List of works - Wolfgang Holzer

17O NMR and 15N NMR chemical shifts of sterically-hindered amides: ground-state destabilization in amide electrophilicity

scientific article published on 01 April 2019

2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents.

scientific article

A Robust, Eco-Friendly Access to Secondary Thioamides through the Addition of Organolithium Reagents to Isothiocyanates in Cyclopentyl Methyl Ether (CPME)

scientific article published on 20 November 2015

A convenient approach to heterocyclic building blocks: synthesis of novel ring systems containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one moiety.

scientific article

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

scientific article published in June 2017

A one-step microwave-assisted synthetic method for an O/S-chemoselective route to derivatives of the first adenosine A3 PET radiotracer

scientific article published on 02 April 2014

A study in desmotropy

scientific article published on 01 July 2008

Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides.

scientific article published in September 2013

An unusual thionyl chloride-promoted C−C bond formation to obtain 4,4'-bipyrazolones.

scientific article

Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii

scientific article published on 16 September 2013

Bromomethyllithium-mediated chemoselective homologation of disulfides to dithioacetals

scientific article published on 11 January 2016

Chemoselective CaO-mediated acylation of alcohols and amines in 2-methyltetrahydrofuran.

scientific article published on 26 March 2013

Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides.

scientific article published on February 2015

Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent

scientific article published on 01 February 2019

Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.

scientific article published on 08 March 2016

Corrigendum: Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization

scientific article published on 22 February 2017

Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations.

scientific article published in July 2009

Design, synthesis and pharmacological evaluation of novel β2/3 subunit-selective γ-Aminobutyric Acid Type A (GABAA) receptor modulators

scientific article published on 23 October 2018

Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.

scientific article

Dipyrazolo[1,5-a:4',3'-c]pyridines - a new heterocyclic system accessed via multicomponent reaction.

scientific article published on 27 December 2012

Efficient Access to All-Carbon Quaternary and Tertiary α-Functionalized Homoallyl-type Aldehydes from Ketones

scientific article

Eulophia macrobulbon - an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract.

scientific article published on 23 November 2016

Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles.

scientific article

Expeditious and Chemoselective Synthesis of α-Aryl and α-Alkyl Selenomethylketones via Homologation Chemistry

scientific article published on 17 April 2018

Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy

scientific article

First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.

scientific article published on 16 May 2006

Heterocyclic analogs of thioflavones: synthesis and NMR spectroscopic investigations.

scientific article published on 25 September 2009

Heterocyclic analogs of xanthiones: 5,6-fused 3-methyl-1-phenylpyrano[2,3-c]pyrazol-4(1H) thiones-synthesis and NMR ((1)H, (13)C, (15)N) data

scientific article

Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones and thiones: synthesis and NMR data.

scientific article

Highly efficient and chemoselective α-iodination of acrylate esters through Morita-Baylis-Hillman-type chemistry.

scientific article published in February 2013

Highly efficient synthesis of functionalized α-oxyketones via Weinreb amides homologation with α-oxygenated organolithiums

scientific article published on 25 May 2016

Homologation of halostannanes with carbenoids: a convenient and straightforward one-step access to α-functionalized organotin reagents

scientific article published on 01 September 2018

Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

scientific article

Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview

Inside Cover: Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview (Adv. Synth. Catal. 18/2014)

Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds

scientific article published on 02 January 2019

Molecular dimensions and structural features of neutral polysaccharides from the seed mucilage of Hyptis suaveolens L

scientific article published on 20 November 2016

Novel thiosemicarbazones derived from formyl- and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents

scientific article published on August 21, 1992

On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols.

scientific article published on 9 January 2018

On the tautomerism of pyrazolones: the geminal 2J[pyrazole C-4,H-3(5)] spin coupling constant as a diagnostic tool

Pyridazines, LXXII: On the Synthesis of Azinium and Diazinium Compounds Structurally Related to Pyridazomycin ⬇️

scientific article published on 01 April 1995

Spiro-fused (C2)-azirino-(C4)-pyrazolones, a new heterocyclic system. Synthesis, spectroscopic studies and X-ray structure analysis

scientific article published in October 2003

Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization.

scientific article

Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.

scientific article published in October 1998

Sustainable Asymmetric Organolithium Chemistry: Enantio‐ and Chemoselective Acylations through Recycling of Solvent, Sparteine, and Weinreb “Amine”

scientific article published on 13 February 2019

Syntheses and odor of "bulky group"-modified sandalwood odorants: isophorono-beta-santalol analogues

scientific article published on 27 April 2006

Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives

scientific article published on 11 November 2019

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

scientific article published on 16 March 2018

Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.

scientific article published on 30 March 2011

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.

