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List of works by Julian Downward

1 Role of phosphoinositide-3-OH kinase in ras signaling

scientific article published on January 1, 1997

1997 Salk Institute/EMBL meeting on Oncogenes and Growth Control, Salk Institute, La Jolla, California, 16–20 August 1997 ⬇️

scientific article published on June 19, 1998

A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

scientific article

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

scientific article published in 2024

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

scientific article

A target for Pl(3) kinase

scientific article published in Nature

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.

scientific article published on 11 June 2018

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.

scientific article

ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma

scientific article published on 03 September 2019

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

scientific article

Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies

scientific article

Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains

scientific article

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

scientific article

Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

scientific article published on April 1999

An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors

scientific article

An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis

scientific article

Analysis of gene expression by microarrays: cell biologist's gold mine or minefield?

scientific article

Analysis of the transcriptional program induced by Raf in epithelial cells

scientific article

Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity

scientific article published on July 1986

Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function.

scientific article published on November 1985

Apoptosis: Ras to the rescue in the fly eye.

scientific article

Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity ⬇️

scientific article published on January 1, 2012

Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

scientific article published on 20 February 2019

Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

scientific article published on 07 August 2019

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

scientific article published in Journal of Biological Chemistry

Autophosphorylation sites on the epidermal growth factor receptor.

scientific article

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

scientific article published on 18 August 2021

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

scientific article

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

scientific article

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

scientific article published on 19 October 2011

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness

scientific article

CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility

scientific article published on 30 March 2006

CUTL1: a key mediator of TGFbeta-induced tumor invasion

scientific article

Cancer: A tumour gene's fatal flaws.

scientific article

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

scientific article (publication date: October 2002)

Cell biology: metabolism meets death

scientific article published in August 2003

Cell cycle: routine role for Ras.

scientific article published on April 1997

Chromosomal instability confers intrinsic multidrug resistance.

scientific article

Chromosomal instability determines taxane response

scholarly article

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.

scientific article

Chromosomal instability, colorectal cancer and taxane resistance

scientific article

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

scientific article

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

scientific article

Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer

scientific article published on 16 July 2020

Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

scientific article published on 2 June 2015

Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure

scientific article published on 17 December 2008

Control of ras activation

scientific article

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

scientific article published on March 2013

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

scientific article published on 21 August 2008

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons.

scientific article

Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells

scientific article

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer.

scientific article published on 27 September 2016

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

scientific article published on 22 May 2012

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

scientific article published on 06 February 2020

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

scientific article published on 01 September 2019

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

scientific article

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

scientific article published on 01 December 2018

Distinct Mechanisms of α5β1Integrin Activation by Ha-Ras and R-Ras

scientific article published in Journal of Biological Chemistry

Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer

scientific article published in January 2005

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

scientific article

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

scientific article (publication date: August 2009)

EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach

scientific article published on 28 September 2015

Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration

scientific article

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

scientific article (publication date: 7 May 1993)

Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts

scientific article published on March 1993

Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.

scientific article published on 14 November 2002

Evaluation of epidermal growth factor receptors in bladder tumours

scientific article published on November 1987

Exchange rate mechanisms

scientific article published in Nature

Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt

scientific article published on May 2006

Expression cloning and characterization of the TGF-beta type III receptor

scientific article

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2

scientific article published on 12 July 2006

Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma

scientific article (publication date: November 1999)

Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells.

scientific article published in August 2004

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

scientific article

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

scientific article published on 28 January 2002

Finding the weakness in cancer.

scientific article

Flicking the Warburg Switch—Tyrosine Phosphorylation of Pyruvate Dehydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells ⬇️

scientific article published on December 23, 2011

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration

scientific article published on 24 July 2012

Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival.

scientific article

Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer

scientific article published on 31 October 2008

Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation

scientific article

Genetic and cellular mechanisms of oncogenesis

scientific article published on 7 February 2009

Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer

scientific article published on 31 August 2012

Guidelines for the use of cell lines in biomedical research

scientific article published on 12 August 2014

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

article

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

scientific article published on 21 September 2016

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.

