List of works by L. David Sibley

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

scientific article

A conserved ankyrin repeat-containing protein regulates conoid stability, motility and cell invasion in Toxoplasma gondii. ⬇️

scientific article published on 21 December 2017

A human origin type II strain of Toxoplasma gondii causing severe encephalitis in mice

scientific article published on 5 June 2006

A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii

scientific article published on 8 November 2011

A novel actin-related protein is associated with daughter cell formation in Toxoplasma gondii

scientific article

A role for coccidian cGMP-dependent protein kinase in motility and invasion

scientific article published in March 2004

A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii

scientific article

A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma

scientific article

AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse.

scientific article published on 16 March 2018

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii

scientific article

Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii

scientific article

Actin filament polymerization regulates gliding motility by apicomplexan parasites

scientific article

Actin in the parasiteToxoplasma gondii is encoded by a single copy gene,ACT1 and exists primarily in a globular form ⬇️

scientific article published on January 1, 1997

Actin-like protein 1 (ALP1) is a component of dynamic, high molecular weight complexes in Toxoplasma gondii

scientific article published on January 2010

Acute virulence in mice is associated with markers on chromosome VIII in Toxoplasma gondii

scientific article published on December 1996

Albumin extravasation rates in tissues of anesthetized and unanesthetized rats

scientific article published in May 1989

Aldolase Forms a Bridge between Cell Surface Adhesins and the Actin Cytoskeleton in Apicomplexan Parasites ⬇️

scientific article published on April 1, 2003

Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells

scientific article published on April 2009

An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3

scientific article published on 15 July 2020

An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques ⬇️

scientific article

Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9.

scientific article published on 11 January 2016

ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites

scientific article

Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii

scientific article

Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis

scientific article published on 13 August 2007

Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model

scientific article published on 27 July 2009

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens

scientific article

Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii

scientific article published on May 1995

Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins

scientific article

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites

scientific article

CRISPR-mediated Tagging with BirA Allows Proximity Labeling in Toxoplasma gondii.

scientific article published in March 2018

CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection

scientific article published on 31 March 2014

Calcium regulation and signaling in apicomplexan parasites.

scientific article published on January 2008

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

scientific article

Calcium-dependent signaling and kinases in apicomplexan parasites

scientific article published on June 2009

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii ⬇️

scientific article

Cell invasion by un-palatable parasites

scientific article

Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole

scientific article

Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii ⬇️

scientific article published on September 1, 1997

Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii

scientific article

Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites

scientific article

Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa

scientific article published on 2 June 2006

Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii

scientific article

Conditional Knockdown of Proteins Using Auxin-inducible Degron (AID) Fusions in Toxoplasma gondii.

scientific article published in February 2018

Congenital Toxoplasmosis in France and the United States: One Parasite, Two Diverging Approaches

scientific article

Construction of a molecular karyotype for Toxoplasma gondii

scientific article published on April 1, 1992

Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii

scientific article

Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

scientific article published on 9 July 2015

Crystallization and preliminary X-ray structural analysis of nucleoside triphosphate hydrolases from Neospora caninum and Toxoplasma gondii

scientific article

Cytoskeleton of apicomplexan parasites

scientific article

Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans

scientific article published on 20 May 2015

Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis

scientific article published on June 1997

Development of CRISPR/Cas9 for Efficient Genome Editing in Toxoplasma gondii

scientific article

Development of forward genetics in Toxoplasma gondii

scientific article published on 28 February 2009

Dinitroanilines bind alpha-tubulin to disrupt microtubules

scientific article published on 23 January 2004

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

scientific article published on 24 January 2019

Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii

scientific article published in March 2002

Distinct signalling pathways control Toxoplasma egress and host-cell invasion

scientific article

Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.

scientific article

Enhanced detection of multiply phosphorylated peptides and identification of their sites of modification

scientific article published on 29 August 2013

Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii

scientific article published on September 1999

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro

Evaluation of the safety and immunogenicity of a candidate tuberculosis vaccine, MVA85A, delivered by aerosol to the lungs of macaques

scientific article published on 27 February 2013

Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii

scientific article

Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites

scientific article

Expressed sequence tag (EST) analysis of Gregarine gametocyst development

scientific article

Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes.

scientific article

Food- and waterborne pathogens: you are (infected by) what you eat!

scientific article published on April 2004

Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis

scientific article published on 22 May 2009

Functional Analysis of the Role of Toxoplasma gondii Nucleoside Triphosphate Hydrolases I and II in Acute Mouse Virulence and Immune Suppression

scientific article published on 18 April 2016

Functional analysis of rhomboid proteases during Toxoplasma invasion

scientific article

Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D.

