List of works - Berthold Kastner

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

scientific article

A protein map of the yeast activated spliceosome as obtained by electron microscopy

scientific article published on July 2016

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

scientific article published on 5 July 2016

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

scientific article

Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex

scientific article published on 24 May 2012

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

scientific article

Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes

scientific article

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

scientific article published on 25 July 2017

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

scientific article published on 11 January 2017

Discriminatory RNP remodeling by the DEAD-box protein DED1.

scientific article

Exon, intron and splice site locations in the spliceosomal B complex

scientific article published on 18 June 2009

Functional organization of the Sm core in the crystal structure of human U1 snRNP

scientific article

GraFix: sample preparation for single-particle electron cryomicroscopy

scientific article

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

scientific article

Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

scientific article published on June 2006

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

scientific article

Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry

scientific article published on 26 April 2010

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

scientific article published on 26 November 2020

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

scientific article

Molecular architecture of the human U4/U6.U5 tri-snRNP

scientific article

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

scientific article

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

scientific article

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

scientific article published on July 2006

Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex

scientific article published on 18 November 2015

Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry

scientific article

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.

scientific article published in August 2009

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site

scientific article published on 18 September 2015

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

scientific article published on 12 January 2018

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy

scientific article

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

scientific article

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

scientific article published on 18 April 2004

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

scientific article

List of works by Berthold Kastner

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

A protein map of the yeast activated spliceosome as obtained by electron microscopy

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

Discriminatory RNP remodeling by the DEAD-box protein DED1.

Exon, intron and splice site locations in the spliceosomal B complex

Functional organization of the Sm core in the crystal structure of human U1 snRNP

GraFix: sample preparation for single-particle electron cryomicroscopy

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

Molecular architecture of the human U4/U6.U5 tri-snRNP

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex

Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.