List of works - Tsuyoshi Hirota

A genome-wide RNAi screen for modifiers of the circadian clock in human cells

scientific article

A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins

scientific article published in 2022

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.

scientific article published on 8 May 2015

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.

scientific article

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

scientific article published on 23 January 2019

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ

scientific article published on 15 February 2019

Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO-E2-E3 Ligase Ternary Complexes

scientific article published on 06 September 2019

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

scientific article published on 26 May 2016

Circadian proteomics of the mouse retina.

scientific article

Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition.

scientific article

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

scientific article published on 26 September 2019

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

scientific article

DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping

scientific journal article

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock.

scientific article

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

scientific article published on 26 February 2020

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

scientific article

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

scientific article

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.

scientific article published on September 2009

Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen

scientific article published on 27 August 2019

Identification of small molecule activators of cryptochrome

scientific article

Identification of small-molecule modulators of the circadian clock.

scientific article published on 12 December 2014

In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock

scientific article published on 6 October 2014

Isoform-selective regulation of mammalian cryptochromes

scientific article published on 30 March 2020

Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.

scientific article

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

article published in the Proceedings of the National Academy of Sciences of the United States of America

Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.

scientific article published on 24 June 2005

List of works by Tsuyoshi Hirota

A genome-wide RNAi screen for modifiers of the circadian clock in human cells

A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ

Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO-E2-E3 Ligase Ternary Complexes

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

Circadian proteomics of the mouse retina.

Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition.

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock.

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.

Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen

Identification of small molecule activators of cryptochrome

Identification of small-molecule modulators of the circadian clock.

In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock

Isoform-selective regulation of mammalian cryptochromes

Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.