List of works by Tom van der Poll

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts

scientific article

A guiding map for inflammation

scientific article published on July 2017

A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission

scientific article published on 29 June 2015

A new murine model to study musculoskeletal tuberculosis (short communication).

scientific article published on 8 February 2014

A new murine model to study the pathogenesis of tuberculous meningitis

scientific article

A new twist on the legend of granulocyte colony-stimulating factor in acute lung injury?

scientific article published in April 2009

A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense

scientific article

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the i

scientific article published on 25 November 2020

A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh

scientific article

A short contemporary history of disseminated intravascular coagulation

scientific article

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

scientific article

A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent

scientific article

AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation

scientific article published on 15 January 2013

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice

scientific article published on 2 October 2017

Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice.

scientific article

Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

scientific article

Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans

scientific article published on 04 March 2005

Activation of Coagulation by Administration of Recombinant Factor VIIa Elicits Interleukin 6 (IL-6) and IL-8 Release in Healthy Human Subjects ⬇️

scientific article published on May 1, 2003

Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide.

scientific article

Activation of factor VII-activating protease in human inflammation: a sensor for cell death

scientific article published on 5 April 2011

Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia

scientific article published on 29 March 2004

Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis

scientific article

Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice.

scientific article published in February 2008

Acute stress elicited by bungee jumping suppresses human innate immunity

scientific article published on 10 December 2010

Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.

scientific article published on 27 February 2003

Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia

scientific article published on 25 September 2002

Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration

scientific article

Animal and human models for sepsis

scientific article

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia

scientific article

Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia

scientific article

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults

scientific article published on 4 August 2016

Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study

scientific article published on 15 June 2016

Anticoagulant Therapy for Acute Lung Injury or Pneumonia ⬇️

scientific article published on May 1, 2003

Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers

scientific article published on 30 June 2005

Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi

scientific article published on 7 August 2017

Are histones real pathogenic agents in sepsis?

scientific article published on 27 December 2017

Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumonia

scientific article

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients

scientific article published on 11 August 2017

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients

scientific article published on 06 August 2016

Asthma and coagulation

scientific article

Baroreflex sensitivity is higher during acute psychological stress in healthy subjects under β-adrenergic blockade

scientific article published on February 2011

Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury

scientific article

Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications

scientific article

Beyond sepsis: activated protein C and ischemia-reperfusion injury

scientific article published on May 2004

Bidirectional relation between inflammation and coagulation

scientific article published on June 2004

Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial.

scientific article

Biomarkers in Sepsis

scientific article published on 12 October 2017

Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model

scientific article

Borrelia burgdorferi clinical isolates induce human innate immune responses that are not dependent on genotype

scientific article published on 17 June 2015

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

scientific article

Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia

scientific article

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

article

C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice

scientific article

CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

scientific article

CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia.

scientific article

CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis

scientific article published on 3 April 2008

CD14 plays a limited role during influenza A virus infection in vivo

scientific article

CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome

scientific article published on 11 September 2006

CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophages

scientific article published on 9 November 2009

CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia

scientific article

CD44 is protective during hyperoxia-induced lung injury

scientific article published on 12 May 2010

CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats

scientific article published in January 2003

Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis

scientific article published on 17 February 2009

Characteristics and Outcome of Patients With AIDS in Dutch ICUs Between 1997 and 2014.

scientific article

Characterization of a pneumococcal meningitis mouse model

scientific article

Chemotactic factors in cerebrospinal fluid during bacterial meningitis

scientific article

Chronic healthcare expenditure in survivors of sepsis in the intensive care unit.

scientific article published on 9 July 2016

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

scientific article published on 29 August 2017

Clinical Characteristics and Outcomes of Patients With Cellulitis Requiring Intensive Care

scientific article published on 15 March 2017

Coagulation and sepsis

scientific article published on 19 November 2016

Coagulation biomarkers in critically ill patients

scientific article

Coagulation in patients with severe sepsis

scientific article

Coagulation in sepsis: all bugs bite equally

scientific article

Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis

scientific article

Community-acquired bacterial bloodstream infections in HIV-infected patients: a systematic review

scientific article

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients

scientific article published on 6 June 2016

Compartmentalisation of cytokines and cytokine inhibitors in ventilator-associated pneumonia.

