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List of works by Zhiheng Xu

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. ⬇️

scientific article

Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.

scientific article published on 04 May 2009

Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae.

scientific article

BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP.

scientific article published in September 2014

Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression

scientific article published in July 2013

Cbl negatively regulates JNK activation and cell death

scientific journal article

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

scientific article published on 26 April 2001

Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children

scientific article published on 08 July 2019

Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs.

scientific article published on 29 March 2006

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.

scientific article published on 28 April 2015

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

scientific article published on 10 March 2022

Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2.

scientific article published on 20 May 2010

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

scientific article published on 4 March 2013

Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells.

scientific article

Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH

scientific article published on 01 January 2007

JNK activation mediates the apoptosis of xCT-deficient cells.

scientific article

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

scientific article published on 19 December 2018

Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway.

scientific article

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

scientific article

POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila.

scientific article

Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop.

scientific article published on November 2005

Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

scientific article published on 17 August 2004

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.

scientific article published on 23 August 2017

Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.

scientific article

Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis

scientific article

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease

scientific article published on 10 October 2006

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.

scientific article published on 22 September 2017

Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity

scientific article

Treatment of SARS-CoV-2-induced pneumonia with NAD<sup>+</sup> and NMN in two mouse models

scientific article published on 29 April 2022

Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children

scientific article published on 02 August 2020

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

scientific article published on 27 February 2019

cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.

scientific article published on 13 November 2017

cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development

article published in the Proceedings of the National Academy of Sciences of the United States of America

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