scientific article published on 10 February 2006

Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database

scientific article

Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii ⬇️

scientific article published on December 1, 1992

Genetic Mapping of Pathogenesis Determinants in Toxoplasma gondii

scientific article published on 17 June 2016

Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America

scientific article

Genetic approaches to studying virulence and pathogenesis in Toxoplasma gondii

scientific article

Genetic basis of pathogenicity in toxoplasmosis

scientific article published on January 1996

Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil

scientific article

Genetic diversity of Toxoplasma gondii in animals and humans

scientific article

Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker

scientific article

Genotyping Toxoplasma gondii from wildlife in Pennsylvania and identification of natural recombinants virulent to mice

scientific article published on 14 November 2013

Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis

scientific article

Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains

scientific article published on December 2005

Geographic separation of domestic and wild strains of Toxoplasma gondii in French Guiana correlates with a monomorphic version of chromosome1a

scientific article

Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites

scientific article published on September 2005

Gliding motility: an efficient mechanism for cell penetration

scientific article

Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages

scientific article published on 19 March 2012

Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii

scientific article published on August 2008

Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii

scientific article

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

scientific article published on 28 August 2018

Hormone profiles of mares affected by the mare reproductive loss syndrome

scientific article published on 23 March 2008

Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii.

scientific article published in August 2002

How apicomplexan parasites move in and out of cells

scientific article

Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii

scientific article

Identification of small-molecule inhibitors of nucleoside triphosphate hydrolase in Toxoplasma gondii

scientific article

Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae

scientific article published on August 1988

Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice

scientific article

Influence of saline infusion on blood-tissue albumin transport

scientific article

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

scientific article published on 21 September 2017

Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

scientific article published on 9 November 2015

Inhibition of Nitric Oxide Production in Activated Macrophages Caused by Infection Occurs by Distinct Mechanisms in Different Mouse Macrophage Cell Lines

scientific article published in 2018

Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan

scientific article

InsP3 Signaling in Apicomplexan Parasites

scientific article

Interstitial exclusion of IgG in rat tissues estimated by continuous infusion

scientific article published in January 1994

Interstitial exclusion of albumin in rat tissues measured by a continuous infusion method

scientific article published on October 1, 1992

Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells

scientific article

Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages

scientific article published on March 1987

Intracellular parasite invasion strategies

scientific article published on April 2004

Invasion and intracellular survival by protozoan parasites

scientific article published on March 2011

Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring ⬇️

scientific article

Invasion of Toxoplasma gondii occurs by active penetration of the host cell.

scientific article published in June 1995

Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii

scholarly article

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

scientific article published on 7 January 2016

Macrophage interactions in toxoplasmosis

scientific article

Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption

scientific article published on December 2016

Measuring the casemix of physician practices in primary-care reform models in Ontario, Canada

scientific article

Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii

scientific article published on 29 February 2008

Migration of Toxoplasma gondii across biological barriers

scientific article

Modulation of innate immunity by Toxoplasma gondii virulence effectors

scientific article

Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2.

scientific article published in February 1997

Molecular characterization of a thrombospondin-related anonymous protein homologue in Neospora caninum

scientific article published in March 2000

Molecular partitioning during host cell penetration by Toxoplasma gondii

scientific article published in November 2004

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro.

scientific article

Monocytes mediate mucosal immunity to Toxoplasma gondii

scientific article published on 27 May 2010

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

scientific article published in 2024

Mycobacterial lipoarabinomannan inhibits gamma interferon-mediated activation of macrophages

scientific article published on May 1988

Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon

scientific article published on February 1987

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages

scientific article published in 2018

Neospora caninum: tachyzoites express a potent type-I nucleoside triphosphate hydrolase

scientific article published on November 1998

NextGen sequencing reveals short double crossovers contribute disproportionately to genetic diversity in Toxoplasma gondii

scientific article published on 23 December 2014

No more free lunch

scientific article published in February 2002

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii

scientific article

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of <i>Toxoplasma gondii</i> infection

scientific article published on 06 December 2021

Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii

scientific article

Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii

scientific article published on 02 October 2009

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

scientific article

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

scientific article

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii

scientific article

Plants, endosymbionts and parasites: Abscisic acid and calcium signaling

scientific article

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

scientific article

Plasma volume expansion with colloids increases blood-tissue albumin transport

scientific article published on April 1, 1992

Polymorphic secreted kinases are key virulence factors in toxoplasmosis

scientific article published on December 2006

Population biology of Toxoplasma gondii

scientific article

Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps

scientific article published on January 2008

Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype

scientific article published in March 2004

Protozoan persister-like cells and drug treatment failure

scientific article published on 23 August 2019

REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data

scientific article

Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex

scientific article

Reassessment of the role of aromatic amino acid hydroxylases and the effect of infection by Toxoplasma gondii on host dopamine

scientific article

Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome

scholarly article

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

scientific article

Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host-cell vacuoles occupied by Toxoplasma gondii.

