List of works - Luke I Szweda

A quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring

scientific article

Age-dependent declines in proteasome activity in the heart

scientific article published in January 2002

Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems.

scientific article

Aging: a shift from redox regulation to oxidative damage

scientific article published on December 2006

Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy

scientific article published on 31 October 2002

Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal

scientific article

Autophagocytosis of mitochondria is prominent in Alzheimer disease

scientific article

Cardiac ischemia/reperfusion, aging, and redox-dependent alterations in mitochondrial function

scientific article published on December 2003

Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy

scientific article published on 21 October 2004

Coenzyme A-mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice.

scientific article published on 14 March 2018

Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity

scientific article

Dissociation of cytochrome c from the inner mitochondrial membrane during cardiac ischemia

scientific article

Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

scientific article published on 19 February 2007

Enhanced cardiac fatty acid utilization induced by high dietary fat: a potential regulatory role for mitochondrial aconitase.

scientific article published in June 2012

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

scientific article

Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via upregulation of nicotinamide metabolism

scientific article published on 15 September 2017

Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification

scientific article

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

scientific article published on 5 April 2005

High dietary fat selectively increases catalase expression within cardiac mitochondria

scientific article published on 30 November 2012

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.

scientific article published on 22 November 2017

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

scientific article published on 12 November 2011

Hypoxia induces heart regeneration in adult mice

scientific article published on 31 October 2016

Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells

scientific article

Immunochemical detection of a fluorophore derived from the lipid peroxidation product 4-hydroxy-2-nonenal and lysine

scientific article published in January 2002

In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model

scientific article

Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes

scientific article published on 24 February 2006

Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate

scientific article (publication date: November 2004)

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

scientific article published in February 2018

Intraretinal leakage and oxidation of LDL in diabetic retinopathy

scientific article

Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion

scientific article

Ketogenic Diets Enhance Lung Cancer Reponse To Therapy

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts

scientific article published on 06 June 2013

Lipid peroxidation during human cerebral myelination

scientific article

Lysine Acetylation Activates Mitochondrial Aconitase in the Heart

scientific article published on 19 June 2015

Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity

scientific article published in July 2005

Mechanisms for countering oxidative stress and damage in retinal pigment epithelium

scientific article published on January 2012

Mitochondrial protein oxidation and degradation in response to oxidative stress and aging

scientific article

Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration

scientific article published on 14 January 2009

Modulation of mitochondrial complex I activity by reversible Ca2+ and NADH mediated superoxide anion dependent inhibition

scientific article

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

scientific article published on 6 April 2018

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

scientific article published on 14 October 2015

Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase

scientific article

Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury

scientific article published in September 2004

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

scientific article published on 30 January 2013

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein

scientific article

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress

scientific article

Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria

scientific article published on 31 August 2004

Proteolysis, free radicals, and aging

scientific article

Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart

scientific article

Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries

scientific article published on July 2002

Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria

scientific article published on 21 June 2013

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning

scientific article published on 26 August 2009

Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability

scientific article published on 17 November 2016

Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation

scientific article published on 16 June 2005

Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status

scientific article published in April 2003

Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid

scientific article

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

scientific article published in October 2002

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

scientific article published on 30 January 2014

Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function

scientific article published in July 2005

Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

scientific article published on 9 July 2004

α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor

scientific article

List of works by Luke I Szweda

A quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring

Age-dependent declines in proteasome activity in the heart

Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems.

Aging: a shift from redox regulation to oxidative damage

Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy

Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Cardiac ischemia/reperfusion, aging, and redox-dependent alterations in mitochondrial function

Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy

Coenzyme A-mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice.

Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity

Dissociation of cytochrome c from the inner mitochondrial membrane during cardiac ischemia

Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

Enhanced cardiac fatty acid utilization induced by high dietary fat: a potential regulatory role for mitochondrial aconitase.

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via upregulation of nicotinamide metabolism

Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

High dietary fat selectively increases catalase expression within cardiac mitochondria

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

Hypoxia induces heart regeneration in adult mice

Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells

Immunochemical detection of a fluorophore derived from the lipid peroxidation product 4-hydroxy-2-nonenal and lysine

In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model

Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes

Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

Intraretinal leakage and oxidation of LDL in diabetic retinopathy

Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion

Ketogenic Diets Enhance Lung Cancer Reponse To Therapy

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts

Lipid peroxidation during human cerebral myelination

Lysine Acetylation Activates Mitochondrial Aconitase in the Heart

Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity

Mechanisms for countering oxidative stress and damage in retinal pigment epithelium

Mitochondrial protein oxidation and degradation in response to oxidative stress and aging

Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration

Modulation of mitochondrial complex I activity by reversible Ca2+ and NADH mediated superoxide anion dependent inhibition

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase

Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress

Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria

Proteolysis, free radicals, and aging

Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart

Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries

Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning

Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability

Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation

Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status

Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function

Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor