List of works - Anja Capell

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

scientific article published on 15 June 2006

A non-amyloidogenic function of BACE-2 in the secretory pathway

scientific article

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

scientific article

Apical sorting of beta-secretase limits amyloid beta-peptide production

scientific article

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

scientific article published on October 2004

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

scholarly article by Marc Suárez-Calvet et al published December 2018 in EMBO Molecular Medicine

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

scientific article published on 25 June 2012

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

scientific article published on 10 January 2019

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

scholarly article by Julia K Götzl published in September 2018

Gamma-secretase activity is associated with a conformational change of nicastrin

scientific article published on 18 March 2003

Gamma-secretase complex assembly within the early secretory pathway

scientific article

Impaired protein degradation in FTLD and related disorders

scientific article

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

scientific article published on 14 September 2020

Masking of transmembrane-based retention signals controls ER export of gamma-secretase

scientific article

Mechanisms of granulin deficiency: lessons from cellular and animal models

scientific article

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

scientific article

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion

scientific article published on 5 November 2007

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

scientific article published in July 1998

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

scientific article published on 5 November 2003

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

scientific article

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

scientific article published on 29 July 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

scientific article

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

scientific article (publication date: 22 November 2002)

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression

scientific article

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

scientific article

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin

scientific article published on 29 December 2015

Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells

scientific article

Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation

article

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

scientific article published on 8 May 2017

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

scientific article

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

scientific article

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

scientific article published on 18 November 2004

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects

scientific article

List of works by Anja Capell

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

A non-amyloidogenic function of BACE-2 in the secretory pathway

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

Apical sorting of beta-secretase limits amyloid beta-peptide production

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Gamma-secretase activity is associated with a conformational change of nicastrin

Gamma-secretase complex assembly within the early secretory pathway

Impaired protein degradation in FTLD and related disorders

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Masking of transmembrane-based retention signals controls ER export of gamma-secretase

Mechanisms of granulin deficiency: lessons from cellular and animal models

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin

Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells

Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects