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List of works by Jau-Shyong Hong

(+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat.

scientific article published on 29 March 2008

3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro.

scientific article

3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.

scientific article

5,5-Diphenylhydantoin antagonizes neurochemical and behavioral effects of p,p'-DDT but not of chlordecone.

scientific article published in December 1986

A 35 kDa Fos-related antigen is co-localized with substance P and dynorphin in striatal neurons.

scientific article published in April 1992

A glutamate antagonist blocks perforant path stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus ⬇️

scientific article published on October 25, 1991

A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy.

scientific article

A novel inhibitory effect of naloxone on macrophage activation and atherosclerosis formation in mice.

scientific article published on 17 October 2006

A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.

scientific article published on 4 March 2015

A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation

scientific article published on 20 November 2006

A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment

scientific article

A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year

scientific article published on August 1997

ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

scientific article published on 01 February 2020

ALDH2 polymorphism, associated with attenuating negative symptoms in patients with schizophrenia treated with add-on dextromethorphan.

scientific article

Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

scientific article published on 01 July 1995

Add-on Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study.

scientific article published on 15 April 2018

Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder.

scientific article published on 18 July 2013

Age-related changes in opioid peptide concentrations in brain and pituitary of spontaneously hypertensive rats. Effect of antihypertensive drugs and comparison with deoxycorticosterone acetate and salt hypertension

scientific article published on January 1, 1992

Alteration of cerebral neurotransmitter receptor function by exposure of rats to manganese

scientific article published on 01 November 1981

Alterations in GABA metabolism and Met-enkephalin content in rat brain following repeated electroconvulsive shocks

scientific article published on September 1, 1978

Alterations in retinal neurotransmitter receptors and neuropeptides of the chick by kainic acid and acrylamide ⬇️

scientific article published on September 5, 1983

Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation.

scientific article

Angiotensin II receptors are coupled to omega-conotoxin-sensitive calcium influx in bovine adrenal medullary chromaffin cells

scientific article published on April 1, 1992

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

scientific article

Apomorphine induction of AP-1 DNA binding in the rat striatum after dopamine depletion.

scientific article published in September 1992

Basal expression of 35 kDa fos-related antigen in olfactory bulb

scientific article published on 01 December 1995

Behavior, neurochemistry and histology after intranigral lipopolysaccharide injection.

scientific article

Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate.

scientific article published in January 1989

Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells

scientific article published on 01 January 1993

Brain injury in a dish: a model for reactive gliosis

scientific article (publication date: 1994)

CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses

scientific article

Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia.

scientific article published on 5 May 2007

Cerebral ischemia/reperfusion injury in rat brain: effects of naloxone.

scientific article published in May 2001

Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat

scientific journal article

Changes of hippocampal Met-enkephalin content after recurrent motor seizures

scientific article published in Nature

Changes of proenkephalin and prodynorphin mRNAs and related peptides in rat brain during the development of deep prepyriform cortex kindling

scientific article published on 01 December 1989

Characterization of dynorphin-containing neurons on dissociated dentate gyrus cell cultures

scientific article published on October 23, 1992

Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17

scientific article published on 01 April 1987

Chlordecone (Kepone) exposure in the neonate selectively alters brain and pituitary endorphin levels in prepuberal and adult rats.

scientific article published in October 1982

Chlordecone-induced tremor: quantification and pharmacological analysis.

scientific article published in November 1982

Chronic microglial activation and progressive dopaminergic neurotoxicity.

scientific article published on November 2007

Chronic treatment with haloperidol accelerates the biosynthesis of enkephalins in rat striatum.

scientific article

Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase.

scientific article published on 16 May 2016

Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation ⬇️

scientific article published on August 26, 2011

Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder

scientific article published on 07 June 2016

Constitutive expression of AP-1 transcription factors in the rat adrenal. Effects of nicotine.

