List of works - Ruth Luthi-Carter

A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase

scientific article

A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease

scientific article

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

scientific article

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

scientific article

An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer

scientific article

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

scientific article

Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

scientific article

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

scientific article published on 24 February 2009

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

scientific article published on April 2010

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

scientific article

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

scientific article published in December 2003

Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.

scientific article

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

scientific article

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models

scientific article published on 02 October 2015

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

scientific article

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease

scientific article

Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation

scientific article

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

scientific article published on 12 May 2010

Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease

scientific article

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

scientific article published on 12 July 2010

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

scientific article

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

scientific article published in August 2002

Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease

scientific article published in August 2010

Expression analysis of novel striatal-enriched genes in Huntington disease

scientific article

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease ⬇️

scientific article published on February 18, 2011

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

scientific article

Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease

scientific article

HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo

scientific article (publication date: 2013)

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

scientific article (publication date: November 2013)

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

scientific article

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice ⬇️

scientific article published on October 15, 2003

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons ⬇️

scientific article published on December 20, 2010

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

scientific article

Involvement of autophagy in hypoxic-excitotoxic neuronal death

scientific journal article

MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition

scientific article published on February 2013

MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms

scientific article

Modulation of nucleosome dynamics in Huntington's disease

scientific article

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

scientific article

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

scientific article

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

scientific article published on 18 December 2011

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

scientific article published on 17 March 2010

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

scientific article

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

scientific article published on 9 October 2011

Progress towards a vaccine for Huntington's disease

scientific article published in May 2003

Regional and cellular gene expression changes in human Huntington's disease brain

scientific article

Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington’s disease.

scientific article

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

scientific article

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

scientific article published on 9 July 2016

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation

scientific article

Sustained effects of nonallele-specific Huntingtin silencing

scientific article published on March 2009

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter ⬇️

scientific article published on September 22, 2011

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

scientific article

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

scientific article

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

scientific article

What have we learned from gene expression profiles in Huntington's disease? ⬇️

scientific article published on July 12, 2011

List of works by Ruth Luthi-Carter

A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase

A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease

Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease

Expression analysis of novel striatal-enriched genes in Huntington disease

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease ⬇️

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease

HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice ⬇️

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons ⬇️

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

Involvement of autophagy in hypoxic-excitotoxic neuronal death

MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition

MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms

Modulation of nucleosome dynamics in Huntington's disease

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Progress towards a vaccine for Huntington's disease

Regional and cellular gene expression changes in human Huntington's disease brain

Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington’s disease.

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation

Sustained effects of nonallele-specific Huntingtin silencing

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter ⬇️

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

What have we learned from gene expression profiles in Huntington's disease? ⬇️