List of works by Hans-Ulrich Häring

11beta-hydroxysteroid dehydrogenase 2 activity is elevated in severe obesity and negatively associated with insulin sensitivity

scientific article published on 10 April 2008

17alpha-hydroxylase/17,20-lyase deficiency caused by a novel homozygous mutation (Y27Stop) in the cytochrome CYP17 gene

scientific article published on 5 April 2005

35th Annual Meeting of the European Association for the Study of Diabetes

article

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

5 Jahre erfolgreiche translationale Forschung – Deutsches Zentrum für Diabetesforschung

A 60 minute hyperglycemic clamp is sufficient to assess both phases of insulin secretion

scientific article published in June 2000

A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes

scientific article

A 973 valine to methionine mutation of the human insulin receptor: interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells

scientific article

A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice.

scientific article published on 28 April 2018

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

scientific article published on 26 November 2007

A case of acute and intense thoracic pain during a dental treatment

scientific article published on 23 February 2010

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

scientific article

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.

scientific article published on 15 March 2018

A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus

scientific article published on 01 June 1989

A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes

scientific article published on 24 September 2015

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance

scientific article

A novel MR-imaging technique using arterial spin labeling for thyroid gland perfusion in thyrotoxicosis

scientific article published on 01 November 2007

A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6alpha gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids

scientific article (publication date: April 2005)

A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.

scientific article published in May 2000

A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation.

scientific article

A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis

scientific article published in February 2001

A polygenic risk score of lipolysis-increasing alleles determines visceral fat mass and proinsulin conversion

scientific article published on 01 April 2019

A rare cause of hypoglycaemia in a patient with type 2 diabetes

scientific article published on 23 February 2009

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

scientific article published on 09 January 2019

AHSG gene variation is not associated with regional body fat distribution--a magnetic resonance study

scientific article published on 8 April 2009

ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy

scientific article published on 21 January 2017

AMPK Subunits Harbor Largely Nonoverlapping Genetic Determinants for Body Fat Mass, Glucose Metabolism, and Cholesterol Metabolism

scientific article published on 01 January 2020

AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells.

scientific article

Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line

scientific article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Acquired arteriovenous fistula of a finger

scientific article published on 15 March 2019

Acromegaly and end-stage renal disease: a diagnostic challenge.

scientific article published in September 2006

Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion

scientific article

Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types ⬇️

scientific article published on January 15, 1991

Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise

scientific article published on 2 March 2010

Acute adrenocortical insufficiency due to heparin-induced thrombocytopenia with subsequent bilateral haemorrhagic infarction of the adrenal glands

scientific article

Acute effect of glimepiride on insulin-stimulated glucose metabolism in glucose-tolerant insulin-resistant offspring of patients with type 2 diabetes

scientific article published in November 2002

Acute effect of rheopheresis on peripheral endothelial dysfunction in patients suffering from sudden hearing loss

scientific article

Acute effects of hemodialysis on cytokine transcription profiles: evidence for C-reactive protein-dependency of mediator induction

scientific article published on 25 October 2006

Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs

scientific article published in March 2003

Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle

scientific article published on 01 June 1995

Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise

scientific article

Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting

scientific article published in January 2001

Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects

scientific article published on 23 November 2010

Adipocytokines: fat-derived humoral mediators of metabolic homeostasis

scientific article

Adiponectin in youth: response to Bacha et al.

scientific article published in June 2004

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis

scientific article published on 4 October 2005

Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans

scientific article published on 30 October 2008

Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones

scientific article published in July 2005

Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood

scientific article published on 19 October 2020

Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension

scientific article published in January 2005

Advances in reverse transcription polymerase chain reaction analysis of cellular mRNA levels of transforming growth factor-beta1 by capillary electrophoresis with laser-induced fluorescence detection

scientific article

Advantages in the analysis of UDP-sugars by capillary electrophoresis-comparison of the conventional HPLC method with two new capillary electrophoretic micro-procedures

scientific article

Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study.

scientific article published on 6 July 2005

Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans.

scientific article published on 9 July 2013

Alkaline liquid chromatography/electrospray ionization skimmer collision-induced dissociation mass spectrometry for phosphopeptide screening

scientific article published in January 2001

Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals

scientific article

Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.

scientific article

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients ⬇️

scientific article published on June 1, 1991

Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function

scientific article published in February 2003

Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects

scientific article published on July 1993

Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

scientific article published in January 1999

An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial

scientific article published on 29 December 2018

An Accurate Risk Score Based on Anthropometric, Dietary, and Lifestyle Factors to Predict the Development of Type 2 Diabetes: Response to Schwarz et al

article

An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta

scientific article published on May 1987

An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans

scientific article

An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes

scientific article published in March 2007

An altered IGF-I receptor is present in human leukemic cells ⬇️

scientific article published on June 5, 1990

An extended fatty liver index to predict non-alcoholic fatty liver disease

scientific article published on 12 January 2017

Analysis of traditional Chinese anticancer drugs by capillary electrophoresis

scientific article published on 01 February 1998

Androgen receptor overexpression in prostate cancer in type 2 diabetes

scientific article published on 5 December 2017

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.

scientific article published on 8 July 2017

Angiotensin I-converting enzyme gene polymorphism, coronary artery disease and myocardial infarction. An angiographically controlled study

scientific article published on 01 September 1999

Angiotensin II induces human TGF-beta 1 promoter activation: similarity to hyperglycaemia

scientific article

Antihyperglycaemic therapies and cancer risk

scientific article published on 17 September 2014

Apelin Serum Levels are not Associated with Early Atherosclerosis or Fat Distribution in Young Subjects with Increased Risk for Type 2 Diabetes

scientific article published on 24 January 2011

Apoptosis induced by free fatty acids

scientific article

Application of capillary electrophoresis in clinical chemistry: the clinical value of urinary modified nucleosides

scientific article published on 01 August 2000

Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome

scientific article

Assessing the shape of the glucose curve during an oral glucose tolerance test

scientific article published in April 2003

Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes

scientific article published on 01 September 2000

Association between angiotensin I-converting enzyme genotypes, extracranial artery stenosis, and stroke

scientific article published in September 1998

Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study

article

Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes

scientific article published in February 2009

Association of Fetuin-A Level and Diabetes Risk

scientific article published in The Journal of the American Medical Association

Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy People ⬇️

scientific article published on November 18, 2003

Association of Lower Plasma Fetuin-A Levels With Peripheral Arterial Disease in Type 2 Diabetes: Response to Eraso et al

scientific article published on 29 March 2010

Association of Plasminuria with Overhydration in Patients with CKD

scientific article published on March 2016

Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans

scientific article

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

scientific article published on 13 January 2009

Association of impaired phosphatidylinositol 3-kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Wern

scientific article published on February 2000

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

scientific article

Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion

scientific article

Association of somatostatin receptor 2 immunohistochemical expression with [111In]-DTPA octreotide scintigraphy and [68Ga]-DOTATOC PET/CT in neuroendocrine tumors

scientific article published on 26 April 2010

Association of the -514C-->T polymorphism in the hepatic lipase gene (LIPC) promoter with elevated fasting insulin concentrations, but not insulin resistance, in non-diabetic Germans

scientific article

Association of the ACE gene I/D polymorphism with insulin sensitivity depends on the presence of additional macroangiopathic risk factors

scientific article published in January 2002

Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels

scientific article published on 23 October 2008

Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes

scientific article published in January 2002

Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.