scientific article published on October 1992

Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis

scientific article published on 15 May 2009

Correction to: Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

scientific article published on 01 May 2019

Correlation of cytokines, BDNF levels, and memory function in patients with opioid use disorder undergoing methadone maintenance treatment.

scientific article published on 25 July 2018

Correlation of neurochemical and behavioral effects of triethyl lead chloride in rats.

scientific article

Correlation of plasma brain-derived neurotrophic factor and metabolic profiles in drug-naïve patients with bipolar II disorder after a twelve-week pharmacological intervention.

scientific article published on 6 August 2014

Corrigendum: Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy

scientific article published on 15 June 2017

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.

scientific article

Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

scientific article published in August 2003

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

scientific article

Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture.

scientific article published on 27 March 2008

Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra.

scientific article published in September 2002

DNA binding activity of CREB transcription factors during ontogeny of the central nervous system.

scientific article published on May 1995

Decreased glutamate release correlates with elevated dynorphin content in the hippocampus of aged rats with spatial learning deficits ⬇️

scientific article published on October 1, 1991

Deep prepyriform cortex kindling differentially alters the levels of prodynorphin mRNA in rat hippocampus and striatum

scientific article published on 01 August 1989

Detection of two endorphin-like peptides in nucleus caudatus

scientific article published on June 1, 1978

Determination of methionine enkephalin in discrete regions of rat brain

scientific article published on October 7, 1977

Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment ⬇️

scientific article published on September 19, 2012

Dextromethorphan Efficiently Increases Bactericidal Activity, Attenuates Inflammatory Responses, and Prevents Group A Streptococcal Sepsis ⬇️

scientific article published on January 3, 2011

Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder

scientific article published on 01 February 2020

Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid.

scientific article

Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

scientific article published in April 2003

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

scientific article

Differential modulation of striatonigral dynorphin and enkephalin by dopamine receptor subtypes.

scientific article published in January 1990

Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

scientific article published in February 2002

Dithiothreitol augments renin activity by an action on renin substrate

scientific article published on 01 February 1977

Dopamine stimulates [3H]phorbol 12,13-dibutyrate binding in cultured striatal cells

scientific article published on April 1, 1992

Dopamine-Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia ⬇️

scientific article published on May 1, 1991

Dopaminergic regulation of tachykinin metabolism in the striatonigral pathway.

scientific article

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock.

scientific article published in March 1986

Effect of chlordecone exposure on thermoregulation in the rat.

scientific article published in January 1986

Effect of low temperature on the release of vasopressin from the isolated bovine neurohypophysis.

scientific article published in January 1974

Effect of manganese treatment on the levels of neurotransmitters, hormones, and neuropeptides: modulation by stress.

scientific article published in August 1984

Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder

scientific article

Effects of 5,5-diphenylhydantoin (phenytoin) on neurobehavioral toxicity of organochlorine insecticides and permethrin.

scientific article published in May 1985

Effects of chlordecone exposure on brain neurotransmitters: possible involvement of the serotonin system in chlordecone-elicited tremor

scientific article published on 01 April 1984

Effects of corticosterone on shaking and seizure behavior induced by deep prepyriform cortex kindling.

scientific article

Effects of habenular lesions on the substance P content of various brain regions

scientific article published on December 24, 1976

Effects of lithium and haloperidol administration on the rat brain levels of substance P ⬇️

scientific article published on March 1, 1983

Effects of long-term administration of antipsychotic drugs on enkephalinergic neurons

scientific article published on January 1, 1980

Effects of p,p'-DDT on the rat brain concentrations of biogenic amine and amino acid neurotransmitters and their association with p,p'-DDT-induced tremor and hyperthermia.

scientific article published on November 1985

Effects of perinatal exposure to chlordecone (Kepone) on neuroendocrine and neurochemical responsiveness of rats to environmental challenges

scientific article published on October 1, 1982

Effects of rewarming the bovine neurohypophysis in vitro: release of vasopressin and lactic dehydrogenase.

