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List of works by Ryota Hashimoto

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.

scientific article published on 20 February 2014

A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls

scientific article published in March 2010

A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia

scientific article

A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes.

scientific article published on 3 August 2011

A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder

scientific article published on 19 August 2007

A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects.

scientific article

A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait

scientific article published on 24 February 2012

A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population

scientific article published on 17 February 2012

A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

scientific article published on 23 April 2010

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk

scientific article published on 22 July 2020

Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions

scientific article

Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging.

scientific article published on January 2009

Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice.

scientific article

An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population

scientific article published on 01 August 2013

An integrated eye movement score as a neurophysiological marker of schizophrenia

scientific article published in November 2014

Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening

scientific article published on 13 March 2012

Antipsychotic medication and cognitive function in schizophrenia.

scientific article published on 21 June 2006

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

scientific article published on 19 June 2013

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

scientific article published on 16 March 2020

Association study between the pericentrin (PCNT) gene and schizophrenia.

scientific article published on 24 November 2009

Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study

scientific article published on 23 February 2009

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

scientific article

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

scientific article

Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.

scientific article published on 13 June 2008

Brain morphological and functional features in cognitive subgroups of schizophrenia

scientific article published on 27 December 2019

Casein kinase II is responsible for phosphorylation of NF-L at Ser-473.

scientific article

Common genetic variants influence human subcortical brain structures

scientific article

Common variants at 1p36 are associated with superior frontal gyrus volume

scientific article

Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients

scientific article

Convergence of placenta biology and genetic risk for schizophrenia

scientific article published on 28 May 2018

Correlated alterations in serotonergic and dopaminergic modulations at the hippocampal mossy fiber synapse in mice lacking dysbindin.

scientific article published on 23 March 2011

DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain

scientific article published on 14 April 2015

Decreased α event-related synchronization in the left posterior temporal cortex in schizophrenia: a magnetoencephalography-beamformer study.

scientific article published on 27 July 2011

Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence

scientific article published on 18 November 2013

Development of individual fitness score for conformity of prescriptions to the “Guidelines For Pharmacological Therapy of Schizophrenia”

scientific article published in 2022

Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multisite study

scientific article published on 04 November 2019

Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms

scientific article published on 01 October 2008

Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease

scientific article

Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry.

scientific article published in December 2012

Domain- and Site-Specific Phosphorylation of Bovine NF-L by Rho-Associated Kinase ⬇️

scientific article published on April 17, 1998

Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity.

scientific article published on 20 April 2008

Duplication of the NPHP1 gene in patients with autism spectrum disorder and normal intellectual ability: a case series

scientific article published on 6 August 2014

Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers

scientific article published on 31 January 2008

Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization

scientific journal article

Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain

scientific article

Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia

scientific article published on 21 April 2011

Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus.

scientific article published on 6 February 2006

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

scientific article

Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia

scientific article published on 12 April 2013

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia

scientific journal article

Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A.

scientific article published on 23 September 2012

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia ⬇️

scientific article published on March 1, 2004

Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia.

scientific article published on 28 March 2014

Eye-movement characteristics of schizophrenia and their association with cortical thickness

scientific article published on 13 June 2019

Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study

scientific article published on 26 February 2010

Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample

scientific article published on 20 February 2008

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells. ⬇️

scientific article published on 19 September 2017

Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene

scientific article

Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis

scientific article published on 27 March 2012

Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia.

scientific article published on 26 February 2014

Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder

scientific article

Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

scientific article published on 11 February 2010

Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume.

scientific article published on 4 June 2014

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

scientific article published on 21 January 2016

Genome-wide Association Analysis of Eye Movement Dysfunction in Schizophrenia

scientific article published in Scientific Reports

Genome-wide association study of atypical psychosis.

scientific article published in October 2013

Genome-wide association study of cognitive decline in schizophrenia

scientific article

Genome-wide association study of schizophrenia in a Japanese population

scientific article published on 15 September 2010

Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes

scientific article published on 22 December 2014

High dopamine turnover in the brains of Sandy mice.

scientific article

High-resolution copy number variation analysis of schizophrenia in Japan.

scientific article

How to diagnose the 22q11.2 deletion syndrome in patients with schizophrenia: a case report

scientific article published on 24 September 2013

Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin.

scientific article

IQ decline and memory impairment in Japanese patients with chronic schizophrenia.

scientific article published on 28 January 2008

Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches

scientific article published on 22 October 2009

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling

scientific article published on 7 September 2006

Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene

scientific article published on 30 March 2011

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

scientific article

Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.

scientific article published on 26 August 2008

Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: a two-channel near-infrared spectroscopy study.

scientific article published on 20 January 2009

Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test.

