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List of works by Gabriel Núñez

3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome

scientific article

30

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

scientific article

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis ⬇️

scientific article published on May 4, 2011

A New Twist on the PYRIN Mediterranean Coast ⬇️

scientific article published on May 27, 2011

A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells

scientific article

A complex microworld in the gut: Harnessing pathogen-commensal relations

scientific article published on 01 August 2012

A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome

scientific article published on 28 August 2009

A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.

scientific article published on 15 January 2013

A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion

scientific article

A putative role for human BFK in DNA damage-induced apoptosis

scientific article

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

scientific article

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice

scientific article published on 01 April 2019

A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death

scientific article

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases ⬇️

scientific article published on April 28, 1998

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

scientific article

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

scientific article published on 07 October 2009

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

scientific article published on 17 January 2017

An Enteric Pathogen Subverts Colonization Resistance by Evading Competition for Amino Acids in the Gut

scientific article published on 17 July 2020

Apoptosis in keratinocytes is not dependent on induction of differentiation

scientific article published on 01 January 1997

Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

scientific article published on 14 August 2018

Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B ⬇️

scientific article published on May 25, 2012

Bcl-2 Orchestrates a Cross-talk between Endothelial and Tumor Cells that Promotes Tumor Growth

scientific article published on 15 October 2007

Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines.

scientific article

Bcl-2: B cell life, death and neoplasia

scientific article published on 01 January 1990

Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation ⬇️

scientific article published on April 14, 1998

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice

scientific article

CIDE, a novel family of cell death activators with homology to the 45kDa subunit of the DNA fragmentation factor ⬇️

scientific article published on May 1, 1998

CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10

scientific article (publication date: 9 April 1999)

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis ⬇️

scientific article published on September 30, 1997

Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells

scientific article

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo

scientific article

Caspase-1 inflammasomes in infection and inflammation

scientific article published on 18 April 2007

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

scientific article published on 10 November 2015

Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development

scientific article published on 2 December 2002

Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

scientific article published on 12 August 2009

Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation

scientific article published on April 2009

Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloantigens

scientific article

Control of pathogens and pathobionts by the gut microbiota

scientific article

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

scientific journal article

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein

scientific article

Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.

scientific article published on September 2008

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

scientific article

Cutting Edge: Crohn’s Disease-Associated Nod2 Mutation Limits Production of Proinflammatory Cytokines To Protect the Host from Enterococcus faecalis-Induced Lethality ⬇️

scientific article published on August 17, 2011

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

scientific article published on 19 June 2009

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

scientific article

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux

scientific article

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

scientific journal article

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 ⬇️

scientific article published on April 26, 2012

Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity

scientific article published on 13 March 2001

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

scientific article published on May 1990

Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo

scientific article published on May 1995

Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans.

scientific article published in September 2000

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

scientific article published on 7 April 2015

Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes

scientific article published in April 2006

Divergence of the systemic immune response following oral infection with distinct strains ofPorphyromonas gingivalis

scientific article published in August 2012

Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death

scientific article

Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice

scientific article published on 01 June 2019

Erratum: Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

scientific article published on 01 August 2016

Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.

scientific article

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

scientific article published on March 2010

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells

scientific article

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

scientific article

Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.

scientific article published on January 2014

Gut microbiota and systemic immunity in health and disease

scientific article published on 24 December 2020

Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury

scientific article published on 28 October 2013

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.

scientific article

Host-microbiota interactions in inflammatory bowel disease

scientific article published on 31 January 2020

Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2.

scientific article published on 21 August 2013

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.

scientific article published on 30 April 2015

IL-18 is not therapeutic for neovascular age-related macular degeneration

scientific article published on December 2014

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections

scientific article published on 03 February 2017

Identification and functional characterization of EseH, a new effector of the type III secretion system of Edwardsiella piscicida

scientific article published on July 2016

Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD

scientific article published on 01 January 1999

Immunology. Orchestrating inflammasomes

scientific article published on September 2012

In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus

scientific article published on 24 April 2014

Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell apoptosis induced by vacuolar type H(+)-ATPase inhibitor

scientific article published on 01 January 1998

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

scientific article published in Journal of Biological Chemistry

Inflammasomes as microbial sensors

scientific article published on March 2010

Inflammasomes in Intestinal Inflammation and Cancer ⬇️

scientific article published on October 15, 2011

Influence of donor microbiota on the severity of experimental graft-versus-host-disease

scientific article

Innate Nutritional Immunity

scholarly article by Gabriel Núñez et al published 1 July 2018 in Journal of Immunology

