List of works - Jurgen Seppen

A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase

scientific article published on 20 September 2012

Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity.

scientific article published on 11 August 2016

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats

scientific article published on 3 April 2006

Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model

scientific article published on 9 April 2015

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

scientific article published on February 2008

Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors

scientific article published on August 2000

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo

scientific article

Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase

scientific article published on March 1996

Bilirubin, the Gold Within

scientific article published on 30 October 2012

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo

scientific article published on 10 May 2017

Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications

scientific article

Biological pacing by gene and cell therapy

scientific article published on January 2007

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

article

Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases

scientific article published on 17 January 2012

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

scientific article

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity

scientific article published on 4 August 2011

DLK1, a serum marker for hepatoblastoma in young infants

scientific article published on 16 December 2011

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase

scientific article published in December 1994

Domain-wide regulation of gene expression in the human genome

scientific article

Doxycycline Regulated Lentiviral Vectors

scientific article published on 01 January 2010

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes

scientific article

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer

scientific article

Gene therapy to create biological pacemakers

scientific article published on 18 October 2006

Human fetal liver cells for regulated ex vivo erythropoietin gene therapy

scientific article

Human liver endothelial cells, but not macrovascular or microvascular endothelial cells, engraft in the mouse liver

scientific article published on 3 October 2012

Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats

scientific article

Immunoaffinity Purification and Reconstitution of the Human Bilirubin/Phenol UDP-glucuronosyltransferase Family ⬇️

scientific article published on April 1, 1995

In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

scientific article published in January 2006

Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration

scientific article published on 01 April 1992

Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats

scientific article

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo

article

Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes

scientific article

Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand

scientific article published on 01 January 2000

Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo.

scientific article published on 10 May 2005

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

scientific article published on February 2004

Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes

scientific article

Lentivirus Vectors Encoding Both Central Polypurine Tract and Posttranscriptional Regulatory Element Provide Enhanced Transduction and Transgene Expression

scientific article published on 01 June 2001

Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin.

scientific article

Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer

scientific article

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

scientific article published on 07 January 2019

Lynch syndrome: the patients' perspective

scientific article published on June 2013

Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.

scientific article

Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes

scientific article

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

scientific article

Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide

scientific article published on 13 December 2012

Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64.

scientific article

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

scientific article

Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.

scientific article published on 31 January 2018

Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats

scientific article

Serum-Free Production, Concentration and Purification of Recombinant Retroviruses ⬇️

scientific article published on November 1, 1997

Small animal models of hepatocyte transplantation

scientific article published on January 2009

Specific gene delivery to liver sinusoidal and artery endothelial cells

scientific article published on 24 July 2013

Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery

scientific article published in December 2005

Synthetic gene regulation circuits for control of cell expansion

scientific article

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

scientific article published on 14 March 2012

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

scientific article published on 5 May 2016

The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux

scientific article published on 31 August 2007

Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation.

scientific article

Unedited inhibition of HBV replication by APOBEC3G.

scientific article published in December 2004

[Gluttony and penance--laxatives and 'liver stones']

scientific article published on 01 January 2010

List of works by Jurgen Seppen

A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase

Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity.

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats

Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo

Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase

Bilirubin, the Gold Within

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo

Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications

Biological pacing by gene and cell therapy

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity

DLK1, a serum marker for hepatoblastoma in young infants

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase

Domain-wide regulation of gene expression in the human genome

Doxycycline Regulated Lentiviral Vectors

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer

Gene therapy to create biological pacemakers

Human fetal liver cells for regulated ex vivo erythropoietin gene therapy

Human liver endothelial cells, but not macrovascular or microvascular endothelial cells, engraft in the mouse liver

Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats

Immunoaffinity Purification and Reconstitution of the Human Bilirubin/Phenol UDP-glucuronosyltransferase Family ⬇️

In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration

Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo

Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes

Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand

Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo.

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes

Lentivirus Vectors Encoding Both Central Polypurine Tract and Posttranscriptional Regulatory Element Provide Enhanced Transduction and Transgene Expression

Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin.

Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Lynch syndrome: the patients' perspective

Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.

Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide

Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64.

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.

Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats

Serum-Free Production, Concentration and Purification of Recombinant Retroviruses ⬇️

Small animal models of hepatocyte transplantation

Specific gene delivery to liver sinusoidal and artery endothelial cells

Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery

Synthetic gene regulation circuits for control of cell expansion

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux

Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation.

Unedited inhibition of HBV replication by APOBEC3G.

[Gluttony and penance--laxatives and 'liver stones']