scientific article published on 21 November 2003

Complement deficiency states and associated infections

scientific article published on 31 May 2011

CpG oligodeoxynucleotides enhance host defense during murine tuberculosis

scientific article

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study.

scientific article published on 11 November 2016

Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia

scientific article

DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia

scientific article published on December 2014

Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis

scientific article published in September 2008

Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis).

scientific article published on 13 November 2013

Delineation of the role of Toll-like receptor signaling during peritonitis by a gradually growing pathogenic Escherichia coli

scientific article published on 20 June 2011

Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis.

scientific article published on 26 April 2018

Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis

scientific article

Diabetes and sepsis outcomes--it is not all bad news

scientific article published on 18 February 2009

Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis

scientific article published in February 2010

Differential dose-dependent effects of prednisolone on shedding of endothelial adhesion molecules during human endotoxemia

scientific article published on 18 October 2008

Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis

scientific article

Disseminated intravascular coagulation in infectious disease

scientific article published on June 2010

Disseminated intravascular coagulation: a review for the internist

scientific article

Dynamics of peripheral blood lymphocyte subpopulations in the acute and subacute phase of Legionnaires' disease

scientific article

Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans

scientific article

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans

scientific article published on 13 December 2002

Effects of prednisolone on the systemic release of mediators of cell-mediated cytotoxicity during human endotoxemia

scientific article published in April 2008

Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1.

scientific article published on 26 October 2006

Elevated plasma levels of interferon (IFN)-gamma, IFN-gamma inducing cytokines, and IFN-gamma inducible CXC chemokines in visceral leishmaniasis.

scientific article published in November 2004

Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA.

scientific article published on 6 May 2011

Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation

scientific article published on 17 April 2008

Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis

scientific article published on January 2005

Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis

scientific article

Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia.

scientific article published on 2 April 2015

Endogenous tissue-type plasminogen activator impairs host defense during severe experimental Gram-negative sepsis (melioidosis)*.

scientific article

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

scientific article

Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection.

scientific article

Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis).

scientific article

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia

scientific article published on 14 September 2015

Endothelial injury in sepsis

scientific article

Endothelium: interface between coagulation and inflammation

scientific article

Enterococcal surface protein Esp is not essential for cell adhesion and intestinal colonization of Enterococcus faecium in mice

scientific article

Epidemiology of Multiple Herpes Viremia in Previously Immunocompetent Patients With Septic Shock

scientific article published on 4 February 2017

Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia

scientific article published on 10 February 2017

Erythrocyte glutathione concentration and production during hyperinsulinemia, hyperglycemia, and endotoxemia in healthy humans ⬇️

scientific article published on September 17, 2010

Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

scientific article published on 12 June 2017

Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model

scientific article

Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis

scientific article

Expression and function of transforming growth factor β in melioidosis

scientific article published on 13 February 2012

Expression of human immunodeficiency virus coreceptors CXC chemokine receptor 4 and CC chemokine receptor 5 on monocytes is down-regulated during human endotoxemia

scientific article published on 19 March 2002

Expression of inhibitory regulators of innate immunity in patients with active tuberculosis

scientific article

Expression of intra- and extracellular granzymes in patients with typhoid fever

scientific article published on 27 July 2017

Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis

scientific article

Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients

scientific article published on 23 July 2015

Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein

scientific article published on July 2013

Factor v Leiden mutation in severe infection and sepsis

scientific article

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

scientific article published on 18 May 2015

Future of sepsis therapies

scientific article published on 22 April 2016

Gene expression profiles in alveolar macrophages induced by lipopolysaccharide in humans