scientific article

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion

scientific article published on 14 April 2009

At last, a weight neutral insulin?

scientific article published on 01 September 2004

Autoimmune thyroid disease: arterial spin-labeling perfusion MR imaging

scientific article published on 29 September 2009

Automated label-free quantification of metabolites from liquid chromatography-mass spectrometry data

scientific article

Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes

scientific article published in May 2001

BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells

scientific article published on 28 October 2010

BMI-Independent Effects of Gestational Diabetes on Human Placenta

scientific article published on 01 September 2018

Beta cell function, insulin resistance and plasma adiponectin concentrations are predictors for the change of postprandial glucose in non-diabetic subjects at risk for type 2 diabetes

scientific article published on March 2006

Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockers

scientific article

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

scientific article published on 06 January 2017

Body adiposity index, body fat content and incidence of type 2 diabetes

article by Matthias B Schulze et al published 17 February 2012 in Diabetologia

Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta

scientific article

Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor

scientific article

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

scientific article

Brain insulin sensitivity is linked to adiposity and body fat distribution

scientific article published on 15 April 2020

C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity

scientific article published on February 1995

C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity

scientific article published in April 2004

Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele

scientific article published in February 2002

Cardiorespiratory Fitness, Adiposity, and Mortality

scientific article published in The Journal of the American Medical Association

Cardiorespiratory fitness determines the reduction in blood pressure and insulin resistance during lifestyle intervention

scientific article published in June 2011

Carotid Intima-Media Thickness is a Predictor of Subclinical Myocardial Damage in Men with Type 2 Diabetes Mellitus

scientific article published on 04 March 2020

Catecholamine-induced insulin resistance of glucose transport in isolated rat adipocytes

scientific article published on December 1983

Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes.

scientific article published in February 1987

Causes and metabolic consequences of Fatty liver

scientific article published on 21 August 2008

Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans

scientific article published in August 2017

Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men.

scientific article published on 15 July 2014

Central nervous pathways of insulin action in the control of metabolism and food intake

scientific article published on 01 June 2020

Cerebrocortical beta activity in overweight humans responds to insulin detemir

scientific article

Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

scientific article

Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.

scientific article published in July 2000

Characterization of Hormone-Dependent Pathways in Six Human Prostate-Cancer Cell Lines: A Gene-Expression Study

scientific article published on 07 October 2020

Chemistry and pathobiology of advanced glycation end products.

scientific article

Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans

scientific article published on 29 November 2011

Chronic d-serine supplementation impairs insulin secretion

scientific article published on 25 July 2018

Ciglitazone reverses cAMP-induced post-insulin receptor resistance in rat adipocytes in vitro ⬇️

scientific article published on October 15, 1984

Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity

scientific article

Circulating FGF21 Levels in Human Health and Metabolic Disease

scientific article published on 20 May 2019

Circulating Retinol-Binding Protein-4, Insulin Sensitivity, Insulin Secretion, and Insulin Disposition Index in Obese and Nonobese Subjects: Response to Broch et al

scientific article published on 27 July 2007

Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity

scientific article published on 01 December 1996

Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

scientific article published in April 2013

Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver

scientific article published on 20 March 2013

Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans

scientific article

Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.

scientific article

Clinical characterization of insulin secretion as the basis for genetic analyses

scientific article

Clinical findings in Niemann-Pick disease type B

scientific article published on 01 February 2006

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

scientific article

Comment on Hedderson et al. Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus. Diabetes Care 2014;37:1296–1303

scientific article published on 20 November 2014

Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels

scientific article

Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity

scientific article

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity

scientific article

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects

scientific article published on 14 August 2009

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations

scientific article

Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study

scientific article published in February 2010

Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes

scientific article published on 7 December 2014

Comparison of the automated KRYPTOR chromogranin A assay with the DAKO ELISA

scientific article published on 01 January 2014

Comparison of the diagnostic performance of three natriuretic peptides in hemodialysis patients: which is the appropriate biomarker?.

scientific article published on 30 October 2012

Comparison of the mitogenic potency of regular human insulin and its analogue glargine in normal and transformed human breast epithelial cells

scientific article published on 01 January 2007

Considering Insulin Secretory Capacity as Measured by a Fasting C-Peptide/Glucose Ratio in Selecting Glucose-Lowering Medications

scientific article published on 18 September 2020

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

scientific article

Correlates of venous catecholamine concentrations in patients with type 1 diabetes during a cold pressor test

scientific article published on 01 June 2000

Correlation of imaging techniques to histopathology in patients with diabetic foot syndrome and clinical suspicion of chronic osteomyelitis. The role of high-resolution ultrasound

scientific article published on 01 February 1999

Coupling of insulin binding and insulin action on glucose transport in fat cells ⬇️

scientific article published on May 1, 1981

Cyclic AMP modulates insulin binding and induces post-receptor insulin resistance of glucose transport in isolated rat adipocytes ⬇️

scientific article published on August 30, 1983

Cytokine response of primary human myotubes in an in vitro exercise model

scientific article published on 7 August 2013

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity

scientific article published on 27 July 2017

Decreased insulin sensitivity due to a postreceptor defect as a consequence of ATP-deficiency in fat cells

scientific article published on 01 September 1981

Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro

scientific article published on February 1986

Detection of free fatty acid receptor 1 expression: the critical role of negative and positive controls

scientific article published on 26 January 2014

Deteriorated executive functions in patients with successful surgery for pituitary adenomas compared with other chronically ill patients

scientific article published on 21 December 2010

Determining significant fold differences in gene expression analysis

scientific article published on 01 January 2001

Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.

scientific article published on 21 November 2006

Diabetes Mellitus and Prediabetes on Kidney Transplant Waiting List- Prevalence, Metabolic Phenotyping and Risk Stratification Approach

scientific article published on 23 September 2015

Diabetes und Krebsrisiko

scientific article published on 27 April 2012

Diabetes, insulin, insulin analogues, and cancer

scientific article published on 27 April 2010

Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB

scientific article (publication date: December 2001)

Diagnostic Accuracy of a Novel Chromogenic Direct Thrombin Inhibitor Assay: Clinical Experiences for Dabigatran Monitoring

scientific article published on 6 December 2017

Diagnostic value of hemoglobin A1c for type 2 diabetes mellitus in a population at risk

scientific article published on 24 January 2011

Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention

scientific article published in Scientific Reports

Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention

scientific article published on March 2012

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis

scientific article published in December 2002

Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults

scientific article

Differential effects of intranasal insulin and caffeine on cerebral blood flow

scientific article published on 9 March 2011

Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells

scientific article published on 01 November 2005

Dipyrone (metamizole) metabolites interfere with HPLC analysis of plasma catecholamines but not with the determination of urinary catecholamines

scientific article published on 01 September 2006

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

scientific article published on 17 January 2006

Disseminated epitheloid hemangioendothelioma mimicking symptoms of systemic vasculitis.

scientific article published on 29 August 2005

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

scientific article published on 03 August 2009

Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase

scientific article published on 16 October 2010

Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation

scholarly article by Andras Franko et al published 17 September 2018 in Nutrients

