogen stimulation.

scientific article published in May 1993

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

scientific article published on 21 September 2015

The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.

scientific article

The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model

scientific article

The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse.

scientific article published on June 1997

The role of CD4 vs. CD8 T cells in IDDM.

scientific article

The role of Fas in autoimmune diabetes

scientific article published on 01 April 1997

The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice

scientific article

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

scientific article

The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice

scientific article

The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid

scientific article published on 01 April 1981

The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes

scientific article published on 24 March 2016

The size of the spleen by magnetic resonance imaging in patients with cystic fibrosis; with and without diabetes--a novel observational study.

scientific article

Therapeutic targeting of Syk in autoimmune diabetes

scientific article

To B or not to B--pathogenic and regulatory B cells in autoimmune diabetes.

scientific article

Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes

scientific article published on 09 August 2018

Toll-like receptors and diabetes.

scientific article published on December 2008

Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin

scientific article

Tracking Immunological Responses of Islet Antigen-Specific T Cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes.

scientific article published on 21 January 2016

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

scientific article published in December 2007

Type 1 diabetes and gut microbiota: Friend or foe?

scientific article

Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes

scientific article published on 28 December 2012

Unsupervised clustering reveals a unique Treg profile in slow progressors to type 1 diabetes

scientific article published on 15 January 2021

What can the HLA transgenic mouse tell us about autoimmune diabetes?

scientific article published on 2 September 2004

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