scientific article published in May 1974

Effects of staurosporine on cell morphology, expression of the proenkephalin gene and the secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells

scientific article published on 01 September 1994

Effects of sulpiride and SCH 23390 on methamphetamine-induced changes in body temperature and lethality

scientific article published on 01 August 1995

Elevated basal AP-1 DNA binding activity in developing rat brain.

scientific article published on September 1993

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

scientific article

Endogenous opioids and HIV infection

scientific article published on 01 January 1996

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

scientific article published on 13 March 2008

Enkephalin in bovine adrenal gland: Multiple molecular forms of [met5]-enkephalin immunoreactive peptides

scientific article published on 01 February 1980

Estrogen-like activity of chlordecone (Kepone) on the hypothalamo-pituitary axis: Effects on the pituitary enkephalin system ⬇️

scientific article published on July 1, 1984

Evidence for a role of nigral gamma-aminobutyric acid and substance P in the haloperidol-induced activation of striatal tyrosine hydroxylase ⬇️

scientific article published on July 1, 1978

Expression of the Proenkephalin A Gene and [Met(5)]enkephalin Secretion Induced by Prostaglandin E(2) in Bovine Adrenal Medullary Chromaffin Cells: Involvement of Second Messengers.

scientific article published in February 1993

Expression of the proenkephalin A gene and [Met5]-enkephalin secretion induced by arachidonic acid in bovine adrenal medullary chromaffin cells: involvement of second messengers

scientific article published on 01 February 1995

Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling.

scientific article

Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

scientific article published on January 2012

Gene-environment interactions: key to unraveling the mystery of Parkinson's disease

scientific article

Genotype variant associated with add-on memantine in bipolar II disorder

scientific article published on 9 October 2013

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

scientific article published on 21 February 2018

Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures

scientific article published on 01 December 1995

Glucocorticoids potentiate kainic acid-induced seizures and wet dog shakes

scientific article published on 01 February 1989

Gö6976 protects mesencephalic neurons from lipopolysaccharide-elicited death by inhibiting p38 MAP kinase phosphorylation.

scientific article

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

scientific article

Heightened transcription for enzymes involved in norepinephrine biosynthesis in the rat locus coeruleus by immobilization stress.

scientific article published in April 1999

High concentrations of extracellular potassium enhance bacterial endotoxin lipopolysaccharide-induced neurotoxicity in glia–neuron mixed cultures

article

High doses of aspartame have no effects on sensorimotor function or learning and memory in rats.

scientific article published in January 1991

Hippocampal levels of dynorphin A (1-8) in neonatal and 16-week-old spontaneously hypertensive rats: comparisons with DOCA-salt hypertension.

scientific article

Hippocampal opioid peptides and seizures

scientific article published on January 1, 1992

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

scientific article published on 19 March 2007

Human neuromelanin an endogenous microglial activator for dopaminergic neuron death ⬇️

scientific article published on January 1, 2013

Hypertension and Diagnosis of Parkinson's Disease: A Meta-Analysis of Cohort Studies

scientific article published on 19 March 2018

Hypothalamic-pituitary adrenal (HPAA) axis function in adult Fischer-344 rats exposed during development to neurotoxic chemicals perinatally

scientific article published on July 1, 1984

Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

scientific article published on 21 June 2016

Impairment of an electroconvulsive stimulus on reconsolidation of memories established by conditioning.

scientific article published in February 2013

Implications of prolonged expression of Fos-related antigens.

scientific article published on September 1995

In Vitro Models for Neuroelectrodes: A Paradigm for Studying Tissue–Materials Interactions in the Brain

In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain.

scientific article published on January 2002

Increase of neurotensin content elicited by neuroleptics in nucleus accumbens

scientific article published on 01 November 1980

Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage.

scientific article published on October 1988

Increased enkephalin and dynorphin immunoreactivity in the hippocampus of seizure sensitive Mongolian gerbils

scientific article published on 01 January 1987

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.