Dissociation of GLP-1 and insulin association with food processing in the brain: GLP-1 sensitivity despite insulin resistance in obese humans

scientific article published on 30 September 2015

Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

scientific article published on May 19, 1992

Divergent associations of height with cardiometabolic disease and cancer: epidemiology, pathophysiology, and global implications

scientific article published on 27 January 2016

Dose-Dependent Effects of Intranasal Insulin on Resting-State Brain Activity

scientific article published on 31 October 2017

Dynamics of Glucose Metabolism After Kidney Transplantation

scientific article published on 20 September 2017

Early carotid atherosclerosis in overweight non-diabetic individuals is associated with subclinical chronic inflammation independent of underlying insulin resistance

scientific article published in May 2005

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice

scientific article published on 28 April 2016

Ectopic fat accumulation in human astrocytes impairs insulin action

scientific article published on 16 September 2020

Effect of SGLT2 inhibitors on body composition, fluid status and renin-angiotensin-aldosterone system in type 2 diabetes: a prospective study using bioimpedance spectroscopy

article

Effect of colchicine and vinblastine on the coupling of insulin binding and insulin action in fat cells ⬇️

scientific article published on September 15, 1979

Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene

scientific article

Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes

scientific article published on 13 December 2006

Effect of glimepiride on insulin-stimulated glycogen synthesis in cultured human skeletal muscle cells: a comparison to glibenclamide

scientific article published on December 2002

Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects

scientific article published on 01 September 1998

Effect of insulin detemir, compared to human insulin, on 3T3-L1 adipogenesis

scientific article

Effect of partially purified NSILA on adenylate cyclase, phosphodiesterase and 3',5'-cyclic AMP in fat cells ⬇️

scientific article published on October 1, 1975

Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans

scientific article

Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial

scientific article published on 14 March 2011

Effects of a lifestyle intervention in metabolically benign and malign obesity

scientific article published on 21 December 2010

Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans

scientific article published on 9 January 2015

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

scientific article

Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes

scientific article published in September 2008

Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes

scientific article

Effects of new insulin analogues HMR1964 (insulin glulisine) and HMR1423 on insulin receptors

scientific article

Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial.

scientific article

Effects of stress reduction on cardiovascular risk factors in type 2 diabetes patients with early kidney disease - results of a randomized controlled trial (HEIDIS).

scientific article published on 05 May 2014

Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells

scientific article

Elevated circulating Glutamate associates with subclinical Atherosclerosis independently of established Risk Markers: a cross-sectional study

scientific article published on 05 December 2020

Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease

scientific article published on 4 August 2017

Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids

scientific article published in April 2005

Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial

scientific article published on 10 April 2014

Empagliflozin as add-on to metformin in people with Type 2 diabetes

scientific article published on 14 July 2015

Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial

scientific article published on 20 August 2013

Endothelial NO-synthase intron 4 polymorphism is associated with disturbed in vivo nitric oxide production in individuals prone to type 2 diabetes

scientific article

Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance

scientific article published on 01 April 2000

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

scientific article published on April 2010

Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1

scientific article published on 15 April 2009

Environmental and genetic determinants of fatty liver in humans

scientific article published on 07 May 2010

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

scientific article

Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling

scientific article published on 27 August 2009

Erratum to: A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation

scientific article published on 22 May 2017

Erythropoietin-mediated decrease of the redox-sensitive transcription factor NF-kappaB is inversely correlated with the hemoglobin level

scientific article published on 01 September 2002

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function

scientific article (publication date: 2 December 2010)

Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 diabetic patients

scientific article published in May 1998

Evidence That Two Naturally Occurring Human Insulin Receptor α-Subunit Variants Are Immunologically Distinct ⬇️

scientific article published on January 1, 1992

Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction

scientific article

Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters

scientific article published in February 2003

Evidence for altered transport of insulin across the blood-brain barrier in insulin-resistant humans

scientific article published on 27 December 2013

Evidence for greater oxidative substrate flexibility in male carriers of the Pro 12 Ala polymorphism in PPARgamma2.

scientific article published in March 2002

Evidence for inhibition of leptin secretion by catecholamines in man

scientific article published on 01 January 1998

Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies.

scientific article

Exercise and diabetes: relevance and causes for response variability

scientific article

Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes

scientific article published on 24 April 2012

Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism

scientific article

Extracellular domain splice variants of a transforming protein tyrosine phosphatase alpha mutant differentially activate Src-kinase dependent focus formation

scientific article published on January 2007

Extracorporeal light chain elimination: high cut-off (HCO) hemodialysis parallel to chemotherapy allows for a high proportion of renal recovery in multiple myeloma patients with dialysis-dependent acute kidney injury

scientific article published on 15 December 2011

Extrapancreatic action of the sulphonylurea gliquidone: post-receptor effect on insulin-stimulated glycogen synthesis in rat hepatocytes in primary culture

scientific article published on June 1984

FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

scientific article published on 05 October 2020

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention

scientific article published on 4 June 2016

Family History of Diabetes Is Associated With Delayed Fetal Postprandial Brain Activity

Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research

scientific article published on 24 August 2013

Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS study

scientific article

Fat intake modulates cerebral blood flow in homeostatic and gustatory brain areas in humans

scientific article published on 9 May 2012

Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro

scientific article

Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractions

scientific article published on 13 November 2007

Fetuin-A induces cytokine expression and suppresses adiponectin production

scientific article

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells.

scientific article published on 4 February 2014

Fibroblast Growth Factor 21-Metabolic Role in Mice and Men.

scientific article published on 28 July 2017

Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes

scientific article published on May 2015

Flow associated (endothelium dependent) vasodilation and TSH-levels in young normotensive and normoglycemic subjects

scientific article published in May 2001

Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes

scientific article published on 16 August 2010

For debate: Starling's curve of the pancreas--overuse of a concept?

scientific article published in July 2003

Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume - a combined 1 H MRS and volumetric MRI study in male subjects

scientific article

Functional network connectivity underlying food processing: disturbed salience and visual processing in overweight and obese adults

scientific article published on 14 May 2012

Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans

scientific article published in September 2001

Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity

scientific article published on August 1989

Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas

scientific article published on 24 September 2009

Gen-Umwelt-Interaktion in Pathogenese und Prävention des Diabetes mellitus Typ 2

scientific article published on 31 May 2007

Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes

scientific article

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion

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Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene

scientific article published on 5 August 2016

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene

scientific article published on 6 August 2016

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual

scientific article published on 07 August 2019

Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity

scientific article published on 7 October 2016

Genetic Variations inPPARDandPPARGC1ADetermine Mitochondrial Function and Change in Aerobic Physical Fitness and Insulin Sensitivity during Lifestyle Intervention

scientific article published in May 2007

Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia

scientific article published on 4 April 2011

Genetic determinants of insulin action in polycystic ovary syndrome

scientific article published in May 2005

Genetic determination of body fat distribution and the attributive influence on metabolism

scientific article published on 25 May 2017

Genetic factors and insulin secretion: gene variants in the IGF genes

scientific article published in February 2004

Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians

scientific article

Genetic variants affecting incretin sensitivity and incretin secretion

scientific article published on 17 August 2010

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

scientific article published on February 2013

Genetic variants in MTNR1B affecting insulin secretion

scientific article published on September 2010

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans

scientific article published on 2 May 2013

Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits

scientific article published on 10 November 2018

Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus

scientific article published in May 2008

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population

scientific article published in August 2007

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes

scientific article published on 2 November 2010

Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.

scientific article published on 12 April 2011

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

scientific article published on 14 July 2016

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

scientific article published on 23 October 2018

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors

scientific article published on 30 January 2018

Gestational Diabetes Impairs Human Fetal Postprandial Brain Activity.