scientific article published on 6 December 2012

Gene-expression profiles in murine melioidosis

scientific article

Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis

scientific article

Glyburide reduces bacterial dissemination in a mouse model of melioidosis

scientific article

Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes

scientific article published on 07 April 2014

Granzyme M and K release in human experimental endotoxemia

scientific article

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

scientific article

HIV Coinfection Enhances Complement Activation During Sepsis

scientific article published on 5 February 2015

HIV infection is associated with elevated nucleosomes in asymptomatic patients and during sepsis or malaria

scientific article published on 3 April 2015

HIV infection rather than concurrent opportunistic infections drives most systemic procoagulant, vascular and damage responses - a prospective cohort study in central Africa

scientific article published on 5 January 2017

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis

scientific article

Hemostatic Changes Associated With Increased Mortality Rates in Hospitalized Patients With HIV-Associated Tuberculosis: A Prospective Cohort Study

scientific article

High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis

scientific article published on 14 June 2016

High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling

scientific article

High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia

scientific article published on 16 December 2013

High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei

scientific article published on 19 March 2007

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

scientific article

Host innate immune responses to sepsis

scientific article

Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis

scientific article published on August 2003

Host-pathogen interaction in invasive Salmonellosis

scientific article

Host-pathogen interactions in sepsis

scientific article published on 11 December 2007

Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2.

scientific article published on January 2006

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

scientific article

Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans

scientific article published on 24 June 2008

IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis ⬇️

scientific article published on May 1, 2003

IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection

scientific article published in June 2004

IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice

scientific article published on 9 February 2006

Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display

scientific article

Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment

scientific article published on 27 February 2013

Immune Modulation in Sepsis: Is There a Place for Progranulin?

scientific article published in November 2016

Immunity to Burkholderia pseudomallei

scientific article published on April 2009

Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis).

scientific article

Impact of HIV infection on the haemostatic response during sepsis and malaria

scientific article published on 11 March 2016

Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study

scientific article published on 10 October 2016

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

scientific article

Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice

scientific article published on 30 January 2004

In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands.

scientific article

Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with Sepsis. A Cohort Study.

scientific article

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

scientific article published on 15 March 2016

Increased Early Systemic Inflammation in ICU-Acquired Weakness; A Prospective Observational Cohort Study

scientific article published on 27 March 2017

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

scientific article published on 28 August 2015

Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis

scientific article

Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis

scientific article

Increased intra- and extracellular granzyme expression in patients with tuberculosis

scientific article published on 20 June 2015

Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model

scientific article

Infection and inflammation as risk factors for thrombosis and atherosclerosis

scientific article published on 07 March 2012

Inflammation and coagulation

scientific article published on February 2010

Inflammation patterns induced by different Burkholderia species in mice

scientific article (publication date: 2008)

Inflammation, endothelium, and coagulation in sepsis

scientific article

Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia

scientific article published on 14 December 2005

Inhalation of beta 2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract

scientific article

Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia

scientific article

Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice

scientific article published on 25 May 2004

Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia

scientific article published on 5 April 2012

Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans

scientific article published in March 2003

Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae

scientific article published on 30 July 2007

Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract

scientific article published on 2 June 2006

Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia

scientific article published in October 2003

Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia

scientific article published on 25 September 2012

Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis

scientific article

Interleukin-18 Facilitates the Early Antimicrobial Host Response toEscherichia coliPeritonitis ⬇️

scientific article published on October 1, 2003

Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis

scientific article published in May 2003

Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa

scientific article

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

scientific article published on 27 December 2012

Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia ⬇️

scientific article published on August 1, 1997

Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients

scientific article published on October 2013

Intestinal Enterococcus faecium colonization improves host defense during polymicrobial peritonitis.

scientific article published in September 2009

Intrabronchial activated protein C enhances lipopolysaccharide-induced pulmonary responses

scientific article

Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation

scientific article

Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo

scientific article

Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia

scientific article

Is the septic response good or bad?

scientific article published on September 2007

Kinase activity profiling of pneumococcal pneumonia

scientific article

Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice

scientific article published on April 2006

Leukocyte TLR5 deficiency inhibits atherosclerosis by reduced macrophage recruitment and defective T-cell responsiveness

scientific article published on 16 February 2017

Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis

scientific article

Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study

scientific article

Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia

scientific article

Limited role of kininogen in the host response during gram-negative pneumonia derived sepsis.

