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List of works by Stephen J. O'Keefe

A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.

scientific article published on 7 December 2009

Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations

scientific article

Bacterial overgrowth and liver complications in short bowel intestinal failure patients

scientific article published on 01 February 2006

Candidacy for intestinal transplantation

scientific article published on 01 July 2006

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

scientific article published on 13 September 2007

Clinical Characteristics of Inflammatory Bowel Disease Patients Requiring Long-Term Parenteral Support in the Present Era of Highly Effective Biologic Therapy

scientific article published on 09 August 2020

Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome

scientific article published on 21 August 2018

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

scientific article

Development of a method for the purification of human trypsin by single step affinity chromatography suitable for human isotope incorporation studies

scientific article published on November 30, 1992

Diet, microbiota, and dysbiosis: a 'recipe' for colorectal cancer.

scientific article published on 3 February 2016

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans ⬇️

scientific article published on May 29, 2013

Diet, microorganisms and their metabolites, and colon cancer.

scientific article

Dietary fatty acids modulate chronic colitis, colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice

scientific article published on 01 March 2006

Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans.

scientific article published on 13 April 2004

Duodenal juice total protein and pancreatic enzyme synthesis, turnover, and secretion in patients after acute pancreatitis ⬇️

scientific article published on September 1, 1993

Early jejunal feeding initiation and clinical outcomes in patients with severe acute pancreatitis

scientific article published on January 2011

Ease of donning commercially available latex examination gloves ⬇️

scientific article published on January 1, 1998

Effect of severe undernutrition and subsequent refeeding on gut mucosal protein fractional synthesis in human subjects

scientific article published on 01 January 2007

Endoscopic evaluation of small intestine transplant grafts

scientific article published on 01 October 2012

Enteral feeding patients with gastric outlet obstruction

scientific article published on 01 February 2012

Enteral feeding without pancreatic stimulation.

scientific article published in November 2005

Environmental influences on the high mortality from colorectal cancer in African Americans

scientific article published on September 2007

Fat, fibre and cancer risk in African Americans and rural Africans

scientific article

Feeding the injured pancreas

scientific article published on 01 September 2005

High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis.

scientific article

Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones

scientific article published on 01 January 2003

Hydrogenotrophic microbiota distinguish native Africans from African and European Americans.

scientific article published on 12 March 2012

Impact of Malnutrition and Its Therapy on Liver Transplantation ⬇️

scientific article published on November 1, 1991

Impaired gastric acid and pancreatic enzyme secretion in patients with Crohn's disease may be a consequenece of a poor nutritional state

scientific article published on 01 September 2004

Improvement in specificity of [14C]d-xylose breath test for bacterial overgrowth

scientific article published on 01 August 1997

International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis

scientific article published on 15 May 2019

Interventional procedures

scientific article published on 01 November 2000

Intestinal and multivisceral transplantation: dynamics of nutritional management and functional autonomy

scientific article published in July 2003

Jejunal feeding in patients with pancreatitis

scientific article published on 04 April 2014

Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome

scientific article published on 4 February 2016

Malnutrition and immuno-incompetence in patients with liver disease ⬇️

scientific article published on September 20, 1980

Measurement of gastric and duodenal mucosal protein turnover in humans ⬇️

scientific article published on November 1, 1995

Microbial induction of immunity, inflammation, and cancer

scientific article published in 2011

Nutrition and quality of life following small intestinal transplantation

scientific article published on 22 March 2007

Nutritional Issues in the Short Bowel Syndrome - Total Parenteral Nutrition, Enteral Nutrition and the Role of Transplantation.

scientific article published on 20 October 2015

Nutritional immunomodulation of acute pancreatitis.

scientific article published on April 2007

Nutritional support in acute pancreatitis

scientific article published on 01 August 2004

Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity

scientific article

Physiological evaluation of the severity of pancreatic exocrine dysfunction during endoscopy

scientific article published on 01 July 2007

Products of the colonic microbiota mediate the effects of diet on colon cancer risk.

scientific article

Pyridazine based inhibitors of p38 MAPK.

scientific article published in February 2002

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome ⬇️

scientific article published on February 11, 2011

SAR of 3,4-Dihydropyrido[3,2-d]pyrimidone p38 inhibitors ⬇️

scientific article published on November 17, 2003

Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure

scientific article published on 17 January 2013

Severe acute pancreatitis: nutritional management in the ICU

scientific article published on 01 February 2004

Short bowel syndrome in adults: the need for an interdisciplinary approach and coordinated care.

scientific article published on 13 January 2014

Short bowel syndrome: clinical guidelines for nutrition management

scientific article

Small bowel transplantation

scientific article published on 01 October 2006

State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report

scientific article published in November 2017

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

scientific article

Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects

scientific article published on 17 October 2013

Su1999 Dietary Modulation of the Colonic Gene Expression in High Colon Cancer Risk African Americans

article

Switching to a fibre-rich and low-fat diet increases colonic folate contents among African Americans

scientific article published on 11 July 2018

Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors

scientific article published on 21 March 2010

Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.

scientific article

Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2 ⬇️

scientific article published on August 2, 2012

Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors

scientific article published on 6 November 2006

Targeted therapy of short-bowel syndrome with teduglutide: the new kid on the block

scientific article published on 10 December 2014

Teduglutide for the treatment of short bowel syndrome

scientific article published on 01 December 2011

Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

scientific article published on 11 September 2012

The Influence of Intravenous Infusions of Glucose and Amino Acids on Pancreatic Enzyme and Mucosal Protein Synthesis in Human Subjects ⬇️

scientific article published on 01 September 1998

The Need to Reassess Dietary Fiber Requirements in Healthy and Critically Ill Patients.

scientific article published in March 2018

The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning

scientific article published on 25 February 2010

The association between dietary fibre deficiency and high-income lifestyle-associated diseases: Burkitt's hypothesis revisited

scientific article published on 01 December 2019

The effect of fuel source on amino acid metabolism in critically III patients ⬇️

scientific article published on February 1, 1992

The effect of severe undernutrition and subsequent refeeding on whole-body metabolism and protein synthesis in human subjects.

scientific article published in July 2005

The microbiota and its metabolites in colonic mucosal health and cancer risk.

scientific article published on 06 August 2012

The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha

scientific article

The use of metabolomics in population-based research

scientific article

Therapeutic efficacy of intestinal and multivisceral transplantation: survival and nutrition outcome.

scientific article published on October 2007

Timing of enteral nutrition in acute pancreatitis: meta-analysis of individuals using a single-arm of randomised trials.

scientific article published on 23 July 2014

Total enteral nutrition or total parenteral nutrition for prophylaxis of infection in patients with severe acute pancreatitis?

scientific article published on 17 July 2007

Towards the determination of the nutritional needs of the body and its microbiome in sickness and in health.

scientific article published in March 2014

Trypsin secretion and turnover in patients with acute pancreatitis.

scientific article published on 10 February 2005

WEAK MICROBIAL METABOLITES: A TREASURE TROVE FOR USING BIOMIMICRY TO DISCOVER AND OPTIMIZE DRUGS

scientific article published on 06 August 2020

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

scientific article

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones

scientific article published on 05 June 2006

p38 MAP kinase inhibitors. Part 5: discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold

scientific article published on 01 September 2006

p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design

scientific article published on 30 August 2006

p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones

scientific article published on 18 October 2005

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

scientific article published in January 2003

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