scientific article published on 14 October 2015

Gestational diabetes alters the fetal heart rate variability during an oral glucose tolerance test: a fetal magnetocardiography study.

scientific article published on 28 December 2016

Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial

scientific article

Glimepiride reduces mononuclear activation of the redox-sensitive transcription factor nuclear factor-kappa B.

scientific article

Glitazones: clinical effects and molecular mechanisms

scientific article

Global trends in body-mass index

scientific article published in June 2011

Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men

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Glucosamine induces translocation of protein kinase C isoenzymes in mesangial cells

scientific article published on 01 January 1998

Glucose Measurements at Various Time Points During the OGTT and Their Role in Capturing Glucose Response Patterns

scientific article published on 28 January 2019

Glucose Responsiveness of β-Cells Depends on Fatty Acids

scientific article published on 15 April 2019

Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

scientific article published on 12 December 2019

Glucose oversupply increases Delta9-desaturase expression and its metabolites in rat skeletal muscle

scientific article published on 31 January 2003

Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity

scientific article published on 19 September 2018

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

scientific article published on 14 January 2011

Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets

scientific article published on 16 July 2019

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content

scientific article published on 4 January 2016

Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase

scientific article published on February 1994

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin

scientific article

Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells

scientific article (publication date: June 2003)

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion ⬇️

scientific article published on 29 August 2010

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans

scientific article published on 13 February 2016

Hashimoto's encephalopathy presenting with bipolar affective disorder

scientific article published in June 2005

Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.

scientific article published on 13 April 2011

Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat-selective MRI and volume-localized1H-MR spectroscopy

scientific article published in 2006

Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios

scientific article published on 22 October 2009

High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

scientific article published in December 2012

High Visceral Fat Mass and High Liver Fat Are Associated with Resistance to Lifestyle Intervention*

scientific article published in February 2007

High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention

scientific article published in September 2009

High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease

scientific article

High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention.

scientific article published on 17 September 2011

High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.

scientific article published on 26 January 2007

High cut-off renal replacement therapy for removal of myoglobin in severe rhabdomyolysis and acute kidney injury: a case series

scientific article published on 01 January 2012

High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population

scientific article published in December 2009

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes

scientific article published on 12 January 2018

Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair

scientific article published on 9 August 2017

Hormonal control of cyclic AMP turnover in isolated fat cells ⬇️

scientific article published on August 1, 1976

How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease

scientific article published on January 2008

Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA).

scientific article

Human Prostate Cancer is Characterized by an Increase in Urea Cycle Metabolites

scientific article published on 06 July 2020

Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo

scientific article published in October 2002

Hypomagnesemia and nephrocalcinosis in a patient with two heterozygous mutations in the CLDN16 gene

scientific article published on 01 January 2007

Hypothalamic and Striatal Insulin Action Suppresses Endogenous Glucose Production and May Stimulate Glucose Uptake During Hyperinsulinemia in Lean but Not in Overweight Men.

scientific article published on 7 February 2017

Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans

scientific article published on 24 March 2017

Hypothyroidism due to pseudo-malabsorption of levothyroxine--Case 12/2009

scientific article published on 25 November 2009

IGF-1 protects against dexamethasone-induced cell death in insulin secreting INS-1 cells independent of AKT/PKB phosphorylation

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IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise

scientific article published on 22 April 2010

Identification and characterization of metabolically benign obesity in humans

scientific article

Identification and regulation of xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans

scientific article published on 26 February 2020

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

scientific article

Identification of an in vitro insulin receptor substrate-1 phosphorylation site by negative-ion muLC/ES-API-CID-MS hybrid scan technique

scientific article

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

scientific article published on 18 January 2018

Identification of plasticizers in medical products by a combined direct thermodesorption--cooled injection system and gas chromatography--mass spectrometry

scientific article published on 01 June 1999

Identification of proliferative and mature β-cells in the islets of Langerhans.

scientific article published on 11 July 2016

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

scientific article published on 4 October 2012

Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells

scientific article published on 03 August 2019

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

scientific article

Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice

scholarly article by Susanne Neschen et al published 5 November 2018 in Experimental and Clinical Endocrinology and Diabetes

Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans

scientific article

Impact of different fat depots on insulin sensitivity: predominant role of liver fat.

scientific article published on September 2007

Impact of end-stage renal disease on glucose metabolism-a matched cohort analysis

scientific article published in April 2017

Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: a targeted proteomics approach.

scientific article published on 5 August 2016

Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin receptor

scientific article published on October 1997

Impact of phosphorus restriction and vitamin D-substitution on secondary hyperparathyroidism in a proteinuric mouse model

scientific article published on 29 March 2015

Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies

scientific article

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

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Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss

scientific article published on 29 May 2008

Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

scientific article published on 30 July 2009

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

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Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

scientific article published on 8 January 2009

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

scientific article

Impaired insulin action in the human brain: causes and metabolic consequences

scientific article published on 13 October 2015

Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjects

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Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia

scientific article published on October 2012

In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo

scientific article published on 25 May 2011

In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes

scientific article

InDuo, a novel combined insulin injection and blood glucose monitoring device - effective and save as other devices, and patient preference.

scientific article published in October 2005

Incidence of Hypoglycaemia in Patients with Type 2 Diabetes - A Subgroup Analysis from the GINGER study

scientific article published on 01 March 2013

Increase in serum leptin concentrations in women undergoing controlled ovarian hyperstimulation for assisted reproduction

scientific article

Increased Expressions of Matrix Metalloproteinases (MMPs) in Prostate Cancer Tissues of Men with Type 2 Diabetes

scientific article published on 16 November 2020

Increased Hepatic ACE2 Expression in NAFL and Diabetes-A Risk for COVID-19 Patients?

scientific article published on 04 August 2020

Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans.

scientific article published on 24 February 2018

Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha.

scientific article published in January 2006

Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala

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Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals

scientific article published on 24 July 2020

Increased occurrence of weaknesses in attention testing in patients with Hashimoto's thyroiditis compared to patients with other thyroid illnesses

scientific article published on 25 September 2008

Increased prevalence of antibodies to central nervous system tissue and gangliosides in Hashimoto's thyroiditis compared to other thyroid illnesses

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Independent component analysis in non-hypothesis driven metabolomics: improvement of pattern discovery and simplification of biological data interpretation demonstrated with plasma samples of exercising humans

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Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo

scientific article published on 28 May 2009

Individualisierte Prävention des Typ-2-Diabetes

scientific article published in July 2009

Induction of adiponectin gene expression in human myotubes by an adiponectin-containing HEK293 cell culture supernatant.

scientific article

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

scientific article published on 3 June 2008

Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids

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Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes

scientific article published on 27 January 2017

Inhibition of 11β-HSD1 with RO5093151 for non-alcoholic fatty liver disease: a multicentre, randomised, double-blind, placebo-controlled trial

scientific article published on 17 February 2014

Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1.

scientific article published on October 2001

Initial lag-phase in the action of insulin on glucose transport and cAMP levels in fat cells ⬇️

scientific article published on November 1, 1978

Inositol phospho-oligosaccharides from rat fibroblasts and adipocytes stimulate 3-O-methylglucose transport

scientific article published on November 1993

Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene is associated with coronary artery plaque calcification as assessed by intravascular ultrasound

scientific article published on 01 April 1998

Insulin Resistance and Congestive Heart Failure

scientific article published in The Journal of the American Medical Association

Insulin Resistant Phenotype of Polycystic Ovary Syndrome does not Seem to be Caused by Variation in FTO

scientific article published on 30 July 2012

Insulin Sensitivity and Liver Fat: Role of Iron Load

scientific article published in June 2011

Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus. Influence of body weight

scientific article published on January 1999

Insulin action in the hypothalamus increases second phase insulin secretion in humans

scientific article published on 05 November 2019

Insulin activates GTP binding to a 40 kDa protein in fat cells ⬇️

scientific article published on May 15, 1991

Insulin analogues: impact of cell model characteristics on results and conclusions regarding mitogenic properties

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Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells

scientific article published on 3 August 2005

Insulin binding and action in antibody-induced diabetes in the rat.