scientific article published on 9 November 2017

Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia.

scientific article published on 15 June 2013

Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice

scientific article published on December 2003

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice

scientific article

Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice

scientific article

Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor

scientific article

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.

scientific article published in June 2006

Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung

scientific article

Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism

scientific article published on 10 June 2016

Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.

scientific article published on 10 April 2008

Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit ⬇️

scientific article published on October 29, 2010

Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients

scientific article published in January 2018

Macrophages play a dual role during pulmonary tuberculosis in mice

scientific article published on 29 November 2004

Mast cells impair host defense during murine Streptococcus pneumoniae pneumonia

scientific article published on 13 May 2014

Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis

scientific article published in March 2006

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury

scientific article published in October 2006

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury

scientific article published in January 2008

Mechanisms of action of activated protein C: an evolving story

scientific article

Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei

scientific article

Mesenchymal stem cells as a therapeutic tool to treat sepsis

scientific article

Metabolic modulation of inflammation-induced activation of coagulation

scientific article published on February 2008

Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry

scientific article published on 10 September 2013

Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli.

scientific article

Modular Transcriptional Networks of the Host Pulmonary Response during Early and Late Pneumococcal Pneumonia

scientific article

Modulation of innate immune responses in the treatment of sepsis and pneumonia

scientific article published on March 2004

Modulation of pulmonary innate immunity during bacterial infection: animal studies

scientific article

Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia

scientific article

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

scientific article

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

scientific article (publication date: September 2007)

MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei

scientific article

Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis

scientific article

Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia

scientific article published on 18 March 2015

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia

scientific article published on September 2014

Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome

scientific article published in February 2018

Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury

scientific article published on 15 December 2016

Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats

scientific article published on 9 September 2009

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury

scientific article

Neutrophil extracellular traps in patients with pulmonary tuberculosis

scientific article published on 30 October 2017

Neutrophils are essential for rapid clearance of Enterococcus faecium in mice

scientific article

New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology

scientific article published on January 2004

Norepinephrine in Septic Shock: A Mixed Blessing

scientific article published on 19 August 2020

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

scientific article

Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis).

scientific article

Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).

scientific article

Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.

scientific article published in January 2007

P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia

scientific article published in January 2004

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

scientific article

Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice

scientific article published in February 2009

Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis

scientific article published on 29 June 2015

Plasma and plasma components in the management of disseminated intravascular coagulation

scientific article

Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients

scientific article published on 23 June 2015

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

scientific article

Plasminogen activator inhibitor type I may contribute to transient, non-specific changes in immunity in the subacute phase of murine tuberculosis

scientific article published on 21 March 2012

Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.

scientific article

Platelet glycoprotein VI aids in local immunity during gram-negative pneumonia derived sepsis

scientific article published on 29 November 2017

Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract

scientific article published in December 2004

Pneumococcal meningitis in adults: new approaches to management and prevention

scientific article

Pneumonia models and innate immunity to respiratory bacterial pathogens

scientific article

Potent innate immune response to pathogenic leptospira in human whole blood

scientific article

Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis

scientific article published on 11 July 2016

Pre-ERCP infusion of semapimod, a mitogen-activated protein kinases inhibitor, lowers post-ERCP hyperamylasemia but not pancreatitis incidence

scientific article

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury

scientific article

Preclinical sepsis models

scientific article published on 09 October 2012

Predictive value of the qSOFA score in patients with suspected infection in a resource limited setting in Gabon

scientific article published on 5 November 2016

Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia.

