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List of works by Coen Hemker

A coagulation reagent completely devoid of factor X; relation between clotting time and concentration of factor X

scientific article published on 01 January 1979

A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows

scientific article published on 01 February 1982

A new method for the preparation of artificial factor II reagents from normal human and bovine plasma

scientific article published on 01 March 1977

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X.

scientific article published in March 2013

A quick method for the determination of decarboxyfactor X

scientific article published on June 1, 1978

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.

scientific article

Acquired APC resistance and oral contraceptives: differences between two functional tests

scientific article published on 01 April 1999

Age-dependency of thrombin generation

scientific article published on 01 May 2006

An inhibitor of clot formation in cord plasma

scientific article published on 01 January 1979

Analysis of thrombin generation in plasma.

scientific article published in July 1994

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

scientific article published on 01 June 1990

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

scientific article published on 28 March 2016

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight

scientific article published on September 15, 1992

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

scientific article published in February 1998

Automated determination of heparin with chromogenic substrates

scientific article published on 01 January 1984

Automated spectrophotometric heparin assays. Comparison of methods

scientific article published on 01 January 1984

Calibrated automated thrombin generation measurement in clotting plasma

scientific article (publication date: 2003)

Calibrated automated thrombinography (CAT)

scientific article published on 01 January 2005

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

scientific article

Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in Rats ⬇️

scientific article published on January 1, 1979

Clotting factors secreted by monocytes and macrophages: analytical considerations

scientific article published on 01 January 1985

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation

scientific article published on 15 October 2015

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients

scientific article published on 01 January 1985

Computer evaluation of reference curves for the estimation of extrinsic coagulation factors

scientific article published on January 1, 1978

Contribution of the platelet factor V content to platelet factor 3 activity

scientific article published on 01 May 1980

Data management in thrombin generation.

scientific article

Design and synthesis of thrombin substrates with modified kinetic parameters

scientific article published on 01 September 1995

Development of a sensitive and rapid chromogenic factor IX assay for clinical use

scientific article published on 01 January 1990

Differences in the mechanism of blood clot formation and nanostructure in infants and children compared with adults.

scientific article

Different properties of Factor VIII in von Willebrand's disease with Respectto Recovery in Cryoprecipitate.

scientific article published in January 1974

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system

scientific article published on 01 June 2007

Differential interaction of clotting factors II, VII, IX and X with sephadex and dextran blue.

scientific article published in January 1972

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X.

scientific article published in September 1999

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

scientific article

Elements from in vitro studies that help understand the action of heparins

scientific article published on 01 January 1991

Ellipsometry as a tool to study protein films at liquid-solid interfaces

scientific article published on January 1, 1978

Estimation of the rate constants in the michaelis-menten equations without restrictions as to time scale.

scientific article published in August 1972

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay.

scientific article published on 25 September 2010

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

scientific article published in March 2005

Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule ⬇️

scientific article published on October 23, 1998

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.

scientific article published on 8 April 2004

Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome

scientific article published on 01 January 2004

Fluorogenic Peptide‐Based Substrates for Monitoring Thrombin Activity ⬇️

scientific article published on January 31, 2012

Free factor Xa is on the main pathway of thrombin generation in clotting plasma

scientific article published on 01 September 1989

Functional properties of factor Va subunits after proteolytic alterations by activated protein C

scientific article published on 01 May 1984

Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets

scientific article published on 01 February 1982

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects.

scientific article published on 28 January 2015

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection.

scientific article

Heparin neutralization during collection and processing of blood inhibited by pyridoxal 5'-phosphate

scientific article published on 01 January 1984

Heparin-like inhibitor of blood coagulation in normal newborn

scientific article published in Nature

Heparin-like inhibitor, not vitamin-K deficiency, in the newborn

scientific article published on 01 April 1977

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets

scientific article published on 01 August 1999

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways

scientific article published on 01 March 1997

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

scientific article published on 01 May 2007

Improvements of the method for the preparation of an artificial prothrombin reagent

scientific article published on 01 April 1978

In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system

scientific article published on October 22, 1976

In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase.

scientific article published in April 1978

In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin

scientific article published on 01 August 1981

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

scientific article published on 01 January 1981

Inhibition of blood coagulation factors by serine esterase inhibitors

scientific article published on 01 August 1972

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III

scientific article published on 01 January 1986

Inhibition of tissue factor-factor VIIa-catalyzed factor X activation by factor Xa-tissue factor pathway inhibitor. A rotating disc study on the effect of phospholipid membrane composition

scientific article published on 01 October 1999

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics

scientific article (publication date: March 2004)

Is there value in kinetic modeling of thrombin generation? No (unless…)

scientific article published on 01 August 2012

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord

scientific article published on 01 September 1985

Kinetics of the formation of the factor X activating enzyme of the blood coagulation system

scientific article published on 01 March 1976

Kinetics of thrombin-induced release and activation of platelet factor V

scientific article published on 01 January 1986

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

scientific article published on 25 October 2012

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.

scientific article published on 28 November 2007

Lipid phase transitions and procoagulant activity

scientific article published on April 1, 1979

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion.

scientific article published on 28 January 2016

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery.

scientific article published on 19 December 2013

Monitoring new oral antithrombotics: what we should know before we can decide

scientific article published on 01 December 2010

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry

scientific article published on 01 April 1993

Monitoring platelet dependent thrombin generation in mice

scientific article published on 16 September 2010

NATURE OF PROTHROMBIN BIOSYNTHESIS: PREPROTHROMBINAEMIA IN VITAMIN K-DEFICIENCY

scientific article published on 01 November 1963

New approaches for measuring coagulation.