scientific article

Inflammation in Patients with Schizophrenia: The Therapeutic Benefits of Risperidone Plus Add-On Dextromethorphan ⬇️

scientific article published on June 23, 2012

Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-α by cultured glia

article

Interactions between enkephalinergic and other neuronal systems

scientific article published on January 1, 1978

Interactions of chlordecone (kepone) and mirex with the nicotinic acetylcholine receptor--ion channel complex.

scientific article published in March 1986

Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation.

scientific article published in October 2005

Intrahippocampal distribution of Met5-enkephalin

scientific article published on 01 February 1981

Intrahippocampal injections of a specific mu-receptor ligand PL017 produce generalized convulsions in rats.

scientific article published in February 1988

Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus.

scientific article published in December 2002

Kainate-induced changes in gene expression in the rat hippocampus.

scientific article

Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus.

scientific article

Kainic acid-induced sprouting of dynorphin- and enkephalin-containing mossy fibers in the dentate gyrus of the rat hippocampus.

scientific article published in February 1997

Lack of asymmetrical distribution of receptor binding sites and of neurally active peptides within rat brain.

scientific article published in January 1982

Liposomal melatonin rescues methamphetamine-elicited mitochondrial burdens, pro-apoptosis, and dopaminergic degeneration through the inhibition PKCδ gene

scientific article published on 2 December 2014

Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary.

scientific article published in October 1987

Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs

scientific article published on 01 March 1989

Long-term activation of protein kinase C by nicotine in bovine adrenal chromaffin cells

scientific article published on 01 May 1992

Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment.

scientific article

Long-term heroin use was associated with the downregulation of systemic platelets, BDNF, and TGF-β1, and it contributed to the disruption of executive function in Taiwanese Han Chinese

scientific article published on 27 July 2017

Long-term increase of Sp-1 transcription factors in the hippocampus after kainic acid treatment.

scientific article

Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells

scientific article published on 01 December 1995

Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration

scientific article published on 27 July 2018

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

scientific article

Low-Dose Memantine Attenuated Morphine Addictive Behavior Through its Anti-Inflammation and Neurotrophic Effects in Rats ⬇️

scientific article published on December 29, 2011

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

article

Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy.

scientific article published on 19 May 2015

Low-dose lipopolysaccharide selectively sensitizes hypoxic ischemia-induced white matter injury in the immature brain

scientific article published on July 2010

Low-dose memantine attenuated methadone dose in opioid-dependent patients: a 12-week double-blind randomized controlled trial.

scientific article

MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity

scientific article published on 01 October 2007

MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.

scientific article published on 21 April 2005

Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate: further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation

scientific article published on 01 November 1981

Measurement of beta-endorphin and enkephalins in biological tissues and fluids.

scientific article published in January 1983

Memory Impairment and Plasma BDNF Correlates of the Polymorphism in Patients With Bipolar II Disorder

scientific article published on 27 November 2018

Met5Enkephalin content in brain regions of rats treated with lithium ⬇️

scientific article published on June 1, 1978

Methamphetamine-induced changes in AP-1 binding and dynorphin in the striatum: correlated, not causally related events?

scientific article

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

scientific article (publication date: June 2005)

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

scientific article published in November 2002

Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity.

scientific article

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

scientific article (publication date: 2007)

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity ⬇️

scientific article published on January 13, 2011

Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress.

scientific article published in April 2005

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

scientific article published in August 2007

Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.

scientific article

Microglial regulation of immunological and neuroprotective functions of astroglia

scientific article

Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation.

scientific article

Modulation of Endogenous Opioid Systems by Electroconvulsive Shock.

scientific article

Modulation of adrenal ornithine decarboxylase by chlordecone, p,p'DDT and permethrin.

scientific article published in January 1987

Modulation of striatal enkephalinergic neurons by antipsychotic drugs.

