List of works - Gerd Wallukat

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues

scientific article

A monoclonal antibody against the immunodominant epitope of the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta 1-adrenergic receptor

article

A vision of future treatment in chagas heart disease

scientific article published on 15 December 2013

AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase

scientific article published on 24 February 2003

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

scientific article

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

article published in 2004

Activating auto-antibodies against the AT1 receptor in preeclampsia

scientific article

Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats

scientific article

Activation of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis attenuates the cardiac reactivity to acute emotional stress ⬇️

scientific article published on July 19, 2013

Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy

scientific article published on 23 September 2013

Agonistic AT1 receptor autoantibodies and monocyte stimulation in hypertensive patients*1 ⬇️

scientific article published on October 1, 2003

Agonistic Angiotensin II Type 1 Receptor Autoantibodies in Postpartum Women With a History of Preeclampsia

article

Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy

scientific article

Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma

scientific article published on 12 February 2018

Agonistic antibodies directed at cell surface receptors and cardiovascular disease

Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia

scientific article

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

scientific article published on 29 April 2014

Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia

scientific article published in February 2003

Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia

scientific article published on 7 February 2005

Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats

scientific article

Amyloid-β peptides activate α1-adrenergic cardiovascular receptors

scientific article published on 3 September 2013

An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia

scientific article

Angiotensin II responsiveness after preeclampsia: translational data from an experimental rat model and early-onset human preeclampsia

scientific article published on 13 July 2017

Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats

scientific article published on 16 May 2011

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection

scientific article published in February 2005

Anti-&beta;-Adrenoceptors Autoimmunity Causing `Idiopathic' Arrhythmias and Cardiomyopathy ⬇️

scientific article published on March 22, 2012

Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors

scientific article

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies

scientific article

Aptamer binding and neutralization of β1-adrenoceptor autoantibodies: basics and a vision of its future in cardiomyopathy treatment

scientific article published on August 2011

Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathies ⬇️

scientific article published on August 25, 2011

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids

scientific article published on 23 August 2010

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? ⬇️

scientific article published on February 21, 2013

Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum

scientific article published on 22 May 2018

Autoantibodies Directed Against the Endothelin A Receptor in Patients With Benign Prostatic Hyperplasia

scientific article published on 24 November 2016

Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats

scientific article published on 13 October 2008

Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome ⬇️

scientific article published on August 3, 2011

Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats

scientific article

CD4(+) T Cells Play a Critical Role in Mediating Hypertension in Response to Placental Ischemia

scientific article

Cardiac Troponin T Measured With a Highly Sensitive Assay for Diagnosis and Monitoring of Heart Injury in Chronic Chagas Disease ⬇️

scientific article published on February 1, 2011

Cardiomyopathy - An approach to the autoimmune background

scientific article published on 2 February 2017

Cellular control of nitric oxide synthase expression and activity in rat cardiomyocytes

scientific article published in April 2004

Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability

scientific article

Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy

scientific article published in March 2004

Chemical Composition and Biological Activity of Paris quadrifolia L ⬇️

scientific article published on November 1, 2012

Chronic Chagas disease: from basics to laboratory medicine ⬇️

scientific article published on February 1, 2013

Chronic Chagas’ heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine ⬇️

scientific article published on January 1, 2012

Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease

scientific article published on 27 June 2013

Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange

scientific article published on 23 May 2015

Correction: Functional autoantibodies in patients with different forms of dementia

scientific article published in PLoS ONE

Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia

scientific article published on 15 November 2012

Detection of DCM-associated β1-adrenergic receptor autoantibodies requires functional readouts or native human β1-receptors as targets

scientific article published on 9 October 2015

Difference between beta1-adrenoceptor autoantibodies of human and animal origin-Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology

scientific article published on 9 February 2018

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients

scientific article published in February 2010

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patients

scientific article published on 01 August 2010

Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia

article by Florian Herse et al published March 2007 in Hypertension

Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy

scientific article published on 16 September 2013

Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide

scientific article

Functional autoantibodies in patients with different forms of dementia

scientific article published on 14 March 2018

High throughput bioassay for beta1-adrenoceptor autoantibody detection

scientific article published on 8 June 2016

Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation ⬇️

scientific article published on November 1, 2011

Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.

scientific article published on 24 August 2009

Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes

scientific article

IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia

scientific article published on 21 May 2015

IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy

scientific article

Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients

scientific article published on 8 July 2015

Immunoadsorption can improve cardiac function in transplant candidates with non-ischemic dilated cardiomyopathy associated with diabetes mellitus

scientific article published in May 2015

Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension ⬇️

scientific article published on January 1, 2013

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

scientific article published on 24 June 2013

Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?

scientific article published on 5 December 2006

Long‐term benefits of immunoadsorption in β1‐adrenoceptor autoantibody‐positive transplant candidates with dilated cardiomyopathy ⬇️

scientific article published on August 14, 2012

Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments

scientific article

New insights into beta2-adrenoceptor signaling in the adult rat heart

scientific article published in March 2003

Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation

scientific article

Pathophysiological role of autoantibodies against G-protein-coupled receptors in the cardiovascular system.

scientific article published on January 2005

Patients who have dilated cardiomyopathy must have a trial of bridge to recovery (pro).