Innate immune recognition of flagellin limits systemic persistence of Brucella

scientific article

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease

scientific article published on 15 October 2018

Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis ⬇️

scientific article published on November 28, 2011

Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

scientific article

Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

scientific article

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response

scientific article published in Nature Communications

Intracellular NOD-like receptors in innate immunity, infection and disease

scientific article published on 18 October 2007

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome

scientific article published on 11 June 2015

Kaposi's sarcoma tumor cells preferentially express Bcl-xL.

scientific article published on September 1996

Lack of common NOD2 variants in Japanese patients with Crohn's disease

scientific article

Level of endothelial cell apoptosis required for a significant decrease in microvessel density.

scientific article published on 28 July 2007

Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3

scientific article published on 07 October 2020

MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis

scientific article

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

scientific article published on 13 April 2009

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.

scientific article published in May 2009

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

scientific article published on 24 January 2019

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity

scientific article published in 2022

Mechanism and Regulation of NLRP3 Inflammasome Activation

scientific article published on 23 September 2016

Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.

scientific article published on 3 July 2017

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

scientific article published on 07 November 2019

Microbial metabolite sensor GPR43 controls severity of experimental GVHD

scientific article published in Nature Communications

Microbiota-dependent activation of CD4 <sup>+</sup> T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors

scientific article published on 04 January 2024

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

scientific article published on 30 January 2012

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multiple effects of dendritic cell depletion on murine norovirus infection

scientific article published on May 2013

MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction ⬇️

scientific article published on January 1, 2013

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

scientific article published on 27 January 2016

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

scientific journal article

NOD1 and NOD2: signaling, host defense, and inflammatory disease

scientific article

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages ⬇️

scientific article published on November 24, 2010

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.

scientific article published on April 2017

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice

scientific article published on 11 December 2018

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo

scientific article

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

scientific article

Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils

scientific article published on October 2014

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

scientific article

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

scientific article published on 11 April 2016

Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages

scientific journal article

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen

scientific article published on 16 March 2011

Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense

scientific article published on September 2006

Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model

scientific article published on December 1999

P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.

scientific article published on April 2009

PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation

scientific journal article

Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.

scientific article published in March 2008

Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health

scientific article published on 14 May 2019

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling

scientific article published on 26 March 2010

Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis

scientific article

Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection

scientific article

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop

scientific article published on 10 August 2012

RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

scientific article published on 01 November 2020

RICK promotes inflammation and lethality after gram-negative bacterial infection in mice stimulated with lipopolysaccharide

scientific article published on 2 February 2009

RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis ⬇️

scientific article published on May 15, 1998

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

article

RNase L activates the NLRP3 inflammasome during viral infections

scientific article

Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin-1β

scientific article published on 02 September 2019

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

scientific article

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

scientific article

Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product

scientific article (publication date: 14 March 2003)

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

scientific article published on December 1999

Regulation of the immune system by the resident intestinal bacteria.

scientific article published on 04 February 2014

Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation.

scientific article

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

scientific article published on July 1999

Role of the gut microbiota in immunity and inflammatory disease ⬇️

scientific article published on May 1, 2013

Role of the gut microbiota in the development and function of lymphoid cells.

scientific article published on February 2013

Role of the microbiota in skin immunity and atopic dermatitis

scientific article published on 4 September 2017

Sensing and reacting to microbes through the inflammasomes ⬇️

scientific article published on March 19, 2012

Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.

scientific article

Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

scientific article

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β

scientific article published on 29 April 2019

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

scientific article published on 20 August 2015

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

scientific article published on 01 July 2020

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

scientific article

Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy

scientific article

TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo ⬇️

scientific article published on December 7, 2012

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

scientific journal article

TLR3 increases disease morbidity and mortality from vaccinia infection

scientific article published on January 2008

Targeting cancer cell death with a bcl-xS adenovirus ⬇️

scientific article published on January 1, 1998

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL‐1β production in Helicobacter pylori infected dendritic cells ⬇️

scientific article published on July 25, 2013

The NLR gene family: a standard nomenclature

scientific article

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection ⬇️

scientific article published on 01 November 2018

The NOD2-RICK complex signals from the plasma membrane.

scientific article published on 13 March 2007

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

scientific article published on August 2008

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

scientific article published on 01 June 2007

The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes

scientific article

The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls

scientific article published on 28 June 2008

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

scientific journal article

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

scientific article

The interplay between host immune cells and gut microbiota in chronic inflammatory diseases

scientific article

The protein kinase PKR is critical for LPS‐induced iNOS production but dispensable for inflammasome activation in macrophages ⬇️

scientific article published on March 15, 2013

Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells

scientific article

Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development

scientific article

Unidirectional crosstalk between Bcl-xL and Bcl-2 enhances the angiogenic phenotype of endothelial cells

scientific article published on 15 June 2007

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

scientific article

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

scientific article

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

scientific article

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

scientific article

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