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List of works by David Leake

A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein.

scientific article published on 17 January 2008

A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein.

scientific article published on 22 October 2007

Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein

scientific article published on 01 January 1994

Acidic pH increases the oxidation of LDL by macrophages

scientific article published on 01 November 1993

Aqueous peroxyl radical exposure to THP-1 cells causes glutathione loss followed by protein oxidation and cell death without increased caspase-3 activity

scientific article published on 12 April 2007

Ascorbate does not protect macrophages against apoptosis induced by oxidised low density lipoprotein.

scientific article published on 8 September 2006

Ascorbic acid can either increase or decrease low density lipoprotein modification

scientific article published on 01 March 1994

Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation

scientific article

Cysteamine Decreases Low-Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low-Density Lipoprotein Receptor-Deficient Mice

scientific article published on 08 September 2021

Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice

scientific article published on 26 September 2019

Degree of oxidation of low density lipoprotein affects expression of CD36 and PPARgamma, but not cytokine production, by human monocyte-macrophages

scientific article published on 01 June 2003

Effect of low extracellular pH on NF-κB activation in macrophages

scientific article published on 21 January 2014

Effect of vitamin E on low density lipoprotein oxidation at lysosomal pH

scientific article published on 16 September 2020

Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

scientific article published on 01 September 2002

Flavonoids and the oxidation of low-density lipoprotein

scientific article published on 01 January 2001

Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages

scientific article published on 01 June 1990

High-resolution mapping of the frequency of lipid deposits in thoracic aortae from cholesterol-fed and heritable hyperlipidaemic rabbits

scientific article published on 01 February 1996

Human serum, cysteine and histidine inhibit the oxidation of low density lipoprotein less at acidic pH

scientific article published on 01 September 1998

In vitro antioxidant activity of coffee compounds and their metabolites

scientific article published on 27 July 2007

Induction of antioxidant stress proteins in vascular endothelial and smooth muscle cells: protective action of vitamin C against atherogenic lipoproteins.

scientific article

Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2.

scientific article published on 7 April 2005

Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells

scientific article published on 01 July 1995

Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

scientific article

Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein

scientific article published on 01 September 1994

Low density lipoprotein oxidation by ferritin at lysosomal pH

scientific article published on 01 October 2018

Low density lipoprotein undergoes oxidation within lysosomes in cells.

scientific article published on 19 April 2007

Macrophage antioxidant protection within atherosclerotic plaques

scientific article published on January 2009

Macrophages possess both neutral and acidic protease activities toward low density lipoproteins.

scientific article published in September 1989

Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions

scientific article published on 14 July 2007

Mechanisms by which cysteine can inhibit or promote the oxidation of low density lipoprotein by copper.

scientific article

Modification of the rate of pinocytosis in arterial smooth muscle cells in culture

scientific article published on 01 April 1982

NADPH Oxidase Is Not Essential for Low-Density Lipoprotein Oxidation by Human Monocyte-Derived Macrophages

scientific article published on 01 August 1994

Non-oxidative modification of low density lipoprotein by ruptured myocytes

scientific article published on 01 September 1997

Oxidation affects the flow-induced aggregation of low density lipoprotein and its inhibition by albumin

scientific article published on 01 October 2003

Oxidation of low density lipoprotein by bovine and porcine aortic endothelial cells and porcine endocardial cells in culture

scientific article published on 01 September 1993

Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis.

scientific article published on 25 April 2012

Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis

scientific article published on 01 January 1995

Oxidized low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase-signaling pathways

scientific article published on 22 May 2013

Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid.

scientific article

Properties and subcellular localization of adenosine diphosphatase in arterial smooth muscle cells in culture

scientific article published on 01 February 1983

Properties and subcellular localization of elastase-like activities of arterial smooth muscle cells in culture

scientific article published on 01 November 1983

Proteolytic degradation of low density lipoproteins by arterial smooth muscle cells: the role of individual cathepsins

scientific article published on 01 April 1981

Quantitative studies of pinocytosis by arterial endothelial and smooth muscle cells in culture

scientific article published on 01 August 1981

Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.

scientific article published on 29 January 2004

Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells.

scientific article published on 8 November 2005

The effect of EDTA on the oxidation of low density lipoprotein ⬇️

scientific article published on May 1, 1992

The effect of inhibitors of free radical generating-enzymes on low-density lipoprotein oxidation by macrophages

scientific article published on 01 February 1994

The effect of macrophage stimulation on the uptake of acetylated low-density lipoproteins

scientific article published on 01 September 1989

The effects of free radical scavengers on the oxidation of low-density lipoproteins by macrophages

scientific article published on 01 December 1994

The effects of pH on the oxidation of low-density lipoprotein by copper and metmyoglobin are different

scientific article published on 01 April 1997

The interaction between ruptured erythrocytes and low‐density lipoproteins ⬇️

scientific article published on June 1, 1992

The modification of low density lipoprotein by the flavonoids myricetin and gossypetin.

scientific article

The oxidation of low density lipoprotein by cells or iron is inhibited by zinc

scientific article published on 01 March 1994

The oxidative modification of low density lipoprotein by human lymphocytes

scientific article published on 01 February 1992

Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages

scientific article published on 01 October 1995

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