List of works - Nikolaus Grigorieff

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

scientific article

A dose-rate effect in single-particle electron microscopy

scientific article

A maximum likelihood approach to two-dimensional crystals

scientific article

A primer to single-particle cryo-electron microscopy

scientific article

Ab initio resolution measurement for single particle structures

scientific article

Accurate determination of local defocus and specimen tilt in electron microscopy

scientific article (publication date: June 2003)

Actin filament labels for localizing protein components in large complexes viewed by electron microscopy

scientific article

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

scientific article

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

scientific article

An adaptation of the Wiener filter suitable for analyzing images of isolated single particles

scientific article published on 02 July 2011

Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification.

Atomic Resolution Cryo-EM Structure of β-Galactosidase.

scientific article published on 10 May 2018

Atomic model of an infectious rotavirus particle

scientific article

Automatic estimation and correction of anisotropic magnification distortion in electron microscopes.

scientific article published on 13 August 2015

Beam-induced motion of vitrified specimen on holey carbon film

scientific article published on 16 February 2012

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

scientific article published on 13 August 2015

Clathrin coats at 21Aresolution: a cellular assembly designed to recycle multiple membrane receptors ⬇️

scientific article published on September 1, 1998

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

scientific article published on 20 October 2009

Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer

scientific article published on March 2017

Conformational changes in the Arp2/3 complex leading to actin nucleation

scientific article published on 12 December 2004

Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit

scientific article published on 20 October 2003

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril

scientific article

CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface

scientific article published on 12 May 2017

Direct detection pays off for electron cryo-microscopy ⬇️

scientific article published on February 19, 2013

Electron Crystallography of Two-Dimensional Crystals of Membrane Proteins ⬇️

scientific article published on January 1, 1998

Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution

scientific article

Electron diffraction of a bacterial ClC-type chloride channel.

scientific article

Ensemble cryo-EM elucidates the mechanism of translation fidelity

scientific article published on 24 May 2017

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

scientific article published on 09 May 2016

Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0

scientific article

Ewald sphere correction for single-particle electron microscopy

scientific article published on 9 December 2005

Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1.

scientific article published on 10 July 2017

Frealign: An Exploratory Tool for Single-Particle Cryo-EM.

scientific article

Frealix: model-based refinement of helical filament structures from electron micrographs

scientific article published on 20 March 2014

GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors

scientific article

High-resolution Electron Microscopy of Helical Specimens: A Fresh Look at Tobacco Mosaic Virus

scientific article

Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis

scientific journal article

Interplay of DNA repair with transcription: from structures to mechanisms

scientific article published on 17 October 2012

Likelihood-based classification of cryo-EM images using FREALIGN

scientific article

Location of the dsRNA-Dependent Polymerase, VP1, in Rotavirus Particles

scientific article

Low-resolution structure refinement in electron microscopy.

scientific article

Maturation in action: CryoEM study of a viral capsid caught during expansion

scientific article (publication date: 8 August 2012)

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

scientific article published on 29 May 2015

Mechanism of ribosome rescue by ArfA and RF2.

scientific article published on 16 March 2017

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase

scientific article

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM

scientific article

Molecular model for a complete clathrin lattice from electron cryomicroscopy

scientific article

Movies of ice-embedded particles enhance resolution in electron cryo-microscopy

scientific article

Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy

scientific article

Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy

scientific article published on 18 February 2011

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction

scholarly article

Noise bias in the refinement of structures derived from single particles

scientific article published in December 2004

Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface

scientific article

Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter

scientific article published on 18 May 2012

Outcome of the first electron microscopy validation task force meeting

scientific article (publication date: 8 February 2012)

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

scholarly article

Pentameric Assembly of Potassium Channel Tetramerization Domain-Containing Protein 5

scientific article

Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

scientific article

Physical basis of amyloid fibril polymorphism

scientific article published on 16 February 2018

Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins

scientific article published on 01 March 2020

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

scientific article

Quantitative characterization of electron detectors for transmission electron microscopy

scientific article

Recent progress in understanding Alzheimer's β-amyloid structures

scientific article

Ribosome•RelA structures reveal the mechanism of stringent response activation.

scientific article published on 19 July 2016

SIGNATURE: a single-particle selection system for molecular electron microscopy

scientific article published on 17 June 2006

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.