scientific article published on 13 August 2013

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.

scientific article published on 7 May 2010

Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.

scientific article published on 23 January 2013

Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.

scientific article

Synthesis and complete 1H, 13C and 15N NMR assignment of substituted isoxazolo[3,4-d]pyridazin-7(6H)-ones

scientific article published on 01 March 2005

Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities--development of highly efficacious cytotoxic agents.

scientific article published on 12 August 2010

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter.

scientific article published on 20 January 2015

Synthesis of pyrazole-based hybrid molecules: search for potent multidrug resistance modulators

scientific article published on 22 March 2006

Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents

scientific article published on 12 May 2017

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction approach.

scientific article published on 31 July 2014

Synthesis of α,β-unsaturated α'-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides.

scientific article published on 16 July 2013

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

scientific article published on 16 May 2022

Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.

scientific article published on 24 January 2019

Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism

scientific article

α-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis

scientific article published on 03 April 2018

List of works by Wolfgang Holzer

17O NMR and 15N NMR chemical shifts of sterically-hindered amides: ground-state destabilization in amide electrophilicity

2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents.

A Robust, Eco-Friendly Access to Secondary Thioamides through the Addition of Organolithium Reagents to Isothiocyanates in Cyclopentyl Methyl Ether (CPME)

A convenient approach to heterocyclic building blocks: synthesis of novel ring systems containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one moiety.

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

A one-step microwave-assisted synthetic method for an O/S-chemoselective route to derivatives of the first adenosine A3 PET radiotracer

A study in desmotropy

Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides.

An unusual thionyl chloride-promoted C−C bond formation to obtain 4,4'-bipyrazolones.

Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii

Bromomethyllithium-mediated chemoselective homologation of disulfides to dithioacetals

Chemoselective CaO-mediated acylation of alcohols and amines in 2-methyltetrahydrofuran.

Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides.

Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent

Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.

Corrigendum: Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization

Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations.

Design, synthesis and pharmacological evaluation of novel β2/3 subunit-selective γ-Aminobutyric Acid Type A (GABAA) receptor modulators

Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.

Dipyrazolo[1,5-a:4',3'-c]pyridines - a new heterocyclic system accessed via multicomponent reaction.

Efficient Access to All-Carbon Quaternary and Tertiary α-Functionalized Homoallyl-type Aldehydes from Ketones

Eulophia macrobulbon - an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract.

Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles.

Expeditious and Chemoselective Synthesis of α-Aryl and α-Alkyl Selenomethylketones via Homologation Chemistry

Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy

First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.

Heterocyclic analogs of thioflavones: synthesis and NMR spectroscopic investigations.

Heterocyclic analogs of xanthiones: 5,6-fused 3-methyl-1-phenylpyrano[2,3-c]pyrazol-4(1H) thiones-synthesis and NMR ((1)H, (13)C, (15)N) data

Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones and thiones: synthesis and NMR data.

Highly efficient and chemoselective α-iodination of acrylate esters through Morita-Baylis-Hillman-type chemistry.

Highly efficient synthesis of functionalized α-oxyketones via Weinreb amides homologation with α-oxygenated organolithiums

Homologation of halostannanes with carbenoids: a convenient and straightforward one-step access to α-functionalized organotin reagents

Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview

Inside Cover: Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview (Adv. Synth. Catal. 18/2014)

Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds

Molecular dimensions and structural features of neutral polysaccharides from the seed mucilage of Hyptis suaveolens L

Novel thiosemicarbazones derived from formyl- and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents

On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols.

On the tautomerism of pyrazolones: the geminal 2J[pyrazole C-4,H-3(5)] spin coupling constant as a diagnostic tool

Pyridazines, LXXII: On the Synthesis of Azinium and Diazinium Compounds Structurally Related to Pyridazomycin ⬇️

Spiro-fused (C2)-azirino-(C4)-pyrazolones, a new heterocyclic system. Synthesis, spectroscopic studies and X-ray structure analysis

Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization.

Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.

Sustainable Asymmetric Organolithium Chemistry: Enantio‐ and Chemoselective Acylations through Recycling of Solvent, Sparteine, and Weinreb “Amine”

Syntheses and odor of "bulky group"-modified sandalwood odorants: isophorono-beta-santalol analogues

Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.

Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.

Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.

Synthesis and complete 1H, 13C and 15N NMR assignment of substituted isoxazolo[3,4-d]pyridazin-7(6H)-ones

Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities--development of highly efficacious cytotoxic agents.

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter.

Synthesis of pyrazole-based hybrid molecules: search for potent multidrug resistance modulators

Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction approach.

Synthesis of α,β-unsaturated α'-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides.

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.

Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism

α-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis