List of works - Pawel Swietach

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

scientific article published on 20 January 2019

A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes

scientific article published on 13 April 2019

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

scientific article published on 31 March 2022

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

scientific article

Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII.

scientific article published on 12 September 2013

Ca2+-mobility in the sarcoplasmic reticulum of ventricular myocytes is low.

scientific article published on 4 April 2008

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

scientific article published on 01 August 2018

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

scientific article published on 3 April 2017

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels

scientific article published on 15 November 2015

Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.

scientific article

Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity

scientific article published on 12 June 2020

Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.

scientific article

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

scientific article published on 17 May 2016

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication.

scientific article published on 28 November 2017

Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.

scientific article published on 23 February 2011

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

article

Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.

scientific article

Facilitation by intracellular carbonic anhydrase of Na+ -HCO3- co-transport but not Na+ / H+ exchange activity in the mammalian ventricular myocyte.

scientific article published on 2 December 2013

Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes.

scientific article published on November 2002

Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig.

scientific article

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.

scientific article published on 15 March 2007

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH ⬇️

scientific article published on April 18, 2013

Hydrogen ion dynamics in human red blood cells.

scientific article

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin

scientific article

Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.

scientific article published on 24 July 2014

Intracellular pH regulation in heart.

scientific article

Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.

scientific article

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

scientific article published on 18 April 2016

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

scientific article published on 04 April 2019

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

scientific article published in May 2022

Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte

scientific article

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study

scientific article

Modeling calcium waves in cardiac myocytes: importance of calcium diffusion

scientific article

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes

scientific article

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1

scientific article published on 19 November 2019

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths

scientific article published on 7 September 2017

Nuclear proton dynamics and interactions with calcium signaling

scientific article

Optimal Thinning of MCMC Output

scientific article published on 3 April 2022

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

scientific article published on 25 June 2018

Proton permeation through the myocardial gap junction.

scientific article published on 4 September 2003

Pumping Ca2+ up H+ gradients: a Ca2(+)-H+ exchanger without a membrane.

scientific article published on 10 February 2014

Rapid CO2 permeation across biological membranes: implications for CO2 venting from tissue.

scientific article published on 20 March 2014

Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer.

scientific article published on 15 November 2015

Recovery from hypoxia-induced internalization of cardiac Na+ /H + exchanger 1 requires an adequate intracellular store of antioxidants

scientific article published on 07 September 2018

Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm.

scientific article published on 25 October 2016

Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes

scientific article published on 21 February 2017

Regulation of tumor pH and the role of carbonic anhydrase 9.

scientific article published on June 2007

S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.

scientific article published on 21 January 2008

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.

scientific article

Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

scientific article published on 22 April 2020

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients

scientific article published on 17 July 2020

Spatial aspects of intracellular pH regulation in heart muscle.

scientific article

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.

scientific article published on 14 October 2009

Spatial regulation of intracellular pH in the ventricular myocyte

scientific article published on 01 June 2005

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid.

scientific article published on 19 August 2016

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

scientific article published on 17 August 2020

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities

scientific article published on 28 December 2020

Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.

scientific article published on 15 August 2003

The chemistry, physiology and pathology of pH in cancer

scientific article published on 03 February 2014

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

scientific article

What is pH regulation, and why do cancer cells need it?

scientific article published on 01 June 2019

pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.

scientific article published on 20 October 2006

pH-Regulated Na(+) influx into the mammalian ventricular myocyte: the relative role of Na(+)-H(+) exchange and Na(+)-HCO Co-transport.

scientific article

List of works by Pawel Swietach

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions

A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII.

Ca2+-mobility in the sarcoplasmic reticulum of ventricular myocytes is low.

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels

Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.

Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity

Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication.

Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.

Facilitation by intracellular carbonic anhydrase of Na+ -HCO3- co-transport but not Na+ / H+ exchange activity in the mammalian ventricular myocyte.

Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes.

Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig.

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH ⬇️

Hydrogen ion dynamics in human red blood cells.

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin

Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.

Intracellular pH regulation in heart.

Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study

Modeling calcium waves in cardiac myocytes: importance of calcium diffusion

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths

Nuclear proton dynamics and interactions with calcium signaling

Optimal Thinning of MCMC Output

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

Proton permeation through the myocardial gap junction.

Pumping Ca2+ up H+ gradients: a Ca2(+)-H+ exchanger without a membrane.

Rapid CO2 permeation across biological membranes: implications for CO2 venting from tissue.

Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer.

Recovery from hypoxia-induced internalization of cardiac Na+ /H + exchanger 1 requires an adequate intracellular store of antioxidants

Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm.

Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes

Regulation of tumor pH and the role of carbonic anhydrase 9.

S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.

Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients

Spatial aspects of intracellular pH regulation in heart muscle.

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.

Spatial regulation of intracellular pH in the ventricular myocyte

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid.

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities

Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.

The chemistry, physiology and pathology of pH in cancer

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

What is pH regulation, and why do cancer cells need it?

pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.

pH-Regulated Na(+) influx into the mammalian ventricular myocyte: the relative role of Na(+)-H(+) exchange and Na(+)-HCO Co-transport.