List of works - Jonathan Waltho

(1)H, (15)N and (13)C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2.

scientific article published on 22 November 2017

(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis

scientific article

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

scientific article published on 08 August 2019

1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride.

scientific article published on 2 September 2017

1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol

scientific article published on 15 December 2016

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

scholarly article

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

scientific article

A method for the reversible trapping of proteins in non-native conformations.

scientific article published in December 2008

A pulse--radiolysis approach to fast reductive cleavage of a disulfide bond to uncage enzyme activity.

scientific article published on 9 August 2008

A reassessment of copper(II) binding in the full-length prion protein

scientific article published on November 2006

A thiol labelling competition experiment as a probe for sidechain packing in the kinetic folding intermediate of N-PGK

scientific article published on 12 September 2006

Allomorphy as a mechanism of post-translational control of enzyme activity

scientific article published on 02 November 2020

Amplification of bifunctional ligands for calmodulin from a dynamic combinatorial library

scientific article published in January 2006

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

scientific article published on 22 February 2022

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

scientific article published on 5 March 2008

Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches

scientific article published on 12 May 2017

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

scientific article

Beyond the EX1 limit: probing the structure of high-energy states in protein unfolding.

scientific article published in February 2004

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

scientific article

Comparison of backbone dynamics of monomeric and domain-swapped stefin A

scientific article published on 01 February 2004

Conformational properties of beta-PrP.

scientific article published on 15 April 2009

Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase

scientific article

Determinants of DNA-binding specificity of ETS-domain transcription factors

scientific article published on July 1996

Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.

scientific article

Enhanced ligand affinity for receptors in which components of the binding site are independently mobile.

scientific article published in January 2005

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Essential role of proline isomerization in stefin B tetramer formation

scientific article

Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase

scientific article published on 24 March 2006

Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.

scientific article published on 22 October 2007

Fast protein motions are coupled to enzyme H-transfer reactions

scientific article published on 11 February 2013

Folding kinetics of the human prion protein probed by temperature jump.

scholarly article

Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms

scientific article published on 29 March 2019

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride

scientific article published in February 2009

Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology.

scientific article

Location and properties of metal-binding sites on the human prion protein.

scientific article published on 03 July 2001

Mapping Hidden Residual Structure within the Myc bHLH-LZ Domain Using Chemical Denaturant Titration

scientific article published on 08 August 2019

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions.

scientific article published on 12 October 2012

Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. Karn

article

Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes.

scientific article published on 8 November 2016

Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix. ⬇️

scientific article

Modulation of contact order effects in the two-state folding of stefins A and B.

scientific article

Myc Phosphorylation in its Basic Helix-Loop-Helix Region Destabilizes Transient α-Helical Structures, Disrupting Max and DNA Binding.

scientific article published on 25 April 2018

N-terminal domain of prion protein directs its oligomeric association

scientific article

Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

scientific article

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

scientific article

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging

scientific article published in July 2005

Pharmacological chaperone for the structured domain of human prion protein.

scientific article

Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase.

scientific article

Real-time pure shift ¹⁵N HSQC of proteins: a real improvement in resolution and sensitivity

scientific article published on 4 March 2015

Reflections on biocatalysis involving phosphorus.

scientific article published on October 2012

Simultaneously enhancing spectral resolution and sensitivity in heteronuclear correlation NMR spectroscopy

scientific article

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.

scientific article

Structural effects of the highly protective V127 polymorphism on human prion protein

scientific article published on 29 July 2020

Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.

scientific article

Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease

scientific article

The DNA recognition subunit of a DNA methyltransferase is predominantly a molten globule in the absence of DNA.

scientific article published in November 1994

The denatured state under native conditions: a non-native-like collapsed state of N-PGK.

scientific article published on 11 January 2006

The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates.

scientific article published in February 2009

The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.

scientific article

The roughness of the protein energy landscape results in anomalous diffusion of the polypeptide backbone

scientific article

Versatile low-molecular-weight hydrogelators: achieving multiresponsiveness through a modular design.

scientific article published on 26 July 2011

Wild-type and met-65-->Leu variants of human cystatin A are functionally and structurally identical

scientific article published on 01 December 2000

α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.

scientific article

List of works by Jonathan Waltho

(1)H, (15)N and (13)C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2.

(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride.

1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

A method for the reversible trapping of proteins in non-native conformations.

A pulse--radiolysis approach to fast reductive cleavage of a disulfide bond to uncage enzyme activity.

A reassessment of copper(II) binding in the full-length prion protein

A thiol labelling competition experiment as a probe for sidechain packing in the kinetic folding intermediate of N-PGK

Allomorphy as a mechanism of post-translational control of enzyme activity

Amplification of bifunctional ligands for calmodulin from a dynamic combinatorial library

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

Beyond the EX1 limit: probing the structure of high-energy states in protein unfolding.

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

Comparison of backbone dynamics of monomeric and domain-swapped stefin A

Conformational properties of beta-PrP.

Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase

Determinants of DNA-binding specificity of ETS-domain transcription factors

Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.

Enhanced ligand affinity for receptors in which components of the binding site are independently mobile.

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Essential role of proline isomerization in stefin B tetramer formation

Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase

Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.

Fast protein motions are coupled to enzyme H-transfer reactions

Folding kinetics of the human prion protein probed by temperature jump.

Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride

Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology.

Location and properties of metal-binding sites on the human prion protein.

Mapping Hidden Residual Structure within the Myc bHLH-LZ Domain Using Chemical Denaturant Titration

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions.

Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. Karn

Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes.

Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix. ⬇️

Modulation of contact order effects in the two-state folding of stefins A and B.

Myc Phosphorylation in its Basic Helix-Loop-Helix Region Destabilizes Transient α-Helical Structures, Disrupting Max and DNA Binding.

N-terminal domain of prion protein directs its oligomeric association

Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging

Pharmacological chaperone for the structured domain of human prion protein.

Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase.

Real-time pure shift ¹⁵N HSQC of proteins: a real improvement in resolution and sensitivity

Reflections on biocatalysis involving phosphorus.

Simultaneously enhancing spectral resolution and sensitivity in heteronuclear correlation NMR spectroscopy

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.

Structural effects of the highly protective V127 polymorphism on human prion protein

Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.

Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease

The DNA recognition subunit of a DNA methyltransferase is predominantly a molten globule in the absence of DNA.

The denatured state under native conditions: a non-native-like collapsed state of N-PGK.

The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates.

The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.

The roughness of the protein energy landscape results in anomalous diffusion of the polypeptide backbone

Versatile low-molecular-weight hydrogelators: achieving multiresponsiveness through a modular design.

Wild-type and met-65-->Leu variants of human cystatin A are functionally and structurally identical

α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.