scientific article published on 4 December 2013

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

scientific article (publication date: 5 November 1999)

How to Fool a Wonder Drug: Truncate and Dimerize

Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

scientific article

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

scientific article published on 07 February 2020

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

scientific article

Identification of a nucleotide exchange-promoting activity for p21ras

scientific article

Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma

scientific article

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

scientific article

Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene

scientific article

Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

scientific article

Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression

scientific article

Inhibiting the RAS-PI3K pathway in cancer therapy.

scientific article

Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs

scientific article published on 4 June 2007

Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis

scientific article

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation

scientific article published in Journal of Biological Chemistry

Interaction of Ras with phosphoinositide 3-kinase gamma

scientific article published on September 1997

Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

scientific article

Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor β chain

scholarly article by Manuel Izquierdo et al published March 1992 in European Journal of Immunology

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

scientific article

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

scientific article (publication date: 8 March 2012)

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

scientific article published on September 1999

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

scientific article published in December 2005

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

scientific article published on March 1994

Involvement of survival motor neuron (SMN) protein in cell death

scientific article published on October 2002

KSR: a novel player in the RAS pathway

scientific article published on December 1995

Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells

scientific article

Lipid-Regulated Kinases: Some Common Themes at Last ⬇️

scientific article published on January 30, 1998

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

scientific article

Many faces of Ras activation

scientific article published on 21 May 2008

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

scientific article published on May 1997

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

scientific article published on September 2000

Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates

scientific article published on January 1995

Measurements of GTP/GDP exchange in permeabilized fibroblasts

scientific article published on January 1995

Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac

scientific article (publication date: 14 February 2003)

Mechanisms and consequences of activation of protein kinase B/Akt ⬇️

scientific article published on April 1, 1998

Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers

scientific article

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

scientific article published on 21 November 2008

Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor

scientific article

Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy

scientific article published on May 2003

Multiple ras effector pathways contribute to G(1) cell cycle progression

scientific article published on July 1999

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

scientific article

Navigating gene expression using microarrays--a technology review

scientific article

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

scientific journal article

New exchange, new target

scientific article published in Nature

Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta

scientific article published on 12 May 2009

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

scientific article published on 5 December 2017

Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway

scientific article published on August 2002

Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer

scientific article published on September 2015

PI 3-kinase, Akt and cell survival

scientific article published on April 2004

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

scientific article published on 25 July 2010

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

scientific article published on 14 May 2013

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

scientific article published on 28 February 2011

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

scientific article

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

scientific article published on March 2009

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

scientific article published in September 2005

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

scientific article published on September 1997

Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.

scientific article published on 26 July 2018

Phosphatidylinositol 3' kinase: one of the effectors of Ras.

scientific article published on February 1996

Phosphatidylinositol-3-OH kinase as a direct target of Ras

scientific article (publication date: 18 August 1994)

Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms

scientific article published on 14 June 2006

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

scientific article published on July 1998

Plugging the GAPs

scientific article published on 01 December 1991

Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

scientific article published on February 2006

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells

scientific article

Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

scientific article

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

scientific article published on April 1998

Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor

scientific article published on April 1989

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial-Mesenchymal Transition

scientific article published on 19 March 2021

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

scientific article published in January 1997

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

scientific article published on 27 June 2019

RAS Interaction with PI3K: More Than Just Another Effector Pathway

scientific article

RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?

scientific article

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

scientific article

RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.

scientific article

RAS mutation status and bortezomib therapy for relapsed multiple myeloma.

scientific article published on 12 January 2015

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

scientific article

RAS's cloak of invincibility slips at last?

scientific article published on 01 January 2014

RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

scientific article

RNA interference

scientific article published on May 2004

RNA interference libraries prove their worth in hunt for tumor suppressor genes

scientific article published in June 2005

RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy?

scientific article

RNA interference-based functional genomics in cancer research--an introduction

scientific article published in November 2004

Rac and Rho in tune

scientific article published in Nature

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

scientific article

Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin

scientific article published on 5 June 2006

Ras activation of phosphatidylinositol 3-kinase and Akt.

scientific article published in January 2001

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

scientific article published on 14 January 2002

Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis

scientific article published on 31 August 2007

Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.

