List of works - Jacques Hugon

A case series of alcoholic patients with episodic memory impairment resembling Alzheimer's disease: the use of CSF biomarkers

scholarly article by Claire Paquet et al published July 2010 in Alzheimer's and Dementia

A cortical form of CADASIL with cerebral Aβ amyloidosis.

scientific article published on 19 October 2010

Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

scientific article

Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

scientific article published on 4 September 2006

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study

scientific article published on 20 August 2020

BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis

scientific article published in December 2002

Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses

scientific article published in May 2006

Biomarker profiles of Alzheimer's disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau.

scientific article published on 14 May 2019

Biomarkers in Sporadic and Familial Alzheimer's Disease

scientific article published on July 2015

Blood-Based Kinase Assessments in Alzheimer's Disease

scholarly article by Jacques Hugon et al published 2018 in Frontiers in Aging Neuroscience

Brimapitide Reduced Neuronal Stress Markers and Cognitive Deficits in 5XFAD Transgenic Mice.

scientific article

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway

scientific journal article

CSF AD BIOMARKERS IN MEMORY CLINIC PATIENTS: THE EP.L.M.FR STUDY

CSF AMYLOID-β 42/40 RATIO IN CLINICAL SETTINGS: A MULTICENTRIC STUDY

CSF Aβ 1-42 levels and glucose metabolism in Alzheimer's disease

scholarly article by Julien Dumurgier et al published July 2012 in Alzheimer's and Dementia

CSF Aβ₁₋₄₂ levels and glucose metabolism in Alzheimer's disease

scientific article published in January 2011

CSF level of β-amyloid peptide predicts mortality in Alzheimer's disease

scientific article published on 28 March 2019

Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease

scientific article

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

scientific article published on 29 August 2017

Could PKR inhibition modulate human neurodegeneration?

scientific article published in October 2009

Could non coding RNA be involved in Alzheimer's disease?

scientific article published on 20 February 2007

DOWNREGULATED APOPTOSIS AND AUTOPHAGY AFTER ANTI-Aβ IMMUNOTHERAPY IN ALZHEIMER'S DISEASE.

scientific article

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease

scientific article published on 11 October 2007

Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity

scientific article published on 11 September 2016

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

scientific article published on 7 January 2015

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

scientific article published in June 2015

Elevated ALS Biomarker Levels in CSF of a FTD Patient at the Presymptomatic Stage of ALS.

scientific article published on 17 November 2017

Emotional memory enhancement in respect of positive visual stimuli in Alzheimer's disease emerges after rich and deep encoding

scientific article published on 24 January 2015

Exacerbated CSF abnormalities in younger patients with Alzheimer's disease

scientific article published on 13 February 2013

Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease

scientific article

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease

scientific article published on 27 September 2006

Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes

scientific article published on 20 March 2006

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response ⬇️

scientific article published on October 13, 2011

Hepatitis C virus controls interferon production through PKR activation

scientific article

IMPACT OF CEREBROSPINAL FLUID BIOMARKERS OF ALZHEIMER'S DISEASE IN CLINICAL PRACTICE: A MULTICENTRIC STUDY

Impact of pain on cognitive functions in primary Sjögren syndrome with small fiber neuropathy: 10 cases and a literature review

scientific article

Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: the PLM Study

scientific article published on January 2013

Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease

scientific article published on 26 January 2012

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

scientific article published on May 2015

Intersite variability of CSF Alzheimer's disease biomarkers in clinical setting

scientific article published on 8 November 2012

Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: the cognitive reserve theory

scientific article

Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration

scientific article published in December 2002

Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly

scientific article

Low molecular weight Abeta induces collapse of endoplasmic reticulum

scientific article published on 5 February 2009

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

scientific article

Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity

scientific article published in April 2004

Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells ⬇️

scientific article published on April 15, 2011

Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease

scientific article published on 3 October 2010

Neprilysin, cardiovascular, and Alzheimer's diseases: the therapeutic split?

scientific article published on 29 January 2015

Neural correlates of episodic memory in the Memento cohort.

scientific article

Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation

scientific article published on 17 February 2015

Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease.

scientific article published in February 2009

Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease

scientific article

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

scientific article published on 28 January 2012

P3-305: Increased expression of the PKR modulators, PACT And TRBP, in the brains of patients with Alzheimer's disease (AD)

scholarly article by Claire Paquet et al published July 2008 in Alzheimer's and Dementia

PKR involvement in Alzheimer's disease

scientific article published on 5 October 2017

PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

scientific article published on 4 February 2009

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

scientific article

Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

article published in 2013

Peripheral p70S6k levels and emotional memory in patients with Alzheimer's disease

scientific article published on 13 November 2006

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

scientific article published in December 2002

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

scientific article published on 16 February 2018

Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease

scientific article (publication date: 2015)

Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF biomarkers

scientific article published on 9 January 2018

Rethinking Alzheimer's diseases

scientific article published on September 1, 2011

Screening for cognitive and affective dysfunction in patients suspected of mild cognitive impairment

scientific article published on 12 February 2014

Targeting miRNAs in Alzheimer's disease.

scientific article published in November 2008

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease ⬇️

scientific article published on September 16, 2011

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide

scientific article published on November 2006

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation

scientific journal article

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease

scientific article published on 03 October 2016

The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease

scientific article published in November 2005

The role of attention in emotional memory enhancement in pathological and healthy aging

scientific article

The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials

scientific article published on 12 April 2014

Time Orientation and 10 Years Risk of Dementia in Elderly Adults: The Three-City Study

scientific article published on July 2016

Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity

scientific article

Utility of CSF biomarkers in psychiatric disorders: a national multicentre prospective study

scientific article published on 13 June 2016

Who needs cerebrospinal biomarkers? A national survey in clinical practice

scientific article published in January 2014

[Molecular and therapeutic approaches of the Alzheimer's disease].

scientific article

mTOR-dependent signalling in Alzheimer's disease

scientific article

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

scientific article

List of works by Jacques Hugon

A case series of alcoholic patients with episodic memory impairment resembling Alzheimer's disease: the use of CSF biomarkers

A cortical form of CADASIL with cerebral Aβ amyloidosis.

Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study

BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis

Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses

Biomarker profiles of Alzheimer's disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau.

Biomarkers in Sporadic and Familial Alzheimer's Disease

Blood-Based Kinase Assessments in Alzheimer's Disease

Brimapitide Reduced Neuronal Stress Markers and Cognitive Deficits in 5XFAD Transgenic Mice.

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway

CSF AD BIOMARKERS IN MEMORY CLINIC PATIENTS: THE EP.L.M.FR STUDY

CSF AMYLOID-β 42/40 RATIO IN CLINICAL SETTINGS: A MULTICENTRIC STUDY

CSF Aβ 1-42 levels and glucose metabolism in Alzheimer's disease

CSF Aβ₁₋₄₂ levels and glucose metabolism in Alzheimer's disease

CSF level of β-amyloid peptide predicts mortality in Alzheimer's disease

Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

Could PKR inhibition modulate human neurodegeneration?

Could non coding RNA be involved in Alzheimer's disease?

DOWNREGULATED APOPTOSIS AND AUTOPHAGY AFTER ANTI-Aβ IMMUNOTHERAPY IN ALZHEIMER'S DISEASE.

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease

Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

Elevated ALS Biomarker Levels in CSF of a FTD Patient at the Presymptomatic Stage of ALS.

Emotional memory enhancement in respect of positive visual stimuli in Alzheimer's disease emerges after rich and deep encoding

Exacerbated CSF abnormalities in younger patients with Alzheimer's disease

Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease

Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response ⬇️

Hepatitis C virus controls interferon production through PKR activation

IMPACT OF CEREBROSPINAL FLUID BIOMARKERS OF ALZHEIMER'S DISEASE IN CLINICAL PRACTICE: A MULTICENTRIC STUDY

Impact of pain on cognitive functions in primary Sjögren syndrome with small fiber neuropathy: 10 cases and a literature review

Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: the PLM Study

Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

Intersite variability of CSF Alzheimer's disease biomarkers in clinical setting

Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: the cognitive reserve theory

Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration

Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly

Low molecular weight Abeta induces collapse of endoplasmic reticulum

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity

Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells ⬇️

Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease

Neprilysin, cardiovascular, and Alzheimer's diseases: the therapeutic split?

Neural correlates of episodic memory in the Memento cohort.

Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation

Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease.

Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

P3-305: Increased expression of the PKR modulators, PACT And TRBP, in the brains of patients with Alzheimer's disease (AD)

PKR involvement in Alzheimer's disease

PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

Peripheral p70S6k levels and emotional memory in patients with Alzheimer's disease

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease

Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF biomarkers

Rethinking Alzheimer's diseases

Screening for cognitive and affective dysfunction in patients suspected of mild cognitive impairment

Targeting miRNAs in Alzheimer's disease.

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease ⬇️

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease

The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease

The role of attention in emotional memory enhancement in pathological and healthy aging

The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials

Time Orientation and 10 Years Risk of Dementia in Elderly Adults: The Three-City Study

Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity

Utility of CSF biomarkers in psychiatric disorders: a national multicentre prospective study

Who needs cerebrospinal biomarkers? A national survey in clinical practice