List of works - Laurent Vergnes

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

scientific article

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

scientific article published in May 2018

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13

scientific journal article

ABCC6 localizes to the mitochondria-associated membrane

scientific article

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

scientific article

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma

scientific article published on 30 August 2016

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

scientific article published on March 2013

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

scientific journal article

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

scientific article published on 25 February 2013

Approaches to lipid metabolism gene identification and characterization in the postgenomic era.

scientific article published on 11 July 2006

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

scientific article

Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

scientific article published on 15 August 2003

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

scientific article published on 5 October 2011

Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores

scientific article published on 15 January 2020

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity.

scientific article

Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.

scientific article

Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

scientific article

Expression and secretion of human apolipoprotein A-I in the heart.

scientific article

Expression of human apolipoprotein A-I/C-III/A-IV gene cluster in mice induces hyperlipidemia but reduces atherogenesis

scientific article published on 01 October 2000

Expression of human apolipoprotein A-I/C-III/A-IV gene cluster in mice reduces atherogenesis in response to a high fat-high cholesterol diet.

scientific article published in July 2001

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.

scientific article published on 16 January 2017

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

article

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

scientific article

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle

scientific article published on 30 December 2013

Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.

scientific article

Human apoA-I/C-III/A-IV gene cluster transgenic rabbits: effects of a high-cholesterol diet.

scientific article

Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice

scientific article published on 01 October 1999

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.

scientific article

Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice

scientific article published on 13 October 2015

Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation

scientific article published on 27 August 2020

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

scientific article published on 17 January 2018

KDM4B protects against obesity and metabolic dysfunction

scientific article published on 29 May 2018

Lamin B1 is required for mouse development and nuclear integrity

scientific article

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.

scientific article published on 10 May 2012

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

scientific article published on 26 March 2018

Metabolic state of glioma stem cells and nontumorigenic cells

scientific article

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

scientific article

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

scientific article (publication date: 23 March 2012)

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

scientific article published on 09 May 2016

Regulation of the human apolipoprotein AIV gene expression in transgenic mice

scientific article published on 01 February 1999

Response to Pomozi et al's research commentary

scientific article published on 26 April 2013

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

scientific article published on 18 December 2015

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

scientific article

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

scientific article published on April 2016

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

scientific article published on 7 April 2013

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

scientific article

The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers

scientific article published on 01 October 1997

The apolipoprotein AICIII-AIV gene cluster: sequence of the ApoCIII-ApoAIV intergenic region.

scientific article

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

scientific article

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

scientific article published on 15 November 2011

Zbtb16 has a role in brown adipocyte bioenergetics.

scientific article

List of works by Laurent Vergnes

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13

ABCC6 localizes to the mitochondria-associated membrane

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

Approaches to lipid metabolism gene identification and characterization in the postgenomic era.

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity.

Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.

Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

Expression and secretion of human apolipoprotein A-I in the heart.

Expression of human apolipoprotein A-I/C-III/A-IV gene cluster in mice induces hyperlipidemia but reduces atherogenesis

Expression of human apolipoprotein A-I/C-III/A-IV gene cluster in mice reduces atherogenesis in response to a high fat-high cholesterol diet.

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle

Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.

Human apoA-I/C-III/A-IV gene cluster transgenic rabbits: effects of a high-cholesterol diet.

Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.

Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice

Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

KDM4B protects against obesity and metabolic dysfunction

Lamin B1 is required for mouse development and nuclear integrity

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

Metabolic state of glioma stem cells and nontumorigenic cells

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Regulation of the human apolipoprotein AIV gene expression in transgenic mice

Response to Pomozi et al's research commentary

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers

The apolipoprotein AICIII-AIV gene cluster: sequence of the ApoCIII-ApoAIV intergenic region.

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

Zbtb16 has a role in brown adipocyte bioenergetics.