List of works - Damien J Keating

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

scientific article

A new ‘dual’ in the crown for electrochemistry ⬇️

scientific article published on December 1, 2011

Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism

scientific article published on 22 February 2019

Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking

scientific article published on 24 February 2015

Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms.

scientific article published on 7 June 2012

Aging Differentially Affects Multiple Aspects of Vesicle Fusion Kinetics ⬇️

scientific article published on November 18, 2011

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway

scientific article published on 22 August 2013

Augmented capacity for peripheral serotonin release in human obesity.

scientific article published in March 2018

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

CrossTalk opposing view: 5-HT is not necessary for peristalsis

scientific article published on 01 August 2015

Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

scientific article published on 28 October 2017

Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine

scientific article published on 07 May 2020

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules.

scientific article published on 16 December 2015

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule

scientific article published on 01 August 2019

Exocytosis in non-neuronal cells

scientific article published on 3 March 2016

Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells

scientific article published on 08 May 2019

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

scientific article published on 19 April 2016

Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.

scientific article

Galanin receptor 3--a potential target for acute pancreatitis therapy.

scientific article published on March 2011

Gut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Control

scientific article published on 04 December 2018

HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.

scientific article published on 12 January 2017

Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder

scientific article published on 11 December 2014

Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells

scientific journal article

Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine

scientific article

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins

scientific article published on March 2017

Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.

scientific article published on 17 June 2016

ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells.

scientific article published on 9 May 2018

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle

scientific article published on 28 May 2018

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

scientific article

Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes.

scientific article published on 25 September 2012

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

scientific article published on 16 September 2017

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

scientific article

Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.

scientific article

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine.

scientific article

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism

scientific article published on 29 November 2019

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

scientific article

Metformin Triggers PYY Secretion in Human Gut Mucosa

scientific article published on 01 July 2019

Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes

scientific article published on 06 December 2018

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

scientific article

Purification of α-synuclein containing inclusions from human post mortem brain tissue.

scientific article published on 31 March 2016

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

scientific article

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.

scientific article

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity

scientific article published on 01 February 2013

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating

scientific article published on 01 August 2015

Regional differences in nutrient-induced secretion of gut serotonin.

scientific article

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis

scientific article published on 02 November 2018

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

scientific article published on 24 September 2009

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release

scientific article published on 5 May 2015

Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass

article

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon

scientific article published on 21 September 2017

The 18th International Symposia on Chromaffin Cell Biology

scientific article published on 18 April 2016

The Diverse Metabolic Roles of Peripheral Serotonin.

scientific article published on March 2017

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release

scientific article published on 16 April 2019

The Regulation of Peripheral Metabolism by Gut-Derived Hormones

scientific article published on 01 January 2018

The gut microbiome regulates host glucose homeostasis via peripheral serotonin

scientific article published on 16 September 2019

The neuronal and endocrine roles of RCAN1 in health and disease.

scientific article

The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon.

scientific article

The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia

article

The β-cell/EC axis: how do islet cells talk to each other?

scientific article published on January 2014

Treatment of type 2 diabetes with the designer cytokine IC7Fc

scientific article published on 25 September 2019

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

scientific article published on 21 June 2018

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

scientific article published on 4 September 2017

List of works by Damien J Keating

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

A new ‘dual’ in the crown for electrochemistry ⬇️

Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism

Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking

Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms.

Aging Differentially Affects Multiple Aspects of Vesicle Fusion Kinetics ⬇️

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway

Augmented capacity for peripheral serotonin release in human obesity.

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

CrossTalk opposing view: 5-HT is not necessary for peristalsis

Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules.

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule

Exocytosis in non-neuronal cells

Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.

Galanin receptor 3--a potential target for acute pancreatitis therapy.

Gut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Control

HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.

Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder

Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells

Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins

Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.

ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells.

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes.

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine.

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Metformin Triggers PYY Secretion in Human Gut Mucosa

Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Purification of α-synuclein containing inclusions from human post mortem brain tissue.

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating

Regional differences in nutrient-induced secretion of gut serotonin.

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release

Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon

The 18th International Symposia on Chromaffin Cell Biology

The Diverse Metabolic Roles of Peripheral Serotonin.

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release

The Regulation of Peripheral Metabolism by Gut-Derived Hormones

The gut microbiome regulates host glucose homeostasis via peripheral serotonin

The neuronal and endocrine roles of RCAN1 in health and disease.

The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon.

The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia

The β-cell/EC axis: how do islet cells talk to each other?

Treatment of type 2 diabetes with the designer cytokine IC7Fc

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.