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List of works by Regina Fluhrer

A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases

scientific article published on 6 May 2015

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

scientific article

A non-amyloidogenic function of BACE-2 in the secretory pathway

scientific article

Apical sorting of beta-secretase limits amyloid beta-peptide production

scientific article

CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein

scientific article published on 22 April 2017

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

scientific article

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

scientific article

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

scientific article published on 5 December 2002

In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

scientific article published in 2024

Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins

scientific article

Intramembrane proteolysis by gamma-secretase

scientific article published on 23 July 2008

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases

scientific article published on 03 February 2009

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation

scientific article published on 3 September 2008

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process

scientific article published on March 2015

Latest emerging functions of SPP/SPPL intramembrane proteases

scientific article

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

scientific article published on December 2013

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

scientific article published on 16 November 2012

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

scientific article published on 22 October 2003

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

scientific article

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

scientific article published on 05 July 2018

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

scientific article

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

scientific article

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

scientific article

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins

scientific article published on 7 February 2019

Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?

scientific article

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

scientific article published on 01 May 2019

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

scientific article published on 07 February 2019

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

scientific article published on January 2007

Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells

scientific article published on 15 July 2014

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.

scientific article

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

scientific article

The Intramembrane Protease SPPL2A Is Critical for Tooth Enamel Formation ⬇️

scientific article published on July 1, 2013

The Nicastrin ectodomain adopts a highly thermostable structure ⬇️

scientific article published on November 1, 2011

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

scientific article published on 24 December 2012

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

scientific article published on 07 February 2019

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo

scientific article published on 03 February 2014

The transferrin receptor‐1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase‐like 2b ⬇️

scientific article published on March 1, 2013

The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b) ⬇️

scientific article published on December 22, 2011

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

scientific article published on June 2010

Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model

scientific article published on 30 November 2020

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