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List of works by Ioanna Tzoulaki

A Phenome-wide Mendelian Randomisation study on genetically determined serum urate levels in UK Biobank cohort

scientific article published on 10 May 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure

scientific article

A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

scientific article published on 08 November 2019

A nutrient-wide association study on blood pressure

scientific article

Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders

scientific article published on 17 November 2020

Added Value of Serum Hormone Measurements in Risk Prediction Models for Breast Cancer for Women Not Using Exogenous Hormones: Results from the EPIC Cohort

scientific article published on 28 February 2017

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

scientific article

An Overview of Metabolic Phenotyping in Blood Pressure Research

scientific article published on 10 July 2018

Ankle brachial index and intima media thickness predict cardiovascular events similarly and increased prediction when combined

scientific article published on 25 July 2007

Assessment of claims of improved prediction beyond the Framingham risk score

scientific article

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

scientific article published on 17 July 2017

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

scientific article

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Associations of genetically determined iron status across the phenome: A mendelian randomization study.

scientific article published on 20 June 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Balancing benefit and risk of medicines: a systematic review and classification of available methodologies

scientific article published on 13 May 2014

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

scientific article published on May 2010

Benefit-risk assessment in a post-market setting: a case study integrating real-life experience into benefit-risk methodology.

scientific article published on 5 July 2014

Bias in associations of emerging biomarkers with cardiovascular disease

scientific article published on April 2013

Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses

scientific article

Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

scientific article published on 20 August 2019

Blood pressure loci identified with a gene-centric array

scientific article

C-Reactive Protein, Interleukin-6, and Soluble Adhesion Molecules as Predictors of Progressive Peripheral Atherosclerosis in the General Population

scientific article published on 08 August 2005

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

scientific article published in 2022

Circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study

scientific article published on 14 June 2019

Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

scientific article published on 16 November 2018

Comment on "dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors" (Radiat. Environ. Biophys (2012) 51:165-178) by Schöllnberger et al.

scientific article

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

scientific article published on 30 July 2011

Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: a systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies

scientific article published on 03 April 2018

Comparison with randomized controlled trials as a strategy for evaluating instruments in Mendelian randomization

scientific article published on 25 November 2019

Comparisons of established risk prediction models for cardiovascular disease: systematic review

scientific article

Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease

scientific article published on 22 April 2019

Contributions of risk factors and medical care to cardiovascular mortality trends

scientific article

Contributors

Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

scientific article published in September 2017

Cortisol, Amyloid-β, and Reserve Predicts Alzheimer's Disease Progression for Cognitively Normal Older Adults

scientific article published on 01 January 2019

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts

scientific article

Dementia Incidence in the Elderly Population of Greece: Results From the HELIAD Study

scientific article published on 30 September 2020

Design and analysis of metabolomics studies in epidemiologic research: a primer on -omic technologies

scientific article published on 24 June 2014

Determinants of accelerated metabolomic and epigenetic ageing in a UK cohort: Supplementary tables 2 and 3

scholarly article published 20 September 2018

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort

scientific article published on 03 May 2020

Diabetes mellitus and risk of prostate cancer in the EuropeanProspectiveInvestigation into Cancer and Nutrition

article by Konstantinos K. Tsilidis et al published 3 June 2014 in International Journal of Cancer

Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study

scientific article

Diet, body size, physical activity and risk of prostate cancer: An umbrella review of the evidence.