scientific article

Modulatory effects of [Met5]-enkephalin on interleukin-1 beta secretion from microglia in mixed brain cell cultures

scientific article published on 01 October 1995

Molecular consequences of activated microglia in the brain: overactivation induces apoptosis.

scientific article

Monosodium glutamate exposure in the neonate alters hypothalamic and pituitary neuropeptide levels in the adult

scientific article published on 01 November 1981

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder.

scientific article

Morphinan neuroprotection: new insight into the therapy of neurodegeneration.

scientific article

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration ⬇️

scientific article published on March 28, 2013

NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation.

scientific article published in January 2007

NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

scientific article published on 24 October 2003

NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease

scientific article published on 22 February 2017

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

scientific article

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase

scientific article published on 16 February 2012

Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

scientific article

Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.

scientific article

Neonatal administration of delta-9-tetrahydrocannabinol (THC) alters the neurochemical response to stress in the adult Fischer-344 rat.

scientific article

Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.

scientific article

Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.

scientific article published in March 1990

Neural adaptation in response to chronic imipramine and electroconvulsive shock: evidence for separate mechanisms.

scientific article published in November 1991

NeuroAIDS, drug abuse, and inflammation: building collaborative research activities

journal article published in 2006

Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.

scientific article

Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy.

scientific article

Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals.

scientific article published on 27 April 2016

Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activation by LPS.

scientific article published in February 2001

Neuroprotective and neurogenesis agent for treating bipolar II disorder: add-on memantine to mood stabilizer works.

scientific article published on 5 June 2012

Neuropsychopharmacological understanding for therapeutic application of morphinans ⬇️

scientific article published on October 30, 2010

Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs ⬇️

scientific article published on May 21, 2011

Neurotransmitter-related features of the retinal pigment epithelium

scientific article published on 01 January 1983

Novel anti-inflammatory therapy for Parkinson's disease.

scientific article

Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.

scientific article published on 17 June 2009

On the locaticn of methicnine enkephalin neurons in rat striatum ⬇️

scientific article published on June 1, 1977

On the neurotoxicity of chlordecone: A role for γ-aminobutyric acid and serotonin ⬇️

scientific article published on June 11, 1984

Ontogeny of kainate-induced gene expression in rat hippocampus.

scientific article

Opioid-induced epileptiform bursting in hippocampal slices: higher susceptibility in ventral than dorsal hippocampus.

scientific article

Opioids induce convulsions and wet dog shakes in rats: mediation by hippocampal mu, but not delta or kappa opioid receptors.

scientific article published in February 1989

Oral administration of aspartame is not proconvulsant in rats.

scientific article

PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition

scientific article

PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.

scientific article

PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.

scientific article published on 18 December 2017

Participation of substance P in the action of haloperidol

scientific article published on October 1, 1978

Perforant path stimulation differentially alters prodynorphin mRNA and proenkephalin mRNA levels in the entorhinal cortex-hippocampal region.

scientific article published in April 1990

Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells

scientific article published on 01 September 1992

Pharmacological regulation of AP-1 transcription factor DNA binding activity.

scientific article published on May 1994

Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway.

scientific article published in March 2018

Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.

scientific article published on 4 August 2006

Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

scientific article

Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia

scientific article published on 01 June 2000

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models

scientific article published on 25 February 2015

Postsynaptic location of acrylamide-induced modulation of striatal 3H-spiroperidol binding

scientific article published on 01 July 1982

Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin.

scientific article published in February 2006

Preferential activation of [3H]phorbol-12,13-dibutyrate binding by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures

scientific article published on October 16, 1992

Presence of substance P and GABA in separate striatonigral neurons

scientific article published on November 11, 1977

Pretreatment with antiserum against dynorphin, substance P, or cholecystokinin enhances the morphine-produced anti-allodynia in the sciatic nerve ligated mice.

scientific article published in September 2005

Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures.

scientific article published in January 2003

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.

