List of works - Stefan F Lichtenthaler

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

scientific article published on 13 October 2012

A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular Carcinoma

scholarly article by Sarah Abdullahi et al published 1 December 2018 in Journal of Virology

A new sandwich immunoassay for detection of the α-secretase cleaved, soluble amyloid-β protein precursor in cerebrospinal fluid and serum

scientific article published on January 2013

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

scientific article

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

scientific article published on 30 July 2010

ADAM10 releases the immunoregulator soluble TACI — A novel biomarker for B-cell pathologies

scholarly article by Franziska Hoffmann et al published October 2014 in Journal of Neuroimmunology

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

scientific article published on 28 September 2011

ALTERED METABOLISM OF BACE1 SUBSTRATES SEIZURE PROTEIN 6 AND SEIZURE 6-LIKE PROTEIN 1 IN NIEMANN-PICK TYPE C DISEASE

scientific article published in July 2014

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking ⬇️

scientific article published on February 1, 2012

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

scientific article published on May 2004

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

scientific article published on 12 December 2005

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

scientific article published on 29 January 2016

Between new genetic discoveries and large randomized trials--neurological research in the era of systems medicine

scientific article published on 14 May 2013

Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays

scientific article published on 26 April 2011

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

scientific article

Cell-to-cell propagation of infectious cytosolic protein aggregates

scientific article published on 18 March 2013

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice

scientific article published on 6 March 2013

Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome

scientific article published in May 2018

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

scientific article published on 24 August 2012

Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

scientific article published on 25 September 2015

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

scientific article

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

scientific article

Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers

scientific article published on January 2006

Expression cloning screen for modifiers of amyloid precursor protein shedding

scientific article published on 30 January 2006

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

scientific article

Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region

scientific article published on 26 March 2010

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

scientific article

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

scientific article

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

scientific article published on 17 March 2016

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

scientific article published on 19 February 2016

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.

scientific article

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

scientific article published on 15 January 2013

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

scientific article

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

scientific article

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

scientific article

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

scientific article

Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway

scientific article published on 20 May 2010

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

scientific article published in March 2003

P2-043

PERK activation mitigates tau pathology in vitro and in vivo

scientific article published on February 2017

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

scientific article

Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

scientific article published on 31 May 2013

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

scientific article

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

scientific article published on 14 April 2011

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

scientific article

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

scientific article

Seizure-6 proteins highlight BACE1 functions in neurobiology

scientific article published on 5 December 2016

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis

scientific article published on 11 May 2007

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

scientific article

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

scientific article

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

scientific article

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

scientific article

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond

scientific article published on 17 February 2012

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

scientific article published on 29 October 2015

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

scientific article published on 24 September 2003

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity

scientific article

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

scientific article

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

scientific article

The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding

scientific article

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

scientific article published on 25 November 2002

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

scientific article published on June 2006

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

scientific article

iRHOM2 takes control of rheumatoid arthritis ⬇️

scientific article published on January 25, 2013

iRhoms in the brain - a new frontier?

scientific article published on 20 August 2015

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential ⬇️

scientific article published on 02 December 2010

γ-Secretase directly sheds the survival receptor BCMA from plasma cells

scientific article published on 11 June 2015

List of works by Stefan F Lichtenthaler

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular Carcinoma

A new sandwich immunoassay for detection of the α-secretase cleaved, soluble amyloid-β protein precursor in cerebrospinal fluid and serum

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

ADAM10 releases the immunoregulator soluble TACI — A novel biomarker for B-cell pathologies

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

ALTERED METABOLISM OF BACE1 SUBSTRATES SEIZURE PROTEIN 6 AND SEIZURE 6-LIKE PROTEIN 1 IN NIEMANN-PICK TYPE C DISEASE

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking ⬇️

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

Between new genetic discoveries and large randomized trials--neurological research in the era of systems medicine

Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

Cell-to-cell propagation of infectious cytosolic protein aggregates

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice

Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers

Expression cloning screen for modifiers of amyloid precursor protein shedding

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

P2-043

PERK activation mitigates tau pathology in vitro and in vivo

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

Seizure-6 proteins highlight BACE1 functions in neurobiology

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

iRHOM2 takes control of rheumatoid arthritis ⬇️

iRhoms in the brain - a new frontier?

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential ⬇️

γ-Secretase directly sheds the survival receptor BCMA from plasma cells