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List of works by Sean Joseph

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

scientific article (publication date: 2001)

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

scientific article

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

scientific article published on 01 August 2020

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

scientific article

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism ⬇️

scientific article published on October 1, 2003

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

scientific article

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Discovery of structurally novel, potent and orally efficacious GPR119 agonists

scientific article published on 27 March 2014

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

scientific article published on 04 April 2014

Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis.

scientific article published in September 2001

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

scientific article

Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics

scientific article published on October 2015

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

scientific article published on July 2008

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

scientific article published on 25 January 2016

Neratinib protects pancreatic beta cells in diabetes

scientific article published on 01 November 2019

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

scientific article published on 13 October 2014

Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux.

scientific article published on 11 December 2003

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain

scientific article published on 17 May 2016

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

scientific article published on 23 September 2016

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

scientific article (publication date: 30 August 2002)

Relative Target Affinities of T Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.

scientific article published on 16 January 2018

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,

scientific article published on 26 June 2013

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