List of works - Jamil S Saad

A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

scientific article published on 26 April 2022

Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure.

scientific article

Derepression of SaPIbov1 Is Independent of φNM1 Type 2 dUTPase Activity and Is Inhibited by dUTP and dUMP.

scientific article published on 8 April 2017

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B.

scientific article published on 15 February 2017

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

scientific article published on 29 July 2013

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

scientific article published in October 2015

Dramatic 5'-residue effect on conformer distribution of short oligonucleotide retro models of the cisplatin-DNA cross-link: implications for the Lippard and cross-link distorted base pair steps present in cisplatin-DNA duplex adducts.

scientific article published in February 2002

Editorial: Role of lipids in virus assembly

scientific article published on 5 May 2015

HIV: a vicTIM.

scientific article published on 16 October 2014

Identification of the Calmodulin-Binding Domains of Fas Death Receptor

scientific article

Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch

scientific article

Myristate Exposure in the Human Immunodeficiency Virus Type 1 Matrix Protein Is Modulated by pH ⬇️

scientific article published on November 9, 2010

NMR Studies of Models Having the Pt(d(GpG)) 17-Membered Macrocyclic Ring Formed in DNA by Platinum Anticancer Drugs: Pt Complexes with Bulky Chiral Diamine Ligands

scientific article published on 21 April 2011

NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein

scientific article

Origins of the distortions in the base pair step adjacent to platinum anticancer drug-DNA adducts. Fundamental NMR solution studies utilizing right-handed cross-link models having 5'- and 3'-flanking residues.

scientific article published in September 2009

Pneumococcus with the "6E" cps Locus Produces Serotype 6B Capsular Polysaccharide.

scientific article published on 27 January 2016

Point Mutations in the HIV-1 Matrix Protein Turn Off the Myristyl Switch

scientific article

Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

scientific article published on 24 April 2017

Relationship of solution and protein-bound structures of DNA duplexes with the major intrastrand cross-link lesions formed on cisplatin binding to DNA

scientific article

Reverse micelle encapsulation of membrane-anchored proteins for solution NMR studies

scientific article published on January 2010

Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly ⬇️

scientific article published on February 17, 2012

Single-Stranded Oligonucleotide Adducts Formed by Pt Complexes Favoring Left-Handed Base Canting: Steric Effect of Flanking Residues and Relevance to DNA Adducts Formed by Pt Anticancer Drugs ⬇️

scientific article published on August 5, 2011

Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein

scientific article

Solution Structure of Calmodulin Bound to the Binding Domain of the HIV-1 Matrix Protein

scientific article

Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation.

scientific article

Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.

scientific article

Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.

scientific article published on 11 June 2013

Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly

scientific article published on 22 October 2019

Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane.

scientific article

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

scholarly article

Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly

scientific article published in Journal of Biological Chemistry

Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation

scientific article published on 22 January 2021

Structural characterization of Streptococcus pneumoniae serotype 9A capsule polysaccharide reveals role of glycosyl 6-O-acetyltransferase wcjE in serotype 9V capsule biosynthesis and immunogenicity.

scientific article published on 24 February 2012

Structure of the Myristylated Human Immunodeficiency Virus Type 2 Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Membrane Targeting

scientific article

Targeting the Early Step of Building Block Organization in Viral Capsid Assembly.

scientific article published on 29 May 2015

The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.

scientific article published on 21 November 2016

The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation

scientific article published on 16 May 2020

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

scientific article published on 10 February 2019

The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination.

scientific article

The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery

scientific article published in Journal of Biological Chemistry

The tuberculosis necrotizing toxin is an NAD and NADP glycohydrolase with distinct enzymatic properties

article

Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers ⬇️

scientific article published on February 11, 2013

List of works by Jamil S Saad

A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure.

Derepression of SaPIbov1 Is Independent of φNM1 Type 2 dUTPase Activity and Is Inhibited by dUTP and dUMP.

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B.

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Dramatic 5'-residue effect on conformer distribution of short oligonucleotide retro models of the cisplatin-DNA cross-link: implications for the Lippard and cross-link distorted base pair steps present in cisplatin-DNA duplex adducts.

Editorial: Role of lipids in virus assembly

HIV: a vicTIM.

Identification of the Calmodulin-Binding Domains of Fas Death Receptor

Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch

Myristate Exposure in the Human Immunodeficiency Virus Type 1 Matrix Protein Is Modulated by pH ⬇️

NMR Studies of Models Having the Pt(d(GpG)) 17-Membered Macrocyclic Ring Formed in DNA by Platinum Anticancer Drugs: Pt Complexes with Bulky Chiral Diamine Ligands

NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein

Origins of the distortions in the base pair step adjacent to platinum anticancer drug-DNA adducts. Fundamental NMR solution studies utilizing right-handed cross-link models having 5'- and 3'-flanking residues.

Pneumococcus with the "6E" cps Locus Produces Serotype 6B Capsular Polysaccharide.

Point Mutations in the HIV-1 Matrix Protein Turn Off the Myristyl Switch

Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

Relationship of solution and protein-bound structures of DNA duplexes with the major intrastrand cross-link lesions formed on cisplatin binding to DNA

Reverse micelle encapsulation of membrane-anchored proteins for solution NMR studies

Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly ⬇️

Single-Stranded Oligonucleotide Adducts Formed by Pt Complexes Favoring Left-Handed Base Canting: Steric Effect of Flanking Residues and Relevance to DNA Adducts Formed by Pt Anticancer Drugs ⬇️

Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein

Solution Structure of Calmodulin Bound to the Binding Domain of the HIV-1 Matrix Protein

Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation.

Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.

Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.

Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly

Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane.

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly

Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation

Structural characterization of Streptococcus pneumoniae serotype 9A capsule polysaccharide reveals role of glycosyl 6-O-acetyltransferase wcjE in serotype 9V capsule biosynthesis and immunogenicity.

Structure of the Myristylated Human Immunodeficiency Virus Type 2 Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Membrane Targeting

Targeting the Early Step of Building Block Organization in Viral Capsid Assembly.

The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.

The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination.

The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery

The tuberculosis necrotizing toxin is an NAD and NADP glycohydrolase with distinct enzymatic properties

Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers ⬇️