scientific article

Dietary fiber and health outcomes: an umbrella review of systematic reviews and meta-analyses

scientific article published in March 2018

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Distribution of a subclinical marker of cardiovascular risk, the ankle brachial index, in a rural African population: SASPI study

scientific article

Dopaminergic stimulants and risk of Parkinson’s disease

scientific article published on 11 May 2020

Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

scientific article published on 18 May 2020

Early-Life Factors and Risk of Multiple Sclerosis: An MR-EWAS

scientific article published on 23 October 2020

Education protects against coronary heart disease and stroke independently of cognitive function: evidence from Mendelian randomization

scientific article published on 01 October 2019

Effect of low-dose aspirin on health outcomes: An umbrella review of systematic reviews and meta-analyses

scientific article published on 02 June 2020

Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study

scientific article published on 16 July 2019

Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

scientific article published on 9 December 2016

Environmental factors and risk of multiple sclerosis: Findings from meta-analyses and Mendelian randomization studies

scientific article published on 06 September 2019

Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

scientific article

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

scientific article published on 04 February 2015

Environmental risk factors and nonpharmacological and nonsurgical interventions for obesity: An umbrella review of meta-analyses of cohort studies and randomized controlled trials

scientific article published on 13 July 2018

Erratum to: Methods for evaluating medical tests and biomarkers

scientific article published on 30 March 2017

Estimated 24-Hour Urinary Sodium Excretion and Incident Cardiovascular Disease and Mortality Among 398 628 Individuals in UK Biobank

scientific article published on 06 July 2020

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

scientific article

Exposure to pesticides and diabetes: A systematic review and meta-analysis.

scientific article published on 20 February 2016

External validation of new risk prediction models is infrequent and reveals worse prognostic discrimination

scientific article published on 23 October 2014

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

scientific article published on 13 August 2019

Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits.

scientific article

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

scientific article

Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations with Midlife Blood Pressure Levels and Cardiovascular Events

scientific article published on 18 December 2017

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variants related to antihypertensive targets inform drug efficacy and side effects

Genetically Determined FXI (Factor XI) Levels and Risk of Stroke

article

Genetically Determined Platelet Count and Risk of Cardiovascular Disease

scientific article published on 01 December 2018

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes

scientific article published on 01 July 2020

Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study

scientific article published on 18 October 2019

Genetically predicted circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study

scientific article published on 05 August 2020

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

scientific article published on 01 October 2018

Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

scientific article published on 25 September 2020

Greece giving up on tobacco control.

scientific article published on 30 March 2016

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Hemostatic Factors, Inflammatory Markers, and Progressive Peripheral Atherosclerosis

Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis.

scientific article

Improving Visualization and Interpretation of Metabolome-Wide Association Studies: An Application in a Population-Based Cohort Using Untargeted 1H NMR Metabolic Profiling.

scientific article

Infant locomotive development and its association with adult blood pressure

article

Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study.

scientific article published on 9 January 2007

Investigating nutrition and lifestyle factors as determinants of abdominal obesity: an environment-wide study.

scientific article published on 14 November 2016

Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and Nurses' Health Study (NHS) and NHSII

scientific article

Iron Status and Risk of Stroke

scientific article published on 01 December 2018

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

scientific article

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases

scientific article

Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

scientific article published on 10 January 2020

Literature review of visual representation of the results of benefit-risk assessments of medicinal products

scientific article

Low total and nonheme iron intakes are associated with a greater risk of hypertension

scientific article published on 18 November 2009

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.

scientific article published on 6 February 2018

Mapping the expanded often inappropriate use of the Framingham Risk Score in the medical literature

scientific article

Metabolic syndrome, haemostatic and inflammatory markers, cerebrovascular and peripheral arterial disease: The Edinburgh Artery Study

scientific article published on 3 August 2008

Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study

scientific article published on 01 May 2019

Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-to-treat trial

scientific article

Methods for Evaluating Medical Tests and Biomarkers

article by Gowri Gopalakrishna et al published February 2017 in Diagnostic and Prognostic Research