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Insulin binding and insulin action in rat fat cells after adrenalectomy

scientific article published on 01 October 1980

Insulin detemir causes increased symptom awareness during hypoglycaemia compared to human insulin

scientific article published on 23 July 2009

Insulin effects on beta and theta activity in the human brain are differentially affected by ageing.

scientific article published on 19 November 2008

Insulin glulisine: insulin receptor signaling characteristics in vivo

scientific article published on 01 February 2005

Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance

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Insulin leads to a parallel translocation of PI-3-kinase and protein kinase C zeta

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Insulin modulates food-related activity in the central nervous system

scientific article published on 8 December 2009

Insulin promotes glycogen storage and cell proliferation in primary human astrocytes

scientific article

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells

scientific article

Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer

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Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes ⬇️

scientific article published on April 1, 1993

Insulin receptor kinase defects as a possible cause of cellular insulin resistance

scientific article published in July 1987

Insulin receptor kinase defects in insulin-resistant tissues and their role in the pathogenesis of NIDDM.

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Insulin receptor kinase in human skeletal muscle

scientific article published on 01 July 1985

Insulin receptor phosphorylation in intact adipocytes and in a cell-free system

scientific article published on 01 October 1982

Insulin resistance and insulin sensitizers

scientific article

Insulin resistant young subjects at risk of accelerated atherosclerosis exhibit a marked reduction in peripheral endothelial function early in life but not differences in intima-media thickness

scientific article published on December 2003

Insulin secretion and aging. Implications for insulin therapy in the geriatric patient with diabetes mellitus

scientific article published in April 2003

Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach

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Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10.

scientific article published on 4 April 2002

Insulin sensitivity of the human brain

scientific article published on August 2011

Insulin sensitivity predicts cognitive decline in individuals with prediabetes

scientific article published on 01 November 2020

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

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Insulin signal transduction in normal cells and its role in carcinogenesis

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Insulin signal transduction: possible mechanisms for insulin resistance

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Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity

scientific article published on June 2000

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine

scientific article published on September 1982

Insulin therapy in the type 2 obese diabetic patient. Supplementing the deficit

scientific article published in May 2001

Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma

scientific article published on 01 September 1995

Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin

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Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907

scientific article published on November 23, 2010

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

scientific article published on September 2005

Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats

scientific article published on 01 January 1994

Insulin-like effect of low-dose leptin on glucose transport in Langendorff rat hearts

scientific article published on May 2003

Insulin-like growth factor I-dependent tyrosine kinase activity in stromal cells of human endometrium in vitro ⬇️

scientific article published on 01 June 1992

Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity.

scientific article published on 15 September 2009

Integrated enrichment analysis and pathway-centered visualization of metabolomics, proteomics, transcriptomics, and genomics data by using the InCroMAP software

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Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

scientific article published on 2 January 2018

Intense cholesterol lowering therapy with a HMG-CoA reductase inhibitor does not improve nitric oxide dependent endothelial function in type-2-diabetes--a multicenter, randomised, double-blind, three-arm placebo-controlled clinical trial

scientific article published in June 2005

Intensive insulin therapy combined with metformin in obese type 2 diabetic patients.

scientific article published in March 2000

Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity

scientific article published on 6 September 2016

Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity

scientific article published on 15 September 2001

Interaction of the insulin receptor kinase with serine/threonine kinases in vitro.

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Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt.

scientific article published on 8 March 2005

Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway

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Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity.

scientific article published in June 2009

Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

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Interscapular fat is strongly associated with insulin resistance

scientific article published on 21 July 2010

Intra- and interindividual variability of fatty acid unsaturation in six different human adipose tissue compartments assessed by 1 H-MRS in vivo at 3 T.

scientific article published on 25 May 2017

Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects

scientific article published in November 2004

Intramyocellular lipids and insulin resistance

scientific article published on July 2004

Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity

scientific article published in April 2003

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

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Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women

scientific article published on 25 August 2012

Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans

scientific article published on January 2013

Investigating obesity-associated brain inflammation using quantitative water content mapping

scientific article published on 05 September 2020

Investigation of a capillary electrophoretic approach for direct quantification of apolipoprotein A‐I in serum ⬇️

scientific article published on 01 May 2003

Iodine-induced thyrotoxicosis after ingestion of kelp-containing tea.

scientific article published in June 2006

Jaundice from diabetes therapy

scientific article published on 01 January 2014

Ketoacidosis in a non-diabetic woman who was fasting during lactation

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Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells ⬇️

scientific article published on January 10, 1984

Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity

scientific article published on 29 May 2020

Lack of association between metabolic traits and the -512 polymorphism in FOXC2 in german people with normal glucose tolerance

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Lack of association between the insertion/deletion polymorphism of the angiotensin-converting-enzyme gene and diabetic nephropathy in IDDM patients

scientific article published in May 1998

Late diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

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Leberenzymerhöhung und metabolisches Risiko – Fall 7/2011

scientific article published in July 2011

Leptin Replacement Reestablishes Brain Insulin Action in the Hypothalamus in Congenital Leptin Deficiency

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Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

scientific article published on 01 November 1997

Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity

scientific article published on 19 June 2012

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

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Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids

scientific article published on 01 March 2000

Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect

scientific article published on May 1997

Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas.

scientific article published on 18 May 2011

Letter by Stefan et al regarding article, "Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men".

scientific article published in September 2010

Lifestyle intervention in individuals with normal versus impaired glucose tolerance

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Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints

scientific article published on 18 June 2019

Lipid content in the musculature of the lower leg assessed by fat selective MRI: intra- and interindividual differences and correlation with anthropometric and metabolic data

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Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice

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Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin.

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Liquid chromatography-based determination of urinary free and total N(epsilon)-(carboxymethyl)lysine excretion in normal and diabetic subjects

scientific article published in September 2003

Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans

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Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene

scientific article published on 26 April 2005

Long term effect of a structured inpatient diabetes teaching and treatment programme in type 2 diabetic patients: influence of mode of follow-up

scientific article published on 01 November 1999

Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient

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Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans

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Low performance in attention testing is associated with reduced grey matter density of the left inferior frontal gyrus in euthyroid patients with Hashimoto's thyroiditis

scientific article published on 23 September 2012

Low-molecular-weight heparin prevents high glucose- and phorbol ester-induced TGF-beta 1 gene activation

scientific article published in September 2001

Lower plasma creatinine and urine albumin in individuals at increased risk of type 2 diabetes with factor v leiden mutation

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Lymph node gastrinoma in multiple endocrine neoplasia type 1 - a diagnostic challenge

scientific article published on April 2008

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity

scientific article published on 30 September 2016

Manifestation of thyroid autoimmunity in patients successfully treated for hypercortisolism

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Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action.

scientific article published on March 1990

Maternal Weight, Weight Gain, and Metabolism are Associated with Changes in Fetal Heart Rate and Variability

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Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity

scientific article published on 28 March 2014

Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin

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Measurement of glomerular filtration rate using dynamic magnetic resonance imaging in patients with chronic kidney disease

Measures of adiposity and fat distribution and risk of diabetes

scientific article published in January 2013

Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered

scientific article published on July 1995

Mechanisms Explaining the Relationship Between Metabolically Healthy Obesity and Cardiovascular Risk

scientific article published in June 2014

Medical antihyperglycaemic treatment of type 2 diabetes mellitus: update of the evidence-based guideline of the German Diabetes Association

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Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation

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Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

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Metabolic characterization of a woman homozygous for the Ser113Leu missense mutation in carnitine palmitoyl transferase II.