scientific article

No effect of ethanol intake on thrombin generation parameters

scientific article published on 30 November 2011

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

scientific article published on 21 November 2013

On the clot-promoting activity of human platelets in a one-stage prothrombinase assay

scientific article published on 01 January 1982

On the procoagulant activity of platelets stimulated by collagen and thrombin

scientific article published on 01 March 1984

Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes ⬇️

scientific article published on January 12, 1980

Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity

scientific article published on 01 July 1977

Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X

scientific article published on 01 January 1981

Partial purification of the protein moiety of porcine tissue thromboplastin

scientific article published on 01 January 1977

Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWH.

scientific article published in August 2002

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.

scientific article published in January 2004

Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article ⬇️

scientific article published on June 12, 2013

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.

scientific article published in February 1998

Procoagulant activities in venoms from central Asian snakes ⬇️

scientific article published on January 1, 1991

Procoagulant effect of vitamin K antagonists?

scientific article published on 01 December 2011

Production of thrombin as a probe for mixing of phospholipids in membranes on solid supports

scientific article published on 01 July 1995

Prothrombin activation by prothrombinase in a tubular flow reactor.

scientific article published in January 1995

Prothrombin contributes to the assembly of the factor Va-factor Xa complex at phosphatidylserine-containing phospholipid membranes

scientific article published on 01 November 1995

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

scientific article published on 01 June 2018

Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom.

scientific article published in November 1997

Quantitation of infarct size in man by means of plasma enzyme levels ⬇️

scientific article published on August 1, 1975

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis.

scientific article published in June 2007

Reaction Sequence of Blood Coagulation

scientific article published in Nature

Recollections on thrombin generation.

scientific article published on 10 December 2007

Reconstitution and lipid requirements of porcine tissue thromboplastin ⬇️

scientific article published on July 20, 1977

Reevaluation of some properties of fibrinogen, purified from cord blood of normal newborns

scientific article published on 01 November 1983

Role of accessory components in the activation of vitamin K-dependent coagulation factors

scientific article published on 01 January 1986

Simulation model for thrombin generation in plasma

scientific article published on 01 January 1991

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions

scientific article published on 14 April 2016

Spectrophotometric method for the assay of human blood coagulation factor VIII

scientific article published on 01 January 1987

Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption ⬇️

scientific article published on January 1, 1991

The action of Echis carinatus venom on the blood coagulation system. Demonstration of an activator of factor X

scientific article published on 01 July 1984

The activity state of factor VII in plasma: two pathways for the cold promoted activation of factor VII

scientific article published on 01 February 1986

The application of thrombin generation in real life clinical situations

scientific article published on 14 April 2015

The balance of pro- and anticoagulant processes underlying thrombin generation

scientific article published on 7 January 2015

The contribution of alpha(2)-macroglobulin thrombin to the endogenous thrombin potential

scientific article published on 14 September 2007

The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator

scientific article published on 01 August 1978

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene

scientific article published on 01 April 1987

The effect of fibrin(ogen) on thrombin generation and decay

scientific article published on 26 June 2014

The effect of gamma-carboxyglutamate residues on the enzymatic properties of the activated blood clotting factor X. I. Activity towards synthetic substrates

scientific article published on 01 April 1978

The influence of glycerol on the Ca flux in the isolated perfused rat heart

scientific article published on 01 May 1976

The inhibition of platelet prothrombinase activity by prostacyclin

scientific article published on 01 January 1984

The inhibition of vitamin K-dependent carboxylase by cyanide

scientific article published on 01 January 1982

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin.

scientific article published on 24 February 2010

The placental transport of [3H]vitamin K1 in rats

scientific article published on 01 March 1987

The prolongation of the thrombotest clotting time in newborns

scientific article published on 01 October 1988

The role of gamma-carboxyglutamyl residues in the positive cooperative binding of Ca2+ to blood coagulation factor X

scientific article published on 01 April 1978

The technique of measuring thrombin generation with fluorescent substrates: 4. The H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration.

scientific article published in January 2009

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration

scientific article published on 01 August 2008

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups

scientific article published on 28 October 2015

Thrombin Generation in Zebrafish Blood

scientific article published on 12 February 2016

Thrombin generation and plasma dilution

scientific article published on 01 January 2010

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A ⬇️

scientific article published on August 1, 2011

Thrombin generation assays: accruing clinical relevance.

scientific article published in May 2004

Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time

scientific article published on 01 August 2004

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin.

scientific article published on 17 February 2007

Thrombin generation in whole blood

scientific article published on 28 April 2008

Thrombin generation is extremely sensitive to preheating conditions

scientific article published on 01 January 2011

Thrombin generation: What have we learned? ⬇️

scientific article published on 02 July 2012

Thrombin generation: biochemical possibilities and clinical reality

scientific article published on 01 July 2015

Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network.

scientific article

Thrombin-generating capacity in patients with von Willebrand's disease

scientific article published on 01 December 2007

Use of chromogenic peptide substrates in the determination of clotting factors II, VII, IX and X in normal plasma and in plasma of patients treated with oral anticoagulants

scientific article published on 01 January 1982

Vitamin-K deficiency in the newborn

scientific article published on 01 October 1977

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

scientific article

[Treatment of hemophilia B with PPSB]

scientific article published on 01 February 1968

von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets

scientific article published on 01 March 2003

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