scientific article published on 24 September 2011

Projections of substance P containing neurons from neostriatum to substantia nigra.

scientific article published in February 1977

Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment

scientific article published on July 1994

Prolonged stimulation of bovine adrenal chromaffin cells with arachidonic acid and prostaglandin E2 increases expression of the proenkephalin gene and the secretion of [Met5]-enkephalin

scientific article published on 01 November 1992

Properties of renin granules isolated from rat kidney

scientific article published on October 1, 1976

Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.

scientific article published on 03 May 2009

Protective effect of dextromethorphan against endotoxic shock in mice.

scientific article published on 26 November 2004

Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures.

scientific article published in February 2004

Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity.

scientific article published in April 2006

Purification and properties of the coagulant and anticoagulant principles of Agkistrodon acutus venom

scientific article published on 01 June 1972

Purification and properties of the thrombin-like principle of Agkistrodon acutus venom and its comparison with bovine thrombin

scientific article published on 01 October 1971

Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs ⬇️

scientific article published on April 1, 1978

Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor.

scientific article published in May 2006

Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity.

scientific article

Recurrent convulsions and hippocampal [Met5]-enkephalin content

scientific article published on 01 January 1980

Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron–glia co-cultures

article

Reduction of lipopolysaccharide-induced neurotoxicity in mouse mixed cortical neuron/glia cultures by ultralow concentrations of dynorphins

scientific article published on 01 May 2000

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

scientific article published on 01 August 2000

Regional distribution of LEU and MET enkephalin in rat brain

scientific article published on April 1, 1977

Regionally specific neural adaptation of beta adrenergic and 5-hydroxytryptamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment

scientific article published on 01 September 1988

Regulation of pituitary and brain enkephalin systems by estrogen.

scientific article

Regulation of preproenkephalin expression in astrocytes: is there a role for glia-derived opioid peptides in reactive gliosis?

scientific article published on January 1994

Regulation of prodynorphin gene expression in the hippocampus by glucocorticoids

scientific article published on November 1, 1992

Regulation of proenkephalin expression in C6 rat glioma cells.

scientific article published in December 1992

Regulation of proenkephalin gene expression by angiotensin in bovine adrenal medullary cells: Molecular mechanisms and nature of the second messenger systems.

scientific article published on June 1991

Regulation of the concentration of dynorphin A1-8 in the striatonigral pathway by the dopaminergic system.

scientific article published in November 1986

Regulation of the expression of proenkephalin mRNA in bovine adrenal chromaffin cells: Role of proto-oncogenes.

scientific article published in December 1992

Regulation of the metabolism of striatal dynorphin by the dopaminergic system

scientific article published on 01 July 1988

Regulation of tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA levels in the sympathoadrenal system by the pituitary-adrenocortical axis.

scientific article published in June 1988

Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms.

scientific article

Regulation of tyrosine hydroxylase in olfactory bulb cultures: selective inhibition of depolarization-induced increase by endogenous opioids.

scientific article published on September 1994

Repeated electroconvulsive shocks and the brain content of endorphins

scientific article published on November 16, 1979

Response of neuropeptides and neurotransmitter binding sites in the retina and brain of the developing chick to reduced visual input

scientific article published on 01 January 1983

Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.

scientific article

Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration

scientific article published on 26 November 2013

Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat.

scientific article published in May 1994

Role of inflammation in the pathogenesis of Parkinson's disease: models, mechanisms, and therapeutic interventions.

scientific article

Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10

scientific journal article

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

scientific article

Role of nitric oxide in inflammation-mediated neurodegeneration.

scientific article

Role of omega-conotoxin GVIA-sensitive Ca2+ entry in angiotensin II-stimulated [3H]phorbol 12,13-dibutyrate binding in bovine adrenal medullary cells

scientific article published on 01 July 1993

Role of oxidative stress in epileptic seizures.

scientific article

Roles of the pituitary-adrenocortical axis in control of the native and cryptic enkephalin levels and proenkephalin mRNA in the sympathoadrenal system of the rat

scientific article published on 01 June 1988

Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox.