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Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion

scientific article published on 8 August 2017

Metabolic profiles during an oral glucose tolerance test in pregnant women with and without gestational diabetes

scientific article published on 14 July 2015

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals

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Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

scientific article published on 30 August 2013

Metabolically healthy obesity: the low-hanging fruit in obesity treatment?

scientific article published on 14 September 2017

Metabolomic Characteristics of Fatty Pancreas

scientific article published on 16 May 2019

Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits

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Metabonomics study on the effects of the ginsenoside Rg3 in a beta-cyclodextrin-based formulation on tumor-bearing rats by a fully automatic hydrophilic interaction/reversed-phase column-switching HPLC-ESI-MS approach

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Metformin

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Methods for Proteomics-Based Analysis of the Human Muscle Secretome Using an In Vitro Exercise Model

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Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain

scientific article published on 13 April 2015

Mit Big Data zur personalisierten Diabetesprävention

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Modulation of insulin signalling in non-insulin-dependent diabetes mellitus: significance of altered receptor isoform patterns and mechanisms of glucose-induced receptor modulation

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Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior

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Morning to evening changes of intramyocellular lipid content in dependence on nutrition and physical activity during one single day: a volume selective 1H-MRS study

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Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity?

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Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism

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Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans

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Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions.

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National practice guidelines. New aspects in therapy of type 2 diabetes mellitus

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Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellit

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Neuronal Food Reward Activity in Patients With Type 2 Diabetes With Improved Glycemic Control After Bariatric Surgery

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Neuronal correlates of reduced memory performance in overweight subjects

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New imaging techniques of fat, muscle and liver within the context of determining insulin sensitivity

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New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms

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Nichtalkoholische Steatohepatitis

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No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes

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No influence of the PPARgamma2 Pro12Ala genotype on serum adiponectin concentrations in healthy Europeans

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No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

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Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance

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Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion

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Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes

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Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study

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Novel phenotypes of prediabetes?

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Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys

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Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction

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PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome

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PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

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PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans

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PPARGC1A mRNA levels of in vitro differentiated human skeletal muscle cells are negatively associated with the plasma oleate concentrations of the donors

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Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.

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Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

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Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase

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Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells

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Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals

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Paraadrenal Castleman disease presenting with adrenal hyperandrogenism

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Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes

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Parathyroid hormone after adenectomy for primary hyperparathyroidism. A study of peptide hormone elimination kinetics in humans

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Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function

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Partitioning-defective protein 6 regulates insulin-dependent glycogen synthesis via atypical protein kinase C

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Pathogenesis of insulin resistance: modulation of the insulin signal at receptor level

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Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle

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Pathomechanisms of type 2 diabetes genes

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Pathophysiologic principles of metabolic syndrome. Consequences for early diagnosis and prevention

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Pathophysiology and pharmacological treatment of insulin resistance

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Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

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Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma

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Performance of a novel high sensitivity cardiac troponin I assay in asymptomatic hemodialysis patients - evidence for sex-specific differences

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Periaortic Adipose Tissue Compared With Peribrachial Adipose Tissue Mass as Markers and Possible Modulators of Cardiometabolic Risk

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Peripheral embolism due to bone entrapment of the popliteal artery after valgus osteotomy: a case report

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Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome

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Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction

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Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans

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Pharmacogenetics of oral antidiabetic therapy

Pharmacogenetics: Implications for Modern Type 2 Diabetes Therapy

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Phenotypes of prediabetes and stratification of cardiometabolic risk

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Pheochromocytoma in a patient with sickle-beta-thalassemia.

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Phorbol esters imitate in rat fat-cells the full effect of insulin on glucose-carrier translocation, but not on 3-O-methylglucose-transport activity

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Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes

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Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity ⬇️

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Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

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Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation

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Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism

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Plasma fetuin-A levels and the risk of type 2 diabetes

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Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke

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Plasma homocysteine concentrations in young individuals at increased risk of type 2 diabetes are associated with subtle differences in glomerular filtration rate but not with insulin resistance.

scientific article published in June 2006

Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice.

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Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets.

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Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

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Point mutations in the PDX1 transactivation domain impair human β-cell development and function

Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity

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Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion

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Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action

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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

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Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.

scientific article published on 5 October 2005

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

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Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content: a randomized and controlled dietary intervention study

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Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information

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Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin

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Preanalytical aspects and sample quality assessment in metabolomics studies of human blood

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Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.

scientific article published on 19 March 2018

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus

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Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening

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Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells

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Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity

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Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors

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Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle

scientific journal article

Proteasome inhibition by bortezomib: effect on HLA-antibody levels and specificity in sensitized patients awaiting renal allograft transplantation

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Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells

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Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

scientific article

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells

scientific journal article

Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells

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Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

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Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor

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Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

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Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.

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Protein kinase activity of the insulin receptor from muscle

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Proteolytic processing of the protein tyrosine phosphatase α extracellular domain is mediated by ADAM17/TACE.

scientific article published on 29 May 2012

Pseudopheochromocytoma in Parkinson's disease

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Psychological effects of prevention: do participants of a type 2 diabetes prevention program experience increased mental distress?

scientific article published in January 2009

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples

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Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood.

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Quantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: a study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric data

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RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study

scientific article published in April 2009

Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers

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Reduced adiponectin serum levels in smokers

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Reduced cortical thickness associated with visceral fat and BMI.

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Reduced insulin effect in subclinical fatty liver

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Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPARgamma2?

scientific article published in January 2002

Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes

scientific article published in July 2003

Reducing visceral adipose tissue mass is essential for improving endothelial function in type 2 diabetes prone individuals

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Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans

scientific article published on February 2013

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis

scientific article published on 18 June 2008

Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro

scientific article published on 23 February 2013

Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells

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Regulation of synovial adipocytokines

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Relation of insulin receptor occupancy and deactivation of glucose transport

scientific article published on 01 April 1982

Relationship between serum adiponectin concentration and intramyocellular lipid stores in humans

scientific article published in November 2002

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans

scientific article published on 27 May 2016

Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans.

scientific article published in March 2003

Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans

scientific article published in February 2002

Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans

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Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults

scientific article published on 19 March 2014

Relationships of circulating sex hormone-binding globulin with metabolic traits in humans

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Resistin and adiponectin--of mice and men.