scientific article

Ras regulation: putting back the GTP

scientific article

Ras signalling and apoptosis ⬇️

scientific article published on February 1, 1998

Regulating 56 kinase

scientific article published in Nature

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells

scientific article

Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways

scientific article

Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins

scientific article

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.

scientific article published on 26 September 2013

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

scientific article

Regulatory mechanisms for ras proteins

scientific article published on March 1, 1992

Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer

scientific article

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

scientific article

Requirement of multiple SH3 domains of Nck for ligand binding

scientific article

Rictor is a novel target of p70 S6 kinase-1.

scientific article

Role of Bim in the survival pathway induced by Raf in epithelial cells

scientific article published on April 2004

Role of RAS in the regulation of PI 3-kinase

scientific article published on January 2010

Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor

scientific article published on December 1994

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

scientific article (publication date: 2 May 1997)

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor ⬇️

scientific article published on June 1999

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

scientific article published on July 1992

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

scientific article published on December 2003

Roles of cortactin in tumor pathogenesis

scientific article

SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity

scientific article published on 14 June 2019

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases

scientific article

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

scientific article published on 10 June 2019

SIGNAL TRANSDUCTION: Prelude to an Anniversary for the RAS Oncogene

scientific article

Signatures guide drug choice

scientific article published in Nature

SnapShot: Class I PI3K isoform signaling.

scientific article

SnapShot: Ras Signaling

Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

scientific article published on October 1998

Stimulation of p21 ras upon T-cell activation

scientific article published in Nature

Structural and functional features of a cell surface phosphoglycoprotein associated with tumorigenic phenotype in human fibroblast x HeLa cell hybrids.

scientific article published in February 1986

Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras

scientific article

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

scientific article published on February 1997

T lymphocyte activation signals

scientific article

Targeting RAF: trials and tribulations ⬇️

scientific article published on March 1, 2011

Targeting RAS and PI3K in lung cancer.

scientific article

Targeting RAS signalling pathways in cancer therapy

scientific article (publication date: 2003)

Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor

scientific article published on 31 October 2016

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

scientific article

The GRB2/Sem-5 adaptor protein

scientific article

The Grb2 binding domain of mSos1 is not required for downstream signal transduction

scientific article

The activation of phosphatidylinositol 3-kinase by Ras

scientific article

The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function

scientific article (publication date: 12 October 2000)

The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel

scientific article

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

scientific article published on 05 June 2018

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes ⬇️

scientific article published on April 15, 1992

The ins and outs of signalling

scientific article

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

scientific article

The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi

article

The ras superfamily of small GTP-binding proteins

scientific article published on December 1990

The regulation and function of p21ras in T cells

scientific article

The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth

article

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

scientific article

The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway

scientific article published on June 1999

The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies.

scientific article

The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component

scientific article published on 16 April 2004

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

scientific article

The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner

scientific article published in December 2000

The use of anti-synthetic peptide antibodies to study the v-erb B protein from chicken and rat cells transformed by avian erythroblastosis virus

scientific article

Trachealess--a new transcription factor target for PKB/Akt

scientific article published in December 2001

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

scientific article

Transfer of functional EGF receptors to an IL3-dependent cell line

scientific article published in November 1988

Translational responses to growth factors and stress

scientific article published on February 2009

Tumour-suppression function of KLF12 through regulation of anoikis.

scientific article published on 12 October 2015

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

scientific article

Unraveling the complexity of endocrine resistance in breast cancer by functional genomics

scientific article

Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis

scientific article published on 14 August 2006

Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells

scientific article published in November 2004

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

scientific article

Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

scientific article

Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur

scientific article published on 15 February 2008

WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer

scientific article published on 21 November 2020

WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer

scientific article published on 16 January 2007

YAP and p73: A Complex Affair

article

c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner

scientific article published in May 2003

p110δ, a novel phosphoinositide 3-kinase in leukocytes

scientific article

p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells

scientific article published on 01 May 1993

p21ras mediates control of IL-2 gene promoter function in T cell activation.

scientific article published on December 1992

p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect

scientific article

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