List of works - Laurence Chaperot

A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

scientific article

A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells

scientific article

Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype.

scientific article

Anti-Gal-mediated targeting of human B lymphoma cells to antigen-presenting cells: a potential method for immunotherapy using autologous tumor cells.

scientific article

BDCA1+ cDC2s, BDCA2+ pDCs and BDCA3+ cDC1s reveal distinct pathophysiologic features and impact on clinical outcomes in melanoma patients

scientific article published on 24 November 2020

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl

scientific article

CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells.

scientific article

Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor

scientific article published on 11 March 2010

Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells

scientific article published on 17 July 2015

Circulating and Hepatic BDCA1+, BDCA2+, and BDCA3+ Dendritic Cells Are Differentially Subverted in Patients With Chronic HBV Infection

scientific article published on 04 February 2019

Clinical and biologic features of CD4+CD56+ malignancies

scientific article published on 01 March 2002

Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses

scientific article published on 18 August 2017

Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production.

scientific article published on 24 February 2016

Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort

scientific article published on 14 October 2019

Differentiation of anti-tumour cytotoxic T lymphocytes from autologous peripheral blood lymphocytes in non-Hodgkin's lymphomas

scientific article published on 01 November 2002

Differentiation of antigen-presenting cells (dendritic cells and macrophages) for therapeutic application in patients with lymphoma

scientific article published on 01 September 2000

Diversification of circulating and tumor-infiltrating plasmacytoid DCs towards the P3 (CD80+ PDL1-)-pDC subset negatively correlated with clinical outcomes in melanoma patients

scientific article published on 03 May 2022

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

scientific article

Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

scientific article published on 09 November 2021

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).

scientific article

Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs

scientific article published on 17 April 2017

Exploration of the lysis mechanisms of leukaemic blasts by chimaeric T-cells.

scientific article published on 13 June 2010

Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells

scientific article

Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia.

scientific article published on 8 April 2009

From the study of tumor cell immunogenicity to the generation of antitumor cytotoxic cells in non-Hodgkin's lymphomas.

scientific article

HIV triggers immunoregulatory dendritic cells and regulatory T cells through the non-canonical NF-kB pathway.

scientific article published on 13 September 2012

HLA-A(*)0201(+) plasmacytoid dendritic cells provide a cell-based immunotherapy for melanoma patients.

scientific article

Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

scientific article published on 08 April 2016

Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation.

scientific article

Identification of a leukemic counterpart of the plasmacytoid dendritic cells.

scientific article

In situ leukemic plasmacytoid dendritic cells pattern of chemokine receptors expression and in vitro migratory response

scientific article published on 01 September 2004

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis

scientific article published on 12 March 2019

In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas.

scientific article published on 3 October 2002

Induction of antiviral cytotoxic T cells by plasmacytoid dendritic cells for adoptive immunotherapy of posttransplant diseases.

scientific article published on 29 August 2011

Innate sensing of HIV-infected cells

scientific article

La photochimiothérapie extracorporelle ou l’immunothérapie par cellules modifiées par photochimie

scientific article published on 11 February 2010

Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts

scientific article published on 01 February 2004

Malignant B lymphocytes from non-Hodgkin's lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures: an important role of co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) in stimulation by tumo

scientific article published on 01 December 1995

Mechanisms of TRAIL-induced apoptosis in leukemic plasmacytoid dendritic cells.

scientific article published on December 2006

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation

scientific article published on 28 March 2019

NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells.

scientific article

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

scientific article

P16-52. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.

scientific article published on 22 October 2009

Photochemotherapy Induces a Faster Apoptosis of Alloreactive Activated T Cells Than of Nonalloreactive Resting T Cells in Graft Versus Host Disease

scientific article published on 01 December 2010

Photochemotherapy induces the apoptosis of monocytes without impairing their function.

scientific article published on March 2010

Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept

scientific article published on 18 September 2019

Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications.

scientific article published on 6 April 2017

Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer.

scientific article published on 22 October 2009

Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells

scientific journal article

Quantification of cellular adhesion molecules on malignant B cells from non-Hodgkin's lymphoma

scientific article published on 01 September 1999

Quantitative analysis detects ubiquitous expression of apoptotic regulators in B cell non-Hodgkin's lymphomas

scientific article published on 01 October 1999

Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease

article

Relationships between susceptibility to LAK cell-mediated lysis, conjugate formation and expression of adhesion molecules in B-cell derived non-Hodgkin's lymphomas

scientific article published on 01 December 1997

SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7.

scientific article

Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform.