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Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects

scientific article published on 21 August 2020

Resting-state functional connectivity of the human hypothalamus

scientific article published on 14 August 2014

Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells

scientific article published on September 2000

Retraction

scientific article published in 2002

Retraction Notice to: The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes

scientific article published on 01 October 2020

Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of beta-adrenergic sensitivity after prevention of hypoglycemia

scientific article published on 01 February 2000

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

scientific article published on 22 July 2019

Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites

scientific article published on 14 August 2007

Routine Monitoring of Sodium and Phosphorus Removal in Peritoneal Dialysis (PD) Patients Treated with Continuous Ambulatory PD (CAPD), Automated PD (APD) or Combined CAPD+APD.

scientific article published on 25 May 2017

SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study

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Safety of intranasal human insulin: A review.

scientific article published on 6 March 2018

Safety, efficacy and weight effect of two 11β-HSD1 inhibitors in metformin-treated patients with type 2 diabetes

scientific article published on 9 June 2014

Satisfactory outcome after severe ethanol-induced lactic acidosis and hypoglycemia

scientific article published on 26 December 2007

Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation.

scientific article published in November 2006

Screening and identification of familial defective apolipoprotein B-100 in clinical samples by capillary gel electrophoresis

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Secondary adrenal failure and secondary amenorrhoea following hydromorphone treatment

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Secondary adrenal failure due to long-term treatment with flunitrazepam

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Secretome profiling of primary human skeletal muscle cells

scientific article published on 27 August 2013

Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans

scientific article published on 3 December 2008

Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults

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Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation

scientific article published on June 2000

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta

scientific article

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.

scientific article published on 20 November 2017

Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans

scientific article

Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond

scientific article published on 21 March 2018

Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome

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Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance

scientific article

Serum-free differentiation of 3T3-L1 preadipocytes is characterized by only transient expression of peroxisome proliferator-activated receptor-gamma

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Severe and symptomatic hyponatremia following duloxetine treatment

scientific article published on 18 June 2008

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes

scientific article published on 31 December 2009

Sex-Specific Associations of Testosterone With Metabolic Traits

Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

scientific article published on 29 July 2005

Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry

scientific article published in July 2001

Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry

scientific article published on 13 May 2013

Simultaneous, quantitative analysis of UDP-N-acetylglucosamine, UDP-N-acetylgalactosamine, UDP-glucose and UDP-galactose in human peripheral blood cells, muscle biopsies and cultured mesangial cells by capillary zone electrophoresis

scientific article

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans.

scientific article

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

scientific article

Skeletal Muscle Cells from Insulin-resistant (Non-diabetic) Individuals are Susceptible to Insulin Desensitization by Palmitate ⬇️

scientific article published on October 1, 2003

Soluble urokinase receptor (suPAR) predicts microalbuminuria in patients at risk for type 2 diabetes mellitus

scientific article published on 16 January 2017

Somatostatin receptor expression in a parathyroid hormone-related peptide-secreting pancreatic neuroendocrine tumour causing severe hypercalcaemia

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Specific white matter tissue microstructure changes associated with obesity

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Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP.

scientific article published in July 2009

Spontaneous rupture of malignant adrenal phaeochromocytoma.

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Stable isotope-assisted lipidomics combined with nontargeted isotopomer filtering, a tool to unravel the complex dynamics of lipid metabolism

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Standardized assessment of whole body adipose tissue topography by MRI

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Steroid profile in an adrenocortical carcinoma producing aldosterone

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Stimulated Suicidal Erythrocyte Death in Arteritis

scientific article published on 22 August 2016

Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor

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Stimulatory effect of increased non-esterified fatty acid concentrations on proinsulin processing in healthy humans

scientific article published on 26 October 2000

Structural requirements for cub domain containing protein 1 (CDCP1) and Src dependent cell transformation

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Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state

scientific article published on May 1, 1992

Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression

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Sunitinib specifically augments glucose-induced insulin secretion

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Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans.

scientific article published in October 2000

Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion

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Symptomatic hypoglycemia during imatinib mesylate in a non-diabetic female patient with gastrointestinal stromal tumor

scientific article published in September 2007

Syndrome of inappropriate antidiuretic hormone secretion and ectopic ACTH production in small cell lung carcinoma

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Systemic haemodynamics in haemodialysis: intradialytic changes and prognostic significance.

scientific article published on 26 March 2018

T-helper-1-cell cytokines drive cancer into senescence

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T2* relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-nine subjects-correlation with age, gender, and serum ferritin

scientific article

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

scientific article published on 29 June 2016

TPA inhibits insulin stimulated PIP hydrolysis in fat cell membranes: evidence for modulation of insulin dependent phospholipase C by proteinkinase C.

scientific article published in October 1990

The -8503 G/A Polymorphism of the Adiponectin Receptor 1 Gene Is Associated With Insulin Sensitivity Dependent on Adiposity

scientific article published on 27 January 2006

The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects

scientific article

The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells

scientific article published on 23 July 2013

The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals

scientific article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

scientific article published on 14 May 2013

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies

scientific article

The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

scientific article

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

scientific article published on 29 November 2009

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

scientific article published on 01 December 2018

The Genetic Variant I148M in PNPLA3 Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans.

scientific article published on 6 October 2015

The Gly1057Asp polymorphism in IRS-2 interacts with obesity to affect beta cell function

scientific article published on 01 April 2004

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet

scientific article published on 01 June 2019

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations

scientific article

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans

scientific article published in April 2001

The Hepatokines Fetuin-A and Fetuin-B are up-regulated in the State of Hepatic Steatosis and may differently impact on Glucose Homeostasis in Humans

scientific article published on 14 November 2017

The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition

scientific article published on 25 August 2008

The Medically Complex Living Kidney Donor: Glucose Metabolism as Principal Cause of Donor Declination.

scientific article published on 26 January 2016

The OGTT as test for beta cell function?

scientific article

The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes.

scientific article

The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects

scientific article published on 01 June 1999

The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients.

scientific article published in October 2000

The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain

scientific article

The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention

scientific article published on 6 April 2007

The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.

scientific article published on January 2002

The Relationships of Plasma Adiponectin with a Favorable Lipid Profile, Decreased Inflammation, and Less Ectopic Fat Accumulation Depend on Adiposity

scientific article published in October 2006

The Search for NIDDM genes project: a European Community programme aimed to facilitate the identification of NIDDM genes

scientific article published on 01 January 1998

The TUDID Study - Background and Design of a Prospective Cohort

scientific article published on 10 September 2020

The association between plasma adiponectin and insulin sensitivity in humans depends on obesity

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The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?

scientific article (publication date: 2015)

The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes

retracted scientific article published on June 2013

The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study

scholarly article

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

scientific article published on 7 March 2008

The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells

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The effects of skin temperature and testing site on blood glucose measurements taken by a modern blood glucose monitoring device

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The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia

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The impact of insulin resistance on the kidney and vasculature

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The impact of liver fat vs visceral fat in determining categories of prediabetes

scientific article published on 23 January 2010

The importance of brown adipose tissue

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The inhibitory effect of 2-deoxyglucose on insulin receptor autophosphorylation does not depend on known serine phosphorylation sites or other conserved serine residues of the receptor beta-subunit

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The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity

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The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty acids

scientific article published on 9 October 2009

The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance

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The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects

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The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family

scientific article (publication date: 19 November 1999)

The lipid profile of brown adipose tissue is sex-specific in mice

scientific article published on 14 August 2014

The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin

scientific article published on March 1998

The mechanism of the cellular insulin effect--receptor kinase defect in type II diabetes

scientific article published on March 1989

The metabolically benign and malignant fatty liver

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The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors

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The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein

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The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor

scientific article published on March 1, 1992

The obese brain: association of body mass index and insulin sensitivity with resting state network functional connectivity

scientific article published on 21 April 2011

The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism

scientific article (publication date: August 2002)