scientific article

Reply to "reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity".

scientific article published in August 2015

Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii ⬇️

scientific article (publication date: April 2010)

Rhoptries: an arsenal of secreted virulence factors

scientific article published on 9 November 2007

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii

scientific article published on 20 August 2015

Secreted protein kinases regulate cyst burden during chronic toxoplasmosis.

scientific article published on 23 July 2016

Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice

scientific article

Sensitive and specific identification of Neospora caninum infection of cattle based on detection of serum antibodies to recombinant Ncp29.

scientific article published on May 2002

Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii

scientific article

Solution structure and dynamics of ADF from Toxoplasma gondii

scientific article

Structural evidence for actin-like filaments in Toxoplasma gondii using high-resolution low-voltage field emission scanning electron microscopy

scientific article published on August 2003

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

scientific article

Superoxide dismutase and catalase in Toxoplasma gondii.

scientific article published in April 1986

Sustained high levels of stored drinking water treatment and retention of hand-washing knowledge in rural Kenyan households following a clinic-based intervention

scientific article

Synthesis of chondramide A analogues with modified β-tyrosine and their biological evaluation

scientific article published on 20 October 2011

Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii ⬇️

scientific article published on 10 September 2013

Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice

scientific article

The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases

scientific article published on May 2000

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice

scientific article

The amphipathic alpha helices of the toxoplasma protein GRA2 mediate post-secretory membrane association

scientific article

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii

scientific article published on 20 September 2012

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat.

scientific article published on 13 March 2017

The hitchhiker's guide to parasite dissemination

scientific article published on 08 July 2019

The moving junction, a key portal to host cell invasion by apicomplexan parasites

scientific article

The p29 and p35 immunodominant antigens of Neospora caninum tachyzoites are homologous to the family of surface antigens of Toxoplasma gondii

scientific article

The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18

scientific article (publication date: 2012)

The role of the cytoskeleton in host cell invasion by Toxoplasma gondii

scientific article published on March 1, 1997

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration

scientific article published on 22 July 2019

The secreted kinase ROP18 defends Toxoplasma's border

scientific article

The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains

scientific article

The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival

scientific article published on 10 December 2003

The unusual dynamics of parasite actin result from isodesmic polymerization

scientific article

Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion

scientific article

Total synthesis and configurational assignment of chondramide A.

scientific article published on April 2010

Toxoplasma Actin Is Required for Efficient Host Cell Invasion

scientific article published on 16 June 2015

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

scientific article published on July 2016

Toxoplasma Effectors Targeting Host Signaling and Transcription

scientific article published on July 2017

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

scientific article published on 03 January 2014

Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion

scientific article published on 18 February 2014

Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole

scientific article

Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin

scientific article

Toxoplasma gondii merozoite gene expression analysis with comparison to the life cycle discloses a unique expression state during enteric development

scientific article

Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores

scientific article

Toxoplasma gondii profilin acts primarily to sequester G-actin while formins efficiently nucleate actin filament formation in vitro

scientific article published on 16 March 2012

Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways

scientific article published on June 1999

Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation

scientific article published on 5 March 2007

Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment

scientific article

Toxoplasma gondii: microneme protein MIC2.

scientific article

Toxoplasma gondii: perfecting an intracellular life style

scientific article

Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite

scientific article

Traditional birth attendant training for improving health behaviours and pregnancy outcomes

scientific article (publication date: 20 July 2005)

Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2.

scientific article

Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence

scientific article

Transmembrane insertion of the Toxoplasma gondii GRA5 protein occurs after soluble secretion into the host cell

scientific article published on April 1999

Ultrastructural localization of an intracellular Toxoplasma protein that induces protection in mice

scientific article published on September 1987

Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii

scientific article

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

scientific article

Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages

scientific article

WDFY4 is required for cross-presentation in response to viral and tumor antigens

scientific article

Wick sampling of interstitial fluid in rat skin: further analysis and modifications of the method.

scientific article published in July 1986

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