scientific article published in February 2007

Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung

scientific article published on 15 May 2009

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

scientific article

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia

scientific article published on 5 February 2018

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

scientific article published on 16 February 2015

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

scientific article published on 27 December 2012

Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon

scientific article

Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice

scientific article

Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo

scientific article published on March 2006

Pulmonary tuberculosis induces a systemic hypercoagulable state

scientific article published on 29 October 2014

R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae

scientific article

RAGE Does Not Contribute to Renal Injury and Damage upon Ischemia/Reperfusion-Induced Injury

scientific article published on 04 November 2011

RAGE during infectious diseases

scientific article published on June 2011

Rapid genotyping for tumor necrosis factor-alpha (TNF-alpha)-863C/A promoter polymorphism that determines TNF-alpha response

scientific article published in January 2004

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia

scientific article published on 29 January 2016

Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice

scientific article published on 01 September 2009

Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia.

scientific article

Receptor for advanced glycation end products is protective during murine tuberculosis

scientific article

Recombinant human activated protein C: current insights into its mechanism of action

scientific article published on January 2007

Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients

scientific article

Regulation of pro-and anti-inflammatory host responses

scientific article published on 09 June 2011

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

scientific article

Reply: Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data

scientific article published in November 2015

Reply: FAIM3:PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired Pneumonia: Comparing Apples to Oranges?

scientific article published in January 2016

Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes

scientific article

Role of CD14 in lung inflammation and infection

scientific article published on 09 March 2010

Role of Nucleotide-Binding Oligomerization Domain-Containing (NOD) 2 in Host Defense during Pneumococcal Pneumonia

scientific article published on 16 December 2015

Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice.

scientific article

Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice

scientific article

Role of interleukin 1 receptor like 1 (ST2) in gram-negative and gram-positive sepsis in mice

scientific article published on October 2013

Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia

scientific article

Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo

scientific article

Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis

scientific article published on 10 April 2015

Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome

scientific article

Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation

scientific article published in January 2008

Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice

scientific article published on 30 November 2001

S100A12 and soluble receptor for advanced glycation end products levels during human severe sepsis

scientific article published on September 2013

S100A8/A9 is not involved in host defense against murine urinary tract infection

scientific article

SIRP-α instructs alveolar macrophages to stop eating after pneumonia

scientific article published on 18 May 2020

SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model

scientific article

ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis

scientific article published on 13 March 2009

Safety of vaccinations in patients with cryopyrin-associated periodic syndromes: a prospective registry based study

scientific article published on 6 May 2017

Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice

scientific article

Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization

scientific article

Secondary Infection in Patients With Sepsis--Reply.

scientific article

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types

scientific article published on 24 February 2017

Sepsis and disseminated intravascular coagulation

scientific article published on August 2003

Sepsis and thrombosis

scientific article published on 27 April 2013

Sepsis, coagulation, and antithrombin: old lessons and new insights

scientific article

Sepsis-The Final Common Pathway to Death From Multiple Organ Failure in Infection

scientific article published on June 2016

Sepsis: a roadmap for future research

scientific article published on 19 April 2015

Sepsis: new insights into its pathogenesis and treatment

scientific article published in January 2010

Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia

scientific article

Severe sepsis and septic shock

scientific article

Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study

scientific article published on 28 February 2017

Should all septic patients be given systemic anticoagulation? No.

scientific article published on 13 February 2017

Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae.

scientific article

Soluble ST2 levels are associated with bleeding in patients with severe Leptospirosis

scientific article

Soluble ST2 plasma concentrations predict mortality in severe sepsis

scientific article

Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis.

scientific article published on 15 September 2015

Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection

scientific article published in October 2005

Stimulation of alpha 7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism.

scientific article published in April 2007

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

scientific article

Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis

scientific article published on 13 December 2013

Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia

scientific article

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 18 January 2017

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 17 January 2017

Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans

scientific article published on 01 March 2019

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

scientific article published on 30 July 2011

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

scientific article published on 04 March 2014

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-x03B3.

scientific article

TLR2 deficiency aggravates lung injury caused by mechanical ventilation

scientific article published on July 2014

TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis

scientific article

TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis.