The phorbol ester TPA induces a translocation of the insulin sensitive glucose carrier (GLUT4) in fat cells

scientific article published on 01 May 1990

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

scientific article published on 29 August 2005

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia

scientific article (publication date: September 2002)

The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion

scientific article

The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A.

scientific article published on 23 May 2017

The protein tyrosine phosphatase α modifies insulin secretion in INS-1E cells ⬇️

scientific article published on November 14, 2003

The risk allele load accelerates the age-dependent decline in beta cell function

scientific article published on 27 January 2009

The role of beta-adrenergic sensitivity in the pathogenesis of hypoglycaemia unawareness.

scientific article

The role of hepatokines in metabolism

scientific article published on 22 January 2013

The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.

scientific article published on 13 February 2012

The silent PPARgamma exon 6 CAC(His) --> CAT(His) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany

scientific article published in January 2000

The translocation of the glucose transporter sub-types GLUT1 and GLUT4 in isolated fat cells is differently regulated by phorbol esters

scientific article published on May 1991

The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.

scientific article

The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

scientific article published on June 1991

Thioctic acid--effects on insulin sensitivity and glucose-metabolism

scientific article

Thrombomodulin and coronary heart disease

scientific article published on 01 May 1999

Thyroid perfusion imaging as a diagnostic tool in Graves' disease--arterial spin labeling magnetic resonance imaging vs. colour-coded Doppler ultrasound

scientific article published on 11 October 2012

Thyroid peroxidase antibody positivity is associated with symptomatic distress in patients with Hashimoto's thyroiditis

scientific article published on 21 January 2012

Tissue selectivity of insulin detemir action in vivo.

scientific article published on 29 March 2006

Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture

scientific article published on 25 January 2012

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes

scientific article published on 12 September 2020

Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures

scientific article published in April 2002

Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts

scientific article published on March 1994

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling

scientific article

Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin receptor kinase from rat adipocytes.

scientific article published in March 1986

Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal

scientific article published in November 2001

Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery

scientific article published on 12 June 2015

Type 2 diabetes mellitus and risk of malignancy: is there a strategy to identify a subphenotype of patients with increased susceptibility to endogenous and exogenous hyperinsulinism?

scientific article published on March 2011

Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity

scientific article published on 11 August 2020

Type I hyperlipoproteinemia due to a novel loss of function mutation of lipoprotein lipase, Cys(239)-->Trp, associated with recurrent severe pancreatitis

scientific article published on 01 December 2000

Tyrosine kinase activity of insulin-like growth factor I and insulin receptors in human endometrium during the menstrual cycle: cyclic variation of insulin receptor expression

scientific article published on 01 February 1993

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.

scientific article published on 22 January 2014

Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus

Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms.

scientific article

Upregulation of cholesterol synthesis after acute myocardial infarction--is cholesterol a positive acute phase reactant?

scientific article published on 01 February 1999

Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway

scientific article published on 2 February 2004

Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions.

scientific article

Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection

scientific article published on 27 October 2015

Urinary albumin excretion and noninvasive assessment of peripheral endothelial dysfunction with high-resolution ultrasound in type 2 diabetic subjects and nondiabetic controls

scientific article published in April 2003

Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity.

scientific article published on 2 April 2009

Urinary neutrophil gelatinase-associated lipocalin accurately detects acute allograft rejection among other causes of acute kidney injury in renal allograft recipients

scientific article published in June 2012

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study

scientific article published on 31 August 2009

Validation of the German Diabetes Risk Score with metabolic risk factors for type 2 diabetes

scientific article published in April 2008

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies

scientific article

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

scientific article

Variants in the CD36 Gene Locus Determine Whole-Body Adiposity, but Have No Independent Effect on Insulin Sensitivity

scientific article published on 21 October 2010

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

scientific article published on 11 July 2008

Variation in the CDKAL1 gene is associated with the titer of antibodies to GAD

scientific article published on 01 September 2008

Variation in the FTO gene influences food intake but not energy expenditure

scientific article

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

scientific article published on 05 October 2007

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers

scientific article published on 10 December 2015

Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex

scientific article

Variations inPPARDDetermine the Change in Body Composition during Lifestyle Intervention: A Whole-Body Magnetic Resonance Study

scientific article published in April 2008

Visceral Adiposity Index as an Independent Marker of Subclinical Atherosclerosis in Individuals Prone to Diabetes Mellitus

scientific article published on 19 February 2019

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content

scientific article published on 9 August 2011

Vom Labor zum Patienten – Translationale Diabetesforschung

Weight-sparing effect of insulin detemir: a consequence of central nervous system-mediated reduced energy intake?

scientific article

What role do fat cells play in pancreatic tissue?

scientific article published on 07 May 2019

White blood cell count as a predictor of glucose tolerance and insulin sensitivity. The role of inflammation in the pathogenesis of type 2 diabetes mellitus

scientific article published in February 2004

Working memory-related brain activity is associated with outcome of lifestyle intervention

scientific article published on 2 July 2013

Younger age is a good predictor of better executive function after surgery for pituitary adenoma in adults

scientific article published on 29 July 2009

[68-year-old female patient with dyspnea and hypokalemic hypertension].

scientific article published in October 2007

[Clinical pathways in endocrinology and diabetology]

scientific article published on 01 July 2006

[Diabetic foot syndrome. Etiology and differential therapy]

scientific article published on 01 October 1996

[Early detection of atherosclerosis with high resolution ultrasound exemplified by type II diabetic patients]

scientific article published on 01 February 1998

[Early systolic notched peripheral Doppler flow pattern as an indicator of functional obstruction of the common iliac artery after iatrogenic aortic dissection: a case report]

scientific article

[Hypercalcemic crisis due to primary hyperparathyroidism]

scientific article published on 03 December 2008

[In-vivo 1H-MR spectroscopy: the determination of the intra- and extramyocellular lipid content depending on the insulin effect in the direct offspring of type-2 diabetics]

scientific article

[Indicators of incipient atherosclerosis: demonstration of endothelial dysfunction with high-resolution ultrasound]

scientific article published on 01 June 2003

[Influence of experience on intra- and interindividual variability in assessing peripheral endothelial dysfunction with high resolution ultrasound]

scientific article published in October 2001

[Liver volume, intrahepatic fat and body weight in the course of a lifestyle interventional study: Analysis with quantitative MR-based methods].

scientific article published in April 2015

[Metabolic syndrome--bridge to type II diabetes]

scientific article published on 01 March 1993

[Pathophysiology of insulin resistance]

scientific article published in February 1995

[Phenotypes of prediabetes and type 2 diabetes]

scientific article published on 13 May 2014

[Role of the insulin receptor kinase in the effect of insulin and pathogenesis of type II diabetes]

scientific article published on 01 March 1991

[The effect of fenofibrate on the lipid level in diabetic patients]

scientific article published on 01 September 1983

[The pathogenesis of type II diabetes mellitus]

scientific article published in March 1990

[The thiazolidinones--a new therapeutic agent for type 2 diabetes]

scientific article published on 01 February 1998

c-Fos-driven transcriptional activation of transforming growth factor β-1: inhibition of high glucose-induced promoter activity by thiazolidinediones ⬇️

scientific article published on May 2, 2003

cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation

scientific article published on 06 September 2018

p75, a member of the heat shock protein family, undergoes tyrosine phosphorylation in response to oxidative stress

scientific article published on 01 January 1997

„Metabolomics“ in der Diabetesforschung

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