scientific article published on 3 November 2011

Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures.

scientific article published on October 1995

Serum-dependence of LPS-induced neurotoxicity in rat cortical neurons.

scientific article published on May 2002

Sex-related difference in substance P level in rat anterior pituitary: a model of neonatal imprinting by testosterone.

scientific article published in August 1983

Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.

scientific article published in December 2002

Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain

scientific article published on 01 July 1989

Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. ⬇️

scientific article

Stimulation of adrenal medullary cells in vivo and in vitro induces expression of c-fos proto-oncogene

scientific article published on 01 January 1990

Studies of the coagulant and anticoagulant principles of Formosan crotalid venoms [proceedings]

scientific article published on 01 January 1976

Studies on the possible sites of chlordecone-induced tremor in rats.

scientific article published in September 1983

Study of hepatotoxicity of naltrexone in the treatment of alcoholism

scientific article published in February 2006

Subchronic dietary exposure of rats to chlordecone (Kepone) modifies levels of hypothalamic beta-endorphin.

scientific article published in October 1982

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage

scientific article published on January 2012

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

scientific article

Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs ⬇️

scientific article published on January 1, 1978

Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice

scientific article

Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

scientific article

Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature.

scientific article published on 6 April 2018

Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice.

scientific article published on 15 March 2013

Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.

scientific article published in February 2003

Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures ⬇️

scientific article published on May 1, 1998

Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus

scientific article published on 01 January 1991

Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide

scientific article published on 01 October 2000

TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence

scientific article published on 6 April 2016

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients.

scientific article

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia

scientific article published on 25 January 2014

The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder.

scientific article published on June 2016

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

scientific article published on August 2017

The Differential Levels of Inflammatory Cytokines and BDNF among Bipolar Spectrum Disorders.

scientific article published on 10 February 2016

The effect of kainic acid on the hippocampal content of putative transmitter amino acids

scientific article published on 01 November 1980

The effects of add-on low-dose memantine on cytokine levels in bipolar II depression: a 12-week double-blind, randomized controlled trial.

scientific article published in June 2014

The effects of dextromethorphan on kainic acid-induced seizures in the rat

scientific article published on 01 January 1996

The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures

scientific article published on 01 August 1996

The enkephalin system in the rat anterior pituitary: regulation by gonadal steroid hormones and psychotropic drugs.

scientific article

The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures

scientific article published on 01 June 2000

The prevention of an artifact in receptor binding assay by an improved technique.

scientific article published in May 1982

Therapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder

scientific article published on 16 September 2014

Time dependency of the action of nitric oxide in lipopolysaccharide-interferon-gamma-induced neuronal cell death in murine primary neuron-glia co-cultures

scientific article published on 01 October 2000

Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats.

scientific article published in April 1987

Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease ⬇️

scientific article published on March 30, 2011

Transcriptional regulation of the rat prodynorphin gene

scientific article published on January 1, 1991

Trimethyltin-induced alterations in brain amino acids, amines and amine metabolites: relationship to hyperammonemia.

scientific article published in January 1986

Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells

scientific article published on 01 March 1997

Ultralow doses of dextromethorphan protect mice from endotoxin-induced sepsis-like hepatotoxicity

scientific article published on 26 February 2019

Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation.

scientific article

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

scientific article published on 25 November 2004

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.

scientific article published on 12 September 2006

Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.

scientific article

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

scientific article published on July 2008

[Substance K in the digestive tract of rats]

scientific article published on 01 June 1988

[The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure]

scientific article published on 01 December 1995

beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.

scientific article

p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures

scientific article

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

scientific article

β2-Adrenergic Receptor Activation Prevents Rodent Dopaminergic Neurotoxicity by Inhibiting Microglia via a Novel Signaling Pathway ⬇️

scientific article published on February 18, 2011

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