scientific article published on 29 April 2008

Influence of the NRGN gene on intellectual ability in schizophrenia.

scientific article published in August 2013

KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.

scientific article published on 25 September 2010

Laughter and humor as complementary and alternative medicines for dementia patients.

scientific article

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

scientific article

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

scientific article

Lithium stimulates progenitor proliferation in cultured brain neurons.

scientific article published in January 2003

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity

scientific article

Localized phosphorylation of vimentin by rho-kinase in neuroblastoma N2a cells

scientific article published on 01 October 2000

Longitudinal characteristics of insight and clinical factors in patients with schizophrenia

scientific article published in 2023

Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture.

scientific article

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

scientific article

Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population

scientific article published on 15 August 2012

Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia

scientific article published on 07 August 2008

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

scientific article published on 30 November 2010

Neurocognitive features, personality traits, and social function in patients with schizophrenia with a history of violence

scientific article published in 2022

Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA

scientific article published on 05 June 2020

Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia.

scientific article

Neuroprotective effects of lithium in cultured cells and animal models of diseases.

scientific article

Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

scientific article published on 17 July 2024

No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study

scientific article published on 23 February 2010

No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population

scientific article published on 01 October 2008

No association between the Bcl2-interacting killer (BIK) gene and schizophrenia

scientific article published on 24 July 2009

No association between the NDE1 gene and schizophrenia in the Japanese population

scientific article published on 01 February 2008

No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis

scientific article

No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study.

scientific article published in September 2004

No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia

scientific article published on 09 April 2012

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Opioid therapy for knee osteoarthritis and postoperative persistent pain after knee arthroplasty

scientific article published on 13 August 2014

Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.

scientific article published on 17 March 2014

Personality traits and schizophrenia: evidence from a case–control study and meta-analysis ⬇️

scientific article published on March 5, 2012

Pharmacogenomics of antipsychotics efficacy for schizophrenia ⬇️

scientific article published on February 1, 2011

Phosphorylation of neurofilament-L during LTD

scientific article published on 01 August 2000

Plasma levels of matrix metalloproteinase-9 (MMP-9) are associated with cognitive performance in patients with schizophrenia

scientific article published on 05 February 2020

Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders.

scientific article

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

scientific article published on 13 November 2009

Prescription patterns in patients with schizophrenia in Japan: First-quality indicator data from the survey of "Effectiveness of Guidelines for Dissemination and Education in psychiatric treatment (EGUIDE)" project

scientific article published on 30 June 2020

Pulse exposure of cultured rat neurons to aluminum-maltol affected the axonal transport system.

scientific article published in August 1998

RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.

scientific article published on 21 August 2014

Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse

scientific article

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

scientific article

Relation between remission status and attention in patients with schizophrenia

scientific article published on 8 December 2013

Relationship between autistic traits and social functioning in healthy individuals

scientific article published in 2022

Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects

scientific article published on 10 March 2010

Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects.

scientific article published on 29 October 2011

Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia

scientific article published on 08 September 2013

Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility

scientific article published in November 2010

Role of subcortical structures on cognitive and social function in schizophrenia

scientific article published on 19 January 2018

Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia

scientific article

Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study.

scientific article published on 5 March 2016

Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase II in the apical dendrites during long-term potentiation

scientific article published on 01 July 2000

Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications

scientific article published on 14 March 2015

Subcortical association with memory performance in schizophrenia: a structural magnetic resonance imaging study.

scientific article published on 10 January 2018

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

scientific article

Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

scientific article published in 2023

Tau protein is a potential biological marker for normal pressure hydrocephalus

scientific article published on 01 April 2000

The AKT1 gene is associated with attention and brain morphology in schizophrenia.

scientific article

The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment

scientific article

The KCNH2 gene is associated with neurocognition and the risk of schizophrenia.

scientific article published on 22 September 2011

The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex

scientific article published on 28 April 2011

The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.

scientific article

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis

scientific article published on 3 January 2010

The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis.

scientific article published in January 2010

The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.

scientific article

The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia

scientific article published on 25 October 2013

The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits

scientific article (publication date: 2012)

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.

scientific article published in September 2010

The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia.

scientific article published on 22 February 2013

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.

scientific article published on 04 February 2014

Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression

scientific article

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.

scientific article published on May 2010

Unmet need for major depressive disorders - Findings from the 'Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)' project: A nationwide dissemination, education, and evaluation study

scientific article published on 03 September 2020

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition ⬇️

scientific article published on May 8, 2003

Variants of the RELA gene are associated with schizophrenia and their startle responses

scientific article

White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals

scientific article published on 29 November 2019

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.

scientific article published on 19 November 2015

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.

scientific article

Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography.

scientific article published on 9 December 2009

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization

scientific article published in 2022

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