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List of works by Matthias Geyer

1H, 15N, and 13C assignments of the N-terminal activation domain of Dictyostelium discoideum Formin C

scientific article published on 07 October 2010

A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.

scientific article published in April 2010

A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells.

scientific article published on December 2002

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

scientific article

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.

scientific article published in November 1995

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

scientific article published on 16 November 2021

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells

scientific article

Alternative splicing regulates stochastic NLRP3 activity

scientific article published on 19 July 2019

Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome

scientific article

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1

scientific article

Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

scientific article published in February 2006

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

scientific article published in Journal of Biological Chemistry

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

scientific article (publication date: July 2014)

C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional 1H NMR spectroscopy and X-ray small-angle scattering

scientific article published on 01 August 1991

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

scientific article published in November 2016

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

article

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

scientific article published on 29 April 2020

Chemotactic activity of HIV-1 Nef for human monocytes.

scientific article published on 21 December 2006

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux

scientific article

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

scientific article

Complex formation and light activation in membrane-embedded sensory rhodopsin II as seen by solid-state NMR spectroscopy.

scientific article published in March 2010

Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1

scientific article published on 01 August 1999

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

scientific article

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly

scientific article published on 16 June 2020

D186/D190 is an allele-dependent determinant of HIV-1 Nef function

scientific article published on 22 August 2016

DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

scientific article

Deficiency in coatomer complex I causes aberrant activation of STING signalling

scientific article published on 28 April 2022

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

scientific article published on 21 March 2019

Discovery and resistance mechanism of a selective CDK12 degrader

scientific article published on 22 March 2021

Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres

scientific article

Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.

scientific article published in May 2001

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.

scientific article published on 11 July 2008

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

scientific article

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

scientific article

Exogenous Nef Induces Proinflammatory Signaling Events in Murine Macrophages ⬇️

scientific article published on March 13, 2012

Extracellular HIV-1 Nef increases migration of monocytes.

scientific article published on 16 August 2006

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

scientific article published on 26 February 2013

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.

scientific article published on 30 January 2014

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

scientific article

Fifteen formins for an actin filament: a molecular view on the regulation of human formins.

scientific article published on 25 January 2010

Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses

scientific article published on 10 April 2010

Formins as effector proteins of Rho GTPases

scientific article

Functional characterization of the human Cdk10/Cyclin Q complex

scientific article published on 16 March 2022

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins ⬇️

scientific article published on December 1, 1997

HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis

scientific article

HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity

scientific article published on 11 June 2015

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

scientific article

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.

scientific article published on 22 November 2009

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

scientific article

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

scientific article published on 27 April 2012

In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r

scientific article published on 20 December 2006

Insights into the activation of transcription elongation by lentiviruses: structure of the Cyclin T1-Tat-TAR RNA complex.

scientific article published on 24 September 2009

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

scientific article published on 29 June 2021

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

scientific article published in November 1996

Link between primate lentiviral coreceptor usage and Nef function

scientific article

MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

scientific article

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

scientific article published on 27 March 2019

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice.

scientific article

Mechanistic insights into the translocation of full length HIV-1 Tat across lipid membranes

scientific article published on 27 July 2011

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

scientific article published in December 2017

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

scientific article

Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome

scientific article (publication date: November 2002)

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

scientific article published on 2 May 2017

NMR assignment of the Cyclin T-binding domain of human Hexim1

scientific article published on 23 May 2006

NMR spectroscopic investigation of early events in IAPP amyloid fibril formation

scientific article published on 01 July 2009

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

scientific article

Nef surfaces: where to interfere with function

scientific article published in October 2011

Observation of slow dynamic exchange processes in Ras protein crystals by 31P solid state NMR spectroscopy.

scientific article published in November 2002

Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression

scientific article published on November 2002

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

scientific article

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

scientific article published on 26 February 2019

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

scientific article

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides

scientific article

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

scientific article published on 19 September 2007

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

scientific article

Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs

article

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.

scientific article

Sensitizing HR-proficient cancers to PARP inhibitors

scientific article published on 3 March 2017

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

scientific article

Sequence-specific resonance assignment of the Ras-binding domain of AF6

scientific article published on 01 September 2000

Sequential NMR assignment of the RAS-binding domain of Byr2

scientific article published on 01 April 2000

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

scientific article published in Nature Communications

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations

scientific article published on 20 January 2019

Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

scientific article published on 17 August 2006

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

scientific article

Structural and biochemical analysis of Ras-effector signaling via RalGDS

scientific article published on 01 May 1999

Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter

scientific article published in 2022

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

scientific article

Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1

scientific article

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

scientific article

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

scientific article published on September 1, 1997

Structure, Dynamics, Lipid Binding, and Physiological Relevance of the Putative GTPase-binding Domain of Dictyostelium Formin C

scientific article

Structure--function relationships in HIV-1 Nef.

scientific article

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

scientific article

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

scientific article published in January 1995

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

scientific article

Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

scientific article published on February 2015

Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPgammaNH(2) and GTPgammaF.

scientific article published in July 2002

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

scientific article published on 6 March 2007

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

scientific article

The RNA polymerase II carboxy-terminal domain (CTD) code

scientific article

The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain

scientific article published on 01 March 2001

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

scientific article

The control of HIV transcription: keeping RNA polymerase II on track

scientific article

The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain

scientific article published on 29 March 2019

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21

scientific article published on 01 December 2019

The structure and substrate specificity of human Cdk12/Cyclin K

scientific article

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.

scientific article published on 12 May 2015

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

scientific article (publication date: 7 May 1999)

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

scientific article

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

scientific article published on 10 December 2015

When the Lymphocyte Loses Its Clothes ⬇️

scientific article published on April 1, 2003

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

scientific article

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

scientific article published on 01 March 2020

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