scientific article

TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury

scientific article

TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion

scientific article published on 11 September 2015

Targeting RAGE in sepsis

scientific article published on 11 January 2008

The Enterococcus faecium enterococcal biofilm regulator, EbrB, regulates the esp operon and is implicated in biofilm formation and intestinal colonization

scientific article

The Host Response in Patients with Sepsis Developing Intensive Care Unit-acquired Secondary Infections

scientific article published on 20 January 2017

The Impact of HIV Co-Infection on the Genomic Response to Sepsis

scientific article published on 12 February 2016

The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung

scientific article published in November 2005

The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial

scientific article published on 20 January 2015

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans

scientific article published on June 2015

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

The acute-phase response impairs host defence against Enterococcus faecium peritonitis

scientific article

The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis

scientific article published on 10 May 2005

The coagulation system and its function in early immune defense.

scientific article published on 3 April 2014

The coagulation system in melioidosis: from pathogenesis to new treatment strategies

scientific article published on 25 June 2014

The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis

scientific article

The effect of HIV infection on the host response to bacterial sepsis

scientific article published on 19 October 2014

The effect of inflammation on coagulation and vice versa

scientific article published on June 2011

The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

scientific article

The endothelial protein C receptor and malaria

scientific article

The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense

scientific article (publication date: 15 January 2004)

The immunopathology of sepsis and potential therapeutic targets

scientific article

The impact of HIV infection on blood leukocyte responsiveness to bacterial stimulation in asymptomatic patients and patients with bloodstream infection

scientific article published on 16 May 2016

The impact of HIV on presentation and outcome of bacterial sepsis and other causes of acute febrile illness in Gabon

scientific article published on 11 March 2015

The influence of corticosteroids on the release of novel biomarkers in human endotoxemia

scientific article published on 14 December 2007

The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies

scientific article published in October 2010

The intestinal microbiota and host immune interactions in the critically ill.

scientific article published on 28 February 2013

The lectin-like domain of thrombomodulin hampers host defence in pneumococcal pneumonia

scientific article published on 30 August 2012

The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia

scientific article

The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice

scientific article published on 20 February 2015

The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.

scientific article published in April 2009

The receptor for advanced glycation end products in ventilator-induced lung injury

scientific article published on 2 August 2014

The receptor for advanced glycation end products promotes bacterial growth at distant body sites in Staphylococcus aureus skin infection

scientific article published on 15 June 2015

The remarkable career of leptin: from antidote to obesity to mediator of lung inflammation

scientific article published in February 2014

The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen

scientific article

The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury

scientific article

The role of natural anticoagulants in the pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients

scientific article published on July 2008

The role of receptor for advanced glycation endproducts (RAGE) in infection

scientific article published on 22 March 2011

The structure function of the death domain of human IRAK-M.

scientific article

The systemic pro-inflammatory response in sepsis

scientific article published on 08 June 2010

The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice

scientific article

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

scientific article

Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice

scientific article

Therapeutic intervention in disseminated intravascular coagulation: have we made any progress in the last millennium?

scientific article

Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia

scientific article published on 6 October 2010

Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

scientific article

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice

scientific article

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

scientific article

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide

scientific article published on 30 October 2003

Tissue factor as an initiator of coagulation and inflammation in the lung

scientific article

Tissue factor in infection and severe inflammation

scientific article

Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo

scientific article

Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci

scientific article published on 17 August 2007

Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)

scientific article (publication date: 31 July 2007)

Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

scientific article published on March 2004

Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis

scientific article published in May 2005

Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model

scientific article published on 24 July 2002

Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus

scientific article published in October 2003

Toll-like receptor 9 enhances bacterial clearance and limits lung consolidation in murine pneumonia caused by methicillin resistant Staphylococcus aureus

scientific article published on 24 June 2016

Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury

scientific article

Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis

scientific article

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia

scientific article published on 3 June 2014

Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers

scientific article published on April 2017

Two-way interactions between inflammation and coagulation

scientific article

Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan

scientific article

Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial

scientific article published on 21 April 2014

Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury

scientific article published on 12 May 2009

Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract

scientific article

Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

scientific article published in March 2018

Ventilator-induced lung injury is mediated by the NLRP3 inflammasome

scientific article published in May 2012

Paulina is supported by:

About Paulina

Help