scientific article published on 20 July 2013

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

scientific article published on 25 September 2019

T-cell receptor diversity as a prognostic biomarker in melanoma patients

scientific article published on 23 January 2020

TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

scientific article

Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.

scientific article published on 7 July 2016

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.

scientific article

The avidity of tumor-specific T cells amplified by a plasmacytoid dendritic cell-based assay can predict the clinical evolution of melanoma patients

scientific article published on 25 July 2017

The features of circulating and tumor-infiltrating γδ T cells in melanoma patients display critical perturbations with prognostic impact on clinical outcome

scientific article published on 17 April 2019

Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis.

scientific article

Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells

scientific article published on 15 February 2007

Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells.

scientific article published on January 2006

Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells.

scientific article published on January 2008

[GENiusVac, a novel antitumor vaccine strategy based on allogeneic plasmacytoid dendritic cells]

scientific article published on 22 March 2011

List of works by Laurence Chaperot

A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells

Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype.

Anti-Gal-mediated targeting of human B lymphoma cells to antigen-presenting cells: a potential method for immunotherapy using autologous tumor cells.

BDCA1<sup>+</sup> cDC2s, BDCA2<sup>+</sup> pDCs and BDCA3<sup>+</sup> cDC1s reveal distinct pathophysiologic features and impact on clinical outcomes in melanoma patients

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl

CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells.

Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor

Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells

Circulating and Hepatic BDCA1+, BDCA2+, and BDCA3+ Dendritic Cells Are Differentially Subverted in Patients With Chronic HBV Infection

Clinical and biologic features of CD4+CD56+ malignancies

Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses

Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production.

Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort

Differentiation of anti-tumour cytotoxic T lymphocytes from autologous peripheral blood lymphocytes in non-Hodgkin's lymphomas

Differentiation of antigen-presenting cells (dendritic cells and macrophages) for therapeutic application in patients with lymphoma

Diversification of circulating and tumor-infiltrating plasmacytoid DCs towards the P3 (CD80<sup>+</sup> PDL1<sup>-</sup>)-pDC subset negatively correlated with clinical outcomes in melanoma patients

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).

Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs

Exploration of the lysis mechanisms of leukaemic blasts by chimaeric T-cells.

Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells

Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia.

From the study of tumor cell immunogenicity to the generation of antitumor cytotoxic cells in non-Hodgkin's lymphomas.

HIV triggers immunoregulatory dendritic cells and regulatory T cells through the non-canonical NF-kB pathway.

HLA-A(*)0201(+) plasmacytoid dendritic cells provide a cell-based immunotherapy for melanoma patients.

Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation.

Identification of a leukemic counterpart of the plasmacytoid dendritic cells.

In situ leukemic plasmacytoid dendritic cells pattern of chemokine receptors expression and in vitro migratory response

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis

In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas.

Induction of antiviral cytotoxic T cells by plasmacytoid dendritic cells for adoptive immunotherapy of posttransplant diseases.

Innate sensing of HIV-infected cells

La photochimiothérapie extracorporelle ou l’immunothérapie par cellules modifiées par photochimie

Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts

Malignant B lymphocytes from non-Hodgkin's lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures: an important role of co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) in stimulation by tumo

Mechanisms of TRAIL-induced apoptosis in leukemic plasmacytoid dendritic cells.

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation

NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells.

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

P16-52. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.

Photochemotherapy Induces a Faster Apoptosis of Alloreactive Activated T Cells Than of Nonalloreactive Resting T Cells in Graft Versus Host Disease

Photochemotherapy induces the apoptosis of monocytes without impairing their function.

Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept

Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications.

Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer.

Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells

Quantification of cellular adhesion molecules on malignant B cells from non-Hodgkin's lymphoma

Quantitative analysis detects ubiquitous expression of apoptotic regulators in B cell non-Hodgkin's lymphomas

Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease

Relationships between susceptibility to LAK cell-mediated lysis, conjugate formation and expression of adhesion molecules in B-cell derived non-Hodgkin's lymphomas

SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7.

Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform.

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

T-cell receptor diversity as a prognostic biomarker in melanoma patients

TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.

The avidity of tumor-specific T cells amplified by a plasmacytoid dendritic cell-based assay can predict the clinical evolution of melanoma patients

The features of circulating and tumor-infiltrating γδ T cells in melanoma patients display critical perturbations with prognostic impact on clinical outcome

Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis.

Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells

Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells.

Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells.

[GENiusVac, a novel antitumor vaccine strategy based on allogeneic plasmacytoid dendritic cells]