Minimal and null predictive effects for the most popular blood biomarkers of cardiovascular disease

scientific article published on March 2012

Moderate coffee intake and cardiovascular health; no grounds for concern

scientific article published on 30 May 2018

Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

scientific article published on 20 November 2020

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

scientific article published on 29 July 2019

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

scientific article published on 25 November 2015

Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

scientific article published on 13 January 2020

PAX6 mutations: genotype-phenotype correlations

scientific article

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

scientific article

Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study

scientific article published on 4 July 2016

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

scientific article

Predicting death: an empirical evaluation of predictive tools for mortality

scientific article published on 25 July 2011

Prediction models for cardiovascular disease risk in the general population: systematic review

scientific article

Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

scientific article published on 01 February 2020

Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population ⬇️

scientific article

Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study

scientific article

Prognostic models for outcome prediction in patients with chronic obstructive pulmonary disease: systematic review and critical appraisal

scientific article published on 04 October 2019

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Rare coding variants pinpoint genes that control human hematological traits

scientific article published on 7 August 2017

Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease

scientific article published on 01 March 2006

Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study

scientific article published in April 2010

Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study

scientific article published on 15 July 2008

Relation of unprocessed, processed red meat and poultry consumption to blood pressure in East Asian and Western adults

scientific article published on July 2016

Relation of urinary calcium and magnesium excretion to blood pressure: The International Study Of Macro- And Micro-nutrients And Blood Pressure and The International Cooperative Study On Salt, Other Factors, And Blood Pressure

scientific article

Relationship of dietary cholesterol to blood pressure: the INTERMAP study

scientific article

Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected].

scientific article published on 7 July 2008

Relative Value of Inflammatory, Hemostatic, and Rheological Factors for Incident Myocardial Infarction and Stroke

scientific article published on 02 April 2007

Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors

scientific article

Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms

scientific article

Risk factors for adverse clinical outcomes in patients with COVID-19: A systematic review and meta-analysis

scientific article published on 19 May 2020

Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK biobank data

scientific article published on 20 August 2020

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.

scientific article

Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

scientific article published on 03 December 2009

Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts

Risk prediction for renal cell carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective cohort study

scientific article published on 17 December 2020

Salt intakes around the world: implications for public health.

scientific article published on 07 April 2009

Scientific Opinion of the PPR Panel on the follow‐up of the findings of the External Scientific Report ‘Literature review of epidemiological studies linking exposure to pesticides and health effects’

scientific article published in October 2017

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

scientific article published on 09 March 2020

Scientific Opinion on the setting of health-based reference values for metabolites of the active substance terbuthylazine

scientific article published on 04 June 2019

Scientific statement on the coverage of bats by the current pesticide risk assessment for birds and mammals

scientific article published on 29 July 2019

Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis

scientific article published on 14 August 2017

Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease

scientific article published on 01 September 2019

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

scientific article

Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study

scientific article published on 9 April 2008

Sleep, major depressive disorder and Alzheimer's disease: A Mendelian randomisation study

scientific article published on 19 August 2020

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 29 May 2018

Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses.

scientific article published on 3 September 2016

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks

scientific article

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies

scientific article published on 01 June 2019

The Qatar Biobank: background and methods.

scientific article published on 3 December 2015

The added value of genetic information in colorectal cancer risk prediction models: development and evaluation in the UK Biobank prospective cohort study

article

The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses

article

The consequences of adjustment, correction and selection in genome-wide association studies used for two-sample Mendelian randomization

scientific article published on 14 July 2020

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

Trends and inequalities in cardiovascular disease mortality across 7932 English electoral wards, 1982-2006: Bayesian spatial analysis

scientific article published on 4 November 2012

Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.

scientific article

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials

scientific article published on 28 December 2020

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

scientific article published on 25 June 2019

Use of reclassification for assessment of improved prediction: an empirical evaluation

scientific article published on 16 February 2011

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

scientific article

Weighing benefit–risk of medicines: concepts and approaches

article published in 2011

Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

scientific article published on 10 October 2020

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality:

What makes a good predictor?: the evidence applied to coronary artery calcium score

scientific article published in April 2010

Workflow for Integrated Processing of Multicohort Untargeted 1H NMR Metabolomics Data in Large-Scale Metabolic Epidemiology

scientific article

Worldwide Exposures to Cardiovascular Risk Factors and Associated Health Effects: Current Knowledge and Data Gaps

scientific article

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