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List of works by Philip Hinchliffe

1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2.

scientific article

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

scientific article published on 2 March 2017

Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

scientific article published on 12 December 2017

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

scientific article published on 16 September 2019

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

scientific article published on 20 July 2015

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

scientific article published on 14 June 2016

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

scientific article published on 10 January 2020

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

scientific article published on 17 December 2017

Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography

scientific article published on 27 December 2019

Identification of a novel subunit of respiratory complex I from Thermus thermophilus

scientific article published in April 2006

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

scientific article published on 06 January 2017

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

scientific article published on 23 September 2019

Organization of iron-sulfur clusters in respiratory complex I.

scientific article

Resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes

scientific article published on 20 May 2020

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

scientific article published on 2 May 2016

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

scientific article published on 18 July 2016

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

scientific article

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

scientific article published on 6 September 2017

Structure and operation of bacterial tripartite pumps.

scientific article published on 26 June 2013

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

scientific article

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump

scientific article

Structures of sequential open states in a symmetrical opening transition of the TolC exit duct

scientific article

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