scientific article published on July 2007

Peptide based adsorbers for therapeutic immunoadsorption

scientific article

Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy

scientific article published on 31 July 2017

Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension

scientific journal article

Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study.

scientific article

Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy

scientific article

Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy

scientific article

Reduced oxidative stress in parallel to improved cardiac performance one year after selective removal of anti-beta 1-adrenoreceptor autoantibodies in patients with idiopathic dilated cardiomyopathy: data of a preliminary study

scientific article

Reduced uterine perfusion pressure T-helper 17 cells cause pathophysiology associated with preeclampsia during pregnancy

scientific article published on 26 October 2016

Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia

scientific article published on 06 April 2015

Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption

scientific article

Renal ischemia and transplantation predispose to vascular constriction mediated by angiotensin II type 1 receptor-activating antibodies

scientific article

Role of β1-adrenoceptor autoantibodies in the pathogenesis of dilated cardiomyopathy ⬇️

scientific article published on July 18, 2011

Seeking the mechanism(s) of action for corticosteroids in HELLP syndrome: SMASH study ⬇️

scientific article published on February 1, 2013

Spontaneously beating neonatal rat heart myocyte culture-a model to characterize angiotensin II at(1) receptor autoantibodies in patients with preeclampsia

scientific article published in July 2002

The beta-adrenergic receptors

scientific article

The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy

scientific article

The patent situation concerning the treatment of diseases associated with autoantibodies directed against G-protein-coupled receptors

scientific article published on March 2013

Vascular hypothesis revisited: Role of stimulating antibodies against angiotensin and endothelin receptors in the pathogenesis of systemic sclerosis: Cabral-Marques O, Riemekasten G., Autoimmun Rev. 2016 Mar 10. pii: S1568-9972(16)30053-2. doi: 10.1

scientific article published on 11 April 2016

Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia

scientific article published on 16 December 2015

scFv single chain antibody variable fragment as inverse agonist of the beta2-adrenergic receptor

scientific article published on 14 July 2003

β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes

scientific article published on 11 August 2017

List of works by Gerd Wallukat

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues

A monoclonal antibody against the immunodominant epitope of the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta 1-adrenergic receptor

A vision of future treatment in chagas heart disease

AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

Activating auto-antibodies against the AT1 receptor in preeclampsia

Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats

Activation of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis attenuates the cardiac reactivity to acute emotional stress ⬇️

Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy

Agonistic AT1 receptor autoantibodies and monocyte stimulation in hypertensive patients*1 ⬇️

Agonistic Angiotensin II Type 1 Receptor Autoantibodies in Postpartum Women With a History of Preeclampsia

Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy

Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma

Agonistic antibodies directed at cell surface receptors and cardiovascular disease

Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia

Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia

Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats

Amyloid-β peptides activate α1-adrenergic cardiovascular receptors

An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia

Angiotensin II responsiveness after preeclampsia: translational data from an experimental rat model and early-onset human preeclampsia

Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection

Anti-&amp;beta;-Adrenoceptors Autoimmunity Causing `Idiopathic' Arrhythmias and Cardiomyopathy ⬇️

Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies

Aptamer binding and neutralization of β1-adrenoceptor autoantibodies: basics and a vision of its future in cardiomyopathy treatment

Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathies ⬇️

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? ⬇️

Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum

Autoantibodies Directed Against the Endothelin A Receptor in Patients With Benign Prostatic Hyperplasia

Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats

Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome ⬇️

Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats

CD4(+) T Cells Play a Critical Role in Mediating Hypertension in Response to Placental Ischemia

Cardiac Troponin T Measured With a Highly Sensitive Assay for Diagnosis and Monitoring of Heart Injury in Chronic Chagas Disease ⬇️

Cardiomyopathy - An approach to the autoimmune background

Cellular control of nitric oxide synthase expression and activity in rat cardiomyocytes

Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability

Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy

Chemical Composition and Biological Activity of Paris quadrifolia L ⬇️

Chronic Chagas disease: from basics to laboratory medicine ⬇️

Chronic Chagas’ heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine ⬇️

Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease

Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange

Correction: Functional autoantibodies in patients with different forms of dementia

Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia

Detection of DCM-associated β1-adrenergic receptor autoantibodies requires functional readouts or native human β1-receptors as targets

Difference between beta1-adrenoceptor autoantibodies of human and animal origin-Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patients

Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia

Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy

Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide

Functional autoantibodies in patients with different forms of dementia

High throughput bioassay for beta1-adrenoceptor autoantibody detection

Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation ⬇️

Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.

Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes

IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia

IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy

Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients

Immunoadsorption can improve cardiac function in transplant candidates with non-ischemic dilated cardiomyopathy associated with diabetes mellitus

Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension ⬇️

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?

Long‐term benefits of immunoadsorption in β1‐adrenoceptor autoantibody‐positive transplant candidates with dilated cardiomyopathy ⬇️

Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments

New insights into beta2-adrenoceptor signaling in the adult rat heart

Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation

Pathophysiological role of autoantibodies against G-protein-coupled receptors in the cardiovascular system.

Patients who have dilated cardiomyopathy must have a trial of bridge to recovery (pro).

Peptide based adsorbers for therapeutic immunoadsorption

Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy

Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension

Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study.

Anti-β-Adrenoceptors Autoimmunity Causing `Idiopathic' Arrhythmias and Cardiomyopathy ⬇️