scientific article

Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques

scientific article

Single-protein detection in crowded molecular environments in cryo-EM images

scientific article published on 3 May 2017

Structural complexity of a composite amyloid fibril

scientific article

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils

scientific article

Structure and assembly of calcium homeostasis modulator proteins

scientific article published on 27 January 2020

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.

scientific article

Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy

scientific article

Structure of RNA polymerase bound to ribosomal 30S subunit

scientific article published on 13 October 2017

Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

scientific article published on 25 May 2016

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating

scientific article published on 24 October 2004

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly

scientific article

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

scientific article published on 2 July 2015

Structure of the transporter associated with antigen processing trapped by herpes simplex virus

scientific article published on 9 December 2016

Structures of Yeast 80S Ribosome-tRNA Complexes in the Rotated and Nonrotated Conformations

scientific article

Subunit interactions in bovine papillomavirus

scientific article

Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center

scientific article

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

scientific article

Three-dimensional structure of C complex spliceosomes by electron microscopy

scientific article published on 15 February 2004

Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 å in ice ⬇️

scientific article published on April 17, 1998

Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy

scientific article

cisTEM, user-friendly software for single-particle image processing.

scientific article published on 7 March 2018

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

scientific article published on 19 May 2020

List of works by Nikolaus Grigorieff

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

A dose-rate effect in single-particle electron microscopy

A maximum likelihood approach to two-dimensional crystals

A primer to single-particle cryo-electron microscopy

Ab initio resolution measurement for single particle structures

Accurate determination of local defocus and specimen tilt in electron microscopy

Actin filament labels for localizing protein components in large complexes viewed by electron microscopy

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

An adaptation of the Wiener filter suitable for analyzing images of isolated single particles

Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification.

Atomic Resolution Cryo-EM Structure of β-Galactosidase.

Atomic model of an infectious rotavirus particle

Automatic estimation and correction of anisotropic magnification distortion in electron microscopes.

Beam-induced motion of vitrified specimen on holey carbon film

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

Clathrin coats at 21Aresolution: a cellular assembly designed to recycle multiple membrane receptors ⬇️

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer

Conformational changes in the Arp2/3 complex leading to actin nucleation

Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril

CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface

Direct detection pays off for electron cryo-microscopy ⬇️

Electron Crystallography of Two-Dimensional Crystals of Membrane Proteins ⬇️

Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution

Electron diffraction of a bacterial ClC-type chloride channel.

Ensemble cryo-EM elucidates the mechanism of translation fidelity

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0

Ewald sphere correction for single-particle electron microscopy

Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1.

Frealign: An Exploratory Tool for Single-Particle Cryo-EM.

Frealix: model-based refinement of helical filament structures from electron micrographs

GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors

High-resolution Electron Microscopy of Helical Specimens: A Fresh Look at Tobacco Mosaic Virus

Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis

Interplay of DNA repair with transcription: from structures to mechanisms

Likelihood-based classification of cryo-EM images using FREALIGN

Location of the dsRNA-Dependent Polymerase, VP1, in Rotavirus Particles

Low-resolution structure refinement in electron microscopy.

Maturation in action: CryoEM study of a viral capsid caught during expansion

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

Mechanism of ribosome rescue by ArfA and RF2.

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM

Molecular model for a complete clathrin lattice from electron cryomicroscopy

Movies of ice-embedded particles enhance resolution in electron cryo-microscopy

Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy

Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction

Noise bias in the refinement of structures derived from single particles

Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface

Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter

Outcome of the first electron microscopy validation task force meeting

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

Pentameric Assembly of Potassium Channel Tetramerization Domain-Containing Protein 5

Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

Physical basis of amyloid fibril polymorphism

Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

Quantitative characterization of electron detectors for transmission electron microscopy

Recent progress in understanding Alzheimer's β-amyloid structures

Ribosome•RelA structures reveal the mechanism of stringent response activation.

SIGNATURE: a single-particle selection system for molecular electron microscopy

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.

Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques

Single-protein detection in crowded molecular environments in cryo-EM images

Structural complexity of a composite amyloid fibril

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils

Structure and assembly of calcium homeostasis modulator proteins

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.

Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy

Structure of RNA polymerase bound to ribosomal 30S subunit

Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy